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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 1 (1988), S. 493-502 
    ISSN: 1573-7241
    Keywords: acidosis ; verapamil ; spectroscopy ; nuclear magnetic resonance ; cardiac metabolism ; mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metabolic acidosis was produced in two groups of isolated, glucose-perfused beating rat hearts. The first group (control) was untreated whereas the second group was pretreated for 48 h by the addition of verapamil (1.2 g/L) to the drinking water. Untreated hearts all developed asystole during a 30 min perfusion with an acidotic substrate (pH=6.8) or during subsequent reequilibration with physiologic substrate (pH=7.4). Prior to asystole, all untreated hearts showed evidence of severe mechanical and biochemical deterioration evaluated by31P NMR spectroscopy. In contrast, hearts of treated rats showed less mechanical and metabolic deterioration, and all recovered during reequilibration. The mechanism of protection of verapamil against the effects of metabolic acidosis is unclear but appears to be related to preserved mitochondrial function by the drug and not to a reduced demand for energy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-0743
    Keywords: high speed CT ; cine CT scanning ; heart disease ; cardiac imaging ; diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CT scanning provides useful cardiac imaging but has not become a routine clinical tool for heart disease due to long exposure times (2–5 seconds) and the limitation of single slice acquisition. A revolutionary high speed (Cine) CT electron beam scanner was designed at UCSF, with multilevel millisecond scanning speed at rates of 17 scans per second. Table tilt and swivel permits direct imaging in various planes including the half axis view. Images can be analysed as closed loop movies, and quantitation of wall thickening, wall mass and ejection fractions are being validated. High resolution imaging without the need for gated acquisition is a significant advantage over nuclear medicine and magnetic resonance imaging, and physiology can be studied with exercise of other interventions. Fast CT can measure vessel blood flow and has great potential for estimating myocardial perfusion using indicator dilution theory and small peripheral intravenous injection of contrast medium. Cine CT could become the noninvasive modality of choice in cardiovascular diagnosis the scanner has universal application for all organ systems.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-0743
    Keywords: nuclear magnetic resonance ; cardiac imaging ; acquired heart disease ; congenital heart disease ; myocardial tissue characterization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Magnetic resonance imaging (MRI) is a completely noninvasive technique for the evaluation of the cardiovascular system. With a multi-section technique and the spin echo pulse sequence the entire heart can be examined within six to ten minutes. All our cardiac MR studies were performed with electrocardiographic (ECG) gating, to obtain adequate resolution of the cardiac structures. With this technique, patients and animals with a variety of cardiac abnormalities were studied. The examined pathologic conditions included acute and chronic myocardial infarctions and their complications, hypertrophic and congestive cardiomyopathies, congenital heart diseases and pericardial diseases. MRI offers an enormous potential for cardiovascular diagnosis, even beyond the demonstration of pathoanatomy, because of the capability for direct tissue characterization and blood flow measurements.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1352-8661
    Keywords: cine MRI ; ischemic heart disease ; myocardial function ; myocardial perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract Ischemic heart disease is the most frequently encountered cardiac disease. Magnetic resonance imaging (MRI) can be used to investigate several facets of this disease. A number of studies over the past several years have shown the capability of cine MRI for quantifying regional myocardial function and for identifying abnormalities of regional myocardial wall thickening in the basal or vasodilated states due to ischemia. Contrast-enhanced inversion recovery fast gradient echo and echo-planar imaging have been applied for monitoring the first passage of contrast media through the myocardium. This technique has depicted regional perfusion deficits in the basal state or in the vasodilated states induced by vasodilators. Recent studies have also disclosed the feasibility of using MR techniques for displaying the morphology of the major coronary arteries and for measuring blood flow velocity in the coronary arteries and coronary bypass grafts. Thus, MRI has the capability for evaluation of morphology and flow in the coronary arteries and for assessment of function and perfusion of the myocardium.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric cardiology 2 (1982), S. 333-338 
    ISSN: 1432-1971
    Keywords: Dextrocardia ; Polysplenia ; Complex cyanotic heart disease ; Surgery ; Intra-atrial baffle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical, angiocardiographic, and surgical findings in a cyanotic child with dextrocardia, L-loop, laterally inverted but otherwise normally related great arteries, and situs ambiguus are described and compared with other similar cases. Electrocardiographic, echocardiographic, and angiographic data are reviewed, and thesegmental approach to diagnosis is stressed. Both systemic and pulmonary veins returned to the right-sided atrium. Blood then passed either through the mitral valve to the morphologically left ventricle and to the aorta or through an atrial septal defect to a small left-sided atrium, right ventricle, and pulmonary artery. Total correction was undertaken with an intra-atrial baffle to direct pulmonary venous return to the morphologically right ventricle and systemic venous return to the right ventricle. The subpulmonic stenosis was alleviated with an outflow patch.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 18 (1993), S. 56-60 
    ISSN: 1432-0509
    Keywords: Liver, MR studies ; MR, pulse sequences ; MR, rapid imaging ; Liver neoplasms ; MR studies ; MR, contrast enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of excitation-spoiling fat suppression (fatsat) imaging in the detection of liver lesions was assessed comparing short TR/TE and long TR/ TE spin-echo (SE) sequences with and without excitation-spoiling fat suppression in 25 patients at 1.5T. The study included patients with liver metastases (n = 21), primary liver cancer (n=3), and hepatic adenoma (n=1). Liver lesion detection and lesionliver signal-to-noise ratios (SNR) were determined for the various imaging sequences in a prospective fashion. Liver lesion-liver SNR were highest for long TR/TE (2000-2500/70-80) fatsat images (12.7±4.8) compared to long TR/TE regular SE (2000-2500/70-80) images (8.8±5.6) [(p = ns) (not significant)], short TR/TE (200-400/15-20) fatsat images (-6.2±4.8) (p=0.05), and short TR/TE regular SE images (-4.9±3.2) (p〈0.01). Lesion detection was greatest for long TR/TE fatsat (86) followed by long TR/TE regular SE (78) (p=0.05), short TR/TE fatsat (65) (p〈0.01), and short TR/TE regular SE (60) (p〈0.01). The results of this study suggest that excitation-spoiling fat suppression may improve liver lesion detection and conspicuity.
    Type of Medium: Electronic Resource
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