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  • 1
    Electronic Resource
    Electronic Resource
    Neurochemical research 25 (2000), S. 181-188 
    ISSN: 1573-6903
    Keywords: Adenosine ; guanine nucleotides ; GMP ; adenosine A2 receptors ; glutamate ; hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN on adenosine-evoked cellular responses have also been reported. However, the exact mechanism of such interaction is not known. In the present study, we showed that GN potentiated adenosine-induced cAMP accumulation in slices of hippocampus from young rats. However, neither GMP nor the metabotropic glutamate receptor agonist, 1S,3R-ACPD, inhibited the binding of the adenosine receptor agonist [3H]NECA (when binding to adenosine A2 receptors), or the binding of the adenosine A2a receptor agonist [3H]CGS 21680 in hippocampal membrane preparations. GppNHp, probably by interacting with G-proteins, decreased [3H]CGS 21680 binding. [3H]GMP binding was assayed in order to evaluate the GN sites which are not G-proteins. [3H]GMP binding was inhibited by GMP and GppNHp, but not by 1S,3R-ACPD. The interaction of endogenous adenosine with the GMP-binding sites was determined by incubating membranes in the presence or absence of adenosine deaminase (ADA). NECA, CADO, CGS 21680 and CPA (only at the highest concentration used) increased GMP binding in the presence of ADA. However, in the absence of ADA, the control levels of GMP binding were as high as in the presence of added ADA plus adenosine agonists, indicating that endogenous adenosine modulates the binding of GMP. If this site has a neuroprotective role, adenosine may be increasing its neuromodulator and proposed protective action.
    Type of Medium: Electronic Resource
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  • 2
    s.l.: PRME Regional Chapter Brazil, UNDP Office Brazil
    Publication Date: 2018-01-19
    Description: The aim of this paper is to create an indicator that compares the efficiency of countries in converting economic complexity into human development through the Data Envelopment Analysis (DEA) method and econometric validation. The DEA will not only enable comparisons of efficiency across countries, but will also enable the creation of a global indicator and social efficiency rankings.
    Description: O objetivo deste trabalho é criar um indicador que compare a eficiência dos países na conversão da complexidade econômica em desenvolvimento humano através do método de análise de envolvimento de dados (DEA) e validação econométrica. A DEA não só permitirá comparações de eficiência entre países, mas também permitirá a criação de um indicador global e rankings de eficiência social.
    Keywords: O3 ; O4 ; ddc:330 ; Economic Complexity ; Human Development ; Data Envelopment Analysis
    Language: English
    Type: doc-type:conferenceObject
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  • 3
    São Carlos: Universidade Federal de São Carlos | ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften, Leibniz-Informationszentrum Wirtschaft Kiel, Hamburg
    Publication Date: 2020-04-24
    Description: Economic growth is not the unique factor to explain human development. Due to that many authors have prioritized studies to measure the Human Development Index. However, these indices do not analyze how Economic Complexity can increase Human Development. The aim of this paper is to determine the efficiency of a set of nations from Latin America and Asia, to measure a country’s performance in converting Economic Complexity into Human Development, between 2010 and 2014. The method used was Data Envelopment Analysis (DEA), through the Variable Returns of Scale (VRS) Model and Window Analysis. Results showed in 2014, all Asian countries were efficient except China and the Philippines, and Cuba was the benchmark for inefficient countries. Window Analysis showed Japan, Republic of Korea and Singapore were efficient over time. This result confirms the initial hypothesis of this article: the more complex countries are more efficient in generating Human Development.
    Description: Article accepted for publication in the journal Gestão & Produção.
    Description: O crescimento econômico não é o único fator que explica o desenvolvimento humano. Neste aspecto, índices sobre a qualidade de vida têm sido recorrentes na literatura. Entretanto, estes índices não analisam como a complexidade econômica é convertida em desenvolvimento humano. O objetivo deste artigo é mensurar a eficiência dos países latino americanos e asiáticos em converter complexidade econômica em desenvolvimento humano, entre 2010 e 2014. O método utilizado foi o Data Envelopment Analysis (DEA), por meio do modelo de Retornos Variáveis à Escala (BCC) e Análise de Janela. Os resultados demonstraram que, em 2014, todos os países asiáticos foram eficientes, exceto a China e Filipinas. Neste ano, Cuba foi o país que mais serviu de benchmark para os países ineficientes. A análise em janela demonstrou que apenas Japão, Coréia do Sul e Singapura se mantiveram eficientes ao longo do tempo. Este resultado confirma a hipótese inicial deste artigo: economias mais complexas são mais eficientes em gerar desenvolvimento humano.
    Keywords: O15 ; O32 ; ddc:330 ; Data Envelopment Analysis (DEA) ; Window Analysis ; Economic Complexity ; Human Development
    Language: English
    Type: doc-type:article
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