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  • 11
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    ISSN: 1741-038X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology , Economics
    Notes: Widespread recognition of the strategic imperative posed by a turbulent external environment has brought into focus a key challenge for firms - that of increasing involvement in innovation by the staff in the organisation. Much research has suggested that organisations that mobilise a large proportion of their staff to participate in innovation can make significant gains. Achieving this depends on a systematic process of organisational development in which the facilitative patterns of behavioural routines are extended and reinforced, so that they become a major culture change. This paper reports on progress with this organisational development methodology using a detailed case study of its use within a major mining company in South Africa. It makes use of a reference model framework to help structure and direct the change process towards enabling higher involvement in innovation. In particular it explores practical issues involved in moving a large organisation along a path of high involvement innovation.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Applied Surface Science 70-71 (1993), S. 731-736 
    ISSN: 0169-4332
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Thin Solid Films 189 (1990), S. 339-345 
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 32 (1994), S. 197-202 
    ISSN: 1573-7217
    Keywords: DNA flow cytometry ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-one cases of primary breast cancers and their nodal metastases were examined with DNA flow cytometry. No differences were found between the stemline distributions in the primary tumors and nodal metastases. At both sites stemlines clustered around a DNA index of 1.0 (33–40% of cases) and 1.8. The mean S-phase fractions were 7.9 in primary tumors versus 5.6% in nodal metastases (p = 0.02); this difference was also observed if the analysis was restricted to cases with DNA aneuploidy at both sites (10.2 versus 7.6%, p = 0.04). Our results indicate that axillary nodal ploidy and proliferation reflect primary tumor characteristics rather than displaying changes associated with selection during the lymphatic metastatic process. Lymph nodes may have a suppressive effect on the proliferation of tumor cells.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 14 (1998), S. 645-652 
    ISSN: 1573-7284
    Keywords: AIDS ; Back-calculation ; Exposure group ; HIV ; Methodology ; Prevalence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To compare HIV prevalence estimates (total number infected) by using extrapolation from surveys on infection rate and risk behaviour (EIR) in specific segments of the population and back-calculation (BC) on reported AIDS cases. To discuss potential sources of bias and error, and to identify areas for improvement of the methodology. Design: Systematic comparison and epidemiological assessment of data input, underlying assumptions, and output. Methods: Low, possibly unbiased and high estimates of HIV prevalence as of January 1996 for homo/bisexual men, injecting drug users, heterosexual men and women with multiple partners, and blood transfusion recipients and haemophiliacs were derived from surveys and continuous data collections on HIV infection rate and risk behaviour in the Netherlands between 1992 and 1996. These were compared with estimates (point and 95% CI) by empirical Bayesian BC on AIDS cases 1982–1995. Results and conclusions: The estimate of HIV prevalence by EIR was 13,806 with low and high estimates of 9619 and 17,700, respectively. The HIV prevalence estimate by BC was 8812 (95% CI: 7759–9867). The available data from EIR are too limited for accurate estimates of HIV prevalence. EIR estimates could be improved considerably with more precise data on prevalence of risk behaviours and HIV prevalence rate for homosexual men. More confidence can be put in the BC estimates, but these could be underestimates because of the age effect on incubation time, pre-AIDS treatment and relapse of risk behaviour. BC estimates could be improved by a better representation of the incubation time distribution (including the effect of age thereupon), better data on the effectiveness and uptake of pre-AIDS antiretroviral treatment and prophylaxis of opportunistic infections, and on the level of underreporting.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1573-6881
    Keywords: Membrane protein ; rhodopsin ; folding ; intracellular transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract We report studies on the expression of the archaebacterial membrane protein bacteriorhodopsin in Sf9 insect cells and in COS-1 mammalian cells. In both cell systems, the apoprotein bacterio-opsin was expressed at levels of ∼ 1 μg/106 cells. Immunofluorescence studies showed that the expressed protein was accumulated in the endoplasmic reticulum. However, upon addition of all-trans retinal to membranes isolated from either Sf9 or COS-1 cells expressing bacterio-opsin, the characteristic bacteriorhodopsin chromophore (λmax at ∼560 nm) was rapidly generated. This is in contrast to bacterio-opsin expressed in E. coli, which cannot be functionally reconstituted with retinal unless it is first denatured, and then renatured in vitro. These studies demonstrate that the bacterio-opsin expressed is correctly folded and show that localization of a heterologously expressed membrane protein in the endoplasmic reticulum does not necessarily imply that it is misfolded.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Periodica mathematica Hungarica 23 (1991), S. 5-16 
    ISSN: 1588-2829
    Keywords: Continued fractions ; Diophantine approximations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plant pathology 102 (1996), S. 623-633 
    ISSN: 1573-8469
    Keywords: Rhizoctonia solani ; biological control ; naked and testate amoeba ; ciliates ; predation ; bacteria ; parasitism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Because biological control ofRhizoctonia solani in potato with conidial suspensions of the mycoparasiteVerticillium biguttatum was often less successful in sandy soils than in loamy soils, we examined soils of potato fields for the presence of organisms destructive to conidia ofV. biguttatum. Representatives of conidiophagous testate amoebae were frequently present on sclerotium disks ofR. solani infected withV. biguttatum in all soils studied and were most active under moist conditions. Conidiophagous naked amoebae were also numerous, except for two loam soils, and were not sensitive to moist conditions. Conidiophagous ciliates were found in rather low numbers and were most frequently isolated from coarsely structured soils under moist conditions. Conidiophagous flagellates were very infrequently observed. A bacterial type, parasitizing and killing conidia and hyphae ofV. biguttatum, was observed in all soils studied. It produced clusters of cocci fixed to the outside of conidia and hyphae and was most active under moist soil conditions. The possible role of protozoan predators and bacterial parasites in the biological control ofR. solani in potato withV. biguttatum applied at planting is discussed.
    Type of Medium: Electronic Resource
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