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  • 1
    Online Resource
    Online Resource
    München : C.H. Beck
    Keywords: GmbH ; GmbH ; Steuerrecht ; Deutschland ; Deutschland ; Deutschland 03.10.1990- ; GmbH ; Deutschland 03.10.1990- ; GmbH ; Steuerrecht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (LXX, 1714 S.)
    Edition: 5., vollständig überarbeitete und erweiterte Auflage
    DDC: 346.430668
    RVK:
    RVK:
    Language: German
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    München : C.H. Beck
    Keywords: Personengesellschaft ; Gesellschaftsrecht ; Personengesellschaft ; Steuerrecht ; Deutschland ; Deutschland ; Deutschland 03.10.1990- ; Personengesellschaft ; Gesellschaftsrecht ; Deutschland 03.10.1990- ; Personengesellschaft ; Steuerrecht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource , Diagramme
    Edition: 5. Auflage
    Series Statement: Beck-online
    RVK:
    Language: German
    Location Call Number Limitation Availability
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  • 3
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    Wiley-Blackwell
    Publication Date: 2016-05-04
    Description: Age-related macular degeneration (AMD) is a leading cause of vision loss among the elderly. AMD pathogenesis involves chronic activation of the innate immune system including complement factors and microglia/macrophage reactivity in the retina. Here, we show that lack of interferon-β signaling in the retina accelerates mononuclear phagocyte reactivity and promotes choroidal neovascularization (CNV) in the laser model of neovascular AMD. Complete deletion of interferon-α/β receptor (Ifnar) using Ifnar 1 −/− mice significantly enhanced early microglia and macrophage activation in lesion areas. This triggered subsequent vascular leakage and CNV at later stages. Similar findings were obtained in laser-treated Cx3cr1 Cre ER : Ifnar1 fl/fl animals that allowed the tamoxifen-induced conditional depletion of Ifnar in resident mononuclear phagocytes only. Conversely, systemic IFN-β therapy of laser-treated wild-type animals effectively attenuated microgliosis and macrophage responses in the early stage of disease and significantly reduced CNV size in the late phase. Our results reveal a protective role of Ifnar signaling in retinal immune homeostasis and highlight a potential use for IFN-β therapy in the eye to limit chronic inflammation and pathological angiogenesis in AMD. Innate immune activation is a hallmark of age-related macular degeneration (AMD). Here, interferon-beta signaling was identified as an intrinsic regulator of retinal mononuclear phagocytes and therefore as potential therapeutic target for AMD.
    Print ISSN: 1757-4676
    Electronic ISSN: 1757-4684
    Topics: Medicine
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