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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 363 (1993), S. 166-169 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We previously reported that fos-lacZ was expressed, apparently continuously, in cell populations undergoing ter-minal differentiation culminating in death in skin, hair follicle and bone6. These and other results7'10 prompted us to examine other sites of naturally occurring cell death. In the ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 246-249 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The trk gene was inactivated by transfecting D3 embryonic stem (ES) cells with a targeting vector in which 51 amino acids from the Trk kinase catalytic domain have been replaced with a phosphoglycerate kinase (PGK)-neo cassette in the opposite orientation. The targeting vector also contained a ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 29 (2001), S. 404-411 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN result in a range of phenotypic abnormalities that occur with variable penetrance, including neurological features such as macrocephaly, ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 249-251 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mice heterozygous for a targeted mutation in the tyrosine kinase domain of the trkC locus were generated as described in the legend to Fig. 1. These trkCTK + /— mice grow normally and show no obvious anatomical or behavioural defects. Crossing these heterozygous mice produced homozygous ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 11 (1995), S. 107-109 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] For thirty years the weaver mutant mouse has generated an extraordinary amount of interest in the neuro-scientific community: initially as a model for disrupted glial-guided neuronal migration, then for what insights it could provide about the role of granule cells in cerebellar development, and, ...
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 183 (1991), S. 213-219 
    ISSN: 1432-0568
    Keywords: Mouse ; Neurological mutant ; Development ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunoreactivity in OZ42, a neural cell specific antibody that recognizes premigratory cerebellar granule cells, was examined in early postnatal wild-type and weaver mouse cerebella. We find that the OZ42-positive staining in the external granular layer (EGL) is first seen at postnatal day 1 in the most posterior and ventral aspect of midline cerebellum in the wild-type and heterozygous weaver mouse. By postnatal day 4 strong immunoreactivity is observed in the EGL of all cerebellar lobules. This staining is localized to a band of immunoreactive cells present at the interface of the EGL and the molecular layer (ML). In the homozygous weaver cerebellum, OZ42-positive staining is not seen until post-natal day 3. In the postnatal day 4 weaver cerebellum, immunoreactivity is considerably ligther than in littermate control cerebella, and found throughout the width of the EGL (i.e., not localized to the EGL-ML interface). This study demonstrates that the expression of a specific marker of granule cell development is abnormal in the granule cell population of the homozygous weaver mouse, a population of cells known to be intrinsically affected by the action of this mutant gene. In the light of previous studies, which have shown that the weaver phenotype is identifiable as early as the day of birth, and that the OZ42-antigen may be involved with the development process of axonal growth, it is reasonable to suggest that the weaver mutation results in an abnormality in the ability of granule cells to produce and/or stabilize axons.
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