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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 7 (1978), S. 391-404 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A spectrum of lymphomas, sarcomas, and carcinomas were tested for F1 hybrid resistance after s.c. inoculation of small numbers of cells into syngeneic and F1 hybrid mice. Significant F1 resistance was demonstrated against all tumors tested except one. Backcross and/or congenic inoculation tests showed significantH-2 linkage of hybrid resistance against all lymphomas and leukemias tested. There was no linkage betweenH-2 and hybrid resistance within the more limited group of carcinomas and sarcomas. DifferentH-2-linked resistance genes were shown to act against different lymphomas, including some that were induced by the same agent. Some lymphomas induced by different agents in the same strain were also found to differ in their sensitivity to the sameH-2-linked resistance factor. These data suggest the existence of a polymorphic system, probably pseudoallelic, rather than simply allelic in nature.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 346 (1990), S. 476-480 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A mouse mutant lymphoma cell line, RMA-S, expresses at the cell surface 〈10% of the amount of class I molecules compared with RMA mutagenized but unselected control line?'3-and is unable to present endogenous antigens1'4. Rates of synthesis of class I heavy and light chains are normal in RMA-S, ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 340 (1989), S. 443-448 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We describe a cell in which association of a major histocompatibility complex class I heavy chain with β2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of anti-genie peptides with the binding site ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 405 (2000), S. 527-528 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Class I molecules of the major histocompatibility complex (MHC) are normally expressed on the surface of most cells in the body. They serve two purposes in the immune system. T cells use MHC molecules to identify and kill cells that are infected by foreign material, such as viruses. Natural ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 319 (1986), S. 675-678 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] More specifically, the hypothesis5'6 stated that self-MHC genes influence the expression or recognition of inhibitor signals in interactions between potential target cells and natural effector cells. Our experimental approach was to test the prediction that selection for loss of H-2 in tumour lines ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 417-424 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Defects in major histocompatibility complex (MHC) class I–restricted antigen presentation are frequently observed in human cancers and result in escape of tumors from cytotoxic T lymphocyte (CTL) immune surveillance in mice. Here, we show the existence of a unique category of CTLs that can ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 386 (1997), S. 446-447 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In his book River out of Eden\ Richard Dawkins discusses how birds protect their nest and offspring from predators. Citing the Austrian zoologist Wolfgang Schliedt, he points out that the "rule of thumb a turkey mother uses to recognize nest robbers is a dismayingly brusque one: in the vicinity of ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 284 (1980), S. 624-626 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The benzpyrene-induced EL-4 and the Rad-LV-induced P-52-127-166 leukaemias of C57BL/6 origin, are both highly resisted by certain C57BL FI hybrids that have high NK activity in vitro14,15. Also, low-dose inocula of the in vivo maintained ascites lines of the two leukaemias behaved similarly; ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 174-176 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Thymocytes from 2-week-old A/Sn mice were lysed in a 3 h 51Cr release assay with nylon wool passed CBA spleen cellsas NK effectors (Fig. 1). As shown below in Fig. 4, this lytic effect was dose-dependent at effector to target cell ratios below 25:1, whereas higher numbers of effector cells resulted ...
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 260-262 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A truncated soluble form of the murine class I major histocompatibility antigen complex H–2Dd was cloned using an Escherichia coli based system. It was expressed, refolded in vitro and crystallized in a complex with murine β2 microglobulin and the peptide RGPGRAFVTI from the V3-loop of the gp160 HIV-1 protein. Crystals belonging to the space group P212121 with cell dimensions a = 51.3, b = 92.5, c = 108.8 Å were obtained using two different crystallization conditions. The crystals contain one complex per asymmetric unit and diffract to at least 2.4 Å resolution.
    Type of Medium: Electronic Resource
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