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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 544-550 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The σ70 subunit of RNA polymerase plays an essential role in transcription initiation. In addition, σ70 has a critical regulatory role during transcription elongation at the bacteriophage λ late promoter, λPR′. At this promoter, σ70 mediates a pause in early ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 56 (2005), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The σ subunit of bacterial RNA polymerase is strictly required for promoter recognition. The primary (housekeeping) σ factor of Escherichia coli, σ70, is responsible for most of the gene expression in exponentially growing cells. The fact that σ70 is an essential protein has complicated efforts to genetically dissect the functions of σ70. To facilitate the analysis of σ70 function in vivo, we isolated an altered-specificity DNA-binding mutant of σ70, σ70 R584A, which preferentially recognizes a mutant promoter that is not efficiently recognized by wild-type σ70. Exploiting this σ70 mutant as a genetic tool, we establish an in vivo assay for the inhibitory effect of the bacteriophage T4-encoded anti-σ factor AsiA on σ70-dependent transcription. Our results demonstrate the utility of this altered-specificity system for genetically dissecting σ70 and its interactions with transcription regulators.
    Type of Medium: Electronic Resource
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