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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Anxiety Disorders 4 (1990), S. 141-145 
    ISSN: 0887-6185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of women's mental health 2 (1999), S. 107-115 
    ISSN: 1435-1102
    Keywords: Keywords: Partial eating disorders; anorexia nervosa; bulimia nervosa.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eating-related behaviors and general psychopathology were assessed in 642 young Israeli women 10 to 14 days after being drafted to the army. Weight and height were also recorded. Partial eating disorders were defined with the Eating Attitudes Test and selected relevant criteria of the DSM-IV. Compared to subjects with no disturbed eating, individuals with partial anorexia nervosa or partial bulimia nervosa had dieted more in the previous year and reported a greater change in the amount of food intake in times of stress. Partial bulimic subjects fared worse than both other groups in many eating-related parameters. Both groups with partial eating disorders had elevated overall psychopathology compared with controls. This study suggests that subjects with partial eating disorders, particularly partial bulimia nervosa, should be considered a high-risk population that requires early detection.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 106 (1999), S. 911-918 
    ISSN: 1435-1463
    Keywords: Keywords: L-Deprenyl ; neuroleptic-induced parkinsonism ; MAO-B inhibitors ; schizophrenia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. This study examined the potential of L-Deprenyl, a selective monoamine oxidase-B (MAO-B) inhibitor, for the treatment of neuroleptic-induced parkinsonism (NIP). Thirty-one consecutive schizophrenic or schizophreniform patients were treated with haloperidol in a flexible dose design. Nineteen of them developed NIP and were administered adjunctive L-Deprenyl 10 mg/d for six weeks in an open fixed-dose design. One patient had to be withdrawn from the study because of exacerbation of the NIP. Severity of NIP was mild to moderate throughout the whole study period in all other cases. Five patients were considered to require biperiden 2–4 mg/d in addition to L-Deprenyl after two weeks of treatment, although they did not differ from the other 13 patients in any of the variables studied. A significant improvement in NIP was found in both groups of patients, with no psychotic exacerbation or a change in the dosage of haloperidol. These findings suggest that selective MAO-B inhibitors may be effective in some patients with mild to moderate NIP.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1433-8491
    Keywords: Key words War ; Soldiers ; Anxiety ; Israel ; Gulf War
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The impact of stress was investigated among Israeli soldiers during the Gulf War. The study included 40 healthy young adults in active service. Their scores on the Hamilton Anxiety Rating Scale were evaluated during the first week of the war. Our subjects were divided into two equal sub-groups (N=20); combatants and auxiliary personnel. Higher levels of anxiety were found among the combatants. Factor analysis revealed three differing factors: arousal symptoms, numbing and distraction. We discuss the possible explanations for these differences.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 34 (1978), S. 212-213 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The activity of dopamine-beta-hydroxylase was measured in the serum before and immediately after electroconvulsive treatments. No significant difference was observed, suggesting that the seizures did not cause an increase in the peripheral sympathetic tone.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 181 (1981), S. 390-394 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A group of mutants isolated from E. coli K12(tif-1) display a very pleiotropic phenotype. The main characteristic of these mutants, temporarily designated ‘S’ strains, is their ability to suppress a large number of mutations. High efficiency of suppression is correlated with increased thermolability of cellular proteins, indicating an impairment in the fidelity of protein synthesis. Efficient suppression is also accompanied by the appearance of new characteristics like simultaneous resistance to several antibiotic drugs (Sm, Spc, and Mer), and plasmid-like DNA circles. Genetic studies show that the suppressor character is located in the rpoBC region. In a large number of spontaneous Rifr mutants, isolated from these strains, suppression or resistance to drugs is lost. The findings suggest that the phenotype of ‘S’ strains is due to an altered RNA polymerase causing erroneous transcription.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 239 (1993), S. 109-114 
    ISSN: 1617-4623
    Keywords: Drosophila ; melanogaster ; rough ; 97D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The rough homeobox gene of D. melanogaster is required for the correct patterning of the developing eye. The locus maps to cytological location 97D2-5, a region which has not been extensively characterised. As part of our genetic and molecular characterization of rough we carried out an EMS mutagenesis to generate mutants that map to the surrounding region, 97D2-9 which is deleted in Df(3R)ro-XB3. We have generated 1 visible and 13 lethal mutations which, together with the previously described Toll and ms(3)K10 loci, and other unpublished lethals, define nine complementation groups — four lethal, three semi-lethal, one visible and one male-sterile. In addition to rough, one other locus within this region, 1(3)97De, was shown to be required for formation of the normal pattern of photoreceptor cells in the compound eye.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 147 (1976), S. 59-65 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mutant T44(λ) of Escherichia coli K12, grown in the presence of adenine, develops an increased tolerance to streptomycin. In cultures grown on streptomycin, the ts character (tif) may temporarily be suppressed but, on further transfer, both the temperature-sensitive phenotype and streptomycin tolerance disappear. In a cell-free system, the relative efficiency of translation of MS2 and poly U messenger RNAs was, respectively, 75 and 50% lower in extracts from cultures grown at 37° with adenine than in extracts from 30° cultures. Similar results were obtained when adenine was added in vitro to an extract from a culture grown at 37° in the absence of adenine, using MS2 RNA as messenger. Moreover, the 37° extracts showed a much lower misincorporation of isoleucine into polyphenylalanine in the poly U system. In addition, the Mg++ concentration required for optimal translational activity was higher for the 37° than for the 30° extracts. Extracts from a culture grown in L medium at 37° or from a tif -/F′ tif + merodiploid grown at 37° with adenine behaved similarly to that from the 30° culture when poly U was used as messenger RNA. It is suggested that the tif + gene product may play a regulatory role in ribosomal function and the pleiotropic nature of the tif-1 mutation could be due to impairment of translational activity augmented by elevated temperature or by adenine.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 155 (1977), S. 163-169 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A recent study showed that in E. coli T44 (λ) carrying the tif-1 mutation, elevated temperature and adenine can interfere with the translation process. The present study shows that the expression of tif phenotypes (thermoinduction and filamentation) is suppressed by factors which affect ribosomal function. Ethanol suppresses thermoinduction and, in some spc r mutants, both thermoinduction and filamentation are suppressed. An unknown factor(s) in yeast extract suppresses both thermoinduction and filamentation. In thermoresistant ‘revertant’ (ts+), the expression of the ts+ phenotype is suppressed by yeast extract, ethanol, guanosine+cytidine and by the addition of a spc r mutation. This indicates that this phenotype could be due to suppressor mutations, and the interaction between factors affecting ribosomal function and the ts+ phenotype suggests that the suppression of tif in the ts+ strains could operate on the ribosomal level. In vitro studies show that in extracts from either spc r or ts+ strains, or in the presence of ethanol, translational restriction is relieved, suggesting that the suppression of tif phenotypes could involve the translation process.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 151-154 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Hybridization in situ of a genomic DNA fragment containing homoeo-box homology to polytene chromosomes of the salivary gland of D. melanogaster. The cloned fragment was identified by virtue of its homology, under low stringency hybridization conditions (50% formamide, 5 x SSC at 30 °C), ...
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