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  • 1
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer
    Person(s): Marmé, Dieter
    Keywords: Medizin ; Tumorwachstum ; Angiogenese ; Medicine ; Oncology ; Toxicology ; Tumorwachstum ; Angiogenese
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XVIII, 845 S.) , Ill., graph. Darst.
    ISBN: 9783540331766 , 9783540331773
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 36 (1995), S. 139-155 
    ISSN: 1573-7217
    Keywords: vascular endothelial growth factor (VEGF) ; VEGF receptors ; vascular permeability factor ; regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vascular endothelial growth factor (VEGF) / vascular permeability factor (VPS) plays a crucial role for the vascularization of tumors including breast cancers. Tumors produce ample amounts of VEGF, which stimulates the proliferation and migration of endothelial cells (ECs), thereby inducing tumor vascularization by a paracrine mechanism. VEGF receptors (VEGF-Rs) are highly expressed by the ECs in tumor blood vessels. VEGF expression can be induced in various cell types by a number of stimuli including hypoxia, differentiation, growth factors and tumor promoters of the phorbol ester class, such as TPA. The VEGF inductive pathways comprise kinases, oncogenes, tumor suppressor genes, and steroid hormone transcription factors, many of which seem to converge on the activator protein (AP-1) transcription factor. Much less is known about the regulation of VEGF-R expression, which is restricted to ECs. This expression is greatly enhanced in diseased tissue such as solid tumors. So far, it appears that growth factors, cytokines, and tumor promoters are involved in the control of VEGF-R expression. Here we review current knowledge about the regulation of the expression of VEGF and its receptors.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cancer and metastasis reviews 17 (1998), S. 241-248 
    ISSN: 1573-7233
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Biologie in unserer Zeit 3 (1973), S. 162-162 
    ISSN: 0045-205X
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Biologie in unserer Zeit 11 (1981), S. 71-77 
    ISSN: 0045-205X
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 2 (1974), S. 751-768 
    ISSN: 0091-7419
    Keywords: Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Phytochrome (P), a chromoprotein of 120,000 MW, occurs at low concentrations in all higher plants. The chromophore is an open tetrapyrrole. The pigment exists in two light-absorbing forms: Pr, which absorbs at 660 nm, and Pfr, which absorbs at 730 nm. These forms are interconvertible by light. Pr, the physiologically inactive form, exists in dark-grown plants; Pfr, the active form, appears after irradiation with red light, P-mediated responses, of which about 80 are known, range from short-time effects (sec) such as bioelectric potentials, to long-time effects (hr) such as increases in enzymatic activity. Measurements of phototransformation in vivo with polarized light suggest that P is localized in the plasma membrane. Particulate cell fractions contain about 70% of total extractable P if Pfr is present and only 4% if Pr is present. Evidence indicates that the fraction containing Pfr may be the plasma membrane. One can isolate a partially solubilized membrane system, which can be reversibly reconstituted by adding Mg. The reformed vesicles bind Pfr in vitro. Pfr binding increases with decreasing pH and decreases with increasing monovalent cation concentration. Pfr is released from the membrane by far red light (Pr is formed) and by Triton X-100. We suggest that Pfr binding to a membrane induces conformational changes; the functional properties of this membrane are altered, which might lead to the observed phytochrome-mediated responses.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 114 (2000), S. 373-385 
    ISSN: 1432-119X
    Keywords: Lymphangiogenesis Tumor Chorioallantoic membrane VEGF-C Prox 1 Lymphatic invasion Avian embryo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We have used the avian chorioallantoic membrane (CAM) to study the interaction of tumor cells with the lymphatics in vivo. The vascular endothelial growth factor-C (VEGF-C) has been shown to be lymphangiogenic. We have therefore grown VEGF-C-expressing human A375 melanoma cells on the CAM. These tumors induced numerous lymphatics at the invasive front, and compressed or destroyed VEGF receptor (R)-3-positive lymphatics were observed within the solid tumors. The lymphatics in the CAM and in the A375 melanomas could also be demonstrated with an antibody against Prox 1, a highly specific marker of lymphatic endothelial cells. Proliferation studies revealed a BrdU labeling index of 11.6% of the lymphatic endothelial cells in the tumors and at their margins. A great number of melanoma cells invaded the lymphatics. Such interactions were not observed with VEGF-C-negative Malme 3 M melanoma cells. Lymphangiogenesis was inhibited to some extent when A375 melanoma cells were transfected with cDNA encoding soluble VEGFR-3 (sflt4), and the BrdU labeling index of the lymphatics in these tumors was 3.9%. Invasion of lymphatics and growth of blood vascular capillaries were not inhibited by the transfection. Therefore, tumor-induced lymphangiogenesis seems to be dependent to some extent on VEGF-C/flt4 interactions, but invasion of lymphatics seems to be a distinct mechanism.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Plant cell reports 1 (1982), S. 119-122 
    ISSN: 1432-203X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract NAD kinase activity has been found in a soluble, cytoplasmic fraction and in the chloroplasts prepared from green spinach leaves. A small amount of both the cytoplasmic and the chloroplastic NAD kinase activities was retained on a calmodulin-Sepharose affinity column. The cytoplasmic NAD kinase eluted from the affinity column was found to be enhanced by calmodulin in a Ca2+-dependent manner. The chloroplastic enzyme which is located exclusively in the stroma and not in the envelope and thylakoid fractions was not affected by Ca2+ and calmodulin. The stromal fraction of purified chloroplasts contained only a negligible amount of calmodulin, most probably due to cytoplasmic contamination. Based on these data, two different mechanisms for the light-dependent modulation of spinach NAD kinase activity are suggested.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Planta 159 (1983), S. 277-281 
    ISSN: 1432-2048
    Keywords: Calcium uptake ; Calmodulin ; Light, far-red ; Microsome ; Mitochondrion ; Zea (calcium transport)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The kinetic properties of active Ca2+ transport into mitochondria and microsomal membrane vesicles prepared from coleoptiles of dark-and light-grown corn seedlings have been studied. The apparent values for K m and V max for Ca2+ of the mitochondrial transport system from dark-grown plants are about one order of magnitude higher than those from the microsomal transport system. Calmodulin has no effect on the Ca2+ accumulation into mitochondria whereas the apparent maximum transport velocity and affinity for Ca2+ of the microsomal Ca2+-transport system are both increased by calmodulin. When intact corn seedlings are irradiated with far-red light, the calmodulin-induced increase of the apparent maximum transport velocity and affinity for Ca2+ can no longer be observed. From these data it can be concluded that the low cytoplasmic Ca2+ concentration in the cytoplasm of coleoptile cells from dark-grown corn is maintained by a calmodulin-regulated Ca2+ pump. Irradiation with photomorphogenically active far-red light lowers the Ca2+-transport activity and thus causes an increase of the cytoplasmic, free-Ca2+ concentration. The physiological implications will be discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Planta 162 (1984), S. 62-67 
    ISSN: 1432-2048
    Keywords: Calcium (chloroplast movement) ; Calmodulin (chloroplast movement) ; Chloroplast movement (Mougeotia) ; Mougeotia ; Phytochrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A soluble protein was isolated from Mougeotia by chloropromazine-sepharose 4 B affinity chromatography. The protein matches the properties of calmodulin in terms of heat stability, Ca2+-dependent electrophoretic mobility in sodium-dodecyl-sulfate polyacrylamide gels, and its ability to activate cyclic nucleotide phosphodiesterase in a Ca2+-dependent manner. Phytochrome-mediated chloroplast reorientational movement in Mougeotia was inhibited by the calmodulin antagonist trifluoperazine, a hydrophobic compound, or N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a hydrophilic compound; 50% inhibition (IC50) of chloroplast movement is caused by 20–50 μmol l-1 trifluoperazine or 100 μmol l-1 W-7. The Ca2+-calmodulin may act as an intermediate in the chloroplast reorientational response in Mougeotia governed by phytochrome.
    Type of Medium: Electronic Resource
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