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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 11 (1997), S. 653-658 
    ISSN: 1573-7241
    Keywords: bezafibrate ; hypertriglyceridemia ; HDL3 composition ; free cholesterol efflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of bezafibrate, a well-used fibric acid hypolipidemic agent, were investigated in 10 moderately hypertriglyceridemic patients. The aim was to quantify the physico-chemical modifications to high-density lipoprotein subfraction 3 (HDL3) induced by treatment and to assess, in vitro, the alterations in its principal physiological function, the efflux of intracellular free cholesterol. Treatment (200mg/thrice/d for 3 months) resulted in a 48% decrease in plasma triglycerides, with an increase in the HDL cholesterol, due mainly to an increase in the HDL3 (P 〈 0.01). Composition analysis of HDL3indicated an increase in cholesterol esters (P 〈 0.01), free cholesterol (P 〈 0.01), and phospholipids (P 〈 0.01), coupled with a decrease in the protein content of the molecule compared with pretreatment values. Fluorescense anisotropy at 24°C was significantly higher post-treatment than pretreatment (P 〈 0.01). The cholesterol effluxing capacity of pretreatment HDL3 was 28%, and post-treatment this increased to 50% (P 〈 0.01). Multivariate analyses indicated that the increased capacity of HDL3 to promote free cholesterol efflux was, in part, due to increased HDL3 phospholipid content and a more adequate fluidity of the molecule. These findings suggest that bezafibrate induces a lowering of plasma triglycerides and that the resultant physico-chemical alterations of the HDL3 molecule make it more efficient as an acceptor of intracellular free cholesterol.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 40 (1995), S. 1252-1256 
    ISSN: 1573-2568
    Keywords: alcoholic liver cirrhosis ; intestinal bacterial overgrowth ; bacterial translocation ; ascites ; spontaneous bacterial peritonitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 89 patients with alcoholic cirrhosis and 40 healthy subjects were included in a study to assess the prevalence of intestinal bacterial overgrowth and to analyze its relationship with the severity of liver dysfunction, presence of ascites, and development of spontaneous bacterial peritonitis (SBP). Bacterial overgrowth was measured by means of a breath test after ingestion of glucose. Intestinal bacterial overgrowth was documented in 27 (30.3%) of the 89 patients with alcoholic cirrhosis and in none of the healthy subjects. The prevalence of intestinal bacterial overgrowth was significantly higher in cirrhotics with ascites (37.1%) than in those with no evidence of ascites (5.3%) and among patients with Pugh-Child class C (48.3%) than in patients with class A (13.1%) or B (27%). Twelve (17.1%) of the 70 patients with ascites developed an episode of SBP. The prevalence of spontaneous bacterial peritonitis was significantly higher in patients who had intestinal bacterial overgrowth (30.7%) than in patients who did not (9.09%). We conclude that intestinal bacterial overgrowth occurs in approximately one third of patients with cirrhosis secondary to alcohol, particularly in patients with ascites and advanced liver dysfunction. Moreover, bacterial overgrowth may be a condition favoring infection of the ascitic fluid.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 28 (1993), S. 389-393 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Mössbauer spectroscopy has been used to analyse FeS2 thin films obtained by sulphidation of 57Fe evaporated layers. Complementary characterization of the films has been carried out by X-ray diffraction and optical absorption measurements. It is concluded that the two processes (formation and crystallization of FeS2) which lead to polycrystalline FeS2 films are strongly influenced by the temperature at which sulphidation is accomplished. The composition of the films drastically changes at temperatures which depend on the thickness of the Fe film to be sulphidated, and their crystallization seems to show a critical temperature at which the crystallization process is severely altered. Optical properties of the pyrite films seem to depend strongly on their stoichiometry.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 112 (1999), S. 222-226 
    ISSN: 1437-1596
    Keywords: Key words Age estimation ; Human dentin ; Collagen crosslinks ; Deoxypyridinoline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract A new biochemical method for estimation of dental age from human dentin is presented. An adaptation and modification of a dentin protein extraction protocol was developed by which deoxypyridinoline crosslinks were measured using an enzyme immunoassay technique. Deoxypyridinoline, a non-reducible collagen crosslink, was measured in human dentin samples from permanent individual molars. The measurement of this protein in dentin samples from 22 patients with ages ranging from 15 to 73 years old was carried out to obtain an estimate of age at death. By linear regression between deoxypyridinoline values and age, equations for age calculations were computed. The error between the estimated age and the known age at extraction was calculated. Our results show that this method produces an expected associated error on calibration averaging 14.9 years about the mean estimated values, at a 65% level of confidence. Values of sensitivities and specificities were calculated for deoxypyridinoline at different ages. We conclude that determination of deoxypyridinoline in human dentin extracts is a new and reliable procedure, potentially suitable for most forensic laboratories and which could be a useful tool to estimate human dental age. This method could be considered as an alternative method to calculate dental age, contributing to a more accurate estimation of chronological age when used in addition to other morphological or biochemical dental methods.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PCR was used to detect hepatitis C virus (HCV) RNA in serum and peripheral blood mononuclear cells (PBMCs) for evaluation of a six-month course of Interferon therapy in 18 patients with histologically confirmed chronic hepatitis C. At follow-up six months after the end of therapy positive-stranded (genomic) and negative-stranded (anti-genomic, presumptive replicative intermediate) HCV RNA could be detected in PBMCs of all ten patients who either did not respond to therapy or suffered a relapse; genomic strand RNA was detected in five patients who responded but then relapsed. The study confirms that interferon therapy leads to inhibition of HCV replication but not eradication of the virus. Persistence of the virus at extrahepatic sites may explain its reactivation after cessation of interferon therapy.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 323 (1986), S. 105-109 
    ISSN: 1434-601X
    Keywords: 21.60.−n ; 27.50. + e
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The structure of87Y nucleus is described within the framework of the extended clusterphonon model taking into account the coupling of single-proton and two-proton-oneproton-hole configurations with quadrupole and octupole vibrations of the underlying86Sr core. The energy levels and electromagnetic transitions are calculated and compared with available experimental information. Attempts to consider the86Sr as the vibrating core were also made. In this case the cluster was extended to include two-neutron-hole states too. No results are shown since the calculations failed to explain the experimental data.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to assess the implications of dual infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). The HBV and HCV status in 100 patients with chronic hepatitis was analysed. HBV DNA was studied using liquid hybridization and the polymerase chain reaction (PCR). HCV viremia was measured using qualitative and quantitative PCR. The HCV genotype was determined by PCR. Patients were divided into three groups according to their HCV-RNA and HBsAg status: group I consisted of 40 patients with chronic hepatitis caused by HBV; group II, 40 patients with chronic hepatitis caused by HCV; and group III, 20 patients infected with both viruses. The HBV-DNA level was higher in group I than in group III (66.4 vs. 11.5 pg/ml; p〈0.05). Quantification of HCV viremia revealed mean values of 36.9 copies × 105/ml in group II and 5.5 copies/ml × 105 in group III (p〈0.05). The mean aminotransferase level and histological activity were higher in group III. HCV genotype 1b was the predominant type. The data suggest that there is reciprocal inhibition of viral replication in patients with dual HBV and HCV infection. Liver disease appears to be more severe in patients with chronic hepatitis B and C.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 273 (1975), S. 373-380 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The character of the excited levels of115In was analyzed through the decay of115gCd and115mCd. Beta and gamma-ray spectra were recorded, and beta-gamma and gamma-gamma coincidences as well as gamma-gamma angular correlations were performed. Several semiconductor detectors have been used, such as Si(Li) and intrinsic germanium of different volumes and efficiencies. New results on the gamma (35)-gamma (232) angular correlation are presented, as well as confirmatory ones on the gamma (35)-gamma (493) and gamma (484)-gamma (934). Mixing ratios for all these cascades with the corresponding sign are established. The shape factor of the beta spectrum to the 1291.2-keV level is determined for the first time, and a confirmatory value for the shape factor of the beta spectrum to the 934.4-keV level is obtained. Gamma-gamma coincidence experiments show that the 105.3-keV gamma ray follows the 485-keV transition. Theoretical calculations were made to fit the experimental results by using the generalized semimicroscopic model. State vectors for some even-parity states are presented as well as theoretical branching and mixing ratios, and nuclear lifetime.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 324 (1986), S. 403-415 
    ISSN: 1434-601X
    Keywords: 21.60.−n ; 27.50.+e ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An extension of the cluster-(quadrupole-octupole) phonon model is proposed for nuclei withA∼90 to describe simultaneously positive- and negative-parity states, in which quadrupole as well as octupole vibrations of the88Sr core are allowed. The cluster states include particle and particle-hole core excitations. The residual interaction is a delta-function force with spin-spin exchange plus a quadrupole-quadrupole force. The model is applied to87Sr,89Sr,88Y, and90Y nuclei. For each case, energy levels, spectroscopic factors, and electromagnetic properties are calculated and compared with experiment.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of oncology 9 (1998), S. 331-334 
    ISSN: 1569-8041
    Keywords: chemotherapy ; cisplatin ; docetaxel ; non-small-cell lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To evaluate the efficacy and safety of the docetaxel-cisplatin combination in patients with advanced non-small-cell lung cancer (NSCLC). Patients and methods: Chemotherapy-naïve patients with histologically confirmed, measurable stage IIIB or IV NSCLC, a World Health Organization (WHO) performance status of 0–2 and adequate bone marrow, renal, hepatic and cardiac function were eligible for the study. Patients received docetaxel (100 mg/m2) as an one-hour infusion on day 1 and cisplatin (80 mg/m2) as a 30-min infusion with appropriate hydration on day 2. Granulocyte colony-stimulating factor (G-CSF; 150 µg/m2 , SC) was given on days 3 to 13. Treatment was repeated every three weeks. Results: Fifty-three patients were enrolled (28 with stage IIIB and 25 with stage IV). One complete and 23 partial responses were observed (overall response rate (OR): 45%; 95% CI: 34.1%–61.8%). The response rate was 57% and 32% in patients with stages IIIB and IV disease (P = NS). The median time to progression was 36 weeks and the median survival 48 weeks; the one-year survival was 48%. Grade 3–4 neutropenia occurred in 23 patients, 15 of whom were hospitalized for neutropenic fever; two patients died of sepsis. Grade 2 neurotoxicity was observed in six patients and grade 3 in five patients; grade 3 fatigue occurred in seven patients, grade 3–4 mucositis in four patients and grade 3–4 diarrhea in six patients. Mild allergic reactions and oedema were observed in five and four patients, respectively. The median dose intensity was 30 mg/m2 /week for docetaxel and 24 mg/m2 /week for cisplatin, corresponding to 91% and 89% of the specified protocol doses, respectively. Conclusions: The docetaxel–cisplatin combination is an active regimen in advanced NSCLC, but hematologic toxicity remains high despite the prophylactic use of G-CSF.
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