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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 218 (1989), S. 531-535 
    ISSN: 1617-4623
    Keywords: Origin of replication ; Promoter ; Saccharomyces cerevisiae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In an attempt to devise a new assay for ARS-binding proteins we have inserted the HO ARS between the upstream activation site and the TATA region of the yeast CYC1 promoter. A marked reduction in promoter activity is observed. Inactivation of the HO ARS element by point mutation does not restore promoter activity to its original level, although a modest activation is seen. We have also inserted the HO ARS into the intron of the yeast actin gene; although there is no apparent deleterious effect on transcription, the activity of the ARS is abolished in this new environment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Company
    Nature biotechnology 16 (1998), S. 701-702 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A recent commentary by Harry Rubin1 examined the role of telomere loss in cell aging and critically analyzed the demonstration that forced expression of telomerase can extend cell lifespan in vitro2. This was discussed with reference to human aging and cell senescence. We believe his conclusions ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 33 (2003), S. 203-207 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] By imposing a limit on the proliferative lifespan of most somatic cells, telomere erosion represents an innate mechanism for tumor suppression and may contribute to age-related disease. A detailed understanding of the pathways that link shortened telomeres to replicative senescence has been ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 551-551 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ... For lagging-strand DNA replication, short RNA primers (blue) are made by RNA primase. These are then extended by DNA polymerase to form Okazaki fragments. When these RNA primers are removed, there is no way to synthesize lagging-strand sequence that is complementary to the small region at the ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 509-509 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR- Davies et al.1 recently pointed out the sequence similarity between the yeast PPR2 protein2, which is required for transcriptional induction of the URA4 gene, and transcription elongation factor SII (also called TFIIS)3. Since then, the sequence of DST1 (ref. 4) has been published and is ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 400-402 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When human DNA from peripheral blood cells is digested with a frequently cutting restriction enzyme, hybridization with a (TTAGGG)4 oligonucleotide probe detects a range of terminal fragment sizes, averaging around 10 kilobases (kb) (refs 4-6). These are seen as a smear of hybridization signal when ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 398 (1999), S. 191-193 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The potential rewards of understanding ageing are vast, yet the field remains greatly underexplored. Physiological changes in old age — ranging from poor wound healing and a compromised immune system, to cardiovascular problems — can reduce the quality of life for an ever-increasing ...
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  • 8
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Rubin has argued in your commentary and elsewhere that the limited division capacity of primary human cells in vitro is due to the accumulation of "damage" during cell culture. For fibroblasts, this possibility has now been disproven. Telomerase on its own can extend the in vitro ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 9 (1995), S. 104-106 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Human telomeres, the structures found at the tips of chromosomes (Fig. 1), consist of many kilobases of (TTAGGG)n together with various associated proteins (reviewed in ref. 1). Small amounts of these terminal sequences are lost from linear chromosomes each S phase because of incomplete DNA ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 551-552 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Telomeres are specialized structures at the ends of linear chromosomes. They usually consist of tandem arrays of a short DNA sequence (TTAGGG in vertebrates) and associated proteins, and they are thought to have at least two essential functions. First, they stop natural chromosome ends behaving as ...
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