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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 433 (1998), S. 305-309 
    ISSN: 1432-2307
    Keywords: Key words Microdissection technique ; Micromanipulator ; Archival tissue ; Tissue heterogeneity ; Mutations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Formalin-fixed and paraffin-embedded tissues are valuable resources for retrospective analysis of the molecular changes in DNA present in tumour tissues. One common problem that precludes an accurate DNA analysis in a human tissue sample is cellular heterogeneity. We have developed a simple and inexpensive, but micrometrically precise, microdissection technique that allows for selective isolation of minute cell clusters and even single cells from archival tissue sections. The features of our technique include use of a 30G1/2 needle affixed to a mechanical micromanipulator as a dissector sharp enough to be used for dissection of even single cells and use of the stage and focus control knobs of the microscope to scrape the target cells instead of moving the needle during microdissection. The main advantages of this technique over the current methods lie in its simplicity, low cost, easy handling and precision.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 373 (1995), S. 441-444 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To address the possible role of Fas/Fas-ligand interactions in activation-induced apoptosis in T-cell hybridomas, we examined the expression of Fas and Fas-ligand in the hybridoma line Al. 1, which rapidly undergoes apoptosis following activation1'3. Al.l cells do not express cell-surface Fas ...
    Type of Medium: Electronic Resource
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