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  • 1
    Book
    Book
    München : UVK Verlag
    Keywords: Betriebswirtschaftslehre ; Studienabschluss ; Wissenschaftliches Manuskript ; Textproduktion ; Betriebswirtschaftliches Studium ; Wissenschaftliches Arbeiten ; Schriftliche Arbeit ; Ratgeber ; Betriebswirtschaftslehre ; Studienabschluss ; Wissenschaftliches Manuskript ; Textproduktion ; Betriebswirtschaftliches Studium ; Wissenschaftliches Arbeiten ; Schriftliche Arbeit
    Type of Medium: Book
    Pages: 216 Seiten , Illustrationen , 21.5 cm x 15 cm
    ISBN: 9783825251253
    Series Statement: utb. Schlüsselkompetenzen Betriebswirtschaftslehre 5125
    RVK:
    RVK:
    Language: German
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1912
    Keywords: Theophylline ; Isoprenaline ; Calcium ; Ouabain ; Positive inotropic effect ; c-AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of theophylline (3×10−5 M–5×10−3 M), isoprenaline (10−6 M), excess calcium (7.2 mM) and ouabain (3×10−7 M) on force of contraction and c-AMP content were studied in electrically driven (frequency 3 Hz) left auricles isolated from guinea pigs pretreated with reserpine. 1. Theophylline (2×10−3 M) increased c-AMP consistently. The theophylline-induced increase in c-AMP proceeded very rapidly. It became significant after an incubation period of 5 s, reached its peak after 5 min and then remained stable. The positive inotropic effect of theophylline also developed very rapidly, reached its peak after 1 min and then declined. The increase in force of contraction corresponded to the increase in c-AMP, but the decline of the positive inotropic effect occurred while c-AMP remained elevated. 2. The concentration-response curves for the theophylline-induced increases in c-AMP and force of contraction were virtually parallel at concentrations up to 2×10−3 M. 3. Washout of the effects of theophylline on c-AMP and force of contraction was also similar. Complete reversal occurred within 15 min. 4. The effects of theophylline on c-AMP and force of contraction were not affected by 10−7 M propranolol added 30 min before theophylline. 5. Isoprenaline (10−6 M) increased c-AMP and force of contraction to approximately the same extent upon incubation for up to 30 min. 6. Ouabain (3×10−7 M) or the elevation of the extracellular calcium concentration to 7.2 mM increased the force of contraction without producing a detectable increase in c-AMP. 7. It is concluded that the theophylline-produced increase in force of contraction may be the result of an increase in c-AMP and a subsequent increase in slow inward current. This effect may be counteracted by a direct, c-AMP independent effect of theophylline on intracellular calcium stores which could account for the decline of the positive inotropic effect of theophylline during prolonged exposure and at high concentrations. 8. The present data also support the view that the positive inotropic effect of isoprenaline is mediated by c-AMP, whereas the effects of ouabain and excess calcium on force of contraction appear to be independent of the c-AMP system.
    Type of Medium: Electronic Resource
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