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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 22 (1985), S. 35-48 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have previously selected structural variants of the Kk antigen from a (C3 × D2)F1 T-cell lymphoma. Those mutants were identified by the loss of certain epitopes defined by monoclonal antibodies. The variant Kk molecule from HK13.S3 cells is no longer recognized by 40% of the trinitrophenyl-specific, Kk-restricted cytotoxic T lymphocytes. Here we report on the primary structure of the altered Kk molecules from the cell line HK13.S3. Comparison with the parental Kk reveals a single base pair exchange, GCG to GTG, that results in an alanine to valine exchange in position 40 of the protein. This observation emphasizes that minor structural alterations in class I molecules may have a strong effect on the H-2-restricted T-cell response.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 405-407 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have compared the immunological behaviour of some well-characterized LDH preparations, including pure isozymes. Fig. 1. Comparison by double diffusion of pig-heart and beef-heart LDH. Coloration by a LDH specific reaction (ref. 7) The following crystallized enzyme preparations were available, ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 374 (1995), S. 467-470 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A null mutation was introduced into either one or both copies of the vav gene in embryonic stem (ES) cells by homologous recombination (Fig. la, b) and chimaeric mice, designated vav+/ or vavf, were generated. Immunoblot analysis of lys-ates from vav+/ and vav ...
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 96 (1987), S. 0 
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 162 (1998), S. 0 
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: In the human, most IgM+IgD+ as well as CD5* peripheral blood B cells express unmutated V genes and thus can be assigned to a pre-germinal centre (GC) stage of development. The memory B-cell compartment generated in die GC reaction and characterized by cells bearing somatically mutated V-region genes consists not only of class-switched cells, but also of lgM-only B cells and perhaps a subset of IgM+IgD+ B cells expressing the CD27 antigen. Comparison of the rearranged V-region genes of human B-cell lymphomas with those of the normal B-cell subsets allows the identification of the progenitor cells of these tumours in terms of their stage of maturation. On this basis, most B-cell on-Hodgkin lymphomas, and in addition Hodgkin and Reed-Stern berg (HRS) cells in Hodgkin's disease (HD). are derived from B cells ac a GC or post-GC stage of development. The mutation pattern indicates that the precursors of the tumour clones have been stringently selected for expression of a functional antigen receptor with one notable exception: HRS cells in classical (but: not lymphocyte-predominant) HD appear to be derived from “crippled” GC B cells. Sequence analysis of rearranged V genes amplified from single tonsillar GC B cells revealed that the somatic hypermutation process introduces deletions and/or insertions into V-region genes more frequently that indicated by previous investigations. Presumably, this feature of the hypermutation mechanism is often responsible for the generation of heavy chain disease, and also several types of chromosomal translocations of oncogenes into immunoglobulin loci in human B-cell lymphomas.
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 356 (1992), S. 154-156 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The uMT mouse mutant was generated by targeted disruption of the membrane exon of the /JL chain by a neomycin resistance gene in embryonic stem cells, and then introduction of the mutation into the mouse germ line7. Homozygous mutant mice cannot produce B cells because B-cell development is ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 354 (1991), S. 389-392 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The response to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP) coupled to protein carriers is dominated in Ighb mice by antibodies which have the Al light (L) chain and use heavy (H) chain V regions encoded by the VI 86.2 VH gene segment, the FL16.1 D element and any of four JH genes, ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 346 (1990), S. 749-751 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In accordance with the work of Hayakawa et al.7, we raised specific memory B cells in mice by immunization with the highly fluorescent protein phycoerythrin (PE) and characterized them as PE-binding cells that express the B-cell marker B220 and low levels of surface immunoglobulin differing in ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 366-370 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lymphocytes move through the GALT by means of differential expression and activation of adhesion molecules4. Emigration of lymphocytes from the vasculature into tissues requires them to roll along the endothelial cells, arrest and adhere firmly to endothelial cells, and migrate across the ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 381 (1996), S. 751-758 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated ...
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