Computer-assisted multifactor optimization of selectivity in gas chromatography
Stationary phase optimization
Mobile phase optimization
Column temperature optimization
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Summary A computer-assisted method is presented for the simultaneous multifactor optimization (stationary phase loading, column temperature and carrier gas flow rate) of the analytical conditions for the optimum separation of multicomponent samples in gas chromatography. The optimization of the separation over the experimental region is based on a special polynomial from twelve preliminary experiments using the resolution as the selection criterion. Computer scanning technique was used for optimum selection in three dimensions. Excellent agreement was obtained between the predicted data and the experimental results.
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