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  • 1
    Online Resource
    Online Resource
    Wiesbaden : Gabler
    Person(s): Stein, Thomas
    Keywords: Unternehmen ; Lagebericht ; Qualitätssteigerung ; Regulierung ; Deregulierung ; Deutschland ; Hochschulschrift ; Deutschland 03.10.1990- ; Unternehmen ; Lagebericht ; Qualitätssteigerung ; Regulierung ; Deregulierung
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XX, 325 S.)
    Edition: 1. Aufl.
    ISBN: 9783834927040 , 383492704X , 9783834967046
    Series Statement: Gabler Research : Rechnungswesen und Unternehmensüberwachung
    RVK:
    Language: German
    Dissertation note: Zugl.: Frankfurt (Main), Univ., Diss., 2010
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 89 (1967), S. 4221-4222 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    Berlin: Technische Universität Berlin, Institut für Land- und Seeverkehr, Fachgebiet Integrierte Verkehrsplanung
    Publication Date: 2019-06-29
    Description: Bei der Suche nach nachhaltigen Verkehrslösungen für die wachsenden Ballungsräume in Deutschland, aber auch weltweit, dominieren vielfach technische Lösungen die Debatte. Im Umgang mit der weiter wachsenden Verkehrsmenge, Flächenkonflikten, Herausforderungen durch Klimawandel, Ressourcenproblematik und demographischem Wandel, müssen jedoch auch weitere Aspekte betrachtet werden, um in Zukunft eine nachhaltige Mobilität in Städten für alle zu gewährleisten. In diesem Zusammenhang ist das "autofreie Leben" ein vielversprechender Lebens- und Mobilitätsstil, den es durch geeignete Maßnahmen auf Ebene der Stadt- und Verkehrsplanung zu unterstützen gilt. Eine Möglichkeit stellen die vor allem aus dem Neubau bekannten autofreien Wohnquartiere dar. Hier werden die Vorzüge des autofreien Lebens für die Bewohner in ihrer direkten Wohnumgebung erlebbar und durch begleitende Mobilitätsmaßnahmen gefestigt. Die Entwicklung bereits bestehender Wohnquartiere hin zu autofreien oder -armen ist ein nächster Schritt. Statistisch gesehen nimmt die Hauptstadt Berlin in Deutschland hinsichtlich autofreien Lebens eine Vorreiterrolle ein. Der hohe Anteil autofreier Haushalte, nicht nur in der Innenstadt, spiegelt sich jedoch nur unzureichend in der Stadt- oder Verkehrsplanung wider. Anhand einiger Initiativen in Berlin werden Chancen und Hemmnisse für die Realisierung von autofreien Wohnquartieren im Bestand sichtbar.
    Description: The paper at hand discusses requirements and potential obstacles in the process of reshaping existing housing areas into car free settlements in inner-city Berlin as a contribution to sustainable urban and transport development. In 2002, a model project was executed by the Federal German Environmental Agency in Halle (Saale), in which an existing housing area was supposed to be reshaped during an urban regeneration process. Next to this, experiences of existing car-free initiatives in Berlin are also an important part for assessing beneficial resp. impeding factors for such a process. In addition, a closer look is taken into the district of Berlin-Prenzlauer Berg which stands out due to a high rate of car-free households and a high modal share of ecomobility. The discrepancy between the mobility of the people and the presence of cars in their living environment reveals a main issue when trying to implement car free housing measures. While regulatory provisions and planning policies don't seem to be a severe obstacle for reshaping existing settlement into car free neighborhoods, political and communicative issues do so. The local majority of car-free households and their demand for a car-free or reduced environment must be portrayed in the struggle for urban space. Some inner-city districts of Berlin show good potential and possible majorities for reshaping urban space. While little success can be identified looking at the "car free-concept", a broader view reveals good practices which can also contribute to car-free housing and a corresponding development in some areas in Berlin.
    Keywords: ddc:330
    Language: German
    Type: doc-type:workingPaper
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 16 (1977), S. 61-68 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 16 (1977), S. 58-61 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 89 (1967), S. 7125-7126 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 3943-3950 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
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    Unknown
    BioMed Central
    Publication Date: 2016-09-03
    Description: The aim of this study was to use three-dimensional datasets to identify associations between treatment for adult crowding using Invisalign and interproximal enamel reduction (IER) and changes in the bone volume.
    Electronic ISSN: 1472-6831
    Topics: Medicine
    Published by BioMed Central
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  • 9
    Publication Date: 2016-10-20
    Description: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns Nature 538, 7625 (2016). doi:10.1038/nature19823 Authors: Faiyaz Notta, Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W. Wilson, Ashton A. Connor, Robert E. Denroche, Sheng-Ben Liang, Andrew M. K. Brown, Jaeseung C. Kim, Tao Wang, Jared T. Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E. Dick, Lawrence Heisler, Michael A. Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G. T. Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M. Petersen, Liran I. Shlush, Lee Timms, Ming-Sound Tsao, Julie M. Wilson, Christina K. Yung, George Zogopoulos, John M. S. Bartlett, Ludmil B. Alexandrov, Francisco X. Real, Sean P. Cleary, Michael H. Roehrl, John D. McPherson, Lincoln D. Stein, Thomas J. Hudson, Peter J. Campbell & Steven Gallinger Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neoplasm (PanINs) lesions, makes two predictions: first, that pancreatic cancer develops through a particular sequence of genetic alterations (KRAS, followed by CDKN2A, then TP53 and SMAD4); and second, that the evolutionary trajectory of pancreatic cancer progression is gradual because each alteration is acquired independently. A shortcoming of this model is that clonally expanded precursor lesions do not always belong to the tumour lineage, indicating that the evolutionary trajectory of the tumour lineage and precursor lesions can be divergent. This prevailing model of tumorigenesis has contributed to the clinical notion that pancreatic cancer evolves slowly and presents at a late stage. However, the propensity for this disease to rapidly metastasize and the inability to improve patient outcomes, despite efforts aimed at early detection, suggest that pancreatic cancer progression is not gradual. Here, using newly developed informatics tools, we tracked changes in DNA copy number and their associated rearrangements in tumour-enriched genomes and found that pancreatic cancer tumorigenesis is neither gradual nor follows the accepted mutation order. Two-thirds of tumours harbour complex rearrangement patterns associated with mitotic errors, consistent with punctuated equilibrium as the principal evolutionary trajectory. In a subset of cases, the consequence of such errors is the simultaneous, rather than sequential, knockout of canonical preneoplastic genetic drivers that are likely to set-off invasive cancer growth. These findings challenge the current progression model of pancreatic cancer and provide insights into the mutational processes that give rise to these aggressive tumours.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2017-02-02
    Description: Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns Nature 542, 7639 (2017). doi:10.1038/nature20164 Author: Faiyaz Notta, Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W. Wilson, Ashton A. Connor, Robert E. Denroche, Sheng-Ben Liang, Andrew M. K. Brown, Jaeseung C. Kim, Tao Wang, Jared T. Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E. Dick, Lawrence Heisler, Michael A. Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G. T. Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M. Petersen, Liran I. Shlush, Lee Timms, Ming-Sound Tsao, Julie M. Wilson, Christina K. Yung, George Zogopoulos, John M. S. Bartlett, Ludmil B. Alexandrov, Francisco X. Real, Sean P. Cleary, Michael H. Roehrl, John D. McPherson, Lincoln D. Stein, Thomas J. Hudson, Peter J. Campbell & Steven Gallinger Nature538, 378–382 (2016); doi:10.1038/nature19823In this Letter, owing to a typesetter error the ‘received date’ was incorrectly shown as ‘8 August 2015’ instead of ‘27 November 2015’ in both the print and PDF versions; this has been
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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