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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 10 (1991), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Miguez J, Martin F, Aldegunde M. Differential effects of pinealectomv on amygdala and hippocampus serotonin metabolism. J Pineal Res 1991 : 10: 1 W103.〈section xml:id="abs1-1"〉〈title type="main"〉Abstract:The purpose of the present study was to determine the effects of long-term pinealectomy on serotonin metabolism in the amygdala and the hippocampus of male rats. Pinealectomy did not significantly alter either tryptophan or serotonin concentrations in the amygdala or the hippocampus. However, statistically significant decreases in 5-hyroxyindole-3-acetic acid levels and tryptophan hydroxylase activity were found in the amygdala. Monoamine oxidase activity was unchanged in both regions. These results support the involvement of the amygdaloid serotoninergic system in mediating the functions of the pineal gland.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 11 (1991), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In the present study, the effects of long-term pinealectomy on tryptophan, 5-hydroxytryptamine (5-HT or serotonin), 5-hydroxy-3-indoleacetic acid (5-HIAA), and tryptophan hydroxylase and monoamine oxidase activities were studied in preoptic area-anterior hypothalamus (POA-AH) and in the medial and posterior hypothalamus of the rat. After pinealectomy, 5-HT levels decreased significantly in medial hypothalamus but increased in the POA-AH. The levels of 5-HIAA decreased significantly in the POA-AH and medial hypothalamus. Tryptophan levels remained unchanged while tryptophan hydroxylase activity diminished significantly in POA-AH and medial hypothalamus. Monoamine oxidase activity remained unchanged in the hypothalamic regions. These results suggest that pinealectomy induces differential inhibitory actions on the serotoninergic terminal regions, mainly in anterior and medial hypothalamic areas.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of acute treatment with p-chloroamphetamine, d-fenfluramine, and reserpine on intracellular (brain tissue and whole blood) and extracellular (CSF and platelet-free plasma) compartments of 5-hydroxytryptamine (5-HT) in the brain and blood of the same rats have been examined. These treatments affected 5-HT in brain tissue and whole blood similarly (r= 0.823). Reserpine significantly reduced both intracellular pools at 2 and 24 h. p-Chloroamphetamine and d-fenfluramine were more effective on brain tissue 5-HT. The concentration of 5-HT in CSF was significantly increased by all treatments. p-Chloroamphetamine induced a dramatic 70-fold increase of CSF 5-HT, paralleling a 42% decrease in brain tissue. d-Fenfluramine significantly increased CSF 5-HT to 212% of controls and reduced whole brain 5-HT (-23%). The effects of p-chloroamphetamine and d-fenfluramine on 5-HIAA in brain, CSF, and plasma were nonsignificant. Individual values of 5-hydroxyindoleacetic acid (5-HIAA) in CSF and brain were highly correlated (r= 0.855), indicating that CSF 5-HIAA reflects well the concentration of 5-HIAA in brain tissue. Yet the intra- and extracellular concentrations of 5-HIAA were unrelated to the 5-HT changes. This indicates that CSF 5-HIAA does not reflect the active (extracellular) compartment of 5-HT in brain.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Release of endogenous serotonin [5-hydroxy-tryptamine (5-HT)] in the cerebellum of awake rats was characterized using in vivo microdialysis. 5-HT output was increased (∼70%) by local application of KCl (100 mM) and was reduced (∼60%) by both tetrodotoxin (0.5 µM) and omission of Ca2+ from the perfusion fluid. 5-HT release was decreased (∼70%) by the selective 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (0.25 mg/kg, s.c.), and this effect was rapidly reversed by a selective 5-HT1A antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane-carboxamide trihydrochloride (WAY-100635; 0.1 mg/kg, i.p.). These results indicate that a large portion of the measurable 5-HT output in the cerebellum is of neuronal origin, is dependent on impulse flow, and is sensitive to 5-HT1A autoreceptor activation. Further studies examined the relationship between 5-HT levels and general activity of the animals across the light-dark transition and during behavioral manipulations. Both 5-HT levels and behavioral activity were significantly elevated during the dark period, with changes in 5-HT efflux closely paralleling changes in activity. Similar increases (∼40%) in 5-HT output were observed during both feeding and feeding in the presence of a stressor (tail pinch). These findings suggest that behavioral state is an important factor determining neuronal 5-HT release in cerebellum under physiological conditions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Mycopathologia 36 (1968), S. 55-74 
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Summary In some regions of Colombia, the cutaneous test with histoplasmin is positive in 44.4 % of the population. At Valle University it was demonstrated, in the autopsy material, that 45.1 %, of the pulmonary nodules are due to Histoplasmosis. Very few cases of the systemic form are reported in our literature.Gast Galvis was the first in 1944, who discovered the fungus in the liver of a patient who lived in Venezuela and died in Colombia. LaterGast Galvis himself reported a new case in 1953.Carlos Nuñez referred to another case in a child living in the Valley of Sinú. Possibly, the first case diagnosed in life has been demonstated byFernando Sierra et al., who cultured the fungus from the bone marrow. In Medellín,Mario Robledo &Angela Restrepo communicated in 1964 the cases of Histoplasmosis observed during a period of 6 years and among them reported seven cases of the systemic form (one which was a finding of autopsy and the other six were diagnosed during life by means of culture or biopsy). The authors present in this work two cases of systemic Histoplasmosis confirmed during life, by means of histopathological studies and cultures. The authors also revise the national literature referring to that subject and comment the clinical, diagnostic, laboratory and therapeutical aspects of the disease.
    Notes: Resumen En Colombia, existen algunas áreas en las cuales la prueba cutánea con histoplasmina se ha mostrado positiva, hasta en una proporción del 44,4 %. También estudios de material de autopsias, llevados a cabo en la Universidad del Valle, han evidenciado que un 45.1 % de las nodulaciones pulmonares responden a una etiología histoplásmica. Sólo muy contados casos de la forma sistémica se hallan registrados en nuestra literatura. La primera notificación corresponde aGast Galvis en 1944, quien descubrió el hongo en el estudio de un hígado, obtenido por viscerotomía, de un paciente procedente de Venezuela y muerto en territorio Colombiano. Con posterioridad el mismoGast Galvis refiero otro caso en 1953.Carlos Nuñez refiere otro ocurrido en un niño en el Valle del Sinú. Posiblemente el primer caso diagnosticado en vida lo haya demostradoFernando Sierra et al., quienes cultivaron el hongo a partir de la médula ósea.Mario Robledo &Angela Restrepo, en Medellín comunican en 1964 los casos de histoplasmosis observados en un período de seis años, dentro de los cuales relatan siete casos de forma sistémica (un hallazgo de autopsia y seis diagnosticados en vida mediante cultivo o biopsia). Los autores presentan en éste trabajo dos casos de Histoplamosis sistémica comprobada en vida, mediante estudios histopatológicos y cultivo. Hacen una revisión de la bibliografía nacional al respecto y comentan los aspectos clínicos, de diagnóstico, de laboratorio y de tratamiento de la enfermedad.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 22 (1997), S. 87-92 
    ISSN: 1573-6903
    Keywords: Melatonin ; serotonin synthesis ; pineal gland ; brain ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This work examined the influence of the pineal gland and its hormone melatonin on the metabolism of serotonin (5-HT) in discrete areas of the forebrain, such as the Striatum and the nucleus accumbens, and the midbrain raphe. The content of 5-HT and its major oxidative metabolite, the 5-hydroxyindoleacetic acid (5-HIAA), as well as the in-vivo tryptophan hydroxylation rate were examined after long-term pinealectomy (one month) and daily melatonin treatment (500 μg/kg; twice daily for ten days) in pinealectomized rats. Pinealectomy did not alter 5-HT content in any of these brain areas, but it significantly increased the content of 5-HIAA in Striatum and the 5-HIAA/5-HT ratio in nucleus accumbens. The normal values of these parameters were recuperated after administration of exogenous melatonin, but it also increased the rate of tryptophan hydroxylation in both areas. In addition, melatonin treatment decreased the levels of 5-HIAA in dorsal raphe nucleus. These data suggest that the pineal gland, through the secretion of melatonin, modulates the local metabolism of 5-HT in forebrain areas by acting on the oxidative deamination. Moreover, melatonin injected in pinealectomized rats derives in a more extended effect than pinealectomy and induces a stimulation of 5-HT synthesis in the striatum, probably due to a pharmacological effect. These results point to the striatum as a target area for the interaction between pineal melatonin and the serotonergic function, and suggest a differential effect of the melatonin injected on areas containing serotonergic terminals and cell bodies, which may relevant for the mode of action of melatonin and its behavioral effects.
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 103 (1980), S. 77-85 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Fibroblast Growth Factor (FGF) stimulates quiescent Swiss 3T3 cells to initiate DNA synthesis and divide. Cells begin to enter the S-phase after a lag of 13-15 hr, and the rate of initiation of DNA synthesis in the population can be quantified by a first order rate constant, k. A subsaturating concentration of FGF may establish the lag phase, while the value of k is dependent on the FGF concentration present during the second half of the lag phase. Insulin and hydrocortisone enhance the effect of FGF by increasing k without changing the lag phase, and they can act when added at any time after FGF. Prostaglandin E1 (PGE1) causes a decrease in k and a lengthening of the lag phase, and acts only when added during the first 8 hr. None of these agents stimulate DNA synthesis in the absence of FGF.These results show that the stimulation of growth by FGF follows the same basic pattern as was previously shown with Prostaglandin F2α (PGF2α). However, since hydrocortisone inhibits stimulation by PGF2α when added during the first 4 hr of the lag phase, there are clearly differences in some events stimulated by the two growth factors.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 569-572 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human immunodeficiency virus type 1 (HIV-1)–based vectors are currently made by transient transfection, or using packaging cell lines in which expression of HIV-1 Gag and Pol proteins is induced. Continuous vector production by cells in which HIV-1 Gag-Pol is stably ...
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  • 9
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    Unknown
    Amsterdam: Elsevier
    Publication Date: 2019-03-14
    Description: This research has been carried out in order to analyze the development of actions to modify organizational legitimacy. We examine the relationship between the degree of organizational goals implementation and pragmatic legitimacy. Study has been developed on the European Area of Higher Education. We look at this process in the University community of six Spanish universities. The results have shown a significant and positive relationship between the degree of organizational goals implementation and their pragmatic legitimacy.
    Keywords: M10 ; M21 ; ddc:330 ; Strategic implementation ; Legitimacy ; Pragmatic legitimacy ; Strategy ; Institutional theory ; European Area of Higher Education
    Language: Spanish
    Type: doc-type:article
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  • 10
    facet.materialart.
    Unknown
    Amsterdam and Rotterdam: Tinbergen Institute
    Publication Date: 2015-07-09
    Description: We experimentally study the effect of information about competitors’ actions on cartel stability and firms’ incentives to form cartels in Cournot markets. As in previous experiments, markets become very competitive when individualized information is available and participants cannot communicate. In contrast, when communication is possible, results reverse: Markets become less competitive and cartels become more stable when individualized information is available. We also observe that the extra profits that firms obtain thanks to the possibility to communicate are higher when individualized information is present, suggesting that firms have greater incentives to form cartels in that situation.
    Keywords: C92 ; L13 ; L41 ; ddc:330 ; Cournot oligopoly ; Cartels ; Information ; Experiments
    Language: English
    Type: doc-type:workingPaper
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