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  • 1
    Online Resource
    Online Resource
    Berlin [u.a.] : Springer
    Part of " Lecture notes in mathematics"
    Keywords: Approximationstheorie ; Optimierung ; Approximation ; Konferenzschrift 1987 ; Approximationstheorie ; Optimierung ; Approximation
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource
    ISBN: 9783540504436 , 9783540460053
    Series Statement: Lecture notes in mathematics 1354
    DDC: 518
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 14 (1989), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this paper is to explore and detect possible factors associated with the appearance and maintainance of affective disorders in the elderly, special emphasis was put on anxiety and depression Two hundred and seven Cordobese citizens over 65 years of age, filled in a Hospital Anxiety and Depression Questionnaire and a Habit Behavioural Questionnaire The variables sex, hospitalization and family life were controlled The results emphasize the existence of moderate but significant correlations between depression and certain behavioural habits in the elderly, such as appetite, taking walks and sleeping The greater the appetite, food intake, taking of frequent walks and hours of sleep, the more the association with lower levels of depression in the elderly studied Anxiety, on the other hand, only correlates significantly with behavioural habits related to sleep cycles By means of a urufactorial variance analysis, the differential effect of some of the behavioural habits on the aforementioned disorders is shown Using a multiple regression analysis, results of the behavioural habits, which seem to be the best predictors of anxiety and depression in the elderly, are obtained After a discussion of these results, their possible implications in nursing are analysed and a few interesting conclusions are drawn.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 97 (1989), S. 303-311 
    ISSN: 1436-5073
    Keywords: differential kinetic ; single-point method ; cobalt-copper and cobalt-nickel simultaneous determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A procedure is reported for the simultaneous determination of binary mixtures of cobalt(III)-copper(II) and cobalt(III)-nickel(II) by differential kinetic methods based on complex formation reactions with 3-(1′H-1′,2′,4′-triazolyl-3′-azo)-2,6-diaminotoluene. The single-point method is used in both cases. The simultaneous determination of Co-Cu and Co-Ni is possible in the concentration range from 10/1 to 1/1. The interference caused by various ions is also studied. The method has been used to determine cobalt-copper and cobalt-nickel mixtures in synthetic samples, hydrofining catalysts and low alloy steels.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Current genetics 12 (1987), S. 421-428 
    ISSN: 1432-0983
    Keywords: Wine yeasts ; Homothallic/heterothallic strains ; Ethanol-tolerant genes ; Ethanol-sensitive genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The genetic basis of ethanol tolerance was investigated in homothallic and heterothallic ethanol-tolerant wine yeasts. All strains were diploid or nearly diploid and able to sporulate. Some possessed recessive lethal alleles. Their meiotic segregation with regard to ethanol tolerance indicates that recessive alleles able to decrease ethanol tolerance were present in the heterozygosis state in the parental wine strains. The number of genes able to spontaneously mutate to alleles of ethanol sensitivity were greater than these found in auxotrophic phenotypes. In homothallic strains segregation in the second generation has to be explained by the simultaneous presence of aneuploidy and ethanol-sensitive alleles. In non-isogenic strains, genes involved in ethanol tolerance had complementary functions. Although a fairly high number of genes were involved at the various tolerance levels of the wine and laboratory strains, different genes limited growth at different ethanol concentrations indicating that ethanol inhibition is the result of the inhibition of different cellular functions with increasing ethanol concentrations.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Current genetics 15 (1989), S. 7-16 
    ISSN: 1432-0983
    Keywords: Candida ; Saccharomyces ; Cellobiase ; Ethanol inhibition enzyme ; Intergeneric hybrids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Ethanol inhibition of several hydrolases (sucrase, maltase, trehalase, melezitase and cellobiase) has been measured in both highly ethanol-tolerant Saccharomyces strains (R) and in Candida strains less tolerant to ethanol (S). Cells were either grown in the presence of ethanol and the activities of the enzymes measured without preincubation in this alcohol (“in situ” inhibition assay), or the culture was grown in the absence of ethanol and the activities of the enzymes were determined after preincubation and in the presence of this compound (“in vitro” inhibition assay). Ethanol inhibition (Ki values) of sucrase, maltase, trehalase, and melezitase was quite different for these different enzymes in the same strain (R or S), but similar for the same enzyme in different strains (R and S). The Ki values for cellobiase, which is absent from the R strain, were higher when induced than at the basal level and higher in in vitro assays than in in situ assays. This suggests that the inhibition observed in situ is mainly the result of an inhibition of other proteins related to cellobiase (i.e., those involved in its synthesis) but not a direct inactivation of the enzyme by ethanol. Accordingly, when hybrids between Saccharomyces (R) and Candida (S) strains were constructed by protoplast fusion, and cellobiase was measured in the parental Candida strain and some of the hybrids, there was an increase in the Ki values in the in situ assays from 2.25% ethanol in Candida to 5.5% in some of the hybrids.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 74 (1989), S. 227-238 
    ISSN: 1432-1106
    Keywords: Striatonigral fibers ; Nigrostriatal projection ; Histochemistry, Primate ; Substantia nigrapars compacta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A marked histochemical compartmentalization is visible in the substantia nigra of the squirrel monkey in sections stained for acetylcholinesterase (AChE). In nigral regions containing tyrosine hydroxylase-positive neurons, there are AChE-poor and AChE-rich zones, and many of the AChE-poor zones have the form of narrow fingers extending ventrally into an AChE-rich matrix (Jimenez-Castellanos and Graybiel 1987b). The study reported here was carried out to determine whether this histochemical heterogeneity of the primate's substantia nigra is related to the known differentiation within its pars compacta of subdivisions projecting respectively to the caudate nucleus and to the putamen. Retrograde and anterograde labeling in the substantia nigra was elicited by tracer injections placed in the caudate nucleus or putamen and was plotted in relation to patterns of AChE staining and tyrosine hydroxylase immunostaining. Much of the labeling observed was organized according to borders visible with AChE histochemistry: labeled nigral neurons (and afferent fibers) tended to be clustered precisely within the AChE-poor ventrally-extending fingers or to be situated outside these zones. However, projection neurons in these ventrally-extending fingers were not exclusively related either to the caudate nucleus or to the putamen. After injections in the caudate nucleus, labeled neurons were predominantly in the AChE-poor fingers in some cases, but predominantly in AChE-rich nigral zones outside them in other cases. Labeling in and out of the ventrally-extending fingers, and along the edges of the fingers, also occurred following different tracer injections in the putamen. These findings confirm the independent clustering of nigrostriatal neurons projecting respectively to the caudate nucleus and to the putamen. The plan of nigrostriatal connections additionally appears concordant with the histochemical compartmentalization of the substantia nigra that can be detected with acetylthiocholinesterase histochemistry.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Current genetics 13 (1988), S. 461-469 
    ISSN: 1432-0983
    Keywords: rho − mutants ; Wine yeast mitochondria ; Cell viability ; Ethanol-tolerance ; Thermotolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Wine yeasts manifest simultaneously a high tolerance to ethanol, thermotolerance, and a high resistance to the mutagenic effects of ethanol on the mitochondrial genome. The transfer of mitochondria from these strains to laboratory yeasts demonstrate that this genome influences the above parameters, since thermotolerance, ethanol-growth tolerance, and the frequency ofrho − mutants were either totally or partially modified in the laboratory recipient strain. When the death rate and the rate of formation ofrho −mutants were measured under extreme conditions of inhibitory ethanol concentrations and high temperature, a perfect correlation was found between these parameters, and both of them were dependent on the strain of mitochondrial genome. Thus, the transfer of wine yeast mitochondria leads to a lower death rate, and a simultaneous increase in thermotolerance and ethanol tolerance in the recipient strain. These results demonstrate the role that viability plays under conditions of high temperatures and high ethanol concentrations. The greater stability of therho + phenotype shown by the wine yeast mitochondrial genome may be responsible for the increased viability conferred by these mitochondria.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1041
    Keywords: acetylator phenotype ; lupus erythematosus ; sulphamethazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetylator phenotype was determined, using sulphamethazine, in 37 patients with histologically confirmed discoid lupus erythematosus, who were free from visceral damage, and in 157 normal control subjects. Twenty patients (54%) and 90 control subjects (57.4%) were slow acetylators (p not significant). Acetylator polymorphism appears not to be related to the risk of developing pure cutaneous discoid lupus erythematosus.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1432-1041
    Keywords: Parkinsonism ; acetylator phenotype ; sulphamethazine ; debrisoquine oxidation ; drug polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetylator phenotype has been determined using sulphamethazine in 100 patients with Parkinson's disease and in 93 age-matched normal control subjects. Sixty-nine patients and 54 control subjects were classified as slow acetylators (NS). No relation was found among acetylator polymorphism and age at onset or clinical stage of disease. Amongst slow acetylators, the percentage of acetylated sulphamethazine in plasma was significantly lower in patients than in controls. Despite this finding, the results do not support any relationship between acetylator polymorphism and the risk of developing Parkinson's disease.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 18 (1973), S. 89-91 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Familie beschrieben, in welcher 5 Mitglieder von Adipositas dolorosa (Dercumsche Erkrankung) befallen waren. Der Erbgang ist autosomal-dominant.
    Notes: Summary A family in which 5 members were affected with adiposis dolorosa (Dercum's disease) is reported. The pedigree analysis gives evidence of autosomal dominant inheritance.
    Type of Medium: Electronic Resource
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