Computer-assisted optimization of pesticides separation by two-dimensional high-performance thin-layer chromatography
Mobile phase optimization
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Summary A computer-assisted method is presented for optimization of two mobile phase selection for separation of a mixture of eight pesticides in two-dimensional TLC. Optimization of the separation over the experimental region is based on two special polynomial estimations from preliminary runs of two groups. Using D (distance of two spots) as the selection criterion with a two factor statistical scanning technique excellent agreement is obtained between predicted and experimental results.
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