Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Alzheimer's Disease - Window on Molecular Epidemiology
Blackwell Publishing Ltd
Blackwell Publishing Journal Backfiles 1879-2005
Natural Sciences in General
Inheritance of the apolipoprotein E (apo E) ε4 allele has recently been found to be associated with Alzheimer's disease. We have studied the clinical and neuropathological correlates of apolipoprotein E genotype in a large group of Alzheimer's patients. The primary influence on clinical presentation is a shift towards earlier age of onset in individuals who have the apo E ε4 gene: no change in clinical course was observed. In neuropathological studies, we find that the major influence of apo E ε4 is on increased Aβ deposition. These results led to a model of the biological interaction between the apo E protein and Alzheimer's disease.
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