Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nature Publishing Group
Nature Archives 1869 - 2009
[Auszug] Tenofovir, also known as PMPA, R-9-(2-(phosphonomethoxypropyl)adenine, is a nucleotide reverse transcriptase (RT) inhibitor. We have determined the crystal structures of two related complexes of HIV-1 RT with template primer and tenofovir: (i) a ternary complex at a resolution of 3.0 Å of RT ...
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