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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary Ice was produced in a wind tunnel at a laboratory temperature of −10° C by spraying water through a nozzle. An electrically heated cylindrical rod, 30 cm long, 1 cm in diameter, is exposed to various meteorological conditions. The amount of energy needed to keep the rod free of ice is investigated. At a temperature of −15°C and a wind velocity of 20 m/s, 1,1 W/cm2 of projected area are sufficient to keep the rod clear. The result agrees with the theory ofNusselt.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 7139-7144 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Strahlentherapie und Onkologie 176 (2000), S. 265-273 
    ISSN: 1439-099X
    Keywords: Key Words: Ductal pancreatic carcinoma ; Radiotherapy ; Chemotherapy ; Schlüsselwörter: Duktales Pankreaskarzinom ; Strahlentherapie ; Chemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Hintergrund: Das duktale Pankreaskarzinom ist die dritthäufigste bösartige Erkrankung des Verdauungstrakts bei steigender Inzidenz. Immer noch ist die Prognose der Patienten, die von dieser Krankheit betroffen sind, schlecht, sodass das Bemühen nach einer Verbesserung der Behandlung weitergeht. Material und Methode: In einem Übersichtsartikel wird die Rolle der Strahlentherapie bei der adjuvanten und neoadjuvanten Behandlung des nicht metastasierten Pankreaskarzinoms dargestellt. Besondere Beachtung wird dabei Studien geschenkt, die prospektiv, randomisiert durchgeführt wurden. Die Analyse diese Studien erfolgt geordnet nach dem Ausgangsbefund: 1. Operable Tumoren werden adjuvant, neoadjuvant oder intraoperativ bestrahlt. 2. Bei inoperablen Tumoren kann in neoadjuvanter Intention ein “Downstaging” angestrebt werden, um den Tumor resektable zu machen. Ergebnisse: Die Verbreitung neuer radiotherapeutischer Techniken, wie zum Beispiel der Hochvoltbestrahlung, der computergestützten 3-D-Bestrahlungsplanung, der interventionellen Therapie und der Kombination verschiedener Therapiemodalitäten, hat zu einer Vielzahl von Studien geführt. Studien, in denen zusätzlich zur Strahlentherapie eine simultane Chemotherapie durchgeführt wurde, haben deutlich bessere Ergebnisse als solche mit alleiniger Strahlentherapie. Es zeichnet sich ab, dass Patienten mit operablen Tumoren bessere Überlebensraten haben und seltener lokale Rezidive erleiden, wenn der Chirurgie andere Therapiemodalitäten an die Seite gestellt werden. Inoperable Tumoren können unter Umständen nach Tumorverkleinerung dennoch resektabel werden. Schlussfolgerungen: Eine simultane Radiochemotherapie mit den Substanzen 5-FU und Mitomycin C ist ohne höhergradige akute Nebenwirkungen durchführbar. Dieser Behandlungsansatz kann adjuvant indiziert sein, solange keine Fernmetastasierung vorliegt. Die neoadjuvante Radiochemotherapie sollte nur im Rahmen von Studien durchgeführt werden.
    Notes: Background: Ductal pancreatic carcinoma ranks third among malignancies of the gastrointestinal tract and its incidence is rising. Today, patients with this disease still have fatal prognosis necessitating efforts towards more effective treatment. Material and Methods: This report provides a review of adjuvant and neoadjuvant radiotherapy in pancreatic carcinoma without distant metastasis. Particular respect is given to prospective, randomized trials. They are analyzed according to clinical staging: 1. In resectable tumors adjuvant, neoadjuvant or intraoperative radiotherapy is performed. 2. Radiotherapy in neoadjuvant intention is an approach for downstaging to achieve resectability in initially irresectable tumors. Results: The widespread use of new techniques such as supervoltage irradiation, computer based 3-D-planning, interventional therapy and combination of different therapeutic modalities induced a great number of studies. When concomitant chemotherapy was added to radiotherapy, results became significantly better compared to exclusive radiotherapy. It is shown that patients with operable tumors will have better survival rates and lower risk of relapse, if radiochemotherapy is added to surgery. Patients with irresectable tumors possibly can be downstaged and be brought to resection nevertheless. Conclusions: Simultaneous radiochemotherapy with 5-FU and mitomycin C can be performed without elevated risk of acute side effects of higher degree. This approach may be indicated in the case of adjuvant situations in patients free of distant metastases. Neoadjuvant simultaneous radiochemotherapy should only be performed as a part of a clinical trial.
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 440-445 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of 75 analogs of trimethoprim were used in a study correlating mass spectrometric data with biological activity. Using pattern recognition techniques a correlation was obtained. Experiments to elaborate the basis of the correlation are described.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 7 (1994), S. 277-281 
    ISSN: 0952-3499
    Keywords: IL-6 receptor ; gp130 ; basophil ; IL-3 ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In addition to specific ligand binding elements, receptor assembly for interleukin(IL)-6, oncostatin-M, leukaemia inhibitory factor, ciliary neurotrophic factor and IL-11 includes and additional unit, gp130. This molecule is a transmembrane glycoprotein of 130 kDa. In this paper, reviewing molecular, biochemical and functional data on gp130, we describe the dissimilar action of IL-3 on the expression of the binding unit of the IL-6 receptor and that of gp130. According to FACS studies, resting basophils express only IL-6 receptors and no gp130 molecules on the plasma membranes. After incubation with IL-3, the surface appearance and de novo transcription of gp130 was shown by FACS and mRNA polymerase chain reaction analysis.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 373 (1995), S. 441-444 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To address the possible role of Fas/Fas-ligand interactions in activation-induced apoptosis in T-cell hybridomas, we examined the expression of Fas and Fas-ligand in the hybridoma line Al. 1, which rapidly undergoes apoptosis following activation1'3. Al.l cells do not express cell-surface Fas ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 340-343 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HMC-1 is an immature mast cell line expressing several mast cell antigens but not FcsRl (ref. 10). KU812 is an immature basophilic cell line". To identify new cellular mechanisms for the control of IgE production, we tested the ability of these cell lines to induce IgE synthesis in purified B cells ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 20-20 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The killing of target cells by cytotoxic T lymphocytes is an efficient way for the immune system to eliminate virus–infected cells, intracellular parasites and tumor cells. T cells and Natural Killer (NK) cells have two major effector mechanisms: (1) the expression of FasL (CD95L), which ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 19-20 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Using bisindolylmaleimide to enhance the suicide program of activated lymphocytes is a novel therapeutic approach to the treatment of autoimmune disease (pages 42–48 and ...
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 47 (1975), S. 662-665 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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