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  • 1
    Online Resource
    Online Resource
    Berlin : Springer
    Keywords: Deutsch ; Fremdsprache ; Language and education ; Teaching ; Lifelong learning ; Adult education ; Language and languages ; Educational psychology ; Education ; Language Teaching ; Lifelong Learning ; Ethnicity in Education ; Teaching and Teacher Education ; Pedagogic Psychology ; Language Education ; Deutsch ; Fremdsprache
    Abstract: Alphabetisierung – Deutsch als Zweitsprache für Jugendliche und junge Erwachsene Die SchlaU-Lernbox besteht aus zehn Lernheften für Jugendliche und junge Erwachsene (mit Fluchthintergrund). Ein Heft behandelt jeweils ein übergeordnetes Thema und ist untergliedert in einzelne Buchstabenkapitel. - Die SchlaU-Lehrmaterialien richten sich an neuzugewanderte und im Speziellen geflüchtete Jugendliche und junge Erwachsene. Alle Inhalte sind in enger Zusammenarbeit mit den Lehrkräften und SchülerInnen der SchlaU-Schule entstanden und orientieren sich an den Lebensalltagen von jungen Erwachsenen (mit Fluchterfahrung). - Das innovative System aus thematischen Lernheften ist im Klassenverbund oder in der Einzelbetreuung flexibel einsetzbar. Es bietet eine umfangreiche Grundlage für gelungene Alphabetisierungsarbeit. Lebensnahe Themen, jugendliche Illustrationen, variantenreiche Aufgabentypen und online verfügbare Zusatzmaterialien bieten die Möglichkeit, die Freude am Lernen zu entdecken und Sprache zielgerichtet zu erarbeiten. - Das Lehrmaterial baut auf einem ganzheitlichen Methodenkonzept auf, das neben dem Buchstabenerwerb besonderen Wert auf Phonetik und Grafomotorik legt, die Grundkenntnisse der deutschen Alltagssprache vermittelt und erste Grammatik vermittelt. Alltagsweltlich orientierte Inhalte fördern ein motiviertes und sinnhaft-angewandtes Lernen.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (XII, 478 Seiten)
    Edition: 1. Auflage
    ISBN: 9783662562703
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    DDC: 407.1
    RVK:
    Language: German
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  • 2
    Book
    Book
    Berlin [u.a.] : Springer
    Type of Medium: Book
    Pages: XII, 245 S. , Ill., graph. Darst.
    ISBN: 3540211780
    Series Statement: Xpert.press
    DDC: 004
    RVK:
    RVK:
    Language: German
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Scientia Horticulturae 52 (1992), S. 27-35 
    ISSN: 0304-4238
    Keywords: 6-benzyladenine ; Garcinia mangostana ; bud dormancy ; gibberellins ; mangosteen ; plant growth regulators
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimie 75 (1993), S. 209-224 
    ISSN: 0300-9084
    Keywords: PAS genes ; forward and reversed genetics ; isolation of peroxisomes ; peroxisomal mutants ; peroxisomal polypeptide pattern ; peroxisome biogenesis ; peroxisomes ; yeast
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 69 (1995), S. 505-507 
    ISSN: 1432-0738
    Keywords: Key words Glutathione-S-transferase ; Theta polymorphism ; Sister chromatid exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Polymorphism of glutathione S-transferase θ (GSTT1) modulates the toxicity of halogenated alkanes and epoxides in humans. The enzymatic activity of glutathione S-transferase θ and its corresponding gene is lacking in about 30% of the central European population. It has now been demonstrated that the background rate for sister chromatid exchange (SCE) is affected by this particular polymorphism. Smoking as a known inducer of SCE was taken into account. A group of GSTT1-positive subjects exhibited lower SCE rates than GSTT1-negative individuals (7.55±0.77 versus 8.74±1.24 SCE/mitosis, respectively, p〈0.005). Non-smoking GSTT1-positive individuals showed the lowest SCE rate (7.26±0.71 SCE/mitosis), significantly lower than the rates of smoking GSTT1-positive and non-smoking GSTT1-negative subjects (8.14±0.55 SCE/mitosis and 8.12±0.88 SCE/mitosis, respectively, p〈0.025 in both cases). Smoking GSTT1-negative subjects exhibited the highest SCE rates (9.28±1.3 SCE/mitosis). It is hypothesized that GSTT1 is protective against background genotoxic damage. Since ethylene oxide is a proven substrate of GSTT1, the detoxification of this epoxide arising from endogenous ethylene may modulate SCE background rates.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 70 (1996), S. 559-566 
    ISSN: 1432-0738
    Keywords: Key words Glutathione S-transferase ; Erythrocytes ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A new polymorphic form of glutathione S-transferase (GST), metabolising monohalogenated methanes, ethylene oxide and dichloromethane, has been purified from human erythrocytes and characterized. Several characteristics, such as similar elution patterns on different chromatographic matrices, KM-values and activity towards antibodies, confirm a previous assumption that this novel GST is a class θ enzyme. Although the presence or absence of the enzyme activity in human red blood cells is parallel with the polymorphism of the human GST T1 gene, the new GST θ in red blood cells may differ from the known GST T1-1 enzyme from other tissues in terms of substrate specificity, since established GST T1-1 substrates [1,2-epoxy-3-(p-nitro-phenoxy)propane and p-nitrobenzyl chloride] are not metabolized. The substrate specifity of the new enzyme in erythrocytes resembles more closely that of GST T2-2, most likely due to a common N-terminal modification which modifies substrate binding. The new polymorphic GST-isoform in human red blood cells therefore may be considered to represent an N-terminally modified isoform of GST T1-1.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 59 (1981), S. 277-280 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Polycyclic aromatic hydrocarbon-inducible monooxygenase directed toward the substrate benzo(a)pyrene, i.e., “aryl hydrocarbon hydroxylase”, was monitored in cell hybrids formed from mouse RAG cells and several human fibroblasts lines. In RAG cells no aryl hydrocarbon hydroxylase activity was detectable; however, these cells exhibited relatively high levels of NADPH cytochrome C (P-450) reductase (EC. 1.6.2.4). In 12 hybrids lines, induced aryl hydrocarbon hydroxylase segregated with human chromosome 2. The results indicate that the structural gene of the polycyclic aromatic hydrocarbon-inducible monooxygenase or gene(s) involved in the induction of the enzyme is located on human chromosome 2.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geology 23 (1994), S. 214-220 
    ISSN: 1432-0495
    Keywords: Karst ; Well development ; Electrical resistivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Three regolith-collapse sinkholes formed near the Dongola Unit School and the Pentecostal Church in the southern Illinois village of Dongola (Union County) during the spring of 1993. The sinkholes appeared over a three-month period that coincided with development of a new municipal well. The new well was drilled through clay-rich, valley-fill sediment into karstified limestone bedrock. The piezometric surface of the limestone aquifer is above land surface, indicating the presence of an upward hydraulic gradient in the valley and that the valley fill is acting as a confining unit. Pumping during development of the well lowered the piezometric surface of the limestone aquifer to an elevation below the base of the valley fill. It is hypothesized that drainage of water from the sediments, the resulting loss of hydrostatic pressure and buoyant force in overlying sediments, increased intergranular pressure, and the initiation of groundwater flow toward the well resulted in rapid sediment transport, subsurface erosion, and collapse of the valley-fill sediment. The sinkholes follow an approximately east-west alignment, which is consistent with one of the two dominant alignments of passages of nearby joint-controlled caves. A constant electrode-separation resistivity survey of the school playground was conducted to locate areas that might contain incipient sinkholes. The survey revealed a positive resistivity anomaly trending N75E in the southern part of the study area. The anomaly is linear, between 5 and 10 m wide, and its trend either intersects or is immediately adjacent to the three sinkholes. The anomaly is interpreted to be a series of pumping-induced cavities in the valley-fill sediments that formed over a preexisting crevice in the karstified bedrock limestone.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd.
    Addiction 98 (2003), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims  Studies on cognitive processes in alcoholism have reported changes with respect to executive functions and memory, which have been interpreted within the context of different neuropsychological models. The aims of the present study were to investigate (1) the validity of these models and (2) the influence of depression on cognitive functioning in alcoholism.Design, setting and participants  In the present investigation, patients suffering from alcoholism (Alc; n = 30), patients with depression but without alcoholism (Dep; n = 28) and healthy controls (HC; n = 28) were compared on a neuropsychological test battery.Measurements  The test battery included measurements of mood, memory and executive functions. The possible cumulative effect of alcohol and depression was analysed by comparison of depressed alcoholic patients (Dalc) and non-depressed alcoholic patients (NDAlc).Findings  Group comparisons revealed impairments of alcoholic patients with respect to response inhibition, reasoning and free recall, irrespective of depression. Priming, short-term memory as well as verbal fluency abilities were unaffected. Depressive patients showed verbal fluency as well as free recall deficits. However, there was no difference in performance between depressed and non-depressed alcoholics.Conclusions  The specific pattern of neuropsychological deficits of the alcoholic patients supports the frontal lobe hypothesis. The results of the present investigation suggest that these deficits are not generally exacerbated by comorbid depressive symptoms. Further studies, however, are desirable to investigate the relation between executive deficits and depression in alcoholics with evidence of major depression.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 70 (1996), S. 306-309 
    ISSN: 1432-0738
    Keywords: Key words Glutathione S-transferase GSTM1 GSTT1 ; Genotyping ; Phenotyping ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Only limited information is available so far concerning the human glutathione S-transferase isoenzyme class theta encoded by the GSTT1 gene. The aim of the study was to characterize individuals in respect to a polymorphic deletion of the GSTT1 gene and to validate these results with the phenotypical determination of the “conjugator status” according to Hallier et al. (1993). Determination of the GSTT1 genotype was done in 40 healthy adults by using an assay based on internal standard controlled polymerase chain reaction. The GSTT1-1 phenotype was determined by measuring the erythrocyte conjugating activity towards methyl chloride using a gas chromatographic assay. Genotypically, 34 individuals out of 40 were classified as GSTT1 positive; the remainder were negative. These results could be confirmed by phenotyping in all but one case. In the present study the frequency of “non-conjugators” was 15%. Our study demonstrates the reliability of the suggested PCR assay for GSTT1 genotyping which is easier to perform than the phenotyping assay and is not affected by confounding factors.
    Type of Medium: Electronic Resource
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