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  • 1
    Online Resource
    Online Resource
    Washington, D.C. : National Academies Press
    Pages: 1 Online-Ressource (xiv, 75 p.)
    ISBN: 9780309120937 , 0309120934 , 0309120926 , 9780309120920
    Note: Includes bibliographical references (p. 31-32) , Introduction -- Grand challenge : how does the human brain work and produce mental activity? -- Grand challenge : nature versus nurtrure : how does the interplay of biology and experience shape our brains and make us who we are? -- Grand challenge : how do we keep our brains healthy? Do we protect, restore, or enhance the functioning of our brains as we age? -- Inspiring the next generation of scientists -- Challenges and technical limitations -- Ethical considerations -- Conclusion: On the cusp -- Appendixes
    Language: English
    Keywords: Konferenzschrift
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  • 2
    Online Resource
    Online Resource
    Washington, D.C : National Academies Press
    Pages: Online Ressource (xiv, 75 p.)
    Edition: Online-Ausg.
    ISBN: 9780309120937 , 0309120934 , 0309120926
    Note: Includes bibliographical references (p. 31-32). - Description based on print version record , IntroductionGrand challenge : how does the human brain work and produce mental activity? -- Grand challenge : nature versus nurtrure : how does the interplay of biology and experience shape our brains and make us who we are? -- Grand challenge : how do we keep our brains healthy? Do we protect, restore, or enhance the functioning of our brains as we age? -- Inspiring the next generation of scientists -- Challenges and technical limitations -- Ethical considerations -- Conclusion: On the cusp -- Appendixes.
    Parallel Title: Print version From molecules to minds
    Language: English
    Keywords: Electronic books ; Konferenzschrift
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  • 3
    E-Resource
    E-Resource
    Washington, District of Columbia : National Academies Press
    Pages: 1 Online-Ressource (105 pages)
    ISBN: 9780309285674 , 9780309285681
    Language: English
    Keywords: Konferenzschrift
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  • 4
    Online Resource
    Online Resource
    Washington, D.C : National Academies Press
    Pages: Online Ressource (xii, 75 p.) , ill.
    Edition: Online-Ausg.
    ISBN: 9780309148849 , 0309148847
    Description / Table of Contents: "The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system--including psychiatric drugs--are assessed for whether that drug might cause suicidal ideation or behavior. The Institute of Medicine's (IOM) Forum on Neuroscience and Nervous System Disorders hosted a meeting on June 26, 2009, to discuss the FDA's new policy and how to analyze best whether suicidal thoughts predict actual suicidal behavior in the near future."--Publisher's description
    Note: Includes bibliographical references (p. 43-49). - Description based on print version record
    Language: English
    Keywords: Electronic books ; Konferenzschrift
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  • 5
    Online Resource
    Online Resource
    Washington, D.C. : National Academies Press
    Pages: 1 Online-Ressource (xii, 61 p.)
    ISBN: 9780309212229 , 0309212227 , 9780309212212 , 0309212219 , 1283213451 , 9781283213455
    Note: Introduction -- - Overview of the Glutamatergic System -- - Glutamate Biomarkers -- - Treatment Implications of Biomarkers -- - Challenges and Opportunities -- - Appendix A - References -- - Appendix B - Registered Attendees -- - Appendix C - Agenda , Includes bibliographical references (p. 39-43) , Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop
    Language: English
    Keywords: Konferenzschrift
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  • 6
    Online Resource
    Online Resource
    Washington, D.C. : National Academies Press
    Pages: 1 Online-Ressource (xii, 75 p.)
    ISBN: 9780309148849 , 0309148847 , 0309148839 , 9780309148832
    Note: Includes bibliographical references (p. 43-49) , Perspectives from the FDA, academia, and patients -- Data collection and optimization -- Data analysis -- Partnerships, opportunities, collaboration , "The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system--including psychiatric drugs--are assessed for whether that drug might cause suicidal ideation or behavior. The Institute of Medicine's (IOM) Forum on Neuroscience and Nervous System Disorders hosted a meeting on June 26, 2009, to discuss the FDA's new policy and how to analyze best whether suicidal thoughts predict actual suicidal behavior in the near future."--Publisher's description
    Language: English
    Keywords: Konferenzschrift
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  • 7
    E-Resource
    E-Resource
    Washington, D.C. : The National Academics Press
    Pages: 1 online resource (47 pages) , color illustrations
    ISBN: 9780309379724 , 9780309379731
    Note: Description based on online resource; title from PDF title page (ebrary, viewed May 5, 2016)
    Language: English
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  • 8
    Online Resource
    Online Resource
    Washington, DC : National Academies Press
    Pages: 1 Online-Ressource
    ISBN: 9780309161244 , 030916124X , 9780309161251 , 0309161258 , 1283376199 , 9781283376198
    Note: Title from PDF title page , Includes bibliographical references , Biologically based differences between the sexes impact human development and behavior in both obvious and subtle ways. Sex differences are also apparent across the spectrum of health and disease, impacting not only individual health, but also public health, biomedical research, and healthcare delivery. Researchers have begun to elucidate these differences and their potential impact in areas such as pain and pain perception, infection, longevity, disease incidence and course, and cellular response and inflammation. Studies have shown, for example, that males and females can have markedly different responses to certain medications; in some cases these unexpected differences have led to the recall of products from the market (GAO, 2001). In the current era of translational research and personalized medicine, it is increasingly important to take sex differences into account, so that the potential effects of products and therapies can be more fully understood , Introduction -- - Studying sex difference in health and disease -- - Studying sex differences in translational research: examples from four major disease areas -- - Reporting sex differences in research publications -- - Sex differences in drug development: policy and practice -- - Needs, opportunities, and next steps
    Language: English
    Keywords: Konferenzschrift
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  • 9
    Online Resource
    Online Resource
    Washington, DC : National Academies Press
    Pages: Online Ressource
    Edition: Online-Ausg.
    ISBN: 9780309161244 , 030916124X , 9780309161251 , 0309161258 , 1283376199 , 9781283376198
    Description / Table of Contents: Biologically based differences between the sexes impact human development and behavior in both obvious and subtle ways. Sex differences are also apparent across the spectrum of health and disease, impacting not only individual health, but also public health, biomedical research, and healthcare delivery. Researchers have begun to elucidate these differences and their potential impact in areas such as pain and pain perception, infection, longevity, disease incidence and course, and cellular response and inflammation. Studies have shown, for example, that males and females can have markedly different responses to certain medications; in some cases these unexpected differences have led to the recall of products from the market (GAO, 2001). In the current era of translational research and personalized medicine, it is increasingly important to take sex differences into account, so that the potential effects of products and therapies can be more fully understood
    Note: Title from PDF title page. - Includes bibliographical references. - This project was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; AstraZeneca Pharmaceuticals, Inc.; CeNeRx Biopharma; the Department of Health and Human Services' National Institutes of Health (NIH, Contract Nos. N01-OD-4-213) through the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Eye Institute, NIH Blueprint for Neuroscience Research, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke; Eli Lilly and Company; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Merck Research Laboratories; the National Multiple Sclerosis Society; the National Science Foundation (Contract No. OIA-0753701); the Society for Neuroscience; and Wyeth Research, Inc
    Language: English
    Keywords: Electronic books ; Konferenzschrift
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  • 10
    Online Resource
    Online Resource
    Washington, D.C : National Academies Press
    Pages: Online-Ressource (xx, 108 p)
    Edition: Online-Ausg.] Palo Alto, Calif ebrary 2011 Electronic reproduction; Available via World Wide Web
    ISBN: 0309148804 , 9780309148801
    Description / Table of Contents: Mental, neurological, and substance use (MNS) disorders disrupt the lives of individuals and families across the world. The impact of these disorders - which range from epilepsy to depression to alcohol abuse - is especially significant in sub-Saharan Africa, where most of the world's poorest countries are found. Millions of Africans in 47 countries suffer from some type of MNS disorder, and most cannot obtain treatment. Few psychiatrists or other mental health professionals work in sub-Saharan Africa, and those that do usually have private practices in urban centers. Health centers in rural areas, where the majority of the population lives, are few and far between, and drugs tend to be scarce and expensive. As such, many people with MNS disorders go undiagnosed and untreated; they and their families must bear the burden of their disease alone. In August 2009, the Uganda National Academy of Sciences' Forum on Health and Nutrition and the IOM's Forum on Neuroscience and Neurological Disorders hosted a workshop in Kampala, Uganda, to discuss the state of care for MNS disorders in sub-Saharan Africa. More than 150 researchers, providers, patient advocates, and policy specialists attended. Speakers explored strategies to improve the quality and consistency of care, taking into account countries' limited resources, infrastructure, and other realities. This document summarizes the workshop
    Note: "Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Forum on Health and Nutrition , Includes bibliographical references , BackgroundSystems of care for MNS in sub-Saharan Africa -- MNS healthcare policy -- Needs, opportunities, and next steps. , Electronic reproduction; Available via World Wide Web
    Parallel Title: Print version Mental, neurological, and substance use disorders in Sub-Saharan Africa
    Language: English
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