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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Current microbiology 34 (1997), S. 49 -54 
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Streptococcus mutans is an important pathogen in coronal caries and is implicated in dental root decay by its ability to bind collagen from various sources. In the present study, electron microscopic analysis demonstrated the ability of S. mutans to bind and to disrupt collagen fibrils of the amniotic membrane. The synthetic peptide FALGPA, which is similar in structure to collagen, was degraded by S. mutans, with a lower level of FALGPA hydrolytic activity observed in sucrose-grown cells compared with cells grown in the absence of sucrose. Inhibition studies of FALGPA hydrolytic activity showed a pattern characteristic of collagenase activity, with inhibition by 1,10-phenanthroline and EDTA, but not by phenylmethylsulfonyl fluoride (PMSF). Additionally, immunological cross-reactivity was observed between proteins from disrupted cells of S. mutans and antiserum to collagenase from Clostridium histolyticum. Gelatinolytic activity was demonstrated by gelatin zymogram analysis. These findings suggest that collagenolytic activity by S. mutans may be an important virulence factor in dental root decay.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Current microbiology 26 (1993), S. 141-145 
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Amniotic membranes collected after both cesarean and vaginal deliveries were inoculated with group B streptococci (GBS) in this in vitro study. Transmission electron microscopic examination of segments of uninoculated control amniotic membranes revealed compact, wellordered, clearly defined layers of collagen fibrils. Examination by both scanning and transmission electron microscopy of amniotic membrane segments inoculated in vitro with group B streptococci revealed bacterial attachment to the membrane surface and migration through the membrane accompanied by disordered collagen fibril layers. Degradation of the collagen fibrils during bacterial invasion may cause weakening of the amniotic membranes and thus be a contributing factor in cases of premature rupture of membranes associated with group B streptococcal colonization of the mother.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Current microbiology 5 (1981), S. 175-178 
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Neuraminidase production has been found to vary among individual strains of type III group B streptococci (GBS). The production of neuraminidase has been shown to be affected by different environmental factors. In this study, oxygen concentration was found to influence the amount of enzyme produced. The effect of oxygen on enzyme production was examined in a highneuraminidase-producing strain and a low-neuraminidase-producing strain. With the batch culture technique, the following trend of neuraminidase production was observed: Maximum enzyme production occurred at oxygen concentrations of 5% and 10%, intermediate production occurred at 0%, and lowest production occurred at 15% and 20%. Continuous culture technique confirmed these findings at 5% and 15% oxygen concentrations. Since neuraminidase is believed to be a virulence factor in GBS syndrome in neonates, it is possible that maximum enzyme production may occur at oxygen levels similar to those found in neonatal blood.
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 163-170 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sialic acid terminates oligosaccharide chains on mammalian and microbial cell surfaces, playing critical roles in recognition and adherence. The enzymes that transfer the sialic acid moiety from cytidine-5′-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to the terminal positions of these ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 9 (2002), S. 870-876 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. The key determinant of the broad-spectrum β-lactam resistance in MRSA strains is the penicillin-binding protein 2a (PBP2a). Because of its low ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 10 (2003), S. 371-378 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Uncontrolled activation of calpain can lead to necrotic cell death and irreversible tissue damage. We have discovered an intrinsic mechanism whereby the autolysis-generated protease core fragment of calpain is inactivated through the inherent instability of a key α-helix. This ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 8 (2001), S. 848-852 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The structure of the 28 kDa β-lactamase inhibitor protein-II (BLIP-II) in complex with the TEM-1 β-lactamase has been determined to 2.3 Å resolution. BLIP-II is a secreted protein produced by the soil bacterium Streptomyces exfoliatus SMF19 and is able to bind and inhibit TEM-1 with ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature structural biology 7 (2000), S. 108-113 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Phytases catalyze the hydrolysis of phytate and are able to improve the nutritional quality of phytate-rich diets. Escherichia coli phytase, a member of the histidine acid phosphatase family has the highest specific activity of all phytases characterized. The crystal structure of E. coli ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 8 (2001), S. 1031-1036 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Several Gram-negative bacterial pathogens have evolved a type III secretion system to deliver virulence effector proteins directly into eukaryotic cells, a process essential for disease. This specialized secretion process requires customized chaperones specific for particular effector proteins. The ...
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 32 (1999), S. 134-135 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Crystallization at 277 K is routinely practiced in most crystallography laboratories. Data collection from such crystals at this temperature has been facilitated by the widespread use of versatile cryocooling devices capable of maintaining crystals at cryogenic to near room temperatures. However, temperature gradients can potentially develop along a capillary cooled by a gas stream, which may result in condensation around the crystal. A convenient protocol has been developed and used successfully to prevent this problem. By the placement of oil plugs close to both sides of the crystal, the enclosed airspace is kept free of condensation, even while the capillary is cooled for extended periods of time by a gas stream flowing at an angle to the capillary. This technique eliminates the need to work with very short capillaries and can be implemented without modification to an existing cryostat configuration.
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