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  • 1
    Online Resource
    Online Resource
    Wiesbaden : Springer Vieweg
    Keywords: E-Government ; Verwaltung ; Digitalisierung ; Computers / Law and legislation ; Information Systems ; Public administration ; Information systems ; Deutschland ; Legal Aspects of Computing ; Management of Computing and Information Systems ; Public Administration ; Information Systems and Communication Service ; Deutschland 03.10.1990- ; E-Government ; Verwaltung ; Digitalisierung
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XIV, 272 Seiten) , Diagramme (teilweise farbig)
    ISBN: 9783658270292
    DDC: 343.0999
    RVK:
    Language: German
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  • 2
    Online Resource
    Online Resource
    Wiesbaden : Springer VS
    Keywords: Öffentliches Rechnungswesen ; Öffentlicher Haushalt ; Verwaltungsreform ; Deutschland ; Hochschulschrift ; Deutschland 03.10.1990- ; Öffentliches Rechnungswesen ; Öffentlicher Haushalt ; Verwaltungsreform
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    ISBN: 9783658002800 , 9783658002817
    DDC: 300
    Language: German
    Dissertation note: Zugl.: Kaiserslautern, Techn. Univ., Diss., 2012
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 23 (1999), S. 503-508 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Quality of life (QOL) in patients with gastric cancer who underwent total gastrectomy has so far not been studied using the EORTC QLQ-C30 (Quality of Life Core Questionnaire of the European Organization for Research and Treatment of Cancer) as a standardized European QOL instrument. The aim of this study was to evaluate the effect of radical procedures such as extensive lymph node resection and combined resection of adjacent organs on patients' QOL. From 1992 to 1996, 152 patients underwent total gastrectomy. All patients alive on July 1, 1996 were included in the study (77/152). For assessing QOL, the EORTC QOL questionnaire QLQ-C30 version 2.0 and a validated gastric cancer module were sent home to the patients for self-completion. The response rate was 91%. It was possible to evaluate the questionnaires of 62 patients who had undergone resection with curative intent including 13 extended gastrectomies (21%). Of the 62 resections, 50 were combined with D2 lymphadenectomy (80.6%). The global health status was not negatively influenced by D2 lymphadenectomy and extended gastrectomy. Patients with splenectomy were more affected by treatment than patients without splenectomy. Radical gastrectomy combined with D2 lymphadenectomy is the treatment of choice for gastric cancer patients, concerning not just survival but QOL as well.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 346 (1990), S. 374-376 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The endoplasmic reticulum (ER) of rat exocrine pancreas is known to play a central part in the regulation of cytoplasmic free Ca2+ concentration1'7'8. To investigate whether Ca2+ channels are involved in the Ca2+release mechanisms, isolated ER vesicles were fused to giant vesicles (10-100 |xm) by ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 111 (1989), S. 265-275 
    ISSN: 1432-1424
    Keywords: chloride channel ; endocytotic vesicles ; rat kidney ; H+-ATPase ; vacuolar acidification ; vesicle fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Endocytotic vesicles from rat kidney cortex, isolated by differential centrifugation and enriched on a Percoll gradient, contain both an electrogenic H+ translocation system and a conductive chloride pathway. Using the dehydration/rehydration method, we fused vesicles of enriched endosomal vesicle preparations and thereby made them accessible to the patch-clamp technique. In the fused vesicles, we observed Cl− channels with a single-channel conductance of 73±2 pS in symmetrical 140mm KCl solution (n=25). The current-voltage relationship was linear in the range of −60 to +80 mV, but channel kinetic properties dependended on the clamp potential. At positive potentials, two sublevels of conductance were discernible and the mean open time of the channel was 10–15 msec. At negative voltages, only one substate could be resolved and the mean open time decreased to 2–6 msec. Clamp voltages more negative than −50 mV caused reversible channel inactivation. The channel was selective for anions over cations. Ion substitution experiments revealed an anion permeability sequence of Cl−=Br−=I−〉SO 4 2− ≈F−. Gluconate, methanesulfonate and cyclamate were impermeable. The anion channel blockers 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS, 1.0mm) and 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB, 0.1mm) totally inhibited channel activity. Comparisons with data obtained from radiolabeled Cl−-flux measurements and studies on the H+ pump activity in endocytotic vesicle suspensions suggest that the channel described here is involved in maintenance of electroneutrality during ATP-driven H+ uptake into the endosomes.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 104 (1988), S. 275-282 
    ISSN: 1432-1424
    Keywords: anion channel ; endoplasmic reticulum ; vesicle fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Using the method of dehydration and rehydration, rough endoplasmic reticulum (RER) vesicles, isolated by differential centrifugation, can be enlarged to giant liposomes with diameters ranging from 5 to 200 μm. Patch-clamp studies on these giant RER liposomes revealed the existence of a channel with a mean conductance of 260±7 pS (n=23; 140 mmol/liter KCl on both sides). The channel is about four times more permeable for Cl− than for K+. Its activity is strongly voltage regulated. At low potentials (±20 mV) the channel is predominantly in its open state with an open probability near 1.0, whereas it closes permanently at high positive and negative voltages (±70 mV). The channel activity is not influenced by changing the free Ca2+ concentration from 1 mmol/liter to less than 10−9 mol/liter on either side, and is also not affected by typical Cl−-channel blockers like diphenylamine-2-carboxylate (DPC, 1 mmol/liter) or 4-acetamido-4′-isothiocyanatostilbene-2,2′-disulfonic acid (SITS, 1 mmol/liter). Another chloride channel with a singlechannel conductance of 79±6 pS (n=4) was less frequently observed. In the potential range of −80 to +40 mV this channel displayed no voltage-dependent gating. We assume that these anion channels are involved in the maintenance of electroneutrality during Ca2+ uptake in the RER.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 430 (1995), S. 916-922 
    ISSN: 1432-2013
    Keywords: Ca2+-dependent nonselective cation channel ; Ca2+ influx ; Capacitative Ca2+ entry ; Genistein ; Tyrosine kinase inhibitor ; Di-tert-butylhydroquinone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the effect of genistein on the hormone-stimulated Ca2+ influx and on a 28 pS nonselective cation channel in mouse pancreatic acinar cells using the Ca2+ indicator fluo-3 and the patch-clamp technique. The identity of the Ca2u+ influx pathway has not been established in this cell type so far. Therefore we have investigated the Ca2+-dependent nonselective cation channel as a potential pathway for Ca2+ influx. “Capacitative” Ca2+ entry was induced by depletion of intracellular Ca2+ stores with 500 nM acetylcholine or with the Ca2+ ATPase inhibitor 2,5-di-tert- butylhydroquinone. In the presence of 100 μM genistein, Ca2+ release was unimpaired, whereas Ca2+ influx was reversibly suppressed. Patch-clamp experiments demonstrated that genistein had no effect on Ca2+-activated nonselective cation channels, the activity of which was measured in excised membrane patches (inside/out) or in the whole-cell configuration. Therefore we conclude that this 28 pS nonselective cation channel does not contribute to Ca2+ influx into mouse exocrine pancreatic cells. With the exception of genistein and tyrphostin 25, other tyrosine kinase inhibitors such as methyl-2,5-dihydroxycinnamate, lavendustin A, herbimycin A, and tyrphostin B56 were without effect on Ca2+ signalling. Thus, the involvement of tyrosine phosphorylation in the activation of the Ca2+ entry mechanism in mouse pancreatic acinar cells is unclear.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 78 (1998), S. 177-182 
    ISSN: 1439-6327
    Keywords: Key words Paraplegia ; Exercise testing ; Anaerobic threshold ; Heart rate threshold ; Lactate threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The deflection point (DP) of the heart rate in relation to the work rate (WR) of 8 male endurance-trained paraplegics and 11 male physically active sports students was investigated during nonsteady-state incremental arm cranking ergometry (IT) and compared to the 4 mmol · l−1 blood lactate concentration threshold and to blood lactate concentration in steady-state exercise (SST). Heart rate, and lactate concentration from capillary blood, were determined at rest, during IT and SST. The DP was calculated by linear regression analysis of the heart rate during IT. The SST consisted of three consecutive exercise intensities over a period of 8 min at exercise intensities of 10 W below, and at 10 W above the work rate at deflection point (WRDP). No difference was found between the paraplegics and non-handicapped subjects regarding heart rate and blood lactate concentration at rest and during exercise. A DP was established in all the paraplegics and in 72.7% of the non-handicapped subjects, but lactate accumulation was observed in 75% of the paraplegics and in 62.5% of the non-handicapped subjects at the lowest intensity of SST. In summary, endurance-trained paraplegics with an injury level below T5 showed heart rate and blood lactate concentration values comparable to non-handicapped subjects during IT. A linear increase at moderate exercise intensities and a levelling-off at higher to maximal intensities could be identified in all the paraplegics and in 72.7% of non-handicapped subjects. The determination of the anaerobic threshold by DP should be applied with caution, since no causal relationship of DP and the anaerobic threshold was found and the WRDP tended to overestimate threshold values.
    Type of Medium: Electronic Resource
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  • 9
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    Heidelberg: Springer
    Publication Date: 2018-12-07
    Description: Introduction: Self-assessed health (SAH) is a frequently used measure of individuals' health status. It is also prone to reporting heterogeneity. To control for reporting heterogeneity objective measures of true health need to be included in an analysis. The topic becomes even more complex for cross-country comparisons, as many key variables tend to vary strongly across countries, influenced by cultural and institutional differences. This study aims at exploring the key drivers for reporting heterogeneity in SAH in an international context. To this end, country specific effects are accounted for and the objective health measure is concretized, distinguishing effects of mental and physical health conditions. Methods: We use panel data from the SHARE-project which provides a rich dataset on the elderly European population. To obtain distinct indicators for physical and mental health conditions two indices are constructed. Finally, to identify potential reporting heterogeneity in SAH a generalized ordered probit model is estimated. Results: We find evidence that in addition to health behaviour, health care utilization, mental and physical health condition as well as country characteristics affect reporting behaviour. We conclude that observed and unobserved heterogeneity play an important role when analysing SAH and have to be taken into account.
    Keywords: ddc:330 ; reporting heterogeneity ; SHARE ; generalized ordered probit
    Language: English
    Type: doc-type:article
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  • 10
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    Essen: Rheinisch-Westfälisches Institut für Wirtschaftsforschung (RWI)
    Publication Date: 2018-11-06
    Description: The correct definition of the product market and of the geographic market is a prerequisite for assessing market structures in antitrust cases. For hospital markets, both dimensions are controversially discussed in the literature. Using data for the German hospital market we aim at elaborating the need for differentiating the product market and at investigating the effects of different thresholds for the delineation of the geographic market based on patient flows. Thereby we contribute to the scarce empirical evidence on the structure of the German hospital market. We find that the German hospital sector is highly concentrated, confirming the results of a singular prior study. Furthermore, using a very general product market definition such as 'acute in-patient care' averages out severe discrepancies that become visible when concentration is considered on the level of individual diagnoses. In contrast, varying thresholds for the definition of the geographic market has only impact on the level of concentration, while the correlation remains high. Our results underline the need for more empirical research concerning the definition of the product market for hospital services.
    Keywords: L11 ; I11 ; ddc:330 ; hospital market ; concentration ; product market ; geographic market ; Germany
    Language: English
    Type: doc-type:workingPaper
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