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  • 1
    Book
    Book
    New York, NY : Crown Business
    Keywords: Unternehmen ; Entrepreneurship ; Microfabrication ; Micromachining ; Business enterprises
    Type of Medium: Book
    Pages: VIII, 257 S. , Ill., graph. Darst.
    Edition: 1. ed.
    ISBN: 9780307720955 , 9780307720979
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    Language: English
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  • 2
    Book
    Book
    München : Hanser
    Keywords: German language edition - Nonfiction ; Nischen- Marketing ; Internet marketing ; Market segmentation ; Marketing Technological innovations ; Nischen- Marketing
    Type of Medium: Book
    Pages: 287 S. , graph. Darst. , 24 cm
    ISBN: 3446409904
    Uniform Title: The long tail
    DDC: 658.802
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    Language: German
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  • 3
    Book
    Book
    Boston : Houghton Mifflin Harcourt
    Keywords: Public speaking Handbooks, manuals, etc
    Type of Medium: Book
    Pages: xv, 269 pages , 22 cm
    ISBN: 9780544634497
    DDC: 808.5/1
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    Language: English
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  • 4
    Book
    Book
    München : Hanser
    Keywords: Entrepreneurship ; Internet der Dinge ; Produktinnovation ; Eigenproduktion ; Einzelfertigung ; Produktionsprozess ; Internet ; Wissenschaftliche Revolution ; Eigenproduktion ; Entrepreneurship ; Internet der Dinge ; Produktinnovation ; Eigenproduktion ; Einzelfertigung ; Produktionsprozess ; Internet ; Wissenschaftliche Revolution ; Eigenproduktion
    Type of Medium: Book
    Pages: 285 S. , Ill. , 22 cm
    ISBN: 9783446434820 , 3446434828
    Uniform Title: Makers : the new industrial revolution
    DDC: 338.04
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    Language: German
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 72 (1999), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Elevated expression of glial fibrillary acidic protein (GFAP) is associated with astrocyte activation during responses to injury in the CNS. Because transforming growth factor-β1 (TGF-β1) and interleukin-1β (IL-1β) are released during neural responses to injury and because these cytokines also modulate GFAP mRNA levels, it is of interest to define their role in GFAP transcription. The increases of GFAP mRNA in response to TGF-β1 and decreases in response to IL-1β were shown to be transcriptionally mediated in rat astrocytes transfected with a luciferase-reporter construct containing 1.9 kb of 5′-upstream rat genomic DNA. Constructs containing sequential deletions of the rat GFAP 5′-upstream promoter identified a short region proximal to the transcription start (-106 to -53 bp) that provides full responses to TGF-β1 and IL-1β. This region contains an unusual sequence motif with overlapping nuclear factor-1 (NF-1)- and nuclear factor-κB (NF-κB)-like binding sites and homology to known TGF-β response elements. Mutagenesis (3-bp exchanges) in -70 to -68 bp blocked the induction of GFAP by TGF-β1 and the repression by IL-1β. Gel shift experiments showed that the DNA segment -85 to -63 bp was bound by a factor(s) in nuclear extracts from astrocytes. The concentrations of these DNA binding factors were increased by treatment of astrocytes with TGF-β1 and decreased by IL-1β. Binding of these nuclear factors was blocked by mutation of -70 to -68 bp. Despite homology to NF-1 or NF-κB binding sites in the GFAP promoter at segment -79 to -67 bp, anti-NF-κB or anti-NF-1 antibodies did not further retard the gel shift of the nuclear factors/DNA complex. Moreover, astrocytic nuclear proteins do not compete for the specific binding to NF-1 consensus sequence. Thus, nuclear factors from astrocytes that bind to the -85- to -63-bp promoter segment might be only distantly related to NF-1 or NF-κB. These findings are pertinent to the use of GFAP promoter constructs in transgenic animals, because cis-acting elements in the GFAP promoter are sensitive to cytokines that may be elaborated in response to expression of transgene products.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 23 (1990), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 42 (2000), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dimethyl sulfoxide (DMSO), depending upon the concentration and mode of application to the skin, can induce either a non-immunological immediate contact urticaria or an irritant reaction. The dermal cellular infiltrate after open application of varying concentrations of DMSO has been studied in an experimental guinea pig model. The composition of the dermal cellular infiltrate showed a spectrum dependent on the concentration and number of applications of DMSO. The immediate reaction infiltrate 3 h after application of 100% DMSO consisted of 50% granulocytes, basophils being predominant. On the other hand, 12% DMSO applied 3 × daily for 3 days (cumulative insult) caused histologically a cellular reaction in which 80% of the infiltrate consisted of mononuclear cells. The present findings are compared to the microscopic findings in 3 other cutaneous reactions previously studied in this animal model, namely, the Type I immediate hypersensitivity reaction, the Type IV delayed hypersensitivity reaction, and the irritant reaction. Differing cellular infiltrate patterns are discernible at the same time points. The study illustrates the spectrum of inflammatory reactions seen in the skin and provides background information for future clinical studies, for instance, on the role of the basophil granulocyte in immediate contact reactions.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 18-19 (June 2007), p. 277-285 
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Well engineers face ever increasing technical challenge of drilling in complexenvironments and the use of Managed Pressure Drilling(MPD) techniques to control annularpressure for improved drilling performance in the oil industry has growing interest[1-4].Understanding hole cleaning and controlling annular pressure in this complex environment isbecoming increasingly important for a range of applications. The Virtual Well Engineer[VWE] hasbeen identified as the engineering tool to address these issues in order to deliver a successful MPDoperation. The VWE is the product name for a suite of well planning , monitoring and simulationpackages with focus on Managed Pressure Drilling includng underbalanced drilling that allows thewell engineering team to interact with virtual reality. Recent works initiated by the WellEngineering Group at The Robert Gordon University have extended the knowledge of multiphaseflow in a drilling annulus through the tracking of the transient multiphase flow pattern prevailingand effects on hole cleaning , the pressure profiles and identification of hot spots in concentric andeccentric annular sections . The mechanistic models developed at RGU form the core algorithmsfor the VWE. This paper presents the architecture and functional capabilities of the VWE –HydraulicsDTS™ , which is used in simulating well operations
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 17 (2000), S. 141-147 
    ISSN: 1573-904X
    Keywords: microdialysis ; methyl nicotinate ; LDPI ; percutaneous penetration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The aim was to assess the feasibility of cutaneousmicrodialysis as a method to study percutaneous penetration of methyl nicotinatethrough human skin in vitro and in vivo. Methods. Microdialysis was applied in vitro in excised human skin,in isolated dermis, in reconstructed human epidermis and in vivo inthe volar forearm skin of volunteers using methyl nicotinate (MN) asa model compound. After topical application of MN, aliquots of theperfusate were collected and analyzed for the presence of MNspectrophotometrically and by HPLC. In vivo, visual scoring and laser Dopplerperfusion imaging (LDPI) were used to monitor the effects on skinblood flow. Results. In vitro, MN was detected in the dialysate after a 1 minexposure of excised skin to concentrations as low as 25 mM. Higherconcentrations up to 500 mM showed increased levels. Prolongationof the application time to 60 min resulted in increased levels of MNin the perfusate as the duration of application increased. Reconstructedepidermis and isolated dermis showed an almost 2- and 20-fold higherpenetration compared to excised skin, respectively. In vivo, LDPImeasurements showed a rapid increase in skin blood flow afterapplication of 25 to 100 mM MN for 1 min. MN was only detectable inthe microdialysate after application of 100 mM for 10 min (two ofthree subjects). Conclusions. Cutaneous microdialysis may be a tool for comparativestudies linking responses in human skin in vivo to in vitro data usingthe same technique and endpoint.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Skin research and technology 5 (1999), S. 0 
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Confident diagnosis of photosensitivity in patients with light dermatoses requires skin exposure to well determined ultraviolet (UV) light doses, most often from a solar simulator. The traditional test procedure results in a rough classification of skin sensitivity based on the minimal erythema dose (MED) found for each patient. The limited number of constant irradiance doses used during phototesting decreases the precision of the MED value. In the present study we aimed at developing the technical system for the determination of MED by using a single, centrifugally attenuating, UVB provocation.Methods: A divergent UV beam was achieved with the help of an optic lens. To investigate the irradiance profile, an irradiance acquisition system was built that produced three-dimensional intensity maps. In addition, a laser Doppler perfusion imaging (LDPI) system was introduced in the evaluation of the skin response along with visual readings of the same exposed areas, in order to add a quantitative aspect to the assessment of erythema. The procedure was used on one test subject.Results: The divergent UV beam showed the desired profile. With the current setup 20 different UV-dose levels could be discriminated. Relevant UV-dose levels were determined and tested on a subject, which in practice gave results in the form of visual assessment as well as LDPI-images. The visual or LDPI diameter gave the MED. Within the skin reaction, irradiance and the laser Doppler values could be compared mm for mm.Conclusions: A more accurate MED determination with a single UV exposure seems to be feasible by using the proposed method. Though further investigation is required, the technique appears to offer new possibilities for the association of dose to response. In addition LDPI is possibly a useful complement to the visual readings of the skin responses, since the method gives a quantification of the grade of erythema, as opposed to visual (+, ++, +++) readings that are subjective and at best semiquantitative.
    Type of Medium: Electronic Resource
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