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  • 1
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden | Wiesbaden : Springer Spektrum
    Keywords: Applied mathematics ; Engineering mathematics ; Artificial intelligence ; Computer science— Mathematics ; Applications of Mathematics ; Artificial Intelligence ; Math Applications in Computer Science
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIII, 88 S. 38 Abb)
    Edition: 1st ed. 2019
    ISBN: 9783658288860
    Series Statement: BestMasters
    DDC: 519
    Language: German
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  • 2
    Book
    Book
    Stuttgart : Wiss. Verl.-Ges.
    Keywords: Arzneimittel ; Stereochemie ; Arzneimittel ; Stereochemie
    Type of Medium: Book
    Pages: 324 S. , Ill., graph. Darst.
    ISBN: 3804714854
    RVK:
    Language: German
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-9023
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-9023
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 18 (1997), S. 367-372 
    ISSN: 1590-3478
    Keywords: Functional Imaging ; Brain mapping ; Perfusion ; Diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'immagine funzionale del cervello è uno dei più interessanti recenti sviluppi nel campo della risonanza magnetica per immagini. Questa tecnica fornisce informazioni funzionali riguardo il cervello umano, andando oltre la morfologia. Alcune modalità di utilizzo di tale tecnica riguardano gli studi di attivazione cerebrale, perfusione, diffusione. Per esempio, la visualizzazione di attivate regioni corticali durante stimolazioni esterne o durante l'effettuazione di tasks specifiche apre prospettive completamente nuove nell'uso della risonanza magnetica per immagini.
    Notes: Abstract Functional Imaging of the brain is one of the most exciting recent developments in Magnetic Resonance Imaging (MRI). It refers to tecniques which provide functional information about the human brain which goes beyond morphology. Examples are brain activation studies, perfusion and diffusion imaging. For example, the visualization of activated cortical brain regions during external stimulations or while performing specific tasks opens a completely new perspective for the use of MRI.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 212 (1988), S. 219-224 
    ISSN: 1617-4623
    Keywords: Bacillus thuringiensis ; Spodoptera exigua ; Toxin genes ; Specific toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five crystal protein genes have been isolated from DNA of Bacillus thuringiensis entomocidus 60.5, an isolate selected for its high toxicity against Spodoptera littoralis and Spodoptera exigua. Two of these genes belong to a family of well-described crystal protein genes. The toxic properties of the corresponding proteins are similar to those of isolate kurstaki HD1. The other three genes belong to gene families not described before. One of these genes codes for a protein product exhibiting a high degree of specificity towards Spodoptera species, explaining the high toxicity of isolate entomocidus 60.5 against these species. This gene product is much less toxic against larvae of Heliothis virescens and Pieris brassicae. Its coding sequence is separated from a supposed fourth crystal protein gene by a stretch of DNA of 3 kb. The crystal protein encoded by the fifth gene is mainly active against P. brassicae. Homology between the crystal protein genes is limited to the central region of the coding sequences, including the proteolytic cleavage site, except for the first two genes between which homology is extensive.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 331-337 (May 2000), p. 957-964 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-4951
    Keywords: MHC ; HLA-B27 ; Drug design ; Molecular dynamics simulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Starting from the X-ray structure of a class I majorhistocompatibility complex (MHC)-encoded protein (HLA-B*2705), a naturallypresented self-nonapeptide and two synthetic analogues were simulated in thebinding groove of two human leukocyte antigen (HLA) alleles (B*2703 andB*2705) differing in a single amino acid residue. After 200 ps moleculardynamics simulations of the solvated HLA–peptide pairs, some molecularproperties of the complexes (distances between ligand and protein center ofmasses, atomic fluctuations, buried versus accessible surface areas,hydrogen-bond frequencies) allow a clear discrimination of potent from weakMHC binders. The binding specificity of the three nonapeptides for the twoHLA alleles could be explained by the disruption of one hydrogen-bondingnetwork in the binding pocket of the HLA-B*2705 protein where the singlemutation occurs. Rearrangements of interactions in the B pocket, which bindsthe side chain of peptidic residue 2, and a weakening of interactionsinvolving the C-terminal end of the peptide also took place. In addition,extension of the peptide backbone using a β-Ala analogue did notabolish binding to any of the two HLA-B27 subtypes, but increased theselectivity for B*2703, as expected from the larger peptide binding groovein this subtype. A better understanding of the atomic details involved inpeptide selection by closely related HLA alleles is of crucial importancefor unraveling the molecular features linking particular HLA alleles toautoimmune diseases, and for the identification of antigenic peptidestriggering such pathologies.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-4951
    Keywords: Yak ; Subtype specificity ; Structure-activity relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A representative range of pyrimidine nucleoside analogues that are known to inhibit herpes simplex virus (HSV) replication have been used to construct receptor binding site models for the varicella-zoster virus (VZV), thymidine kinase (TK) and human TK1. Given a set of interacting ligands, superimposed in such a manner as to define a pharmacophore, the pseudoreceptor modelling technique Yak provides a means of building binding site models of macromolecules for which no three-dimensional experimental structures are available. Once the models have been evaluated by their ability to reproduce experimental binding data [Vedani et al., J. Am. Chem. Soc., 117 (1995) 4987], they can be used for predictive purposes. Calculated and experimental values of relative binding affinity are compared. Our models suggest that the substitution of one residue may be sufficient to determine ligand subtype affinity.
    Type of Medium: Electronic Resource
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