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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 55 (1975), S. 313-314 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 54 (1975), S. 465-467 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0731-7085
    Keywords: Enloplatin ; assay validation. ; flameless atomic absorption spectrometry (FAAS) ; platinum ; reversed-phase LC
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1041
    Keywords: cefixime ; oral cephalosporin ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty healthy adult volunteers received single 400 mg oral doses of cefixime in an open, randomized, crossover study, administered twice in the fasted state and twice with a standard breakfast. The study design allowed both an evaluation of a potential food effect and also an analysis of both intrasubject and intersubject variability in the fasted and fed state. There was a small but significantly longer (∼1 h) time to peak concentration when the drug was given with food. Peak serum concentrations, area under the curve, and 24 h urinary recovery values were unchanged in the fed and fasted states. The terminal elimination half-life of the drug given after a meal (3.6 h) was slightly longer than that observed after dosing in the fasting condition (3.5 h). The intrasubject and intersubject variabilities were less than 12% and 33% respectively, for both area under the curve and 24 h urinary recovery, and were virtually the same for the fasted and fed occasions. Therefore, the drug may be administered with or without food.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1041
    Keywords: Leucovorin ; l-leucovorin folates pharmacokinetics isomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic values of d,l-leucovorin and l-leucovorin were compared in eight healthy volunteers following oral administration of 25 mg d,l-leucovorin and 12.5 mg l-leucovorin. Serum levels of l-5-for-myltetrahydrofolate, l-5-methyltetrahydrofolate, and total reduced folates were measured by an established microbiological method. Pharmacokinetic data for both preparations were consistent with those previously reported for d,l-leucovorin, with essentially complete first pass metabolism to l-5-methyltetrahydrofolate, the active metabolite. No differences were found between the two preparations in serum concentrations of active folate fractions, AUC, or Cmax, or in clearance and volume of distribution estimates. These data suggest that after administration of 25 mg of d,l-leucovorin, the d-diastereoisomer has no significant effect on the standard pharmacokinetic measurements of the active l-folates.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 56 (1993), S. 317-321 
    ISSN: 1432-0630
    Keywords: 78.55.Et ; 81.10.Dn ; 61.16.Di
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract We report the characterization of solution-synthesized CdTe and HgTe nanocrystals by X-ray diffraction, transmission electron microscopy, and photoluminescence. Methanol solutions of sodium telluride and cadmium iodide or mercury iodide, respectively, are reacted to precipitate the nanocrystalline metal tellurides, while the sodium iodide byproduct remains in solution. The existence of crystalline CdTe, HgTe, and ternary HgCdTe compounds has been demonstrated by powder X-ray diffraction after a post-synthesis sintering process. Precipitated crystallites from this synthesis were analyzed by transmission electron microscopy, which revealed that crystal diameters can vary from approximately 1 nm to 100 nm and that crystals are stoichiometric within the detection limit of the electron microprobe technique. Narrow size ranges can be selected and investigated due to an in-situ separation process in the electron microscope. Photoluminescence is found at energies above the bulk exciton energy for CdTe and is attributed to near-band-gap recombination which is blue-shifted due to quantum confinement. Both low defect luminescence and dark field imaging suggest a high crystalline quality. A comparative characterization by photoluminescence, transmission electron microscopy, and X-ray diffraction evaluates the effects of heat treatments during and after synthesis.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 87 (1982), S. 165-175 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The frequency of interlocking bivalents at first meiotic metaphase of common wheat Triticum aestivum L., which is normally very low, is significantly increased by raising the dosage (from two to three, four and six) of the Ph1 gene, located on the long arm of chromosome 5B (5BL). In several cells more than three bivalents were interlocked in one chain configuration indicating involvement of non-homoeologous bivalents. Plants with reduced dose (one or zero) of Ph1 also exhibited an increased frequency of interlocking but to a lesser extent than those with high gene dosage. However, chains of more than three interlocked bivalents were never observed in these plants, suggesting that with one or zero doses of Ph1 interlocking is restricted to homoeologous bivalents only. Chromosomal arm 5BS affected interlocking in an opposite manner to 5BL; namely, two and four doses of 5BS markedly reduced interlocking frequency. The modification in the frequency of interlocking bivalents by these genetic manipulations represents the first successful attempt to affect interlocking by genetic means. The results are explained on the basis of the hypothesis that this gene system controls somatic and premeiotic association of both homologous and homoeologous chromosomes.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 91 (1985), S. 347-354 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Distances between marked pairs of bivalents were determined at first meiotic metaphase of common wheat (2n=6x=42; genome AABBDD) by tallying the number of bivalents intervening between the marked bivalents. Bivalents of the same genome tended to lie relatively close to one another, whereas those of different genomes were further apart on the metaphase plate. Within each genome the association of telocentric bivalents representing the two different arms of one chromosome was much more intimate than that of genetically nonrelated bivalents. Among chromosomes of different genomes, homoeologous bivalents were relatively closer to one another than nonrelated ones. These results were more pronounced in cells with circularly arranged bivalents on the metaphase plate than in those with a linear arrangement. The data, consistent with previous findings in cold-treated somatic cells, indicate that a similar pattern of chromosomal arrangement exists in somatic and meiotic cells and that chromosomal arrangement observed in arrested metaphases is also maintained on the untreated, functional spindle system.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 91 (1985), S. 355-358 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The spatial relationships between different types of marked pairs of bivalents or trivalents were studied at first meiotic metaphase of tetraploid wheat (2n=4x=28; genome AABB) by tallying the number of intervening bivalents between the marked pair. The study was carried out only in pollen mother cells with circularly arranged metaphases. Telocentric bivalents representing the two different arms of one chromosome were found very close to each other. Nonrelated trivalents of the same genome were significantly closer to each other than nonrelated trivalents of different genomes. Homoeologous trivalents tended to lie relatively close to one another. This pattern of chromosomal arrangement agrees well with previous findings in hexaploid wheat, both in mitotic and meiotic cells. It is concluded that in polyploid wheat the chromosomes of each genome lie relatively close to each other and are spatially separated from those of the other genomes.
    Type of Medium: Electronic Resource
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