Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract A pharmacokinetic study was carried out on six normal healthy adults with average creatinine clearances ranging from 94.8 to 129.3 ml/min. Cefamandole, 15 mg/kg, was administered intravenously over a period of 10 min. Frequent and prolonged samplings of blood and urine were made. Specimens were assayed by a sensitive, accurate, and reproducible HPLC assay. An excellent computer fit to a threecompartment body model was observed. T1/2 α, β, and γ were 5.1, 23.6, and 74.2 min, respectively. The relatively long terminal T1/2 and the area under the curve (AUC) contributed by the γ phase being 31% suggest that a multicompartmental kinetic nature of cefamandole cannot be ignored. Volume of distribution (VDSS)averaged 11.8 liters, and the serum clearance was 200 ml/min. Ninetysix percent was excreted in the urine, and therefore a very high urinary concentration was achieved. The concentration in the plasma exceeds the MIC of many grampositive and negative organisms for many hours.
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