1
Choedon, Tenzin ; Mathan, Ganeshan ; Kumar, Vijay
Springer Science and Business Media LLC
BMC Complementary and Alternative Medicine Vol. 15, No. 1 ( 2015-12)
Springer Science and Business Media LLC
BMC Complementary and Alternative Medicine Vol. 15, No. 1 ( 2015-12)
Staff View
| In: |
BMC Complementary and Alternative Medicine, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2015-12)
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| Type of Medium: |
Online Resource
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| ISSN: |
1472-6882
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
Springer Science and Business Media LLC
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| Publication Date: |
2015
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| detail.hit.zdb_id: |
3037610-5
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2
Wylie, C. C. ; Brown, Derek ; Godsave, S. F. ; Quarmby, J. ; Heasman, Janet
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 1-15
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 1-15
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 1-15
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| Abstract: |
Much is known about determinative events in early amphibian embryos, perhaps more than any other animal group. However, as yet, little attention has been focused on the cytoarchitecture of the oocyte, and the way in which this could regulate asymmetries in the egg, which in turn could lead to developmentally important interactions. The changing cytoarchitecture of the Xenopus oocyte is described with the emphasis on the following:- firstly the polarity; the oocyte is not radially symmetrical at early stages of oogenesis, but shows marked polarity. Secondly, several cytoskeletal elements change their distribution during oogenesis, and again during maturation to form a fertilizable egg. Thirdly, monoclonal antibody methods show that the oocyte develops several asymmetries which are retained in the egg and early embryo, and may be lineage related.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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3
Boucaut, J. C. ; Darribere, T. ; De Li, Shi ; Boulekbache, H. ; Yamada, K. M. ; Thiery, J. P.
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 211-227
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 211-227
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 211-227
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| Abstract: |
In amphibian embryos, fibronectin (FN) assembles as a fibrillar network on the roof of the blastocoel cavity, preceding mesodermal cell migration. Local inversion of the ectoderm to produce a site where no FN is available prevents mesodermal cell migration. Microinjection of monovalent antibodies to FN arrests gastrulation. A complete inhibition of mesodermal cell migration is obtained after microinjection of a synthetic peptide containing the cell binding site sequence of FN. Prevention of interactions between receptors and FN appears to be the primary cause for blockage of gastrulation.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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4
Hausen, Peter ; Wang, Ya Hui ; Dreyer, Christine ; Stick, Reimer ; Müller, Ursula ; Riebesell, Metta
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 17-34
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 17-34
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 17-34
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| Abstract: |
The internal structure of the Xenopus oocyte is reorganized during the hormone-induced egg maturation. A cytological survey of the intracellular movements and changes is described. The behaviour of the nuclear lamina protein and of three nucleoplasmic proteins during these processes was studied by immunocytology. The proteins are finally deposited in the egg in different patterns brought about by their differential behaviour during the process of maturation.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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5
Satoh, Noriyuki
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 257-270
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 257-270
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 257-270
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|---|---|
| Abstract: |
Recent studies on temporal control of early amphibian development are reviewed. It is becoming clear that the development of an embryo is not timed by a single clock set in motion at fertilization, instead each developmental event seems to be timed by its own clock-like mechanism. The timing of developmental events is rigidly determined within embryonic cells, and usually can not be altered experimentally. One exception, however, is the timing of midblastula transition in amphibian embryos; recent studies have shown that its timing is regulated by the nucleocytoplasmic ratio. Several developmental events, particularly those associated with transcriptional activities, require DNA replication prior to their occurrence, suggesting an intimate relationship between DNA replication cycles and their onset. On the other hand, there are many other developmental events where timing is not controlled by the number of cell divisions, DNA replication cycles, or the nucleocytoplasmic ratio. Cytoplasmic machinery with autonomous oscillatory properties is thought to be involved in the timing of these events.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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6
Grunz, Horst
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 349-364
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 349-364
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 349-364
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|---|---|
| Abstract: |
Neural induction and differentiation has been studied using Concanavalin A, cyclic AMP, tunicamycin and calcium ionophore A 23187. Competent ectoderm of Xenopus laevis treated with Concanavalin A differentiates into neural (archencephalic) structures. Binding studies with gold-labelled ConA indicate that the superficial ectodermal layer contains fewer ConA-sensitive sites (α-D-mannoside and α-D-glucoside residues of glycoproteins) than the inner ectodermal layer. The small number of ConA-sensitive sites can be correlated with the fact that the isolated superficial ectoderm layer, in contrast to the inner layer, does not differentiate into neural structures. The gold-ConA particles bound to inner ectoderm are quickly (within 30 minutes) internalized, presumably by receptor-mediated endocytosis. However, endocytosis is not a prerequisite for neural induction. On the contrary ConA apparently must be bound to the plasma membrane for a certain period to initiate neural induction. The rapid internalization of ConA could explain why neural inductions are evoked only if ectoderm is incubated in ConA-containing medium for longer than 30 minutes. On the other hand cyclic AMP or calcium ionophore A 23187 does not elicit neural inductions. On the contrary calcium ionophore A 23187 apparently, inhibits neural and mesodermal differentiation. This effect could be correlated with an increase of intracellular calcium level of the ectodermal target cells, which could influence the permeability of gap junctions resulting in a loss of cell communication, followed by a change of differentiation and pattern formation.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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7
Taylor, Mark A. ; Robinson, Kenneth R. ; Smith, L. Dennis
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 35-51
The Company of Biologists
Development Vol. 89, No. Supplement ( 1985-11-01), p. 35-51
Staff View
| In: |
Development, The Company of Biologists, Vol. 89, No. Supplement ( 1985-11-01), p. 35-51
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|---|---|
| Abstract: |
The induction of amphibian oocyte maturation with progesterone as well as the activation of sea urchin eggs at the time of fertilization result in increased protein synthesis. The increase in both cases involves the recruitment of maternal mRNA onto polysomes. Further, it has been reported that sea urchin eggs, like full-grown Xenopus oocytes, contain no spare translational capacity based on the observation that injected heterologous mRNA is translated only at the expense of endogenous messages. The nature of the limiting component defined by such experiments is not known, but two factors which have been proposed to play a role in regulating protein synthesis are ribosomal protein S6 phosphorylation and intracellular pH. In the current paper, we review the literature and present new evidence on the roles intracellular pH and S6 phosphorylation have in regulating protein synthesis in Xenopus oocytes. We report that pHi does not increase between stage 3 and stage 6, yet the protein synthetic rate increases at least eight fold during the same period. Hence, we conclude that increasing pHi is not a prerequisite for increasing protein synthesis. Moreover, we present three arguments against increased ribosomal protein S6 phosphorylation being sufficient or necessary for increased protein synthesis in Xenopus oocytes. First, the level of S6 phosphorylation does not increase between stages 4 and 6, a period exhibiting a two to three fold increase in protein synthesis. Second, the injection of globin mRNA into stage-4 oocytes increases total protein synthesis two to three fold, but has no effect on S6 phosphorylation. Third, when the injection of globin mRNA into stage-4 oocytes is followed by an injection of MPF, a dramatic increase in S6 phosphorylation is seen, but total protein synthesis is not further stimulated.
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| Type of Medium: |
Online Resource
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| ISSN: |
1477-9129, 0950-1991
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| URL: | |
| DOI: | |
| Language: |
English
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| Publisher: |
The Company of Biologists
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| Publication Date: |
1985
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| detail.hit.zdb_id: |
2007916-3
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| SSG: |
12
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8
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2016-09-26)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2016
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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9
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2017-05-11)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2017
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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10
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2017-06-01)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2017
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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11
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2017-08-08)
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| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2017
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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12
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2017-08-29)
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| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2017
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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13
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2016-08-25)
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| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2016
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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14
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2016-09-29)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2016
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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15
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2016-11-23)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2016
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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16
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2016-11-22)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2016
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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17
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2020-03-25)
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| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2020
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2017-03-15)
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| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2017
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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19
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2019-05-16)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2019
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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20
Staff View
| In: |
Science, American Association for the Advancement of Science (AAAS), ( 2019-12-05)
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|---|---|
| Type of Medium: |
Online Resource
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| ISSN: |
0036-8075, 1095-9203
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| URL: | |
| DOI: | |
| RVK: |
TA 1000
WA 15000
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| Language: |
facet.language.__
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| Publisher: |
American Association for the Advancement of Science (AAAS)
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| Publication Date: |
2019
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| detail.hit.zdb_id: |
128410-1
2066996-3
2060783-0
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| SSG: |
11
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