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  • 1965-1969  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 344 (1968), S. 257-274 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In our study of 1400 percutaneous renal biopsies we have found a new morphological type of renal change: a nephropathy with foam cells, seen in patients without any peculiar clinical characteristics. Two cases of this nephropathy are presented with similar light microscopic changes but widely different electron microscopic findings. We interpret the differences of the electron microscopic studies to be produced by deposits of different nature. In Case 1, the deposits are osmiophilic, probably phospholipid, and of four morphological types. These types are similar to those described in Fabry's and Tay-Sachs's diseases, but in a patient without dermatological or neurological involvement. In Case 2, the deposits are cholesterol. With the electron microscope the vacuoles generally appear empty and partially osmiophilic.
    Notes: Zusammenfassung In unseren Untersuchungen fanden sich unter 1400 Nierenbiopsien 2 Fälle, bei denen es sich um eine neuartige Nephropathie handelte, obwohl keine klinischen Befunde auf eine solche hinwiesen. Histologisch waren beide durch Schaumzellenbildung gekennzeichnet. Elektronenmikroskopisch zeigten sich jedoch unterschiedliche Befunde, die durch Ablagerungen verschiedener Natur bedingt waren. Im ersten Falle waren die Ablagerungen osmiophil, so daß es sich wahrscheinlich um Phospholipide, die in vier verschiedenen Formen erschienen, handelte, die auch bei der Fabryschen und Tay-Sachsschen Krankheit vorliegen. Der Patient jedoch wies weder Hautveränderungen noch neurologische Symptome auf. Im zweiten Falle bestanden die Ablagerungen aus Cholesterin. Elektronenmikroskopisch erschienen die Vacuolen meist leer und nur zum Teil osmiophil.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta diabetologica 6 (1969), S. 523-533 
    ISSN: 1432-5233
    Keywords: Atherosclerosis ; Beta-glucuronidase ; Diabetes ; Early diabetes ; Enzyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resume Les AA. ont mesuré l'activité beta-glucuronidasique dans le sérum de 41 sujets avec une tolérance au glucose diminuée (diabète chimique) et dans un groupe de contrôle de 41 sujets sains. Les résultats ont été les suivants: 1) les sujets normaux de sexe masculin présentent des niveaux sériques de cet enzyme plus élevés que ceux qui ont été observés chez les femmes; 2) les femmes avec diabète chimique présentent des niveaux plus élevés que ceux qui ont été observés chez les femmes saines; 3) il existe une certaine tendance des niveaux enzymatiques du sérum à l'augmentation avec l'âge chez tous les deux groupes; 4) la charge de glucose ne modifie pas les niveaux enzymatiques du sérum; 5) il existe un petit groupe de sujets avec diabète chimique qui présentent des niveaux enzymatiques abnormement élevés; 6) les femmes normales, qui sont soumises à l'administration de contraceptives orales, présentent des niveaux plus élevés que ceux observés chez les autres femmes normales qui n'assument pas le médicament, sans présenter intolerance au glucose. Les AA. discutent sur ces résultats en comparaison des corrélations entre diabète et athérosclérose.
    Abstract: Resumen Se ha medido la actividad de la beta-glucuronidasa en el suero de 41 pacientes con tolerancia a la glucosa disminuida (diabetes química) y en un grupo control de 47 individuos sanos. Los resultados indican que: 1) los varones normales poseen valores más elevados de esta enzima que las hembras normales; 2) las hembras con diabetes química poseen valores más elevados que las hembras normales; 3) existe una ligera tendencia a que los niveles enzimáticos en el suero aumenten con la edad en ambos grupos; 4) la ingestión de una sobrecarga de glucosa no altera los niveles enzimáticos del suero; 5) existe un pequeño grupo de pacientes con diabetes química que exhiben cifras más altas que lo corriente; 6) las mujeres normales que toman agentes anovulatorios orales tienen valores más elevados que las otras mujeres normales sin que presenten intolerancia a la glucosa. Se ha discutido la posible significación de estos hallazgos con respecto a la relación entre diabetes y aterosclerosis.
    Notes: Riassunto Gli AA. hanno misurato l'attività beta-glucuronidasica nel siero di 41 pazienti con diminuita tolleranza al glucosio (diabete chimico) ed in un gruppo di controllo composto di 41 individui sani. I risultati indicano che: 1) i maschi normali presentano livelli serici di questo enzima più alti di quelli delle femmine; 2) le femmine con diabete chimico presentano valori più elevati delle femmine normali; 3) esiste una leggera tendenza dei livelli enzimatici del siero ad aumentare con l'età in entrambi i gruppi; 4) il carico di glucosio non altera i livelli enzimatici del siero; 5) esiste un piccolo gruppo di pazienti con diabete chimico che mostrano livelli enzimatici insolitamente alti; 6) le femmine normali che prendono agenti anovulatori orali hanno valori più elevati che le altre femmine normali che non facciano uso di questo farmaco, senza presentare intolleranza al glucosio. Gli AA. discutono il significato di questi risultati nei confronti dei rapporti tra diabete e aterosclerosi.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 158 (1967), S. 147-163 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 160 (1968), S. 298-312 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Grafting regions of the blastodisc of the chick, labeled with H3-thymidine at Stages 5 and 6 ofHamilton andHamburger, is a very useful technique for following the morphogenetic movements of the grafted material. Areas (E-M) of the blastodisc of 2.75 by 0.55 mm, grafted in the homologous region of an embryo, participate in its morphogenetic movements. The labeled reversed cardiac area can sometimes be incorporated into the host, and a tubular heart can develop which includes some of the graft tissue, Figs. 3, 4, 5, and 6. The morphogenetic movements shaping the anterior intesinal portal and early foregut can occur despite the reversal of a large rectangle of the endomesoderm, Fig. 6. The coelomic epithelium lining the operated side, a part of the myoepicardium of this side, as well as the endoderm of the ventral portion of the foregut, and, more caudally, half of the anterior intestinal portal are derived from the graft as shown by strong radioactive labeling of the cells, Figs. 3, 4 and 6. The morphogenetic movements of the graft endoderm and mesoderm are independent, the pre-heart mesoderm moving in a cranial direction, while the endoderm extends caudally, Figs. 3 and 4. This study raises an interesting question: Can the original cephalic preconal cardiogenic mesoderm regulate to form sinoatrial tissue (and vice versa) ? The evidence obtained in the present investigation is not extensive enough to warrant conclusions as to the important question of “regulation”; for this a considerable number of operated embryos is required in which a recognizable normal heart has developed (up to Stage 12–13).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 13 (1966), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 8 (1968), S. 299-318 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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