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  • 1
    Online Resource
    Online Resource
    [Cham], Switzerland : : Springer,
    Keywords: Mean field theory. ; Game theory. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (165 pages) : , illustrations (some color), graphs.
    ISBN: 9783319389349 (e-book)
    ISSN: 2191-8201
    Series Statement: SpringerBriefs in Mathematics,
    DDC: 530.1595
    Parallel Title: Print version: Gomes, Diogo A. Regularity theory for mean field-games systems.
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham, Switzerland : : Springer,
    Person(s): Diogo, Rui,
    Keywords: Evolution (Biology) ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (260 pages) : , illustrations (some color), photographs
    ISBN: 9783319475813 (e-book)
    DDC: 575
    Parallel Title: Print version: Diogo, Rui. Evolution driven by organismal behavior : a unifying view of life, function, form, mismatches and trends.
    Language: English
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  • 3
    Online Resource
    Online Resource
    Birmingham : : Packt,
    Keywords: Node.js. ; Internet programming. ; Web site development. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (716 pages)
    ISBN: 9781789951615 (e-book)
    DDC: 005.2762
    Parallel Title: Print version: Bojinov, Valentin. Node.js complete reference guide : discover a more sustainable way of writing software with high levels of reusability and collaboration using Node.js.
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham, Switzerland : : Springer,
    Keywords: Business Data processing. ; Python (Computer program language) ; Graphic methods Data processing. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (101 pages).
    ISBN: 9783319564272 (e-book)
    Series Statement: SpringerBriefs in Information Systems
    DDC: 658.054
    Parallel Title: Print version: Ferreira, Diogo R. Primer on process mining : practical skills with Python and Graphviz.
    Language: English
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  • 5
    Online Resource
    Online Resource
    Birmingham ; : Packt,
    Keywords: Computer programming. ; JavaScript (Computer program language) ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (320 pages) : , illustrations
    ISBN: 9781788626835 (e-book)
    DDC: 001.642
    Parallel Title: Print version: Resende, Diogo. Hands-On microservices with Node. js : build, test, and deploy robust microservices in JavaScript.
    Language: English
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  • 6
    Online Resource
    Online Resource
    Birmingham ; : Packt,
    Keywords: JavaScript (Computer program language) ; Software architecture. ; Application software Development. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (543 pages)
    ISBN: 9781838829803 (e-book)
    DDC: 005.2762
    Parallel Title: Print version: Resende, Diogo. Building microservices with javascript : learn quick and practical methods for developing microservices.
    Language: English
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  • 7
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    Unknown
    BioMed Central
    Publication Date: 2012-12-01
    Description: Background: Variations in the major arteries of the upper limb are estimated to be present in up to one fifth of people, and may have significant clinical implications.Case presentationDuring routine cadaveric dissection of a 69-year-old fresh female cadaver, a superficial brachioulnar artery with an aberrant path was found bilaterally. The superficial brachioulnar artery originated at midarm level from the brachial artery, pierced the brachial fascia immediately proximal to the elbow, crossed superficial to the muscles that originated from the medial epicondyle, and ran over the pronator teres muscle in a doubling of the antebrachial fascia. It then dipped into the forearm fascia, in the gap between the flexor carpi radialis and the palmaris longus. Subsequently, it ran deep to the palmaris longus muscle belly, and superficially to the flexor digitorum superficialis muscle, reaching the gap between the latter and the flexor carpi ulnaris muscle, where it assumed is usual position lateral to the ulnar nerve. Conclusion: As far as the authors could determine, this variant of the superficial brachioulnar artery has only been described twice before in the literature. The existence of such a variant is of particular clinical significance, as these arteries are more susceptible to trauma, and can be easily confused with superficial veins during medical and surgical procedures, potentially leading to iatrogenic distal limb ischemia.
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 22 (1997), S. 181-187 
    ISSN: 1573-6903
    Keywords: Glutamate ; [3H]glutamate-binding ; guanine nucleotides ; adenylate cyclase ; G-proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract GMP-PNP, a non-hydrolyzable analog of GTP binds tightly to G-protein in the presence of Mg2+, so that the binding is stable even after exhaustive washings. This property was exploited to prepare membrane samples of rat brain where G-protein GTP-binding sites were saturated with GMP-PNP. Experiments carried out with these membranes showed that GTP, GMP-PNP, GDP-S and GMP (1 mM) inhibit the sodium-independent [3H]glutamate binding by 30–40% [F(4,40) = 5.9; p 〈 .001], whereas only GMP-PNP activates adenylate cyclase activity [F(6,42) = 3.56; p 〈 .01]. The inhibition of sodium-independent [3H]glutamate binding occurred in the absence of Mg2+. These findings suggest that guanine nucleotides may inhibit glutamate binding and activate adenylate cyclase through distinct mechanisms by acting on different sites.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 24 (1999), S. 1067-1074 
    ISSN: 1573-6903
    Keywords: Adenosine A2 receptors ; NECA binding ; guanine nucleotides ; glutamate analog ; cAMP ; chicks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Binding properties of the subtypes of adenosine A2 receptors in membrane preparations and the effects of adenosine receptor ligands on cAMP accumulation in slices from the optic tectum of neonatal chicks have been investigated. [3H]2-[4-(2-p-carboxyethyl)phenylamino]-5'-N-ethylcarboxaminoadenosine (CGS 21680), a selective ligand for adenosine A2a receptors, did not bind to optic tectal membranes, as observed with rat striatal membranes. CGS 21680 also did not induce cyclic AMP accumulation in optic tectum slices. However, 5'-N-ethylcarboxamidoadenosine (NECA), 2-chloro-adenosine or adenosine induced a 2.5- to 3-fold increase on cyclic AMP accumulation in this preparation. [3H]NECA binds to fresh non-washed-membranes obtained from optic tectum of chicks, displaying one population of binding sites, which can be displaced by NECA, 8-phenyltheophylline, 2-chloro-adenosine, but is not affected by CGS 21680. The estimated KD value was 400.90 ± 80.50 nM and the Bmax was estimated to be 2.51 ± 0.54 pmol/mg protein. Guanine nucleotides, which modulate G-proteins activity intracellularly, are also involved in the inhibition of glutamate responses by acting extracellularly. Moreover, we have previously reported that guanine nucleotides potentiate, while glutamate inhibits, adenosine-induced cyclic AMP accumulation in slices from optic tectum of chicks. However, the guanine nucleotides, GMP or GppNHp and the metabotropic glutamate receptors agonist, 1S,3R-ACPD did not alter the [3H]NECA binding observed in fresh non-washed-membranes. Therefore, the adenosine A2 receptor found in the optic tectum must be the adenosine A2b receptor which is available only in fresh membrane preparations, and its not modulated by guanine nucleotides or glutamate analogs.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 24 (1999), S. 1037-1042 
    ISSN: 1573-6903
    Keywords: Lead acetate ; adenylate cyclase ; 5′-guanylylimidodiphosphate ; forskolin ; cerebral cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lead decreased in a dose dependent manner the basal AC activity in membranes of rat cerebral cortex (IC50 = 2.5 ± 0.1 μM). In membranes preincubated under basal conditions, AC activity was stimulated by approximately two and fourfold by 10 μM Gpp(NH)p or forskolin, respectively. Under basal conditions, lead (3 μM) inhibited enzyme activity up to 50%, but was not able to inhibit the Gpp(NH)p- or the forskolin-stimulated AC activity. However, in membranes preincubated with Gpp(NH)p (10 μM), lead (3 μM) had no significant effect on enzyme activity, but it partly blocked the stimulation of AC activity elicited by forskolin (10 μM). In membranes preincubated with 10 μM lead, the addition of 10 μM Gpp(NH)p or forskolin in the incubation medium did not stimulate AC activity. However, when added together in the incubation medium Gpp(NH)p + forskolin produced an increase in enzyme activity. In membranes preincubated with 10 μM lead + 10 μM Gpp(NH)p, Gpp(NH)p (10 μM) or forskolin (10 μM) added alone or in combination to the incubation medium did not stimulate AC activity. Moreover, under these latter conditions lead had no further effect on enzyme activity. These results indicate that lead may interact with G-proteins and with the catalytic subunit of cerebral cortical AC to produce inhibition of the enzyme activity.
    Type of Medium: Electronic Resource
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