Darstellung von phenolischen verbindungen und phenol/formaldehyd-polykondensaten mit ketoxim-, aldoxim- oder 1-methyl-4-hydroxyiminomethylpyridinium-gruppen und deren wirkung auf parathion-methyl® und verwandte verbindungenHerrn Prof. Dr. Chr. P. Pinazzi, Université Du Maine (France), meinem Kollegen und langjährigen Weggefährten, mit allen guten Wüschen zum 60. Geburtstag gewidmet von H. K.
Polymer and Materials
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Thirteen low molecular weight oximes were prepared: one derivative of acetophenone (1), two derivatives of benzophenone (2 and 3), two derivatives of salicylaldehyde containing two phenolic nuclei (4c and 5c), and eight compounds in which a phenol unit is substituted by a 4-hydroxyiminomethylpyridiniummethyl group (8a-f, 10c, and 11c). Besides these compounds polymeric phenol formaldehyde condensates were synthesized which contain units deriving from benzophenoneoxime (15b) or from salicylaldehyde (22b) and condensates containing 4-hydroxyiminomethylpyridiniummethyl groups (23c). A series of low molecular weight and water soluble compounds (8a-f) were proved as antidotes on mice which were poisoned by paraoxon, sarin, soman, or tabun. These compounds showed a distinct but only a little antidote activity in the case of soman and tabun. Adsorption studies of parathion-methyl in a solution of water and methanol (volume ratio 10:1) by the water insoluble polycondensates showed that the oximes adsorb better than the parent carbonyl products.
Type of Medium: