WILBERT

Wildauer Bücher+E-Medien Recherche-Tool

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 308-315 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The transcriptional coactivator p300 is a histone acetyltransferase (HAT) whose function is critical for regulating gene expression in mammalian cells. However, the molecular events that regulate p300 HAT activity are poorly understood. We evaluated autoacetylation of the p300 HAT protein domain to ...
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 312-316 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Post-translational modification of chromatin has profound effects on many biological processes including transcriptional regulation, heterochromatin organization, and X-chromosome inactivation. Recent studies indicate that methylation on specific histone lysine (K) residues participates in many ...
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomedical science 3 (1996), S. 307-318 
    ISSN: 1423-0127
    Keywords: Thyroid hormone receptor ; Metamorphosis ; Transcription regulation ; Xenopus laevis ; Chromatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Thyroid hormone receptors (TRs) are members of the fast growing superfamily of nuclear hormone receptors. They are dual function transcription factors. In the unliganded form, they repress basal transcription of their target genes. The presence of thyroid hormone leads to not only the relief of this repression but also a strong transcriptional activation above the basal level. Mechanistically, thyroid hormone receptors appear to function as heterodimers with 9-cis-retinoic acid receptors both in the absence and in the presence of thyroid hormone. Recent studies indicate that the heterodimers can interact with thyroid hormone response elements in chromatin independently of thyroid hormone and that the receptors have evolved to function efficiently in a chromatin environment, utilizing chromatin assembly to effectively repress transcription in the absence of thyroid hormone and overcoming the repression by chromatin by inducing chromatin disruption in the presence of the hormone. In addition, a number of TR-interacting proteins have been isolated. How these proteins participate in the regulation of transcription by TRs remains to be elucidated. Independent of the exact mechanisms of action, the developmental expression of thyroid hormone receptor genes during amphibian metamorphosis suggests that both the repression and activation functions of the receptors are important for proper control of the temporal and tissue-specific regulation of metamorphosis.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...