WILBERT

Wildauer Bücher+E-Medien Recherche-Tool

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Wiesbaden : Springer
    Person(s): Bock, Michael
    Keywords: Internet ; Kommunikation ; Meinungsfreiheit ; Verfassungsrecht ; Deutschland ; Law ; Constitutional law ; Human rights ; International law ; Intellectual property ; Law ; Human Rights ; Constitutional Law ; International IT and Media Law, Intellectual Property Law ; Hochschulschrift ; Internet ; Kommunikation ; Meinungsfreiheit ; Verfassungsrecht ; Deutschland 03.10.1990-
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XX, 327 Seiten)
    ISBN: 9783658212025
    DDC: 341.48
    Language: German
    Dissertation note: Dissertation Leibniz-Universität Hannover 2018
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Book
    Book
    Jülich : Forschungszentrum, Zentralbibliothek
    Part of " Berichte des Forschungszentrums Jülich"
    Person(s): Bock, Michael
    Keywords: Anaerobe Bakterien ; Biologische Abwasserreinigung ; Chorbenzoesäuren ; Chorbenzoesäuren ; Anaerobe Bakterien ; Biologische Abwasserreinigung
    Type of Medium: Book
    Pages: 113 S. , Ill., graph. Darst.
    Series Statement: Berichte des Forschungszentrums Jülich 2616
    Language: German
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Wiesbaden, Germany : : Springer,
    Person(s): Bock, Michael,
    Keywords: Communication Social aspects. ; Online social networks. ; Information technology Social aspects. ; Information society. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (344 pages).
    ISBN: 9783658212025 (e-book)
    Series Statement: Research (Wiesbaden, Germany)
    DDC: 302.2
    Parallel Title: Print version: Bock, Michael. Übertragbarkeit der Kommunikationsfreiheiten des Artikel 5 GG auf das Internet.
    Language: German
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 48 (1997), S. 175-180 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Dermatomykosen ; Dermatophyten ; Polymerase-Kettenreaktion ; 18S rRNA ; Key words Dermatomycoses ; Dermatophytes ; Polymerase chain reaction ; 18S rRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A polymerase chain reaction (PCR) assay for the detection of dermatophytes was established. The primers ”TR1” and ”TR2” amplify a 581 bp fragment within the gene coding for the small ribosomal subunit (18S rRNA) of fungi. PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds. Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans. Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds. The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals. To evaluate the clinical relevance of the PCR assay, 69 routinely collected skin and nail specimens were examined by PCR and culture. PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive. Sensitivity of PCR (92%) was higher than that of culture (73%). These results show that PCR has advantages over culture for the detection of dermatophytes.
    Notes: Zusammenfassung Ein Nachweissystem für Dermatophyten mittels Polymerase-Kettenreaktion (PCR) wurde entwickelt. Die Primer „TR1” und „TR2” flankieren eine 581 bp lange Sequenz innerhalb des Gens, das für die kleine ribosomale Untereinheit (18S rRNA) von Pilzen kodiert. Mittels PCR ließ sich die DNA von Isolaten der 7 häufigsten Dermatophyten amplifizieren, daneben die von einigen Hefe- und Schimmelpilzen. Durch Hybridisierung mit spezifischen Detektionsoligonukleotiden gelang die Identifizierung von Dermatophyten und Candida albicans. Die Restriktionsfragmentanalyse erlaubte die Abgrenzung der Dermatophyten gegenüber den Hefe- und Schimmelpilzen. Die Spezifität der PCR für Pilze wurde an menschlicher DNA aus 42 Dermis- und Epidermisproben sowie an ausgesuchter tierischer und pflanzlicher DNA überprüft. Um die klinische Relevanz des Verfahrens zu evaluieren, wurden 69 routinemäßig gewonnene Haut- und Nagelproben mit der PCR und der Kultur untersucht. Mit der PCR wurden in 35 und mit der Kultur in 28 der insgesamt 38 positiv bewerteten Patientenproben Dermatophyten nachgewiesen. Die Sensitivität der PCR (92%) war höher als die der Kultur (73%). Das Ergebnis dieser Untersuchung zeigt, daß die PCR Vorteile gegenüber der Kultur beim Nachweis von Dermatophyten hat.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 50 (1999), S. 398-405 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Melanom ; Molekularbiologie ; Mutationen ; Onkogene ; Tumorsuppressorgene ; Key words Melanoma ; Molecular biology ; Mutation ; Oncogene ; Tumor suppressor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The incidence of melanoma, the most aggressive tumor of the skin, is increasing worldwide. The genetic mechanisms responsible for the initiation and progression of melanoma are poorly understood. Mutations of p16 (CDKN2), p53, ras, neurofibromatosis type I gene (NF-1), bcl 2 and the retinoblastoma gene have been described, but none are common. Suggesting heterogeneous mechanisms of carcinogenesis. Both familial inheritance of potential tumor suppressor genes, e.g. p16, and differences in DNA-repair capacity contribute to the individual risk for melanoma. The most important carcinogen for melanoma seems to be UV exposition whose mutagenic effects can be demonstrated by molecular analysis of detected point mutations in relevant genes. The UV-induced DNA damage generates mutations which are capable of activating proto-oncogenes or inactivating tumor suppressor genes, demonstrating the molecular link between UV exposition, DNA damage, mutations and tumor initiation and/or progression. A stage-dependent model of melanoma carcinogenesis analogous to colorectal cancer remains to be established, despite the existence of morphologically and histopathologically well defined melanoma precursor lesions in the skin.
    Notes: Zusammenfassung Das maligne Melanom ist der bösartigste Tumor der Haut mit weltweit steigender Inzidenz. Über die genetischen Veränderungen, welche die Melanominitiation und -progression auslösen und in Gang halten, ist wenig bekannt. Mutationen von p16 (CDKN2), p53, ras, Neurofibromatose Typ I (NF-1), bcl 2 und dem Retinoblastom-Gen (Rb) wurden beschrieben, liegen jedoch sämtlich nur in relativ geringen Prävalenzen bezogen auf alle Melanomerkrankungen vor. Familiäre genetische Alterationen von potentiellen Tumorsuppressorgenen wie dem p16, aber auch interpersonelle Unterschiede in der Reparaturkapazität von UV- und anders bedingten DNA-Schädigungen tragen zum individuellen Melanomrisiko bei. Wichtigstes Karzinogen scheint die UV-Exposition zu sein, deren mutagener Effekt bis in die molekulare Analyse detektierter Punktmutationen entscheidender Gene verfolgt werden kann. Aktivieren UV-induzierte DNA-Schädigungen Protoonkogene oder inaktivieren sie Tumorsuppressorgene, ist die molekularbiologische Kausalkette zwischen UV-Exposition, DNA-Schädigung, Mutation und Tumorinitiation bzw. -progression geschlossen. Ein zum molekularen Mehrstufenkarzinogenesemodell für kolorektale Karzinome analoges stadienabhängiges Modell der Melanomprogression konnte bislang trotz der Existenz von morphologisch und histopathologisch gut abgrenzbaren Melanomvorläuferläsionen der Haut nicht etabliert werden.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 50 (1999), S. 250-256 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Serum-S-100-Protein ; Tumormarker ; Malignes Melanom ; Prognose ; Key words Serum S100 protein ; Tumor marker ; Malignant melanoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary S100 is an acidic-calcium-binding protein, composed as a heterodimer of two isomeric subunits α and β and was first described in cells of neuroendocrine origin. It plays an important role in various cellular processes such as cell differentiation and proliferation and interacts with the tumour suppressor gene p53. S100 is also present in melanoma cells and its immunhistochemical detection is widely used in the histopathological diagnosis of malignant melanoma. S100 has been detected in the serum of patients with malignant melanoma and many clinical studies have been performed to establish this protein as a tumor marker in different stages of the disease. The data suggest that S-100β-protein in serum of patients with malignant melanoma could be an independent prognostic marker and an additional clinical parameter for progression of metastatic disease and serological monitoring during systemic therapy. However there are patients in stage of lymph node- or systemic metastasis with negative S-100β-serum levels and no correlation to the course of disease. Our results confirm the findings for patients in stage III/IV. However, the percentage of S-100β-positive patients in stage III/IV is lower than reported in the literature, if repeatedly positive samples are excluded from statistical analysis. For monitoring in stage I and II it seems to be not helpful.
    Notes: Zusammenfassung S-100 ist ein saures, kalziumbindendes Protein, das als Heterodimer aus 2 isomeren Untereinheiten α und β besteht und erstmalig in Zellen neuroendokrinen Ursprungs beschrieben wurde. Es spielt eine Rolle bei verschiedenen zellulären Prozessen, wie z.B. der Zelldifferenzierung und der Proliferation und interagiert mit dem Tumorsuppressorprotein p53. S-100 ist ebenfalls in Melanomzellen vorhanden, und sein immunhistochemischer Nachweis ist bei der histopathologischen Diagnostik des malignen Melanoms weit verbreitet. Nachdem S-100β im Serum von Patienten mit malignem Melanom nachgewiesen wurde, folgten zahlreiche klinische Studien zur Etablierung dieses Proteins als Tumormarker in verschiedenen Stadien der Erkrankung. Die Resultate zeigen, daß S-100β-Protein im Serum von Patienten mit malignem Melanom ein unabhängiger prognostischer Marker und ein ergänzender klinischer Parameter für die Progression der metastasierten Erkrankung sowie für das Monitoring der Patienten während einer systemischen Therapie sein kann. Bei Lymphknoten- oder Fernmetastasierung gibt es jedoch auch Patienten mit negativen S-100-β-Werten, bei denen eine Korrelation mit dem Krankheitsverlauf nicht hergestellt werden kann. Eigene Ergebnisse bestätigen diese Grundaussage für Patienten im Stadium III/IV. Werden aber wiederholt positive S-100β-Serumwerte bei der statistischen Auswertung nur einmalig berücksichtigt, zeigt sich ein deutlich geringerer Anteil von Patienten im Stadium III/IV mit positiven S-100-Werten, als in der Literatur angegeben. Für das Monitoring im Stadium I und II scheint S-100β nicht geeignet.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Psychological research 40 (1978), S. 37-51 
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Summary An experiment was conducted to investigate the effect of depth of semantic analysis on the recall of sentences presented for comprehension. The depth of semantic analysis was varied by presenting 48 subjects with 24 unambiguous or lexically ambiguous sentences that were either preceded by a picture or not. Each picture showed either one or both interpretations of the respective ambiguous sentence. The sentence remained on display until the subject had pressed a key to indicate that he had understood its meaning. After the presentation of all the sentences the subjects were tested for recall. Ambiguous sentences were equally well understood as unambiguous sentences, but were better recalled when their ambiguity had been noticed. The subject's awareness of sentence ambiguity, and hence the depth of semantic analysis, was found to depend on the pictorial context in which the sentences were presentend. The pictorial context was also found to affect the depth of processing of unambiguous sentences, which, when presented without a picture, were more time-consuming in comprehension and less well recalled than when preceded by a picture. These findings provide the background for a discussion of the interrelations between the comprehension of sentences, the depth of their semantic processing, and the recall of these sentences.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Psychological research 39 (1977), S. 203-220 
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Summary Acting on the assumption that pictures affect the processing of sentences only when providing additional information, the authors used pictures, which in an earlier experiment had failed to influence the retention of noun sentences, as illustrations to semantically undefined pronoun sentences, thus establishing a distinct information gradient between sentence and picture. These pronoun sentences were presented to 48 subjects for recall, in four pictorial conditions: without picture, with unambiguous picture, with subject-ambiguous, and with object-ambiguous picture. As hypothesized, picture-less pronoun sentences were more poorly recalled than picture-enriched pronoun sentences. Moreover, sentences accompanied by subject-ambiguous pictures, in which the grammatical subject could not be clearly identified, scored lower than the same sentences with unambiguous or object-ambiguous pictures. The findings invite a communication-theory analysis of the experimental situation, for which Searle's theory of speech acts is invoked.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Psychological research 48 (1986), S. 99-106 
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Summary Previous research has demonstrated that the emotional properties of words and their imaginability affect their recallability and that verbal material is recalled better when it is related to subjects' current concerns. This study investigates the extent to which this effect of emotion on recall varies as a function of cognitively controllable inference processes and examines the relation of the effects of emotion to those of imaginability and concern-relatedness. Forty different words were presented visually under one of six orienting conditions that varied according to what the subject was asked to rate: their length, pronounceability, concreteness, defineability, the strength of emotion elicited by the word, and the relation of the word to personal concerns. Subjects were then asked to write as many words as they could recall. Words that aroused stronger emotion and were easier to represent in imagery were recalled better than emotionally less arousing and imaginally less evocative words, regardless of the nature of the orienting task. The evidence suggests that the emotional properties of words are evaluated automatically in an early processing stage, without requiring subjects to reflect on word content. Emotional arousal appears to mediate the effects of current concerns on recall. It is correlated with but appears to function independently of word imaginability.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Psychological research 48 (1986), S. 107-112 
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Summary How much does the recall of affectively positive, negative, and neutral words that differ in their emotional impact depend on the conceptual processing of these words? To answer this question one group of subjects were requested to rate the pronounceability of these words (formal orienting task), but were later tested for recall. Subsequently, they were asked to judge the intensity of the emotions aroused by the words. Another group of subjects received the latter, self-related task prior to the first exposure to the words. In both conditions the highly affect-arousing words were better recalled than the less emotional words. The affectively positive words were particularly well recalled, but only by those subjects involved in the formal orienting task. It is concluded that words are evaluated for their emotional content at an early stage of information processing as defined by Craik and Lockhart (1972).
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...