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  • 1
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer
    Part of " Lecture notes in physics"
    Keywords: Relativistische Quantenmechanik ; Elementarteilchenphysik ; Gruppentheorie ; Hadron ; Masse (Physik) ; Hadron ; Massenspektrum ; Hadron ; Relativistischer Effekt ; Konferenzschrift ; Relativistische Quantenmechanik ; Elementarteilchenphysik ; Gruppentheorie ; Hadron ; Masse 〈Physik〉 ; Hadron ; Massenspektrum ; Hadron ; Relativistischer Effekt
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    ISBN: 9783540115861 , 9783540393382
    Series Statement: Lecture notes in physics 165
    Language: English
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  • 2
    Online Resource
    Online Resource
    London, [England] : : Palgrave Macmillan,
    Keywords: Leadership. ; Career development. ; Executive ability Study and teaching. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (252 pages) : , illustrations
    ISBN: 9781137549099 (e-book)
    DDC: 658.4092
    Parallel Title: Print version: Iñiguez de Onzoño, Santiago. Cosmopolitan managers : executive development that works.
    Language: English
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  • 3
    Online Resource
    Online Resource
    Chichester, West Sussex, United Kingdom : : John Wiley & Sons, Ltd,
    Keywords: Pension trusts. ; Portfolio management. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (374 pages)
    ISBN: 9781119437727 (e-book)
    DDC: 332.67254
    Parallel Title: Print version: Koedijk, Kees G. Achieving investment excellence : a practical guide for trustees of pension funds, endowments and foundations.
    Language: English
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  • 4
    Book
    Book
    Boston : Pearson Education
    Keywords: Object-oriented programming (Computer science) ; Java (Computer program language)
    Additional Material: 1 CD-ROM (12cm)
    Type of Medium: Book
    Pages: XXIX, 609 S. , graph. Darst.
    Edition: Preliminary ed.
    ISBN: 0321245741
    DDC: 005.13/3
    RVK:
    Language: English
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  • 5
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    BioMed Central
    Publication Date: 2012-10-07
    Description: Background: Although many diseases have been well characterized at the molecular level, the underlying mechanisms are often unknown. Nearly half of all human genes remain poorly studied, yet these genes may contribute to a number of disease processes. Genes involved in common biological processes and diseases are often co-expressed. Using known disease-associated genes in a co-expression analysis may help identify and prioritize novel candidate genes for further study. Results: We have created an online tool, called GeneFriends, which identifies co-expressed genes in over 1,000 mouse microarray datasets. GeneFriends can be used to assign putative functions to poorly studied genes. Using a seed list of disease-associated genes and a guilt-by-association method, GeneFriends allows users to quickly identify novel genes and transcription factors associated with a disease or process. We tested GeneFriends using seed lists for aging, cancer, and mitochondrial complex I disease. We identified several candidate genes that have previously been predicted as relevant targets. Some of the genes identified are already being tested in clinical trials, indicating the effectiveness of this approach. Co-expressed transcription factors were investigated, identifying C/ebp genes as candidate regulators of aging. Furthermore, several novel candidate genes, that may be suitable for experimental or clinical follow-up, were identified. Two of the novel candidates of unknown function that were co-expressed with cancer-associated genes were selected for experimental validation. Knock-down of their human homologs (C1ORF112 and C12ORF48) in HeLa cells slowed growth, indicating that these genes of unknown function, identified by GeneFriends, may be involved in cancer. Conclusions: GeneFriends is a resource for biologists to identify and prioritize novel candidate genes involved in biological processes and complex diseases. It is an intuitive online resource that will help drive experimentation. GeneFriends is available online at: http://genefriends.org/.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 6
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    Unknown
    BMJ Publishing
    In: BMJ Open
    Publication Date: 2016-08-28
    Description: Introduction Misidentification of the extrahepatic bile duct anatomy during laparoscopic cholecystectomy (LC) is the main cause of bile duct injury. Easier intraoperative recognition of the biliary anatomy may be accomplished by using near-infrared fluorescence (NIRF) imaging after an intravenous injection of indocyanine green (ICG). Promising results were reported for successful intraoperative identification of the extrahepatic bile ducts compared to conventional laparoscopic imaging. However, routine use of ICG fluorescence laparoscopy has not gained wide clinical acceptance yet due to a lack of high-quality clinical data. Therefore, this multicentre randomised clinical study was designed to assess the potential added value of the NIRF imaging technique during LC. Methods and analysis A multicentre, randomised controlled clinical trial will be carried out to assess the use of NIRF imaging in LC. In total, 308 patients scheduled for an elective LC will be included. These patients will be randomised into a NIRF imaging laparoscopic cholecystectomy (NIRF-LC) group and a conventional laparoscopic cholecystectomy (CLC) group. The primary end point is time to ‘critical view of safety’ (CVS). Secondary end points are ‘time to identification of the cystic duct (CD), of the common bile duct, the transition of CD in the gallbladder and the transition of the cystic artery in the gallbladder, these all during dissection of CVS’; ‘total surgical time’; ‘intraoperative bile leakage from the gallbladder or cystic duct’; ‘bile duct injury’; ‘postoperative length of stay’, ‘complications due to the injected ICG’; ‘conversion to open cholecystectomy’; ‘postoperative complications (until 90 days postoperatively)’ and ‘cost-minimisation’. Ethics and dissemination The protocol has been approved by the Medical Ethical Committee of Maastricht University Medical Center/Maastricht University; the trial has been registered at ClinicalTrials.gov. The findings of this study will be disseminated widely through peer-reviewed publications and conference presentations. Trial registration number NCT02558556.
    Keywords: Open access, Gastroenterology and hepatology, Research methods, Surgery
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 42 (1997), S. 165-172 
    ISSN: 1573-7217
    Keywords: node-negative breast cancer ; prognosis ; tumor angiogenesis ; microvessel density ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study on the determination of intratumoralmicrovessel density (MVD) in breast cancer, we haveinvestigated the influence of the observer experience andthe microscopic field size. We have used thesample set reported on earlier in the JNatl Cancer Inst 87: 1797–1798, 1995. This case-controlstudy has shown a positive association of highMVD and unfavorable outcome when comparing node-negative pT1–2breast carcinoma (NNBC) patients with a disease-free periodof over ten years with those with anearly distant relapse.Tumor sections of both outcome groups (favorable: n= 19; unfavorable: n = 19) were immunostainedfor factor VIII related-antigen (FVIII r-Ag). Microvessels werecounted in the areas of most intense vascularization(‘hot spots’), both at magnification × 200 (fieldsize of 0.61 square mm) and × 400(field size of 0.15 square mm), by oneinexperienced and three experienced observers. Microphotographs of individualvascular hot spots were analyzed using overlays resemblingthe two field sizes.The main results obtained are: i) a confirmationof the prognostic value of microvessel density inthe case-control sample set (n = 38) wasestablished by all experienced but not by theunexperienced investigator; ii) both at × 200 and× 400 magnification, angiogenesis quantification in vascular hotspots contained prognostic information.The results of this study indicate that theselection of vascular hot spots in tumor sectionsimmunostained for an antigen expressed on endothelial cellsis more prone to inter-observer variability and moredependent on training than the counting of themicrovessels within predefined hot spots itself. The microscopicmagnification and resulting field size do not influencethe prognostic significance of MVD in NNBC. Thisinformation validates the development of more objective methodsof measuring the amount of angiogenesis within malignanttissue. This will allow more accurate implementation ofthe angiogenesis parameter in multiparametric and prospective prognosticfactor studies in NNBC.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-6881
    Keywords: Metabolic control ; analysis ; and regulation ; control hierarchies ; channelling ; homeostasis ; enzyme organization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The concept of a single rate-limiting step was proven to be too simplistic for understanding control and regulation of metabolism. Consequently, searches have identified relatively few steps with high control. Here we review a number of such searches and indicate what mechanisms may be responsible for this elusiveness of control. It turns out that this elusiveness of control has itself led to increased understanding of the roles played in metabolic control and regulation of such diverse factors as distributiveness of control, condition dependence, enzyme elasticity, homeostasis, control hierarchies, the input into a pathway, coenzyme sequestration, and redundancy and diversity of control function.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Radiophysics and quantum electronics 12 (1969), S. 156-158 
    ISSN: 1573-9120
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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