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  • 1
    Online Resource
    Wiesbaden : Springer Gabler
    Keywords: Management ; Wirtschaft ; Wirtschaftsethik ; Individualismus ; Economics ; Ethics ; Philosophy (General) ; Economics / Methodology ; Economics/ Management Science ; Wirtschaftsethik ; Individualismus
    Type of Medium: Online Resource
    Pages: Online-Ressource (XV, 205 S, online resource)
    ISBN: 9783658035860 , 9783658035853
    DDC: 330.1
    RVK:
    Language: German
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  • 2
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Keywords: Science / Philosophy ; Philosophy of Science
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (VII, 268 S. 3 Abb., 2 Abb. in Farbe)
    ISBN: 9783658140243
    DDC: 501
    Language: German
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  • 3
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Keywords: Science / Philosophy ; Philosophy of Science
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (IX, 244 S. 1 Abb)
    ISBN: 9783658151249
    DDC: 501
    Language: German
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  • 4
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden
    Keywords: Science / Philosophy ; Philosophy of Science
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (IX, 327 S.)
    ISBN: 9783658140434
    DDC: 501
    Language: German
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  • 5
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 62 (1996), S. 172-180 
    ISSN: 0730-2312
    Keywords: chromatin structure ; nuclear matrix ; transcriptional activation ; replication ; recombination ; differentiation ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The tumor suppressor p53 is a multifunctional protein whose main duty is to preserve the integrety of the genome. This function of wild-type p53 as “guardian of the genome” is achieved at different levels, as a cell cycle checkpoint protein, halting the cell cycle upon DNA damage, and via a direct involvement in processes of DNA repair. Alternatively, p53 can induce apoptosis. Mutations in the p53 gene occur in about 50% of all human tumors and eliminate the tumor suppressor functions of p53. However, many mutant p53 proteins have not simply lost tumor suppressor functions but have gained oncogenic properties which contribute to the progression of tumor cells to a more malignant phenotype. The molecular basis for this gain of function of mutant p53 is still unknown. However, mutant (mut) p53 specifically binds to nuclear matrix attachment region (MAR) DNA elements. MAR elements constitute important higher order regulatory elements of chromatin structure and function. By binding to these elements, mut p53 could modulate important cellular processes, like gene expression, replication, and recombination, resulting in phenotypic alterations of the tumor cells. Mut p53 thus could be the first representative of a new class of oncogenes, which exert their functions via long-range alterations or perturbation of chromatin structure and function. © 1996 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 69 (1998), S. 260-270 
    ISSN: 0730-2312
    Keywords: oncogenic function of mutant p53 ; MAR-DNA elements ; MAR-DNA binding by mutant p53 ; MethA p53 ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We recently reported that murine MethA mutant but not wild-type p53 specifically binds to MAR-DNA elements (MARs) with high affinity. Here we show that this DNA binding activity is exerted not only by MethA mutant p53 but also by other murine mutant p53 proteins isolated from the transformed murine BALB/c cell lines 3T3tx and T3T3 and differing in their conformational status. High affinity MAR-DNA binding was not restricted to the XbaI-IgE-MAR-DNA fragment from the murine immunoglobulin heavy chain gene enhancer locus [Cockerill et al. (1987): J Biol Chem 262:5394-5397] used in previous studies, as MethA p53 also specifically interacted with other A/T-rich bona fide MARs. Not only murine but also human mutant p53 proteins carrying the mutational hot spot amino acid exchanges 175Arg→His, 273Arg→Pro, or 273Arg→His bound to the XbaI-IgE-MAR-DNA fragment. We therefore conclude that high affinity MAR-DNA binding is a property common to a variety of mutant p53 proteins. J. Cell. Biochem. 69:260-270, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    ISSN: 0091-7419
    Keywords: cell viability ; nucleotide sugar hydrolysis ; intracelluar glycosylation ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The presence of glycosyltransferases on surfaces of mammalian cells has been reported by many investigators and a biological role for these enzymes in cell adhesion and cell recognition has been postulated. Critical analysis, however, showed 2 major complications regarding the assay for cell surface glycosyltransferases: (1) hydrolysis of the nucleotide sugar by cell surface enzymes and subsequent intracellular use of the free sugar and (2) loss of cell integrity if trypsinized or EDTA-treated cells were used in suspension asays. We have assayed intact, viable cells in monolayer for cell surface glycosyltransferases using conditions under which intracellular utilization of free sugars generated by hydrolysis of the nucleotide sugar was prevented. Our data demonstrate that the presence of galactosyltransferases on the surface of a variety of cells, including established (normal and virally transformed) as well as nonestablished cells, is unlikely. No evidence for the existence of cell surface fucosyl-and sialyltransferases could be obtained, but our data do not exclude the possibility that low levels of these enzymes are present.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 277 (1979), S. 322-324 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig* l Immunoprecipitation of SV40 specific proteins from NP40 cyto-plasmic extracts of Ad2*"ND2-infected HeLa cells using hamster SV40 tumour serum or rabbit anti-T serum. HeLa cells grown in suspension were infected with Ad2+ND2 and labelled from 40-41 h post-infection with 35S-methionine ...
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