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  • 1
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer
    Keywords: Humangenetik ; Lehrbuch ; Humangenetik
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    ISBN: 9783540240365 , 3540240365 , 9783540294795
    Series Statement: Springer-Lehrbuch
    RVK:
    Language: German
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  • 2
    Online Resource
    Online Resource
    Heidelberg : Springer
    Keywords: Humangenetik ; Lehrbuch ; Humangenetik
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 429 S.) , Ill., graph. Darst.
    Edition: 4., neu bearb. Aufl.
    ISBN: 3540326774 , 9783540326779 , 9783540326786
    Series Statement: Springer-Lehrbuch
    RVK:
    Language: German
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  • 3
    Online Resource
    Online Resource
    Wiesbaden, [Germany] : : Springer,
    Keywords: Diseases Causes and theories of causation. ; Human evolution. ; Environmentally induced diseases. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (62 pages) : , illustrations.
    ISBN: 9783658107604 (e-book)
    ISSN: 2197-6716
    Series Statement: essentials,
    DDC: 616.071
    Parallel Title: Print version: Buselmaier, Werner. Evolutionäre medizin : eine einführung für mediziner und biologen.
    Language: German
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 28 (1971), S. 129-134 
    ISSN: 1432-0738
    Keywords: Chemical Mutagenesis ; Host-Mediated Assay ; Nitrosamines ; Point Mutation ; Chemische Mutagenese ; Intra-animale Kultur ; Nitrosamine ; Punktmutationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird untersucht, inwieweit induzierte Veränderungen des Metabolismus die mutagene Wirksamkeit einiger N-Nitrosoverbindungen im host-mediated assay beeinflussen können. Eine Vorbehandlung der Maus mit Tetrachlorkohlenstoff macht es unmöglich, mit Dimethylnitrosamin im host-mediated assay Mutationen auszulösen. Die Vorbehandlung mit Phenobarbital hat keinen Einfluß auf die mutagene Wirkung dieser Verbindung. Methyl-nitroso-nitroguanidin wirkt nur nach parenteraler, nicht nach oraler Applikation, mutagen. Methylnitrosoharnstoff induziert Mutationen bei subcutaner Injektion und oraler Gabe. Die Verschiedenheiten werden auf eine unterschiedliche Resorption zurückgeführt.
    Notes: Abstract The problem to be examined is the extent to which induced changes in metabolism influence the mutagenic activity of several N-nitroso-compounds in the host-mediated assay. After pretreatment with carbon tetrachloride it is impossible to induce mutations with dimethylnitrosamine in the host-mediated assay system. Pretreatment with phenobarbital does not influence the mutagenic activity of this compound. Methyl-nitroso-nitroguanidine has mutagenic effects only when applied parenterally, but not when given orally. Methyl-nitrosourea induces mutations when injected subcutaneously and when given orally. These results may be explained by differences of absorption.
    Type of Medium: Electronic Resource
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