Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1
Nature Publishing Group
Nature Archives 1869 - 2009
[Auszug] The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 Å resolution. The domain contains two BRCT repeats that adopt similar structures and ...
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