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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 56-57 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Resumen Se ha estudiado la actividad catalásica en la sangre de 10.009 españoles residentes en Madrid, por el método deFeinstein 9. Se encontraron 26 individuos cuya actividad catalásica oscila entre el 20% y el 80% de la normal. Estos individuos se consideraron como hipocatalasémicos. Se comparan estos datos con los de otros autores y se discute su posible significado.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 11 (1997), S. 653-658 
    ISSN: 1573-7241
    Keywords: bezafibrate ; hypertriglyceridemia ; HDL3 composition ; free cholesterol efflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of bezafibrate, a well-used fibric acid hypolipidemic agent, were investigated in 10 moderately hypertriglyceridemic patients. The aim was to quantify the physico-chemical modifications to high-density lipoprotein subfraction 3 (HDL3) induced by treatment and to assess, in vitro, the alterations in its principal physiological function, the efflux of intracellular free cholesterol. Treatment (200mg/thrice/d for 3 months) resulted in a 48% decrease in plasma triglycerides, with an increase in the HDL cholesterol, due mainly to an increase in the HDL3 (P 〈 0.01). Composition analysis of HDL3indicated an increase in cholesterol esters (P 〈 0.01), free cholesterol (P 〈 0.01), and phospholipids (P 〈 0.01), coupled with a decrease in the protein content of the molecule compared with pretreatment values. Fluorescense anisotropy at 24°C was significantly higher post-treatment than pretreatment (P 〈 0.01). The cholesterol effluxing capacity of pretreatment HDL3 was 28%, and post-treatment this increased to 50% (P 〈 0.01). Multivariate analyses indicated that the increased capacity of HDL3 to promote free cholesterol efflux was, in part, due to increased HDL3 phospholipid content and a more adequate fluidity of the molecule. These findings suggest that bezafibrate induces a lowering of plasma triglycerides and that the resultant physico-chemical alterations of the HDL3 molecule make it more efficient as an acceptor of intracellular free cholesterol.
    Type of Medium: Electronic Resource
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