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  • 1
    Book
    Book
    München : Hanser
    Keywords: Unternehmensentwicklung ; Strategisches Management ; Unternehmensentwicklung ; Strategisches Management
    Type of Medium: Book
    Pages: XI, 446 S. , zahlr. Ill., graph. Darst. , 28 cm
    Edition: 2., [überarb.] Aufl.
    ISBN: 9783446436312 , 3446436316 , 9783446438422
    DDC: 658.4012
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    Language: German
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg | Berlin, Heidelberg : Springer Vieweg
    Keywords: Engineering design ; Management ; Industrial management ; Mass media ; Law ; Engineering Design ; Innovation ; IT Law, Media Law, Intellectual Property
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XV, 75 Seiten 31 Abb., 30 Abb. in Farbe)
    ISBN: 9783662580165
    Series Statement: Intelligente Technische Systeme – Lösungen aus dem Spitzencluster it’s OWL
    DDC: 620.0042
    Language: German
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  • 3
    Online Resource
    Online Resource
    Berlin ; Heidelberg : Springer
    Keywords: Management ; Wirtschaft ; Unternehmensentwicklung ; Strategisches Management ; Economics ; Industrial management ; Business planning ; Economics ; Organization ; Business Strategy ; Management ; Aufsatzsammlung ; Unternehmensentwicklung ; Strategisches Management
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XVIII, 261 S. 255 Abb., 254 Abb. in Farbe)
    ISBN: 9783662437070 , 9783662437063
    DDC: 658.1
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    Language: German
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  • 4
    Book
    Book
    München [u.a.] : Hanser
    Keywords: Unternehmensplanung ; Strategisches Management ; Unternehmensplanung ; Strategisches Management
    Type of Medium: Book
    Pages: 467 S. , Ill., graph. Darst.
    ISBN: 9783446410558
    DDC: 658.4012
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    Language: German
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  • 5
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Gabler
    Keywords: Management ; Wirtschaft ; Cloud Computing ; Soziale Software ; Economics ; Information Systems ; Management information systems ; Economics/ Management Science ; Cloud Computing ; Soziale Software
    Type of Medium: Online Resource
    Pages: Online-Ressource (XII, 183 S. 64 Abb, digital)
    ISBN: 9783642375675 , 9783642375668
    Series Statement: SpringerLink : Bücher
    DDC: 658.514
    Language: German
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Brain tumor pathology 17 (2000), S. 49-56 
    ISSN: 1861-387X
    Keywords: Low-grade astrocytoma ; Methylation ; RLGS ; CpG island
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The underlying basis of the malignant progression of astrocytomas is a specific and cumulative series of genetic alterations, most of which are confined to high-grade tumors. In contrast, a proportion of low-grade astrocytomas have a relatively normal-appearing genome when examined with standard genetic screening methods. These methods do not detect epigenetic events such as aberrant methylation of CpG island, which result in transcriptional silencing of important cancer genes. To determine if aberrant methylation is involved in the early stages of astrocytoma development, we assessed the methylation status of 1184 genes in each of 14 low-grade astrocytomas using restriction landmark genome scanning (RLGS). The results showed nonrandom and astrocytoma-specific patterns of aberrantly methylated genes. We estimate that an average of 1544 CpG island-associated genes (range, 38 to 3731) of the approximately 45,000 in the genome are aberrantly methylated in each tumor. Expression of a significant proportion of the genes could be reactivated by 5-aza-2-deoxycytidine-induced demethylation in cultured glioma cell lines. The data suggest that aberrant methylation of genes is more prevalent than genetic alterations and may have consequences for the development of low-grade astrocytomas.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mammalian genome 9 (1998), S. 261-262 
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Mammalian genome 3 (1992), S. 197-201 
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A long-range repeat family of more than 50 kb repeat size is clustered in Chromosomes (Chr) 1 of Mus musculus and M. spretus. In M. musculus this long-range repeat family shows considerable variation of copy-number frequency and contains coding regions for at least two genes. In an intron of a gene, which is part of the repeat, a B2 small interspersed repetitive element (SINE) is inserted at identical positions. The B2 element is present in all copies of the long-range repeat family; it was presumably a component of the ancestral single-copy precursor sequence that gave rise by amplification to the repeat family. Copies of the long-range repeat family vary with respect to the number of TAAA tandem repeats in the A-rich 3′ end region of the B2 element. As inferred from polymerase chain reaction (PCR) data, presence and frequency of repeat number variants in the (TAAA)n block are strain and species specific. The B2 element and its flanking regions were sequenced from two copies of the long-range repeat family. Sequence divergence between the two copies (only non-CG base substitutions and deletions/insertions) was determined to be 2.6%. Based on the drift rate in human Alu elements and a correction for the higher drift rates in rodents, and estimate for the divergence time of 1.7 million years was calculated. Since the long-range repeat family is present in M. musculus and M. spretus, it must have evolved by amplification before the separation of the two species about 1–4 million years ago.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 210-217 
    ISSN: 0173-0835
    Keywords: Genomic imprinting ; Restriction landmark genomic scanning ; U2afbp-rs ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Restriction landmark genomic scanning (RLGS) has been used to screen endogenous loci for imprinted patterns of methylation. The screening method is based upon the identification of genetic variation in RLGS profiles between different strains and determining whether specific variant landmarks are transmitted equally to the progeny of reciprocal F1 matings. The RLGS profiles of C57BL/6 (B6) and DBA/2 (D2) and their reciprocal hybrids were produced with two enzyme combinations that used NotI as the landmark enzyme and two combinations that used BssHII. An estimated 13% of the spots are either B5- or D2-specific in these tests, giving a total of nearly 1000 variant loci that were examined for imprinted methylation. Three candidate loci for imprinted regulation were identified in these analyses. We also used crosses of more genetically diverse parents to increase the number of variant loci screened. Interspecific crosses of B6 with the M. musculus strain PWK and intrasubspecific crosses between B6 and the M. molossinus strain MSM expanded the levels of variation between the parental strains in the cross to an estimated 31% and 26%, respectively. The RLGS patterns for one NotI combination and one BssHII profile were examined for each of these crosses, giving approximately 2000 additional loci that were screened for imprinted patterns of methylation. Eight loci with imprinted patterns of transmission were observed out of 3040 loci tested. The chromosomal locations for the three B6 and D2 specific loci, Irlgs 1-3, were identified using BXD recombinant inbred strain analysis. Irlgs 1 and 3 are B6- and D2-specific loci that had the same strain distribution pattern which mapped to the central region of chromosome 9. Irlgs 2 (U2afbp-rs) was mapped to the proximal region of chromosome 11, which was reported as an imprinted region identified with uniparental disomy mice. An imprinted gene, U2 auxiliary factor binding protein-related sequence (U2afbp-rs), was identified for Irlgs2 locus, which encoded 51 kDa protein that had significant homology to the human U2af 35 kDa small subunit.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 233-240 
    ISSN: 0173-0835
    Keywords: Genetic mapping ; Mouse ; Restriction landmark genomic scanning ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Restriction landmark genomic scanning (RLGS) was originally proposed as a high-speed method for surveying a large number of restriction landmarks in genomic DNA. The effort to apply this method to genetic analysis has been made, resulting in developing the new approach for the rapid construction of the genetic map of complex mammalian genomes (RLGS spot mapping). Especially, the use of NotI as the restriction landmark for genetic studies suggests that there is a high probability that a significant number of these RLGS loci will be associated with CpG islands of functional genes. Moreover, it is possible to use the RLGS spot mapping to analyze genetic map-poor species very rapidly for linkage of recessive mutations or segregating traits, because it does not rely upon cloned probes or sequences. In this paper, we summarize the progress that has been made in the practical application of the RLGS method to genetic analysis using congenic strains, recombinant inbred (RI) strains, and in interspecific backcrosses of mice.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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