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  • 1
    Book
    Book
    Frankfurt am Main [u.a.] : Campus-Verl.
    Keywords: Dell Computer Corporation ; Strategisches Management ; Dell Computer Corporation ; Strategisches Management
    Type of Medium: Book
    Pages: 269 S. , graph. Darst.
    ISBN: 3593363720
    Uniform Title: Direct from Dell
    RVK:
    RVK:
    Language: German
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  • 2
    Online Resource
    Online Resource
    Cambridge : Royal Society of Chemistry
    Keywords: Hydrogène (combustible) ; Énergies renouvelables - Prévision ; Wasserstoff ; Energie ; Wasserstoffenergietechnik ; Hydrogen as fuel ; Power resources ; Hydrogène (Combustible) ; Ressources énergétiques ; Wasserstoff ; Energie ; Wasserstoffenergietechnik
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (338 p.) , 90 b&w, ill
    ISBN: 184755802X , 9781847558022
    DDC: 333.794
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 19 (1994), S. 489-499 
    ISSN: 1573-6903
    Keywords: Cultured neurons ; glutamate receptors ; NMDA ; transcription factors ; immediate early genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes, such as c-fos, fosB, c-jun, junB, junD, c-myc, and zif/268. The addition of glutamate (100 μM) to the culture medium rapidly activated c-fos, fosB, c-jun, junB and zif/268 gene expression, reaching the maximal level at 30–60 minutes for zif/268 and at 60 minutes for the other genes. The onset of fosB mRNA accumulation was slightly delayed in comparison to the other genes. No clear induction was found for junD and c-myc. Different glutamate receptor agonists, such as NMDA, kainate, quisqualate, trans-(±)-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) were able to increase c-fos, c-jun, and zif-268 mRNA levels with rapid and transient kinetics similar to those observed after glutamate treatment. Similar results were obtained for junB and fosB after kainate and quisqualate stimulation. Pretreatment with MK-801, a non competitive NMDA antagonist, produced an almost complete inhibition of glutamate-driven expression of transcription factor genes, thus suggesting that NMDA receptor plays a major role in glutamate induced-gene expression. On the contrary the kainate/AMPA receptor antagonist, DNQX, did not influence glutamate induced-gene expression. Under the conditions used in the present study, NMDA was effective in inducing the simultaneous activation of several IEGs even when added to the culture medium containing millimolar concentration of magnesium. When experiments were performed in Krebs solution, NMDA was effective in stimulating zif/268 and c-fos mRNAs only in the absence of Mg2+, while glutamate activated c-fos and zif/268 both in the presence and absence of magnesium ions. As expected, NMDA effect was fully inhibited by MK-801. The level of AP-1 DNA binding activity, as measured by electrophoretic mobility shift assay, increased after addition of glutamate and NMDA to cultured neurons and such increase was antagonized by the pretreatment with MK-801.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Theory and society 13 (1984), S. 621-631 
    ISSN: 1573-7853
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Theory and society 7 (1979), S. 307-318 
    ISSN: 1573-7853
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung DC-Charakteristica einiger Psychopharmaka (Chlorprothixen, Prothixen, Clopenthixol, Meprotixol, Amitriptylin und Nortriptylin), deren Metaboliten und Derivate in 6 verschiedenen azeotropen Laufmittelsystemen werden beschrieben und die Fluorescenzmaxima dieser Verbindungen in 60%iger Schwefelsäure angegeben. Am Beispiel des Chlorprothixens und Chlorprothixensulfoxids wird die gemeinsame sowie separate Isolierung und quantitative Bestimmung von Wirkstoffen aus biologischem Material gezeigt. Fluorimetrische Unterschiede bei Clopenthixol und Flupentixol gegenüber deren Metaboliten ermöglichen die Bestimmung der Wirksubstanzen im Gemisch.
    Notes: Abstract TLC characteristics are described of some psychopharmacological agents (Chlorprothixen, Prothixen, Clopenthixol, Flupentixol, Meprotixol, Amitriptylin und Nortriptylin) and of their metabolites and derivatives in six different developing solvent systems as well as the fluorescence maxima of these compounds in 60% sulphuric acid. By way of the examples of Chlorprothixen and Chlorprothixen sulphoxide the isolation of reactive agents from biological material and their determination are shown. The determination of Clopenthixol and Flupentixol in mixtures with their corresponding metabolites is possible due to differences in their fluometric spectra.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Keywords: Untersuchung der Fluorescenz von N-Arylanthranilsäuren, Flufenaminsäure ; Einfluß von Probenbehandlung, Lösungsmittel und Halogenessigsäure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Der Einfluß der Probenvorbehandlung von Flufenaminsäure [N-(α,α,α-Trifluoro-m-tolyl)-anthranilsäure] und anderen N-Aryl-anthranilsäuren (Alkalibehandlung und Oxydation) sowie der Einfluß des zur Fluorescenzmessung verwendeten Lösungsmittels und der zugesetzten Halogenessigsäure auf die Fluorescenzintensität wird untersucht. Säurederivate (Ester, Amide usw.) müssen zuvor durch Hydrolyse in freie Säuren überführt werden. Zur Fluorescenzauslösung sind Lösungsmittel mit DK = 0 erforderlich, die verwendeten Halogenessigsäuren (Mono-, Di- und Trihalogenessigsäure; X = Cl, Br und F) mit pK a-Werten 〈1 sind geeignet, Säuren mit geringem Dissoziationsgrad völlig ungeeignet. Arylsubstitution beeinflußt die Lage der Fluorescenzmaxima, aber kaum die Fluorescenzintensität. Auch Anthranilsäure fluoresciert in CCl4/Trichloressigsäure, die m- und p-Analoga der Anthranilsäure sowie Diphenylamin fluorescieren in diesem Medium dagegen nicht.
    Notes: Abstract The influence of a pretreatment of flufenamic acid and other N-aryl-anthranilic acids by alkaline saponification and oxidation, as well as the influence of the solvent and the added halogenoacetic acid on fluorescence intensity has been investigated. Derivatives of the flufenamic acid (e.g. esters or amides) must first be hydrolyzed. To render the solution fluorescent solvents with a DK = 0 are required. The halogeno-acetic acids (e.g. mono-, di-, trichloro-, -bromo- and -fluoroacetic acids) with a pK a-value 〈1 are suitable. Acids with a pK a-value 〉1 are completely unsuitable. Arylsubstituation influences the position of the fluorescence maxima but not the intensity. Anthranilic acid itself shows fluorescence in chloroform-trichloroacetic acid while their m- and p-analogues as well as diphenylamine do not.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Keywords: Best. von Benzhydrol, Benzhydrolglucuronid in Harn ; Chromatographie, Dünnschicht/Spektralphotometrie, UV ; renale Elimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Keywords: Bestimm. von Propyphenazon in Blut ; Chromatographie, Dünnschicht Spektralphotometrie, UV ; Pharmakokinetik Hund, Blutspiegel Mensch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Keywords: Best. von Tryptophan in Gehirn ; Chromatographie, Dünnschicht/Fluorimetrie ; neben Metaboliten und Derivaten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde eine Methode zur Bestimmung von Tryptophan in Gehirn ausgearbeitet. Diese führt in Gegenwart von Formaldehyd und Salpetersäure zu einem Fluorophor (Typ Norharman), der — im Gegensatz zu ähnlichen Formaldehydreaktionen mit HCl u. a. — nur von Tryptamin schwach gestört wird. Serotonin, 5-Hydroxytryptophan, Xanthurensäure, 3Hydroxyanthranilsäure und 5-Hydroxyindolessigsäure stören die fluorimetrische Bestimmung (374/450 nm) nicht. Es kann sogar auf vorherige DC-Trennung verzichtet werden. Geschlechts- und altersspezifische Unterschiede des Tryptophangehalts im Rattenhirn sind nicht stark ausgeprägt.
    Notes: Summary A method for the determination of tryptophan in the brain was developed, which is based on the formation of a fluorophore (374/450 nm) in the presence of formaldehyde and nitric acid. In contrast to similar methods which use formaldehyde and hydrochloric acid, tryptamine interferes only weakly. Serotonin, 5-hydroxytryptophan, xanthurenic acid, 3-hydroxyanthranilic acid and 5-hydroxyindoleacetic acid do not interfere, t.l.c. separation prior to fluorophore formation can be omitted. Influence of sex and age on the tryptophan content in rat brain are not very marked.
    Type of Medium: Electronic Resource
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