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  • 1
    Book
    Book
    Oxford : Macmillan | [Ismaning] : [Hueber]
    Person(s): Emmerson, Paul
    Keywords: Englisch ; Fachsprache ; E-Mail ; Aufgabensammlung ; Englisch ; Fachsprache ; E-Mail
    Type of Medium: Book
    Pages: 96 S.
    Edition: 1. publ.
    ISBN: 1405012943 , 3190028842 , 9783190028849
    DDC: 420
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    Language: English
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  • 2
    Book
    Book
    Oxford : Macmillan | [Ismaning] : Hueber
    Person(s): Emmerson, Paul
    Keywords: Englisch ; Fachsprache ; E-Mail ; Aufgabensammlung ; Englisch ; Fachsprache ; E-Mail
    Type of Medium: Book
    Pages: 111 S. , graph. Darst.
    Edition: 2. ed., updated ed.
    ISBN: 9780230448551 , 9783191728847
    DDC: 420
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    Language: English
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  • 3
    Book
    Book
    Oxford : Macmillan
    Associated volumes
    Person(s): Emmerson, Paul
    Keywords: Englisch ; Wirtschaftssprache ; Lehrmittel ; Englisch ; Wirtschaftssprache ; Lehrmittel
    Type of Medium: Book
    Series Statement: English language teaching
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    Language: English
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 73 (1999), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The influence of membrane microviscosity on μ-opioid agonist and antagonist binding, as well as agonist efficacy, was examined in membranes prepared from SH-SY5Y cells and from a C6 glioma cell line stably expressing the rat μ-opioid receptor (C6μ). Addition of cholesteryl hemisuccinate (CHS) to cell membranes increased membrane microviscosity and reduced the inhibitory effect of sodium and guanine nucleotides on the affinity of the full agonists sufentanil and [D-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO) for the μ-opioid receptor. Binding of the antagonists [3H]naltrexone and [3H]diprenorphine and the partial agonist nalbuphine was unaffected by CHS. The effect of CHS on agonist binding was reversed by subsequent addition of cis-vaccenic acid, suggesting that the effect of CHS is the result of increased membrane microviscosity and not a specific sterol—receptor interaction. CHS addition increased the potency of DAMGO to stimulate guanosine-5′-O-(3-[35S]thio)triphosphate binding by fourfold, whereas the potency of nalbuphine was unaffected. However, nalbuphine efficacy relative to that of the full agonist DAMGO was strongly increased in CHS-treated membranes compared with that in control membranes. Membrane rigidification also resulted in an increased efficacy for the partial agonists meperidine, profadol, and butorphanol relative to that of DAMGO as measured by agonist-stimulated GTPase activity in control and CHS-modified membranes. These findings support a regulatory role for membrane microviscosity in receptor-mediated G protein activation.
    Type of Medium: Electronic Resource
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