WILBERT — Wildauer Bücher+E-Medien Recherche-Tool

1

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CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival (2018)

P. S. Zeiner, J. Zinke, D. J. Kowalewski, S. Bernatz, J. Tichy, M. W. Ronellenfitsch, F. Thorsen, A. Berger, M. T. Forster, A. Muller, J. P. Steinbach, R. Beschorner, J. Wischhusen, H. M. Kvasnicka, K. H. Plate, S. Stefanović…

BioMed Central

In: Acta Neuropathologica Communications

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Publication Date: 2018-03-05

Description: Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Hum...

Electronic ISSN: 2051-5960

Topics: Medicine

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2

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Scalable non-negative matrix tri-factorization (2018)

Andrej Čopar, Marinka žitnik and Blaž Zupan

BioMed Central

In: BioData Mining

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Publication Date: 2018-03-06

Description: Matrix factorization is a well established pattern discovery tool that has seen numerous applications in biomedical data analytics, such as gene expression co-clustering, patient stratification, and gene-disea...

Electronic ISSN: 1756-0381

Topics: Biology , Computer Science

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3

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A rare case of avascular necrosis in sickle cell trait: a case report (2018)

William J. Sanders

BioMed Central

In: BMC Hematology

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Publication Date: 2018-03-06

Description: Sickle cell trait is usually an asymptomatic presentation of a patient with slightly different hemoglobin molecule makeup than normal. It is similar to a more serious disease, sickle cell disease, in which a p...

Electronic ISSN: 1471-2326

Topics: Medicine

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4

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Selling my sheep to pay for medicines – household priorities and coping strategies in a setting without universal health coverage (2018)

Onarheim Kristine Husøy, Sisay Mitike Molla, Gizaw Muluken, Moland Karen Marie, Norheim Ole Frithof and Miljeteig Ingrid

BioMed Central

In: BMC Health Services Research

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Publication Date: 2018-03-06

Description: The first month of life is the period with the highest risk of dying. Despite knowledge of effective interventions, newborn mortality is high and utilization of health care services remains low in Ethiopia. In...

Electronic ISSN: 1472-6963

Topics: Medicine

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5

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More is less, less is more, or does it really matter? The curious case of impact of azacitidine administration schedules on outcomes in patients with myelodysplastic syndromes (2018)

Rory M. Shallis and Amer M. Zeidan

BioMed Central

In: BMC Hematology

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Publication Date: 2018-03-06

Description: Myelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progressio...

Electronic ISSN: 1471-2326

Topics: Medicine

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6

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Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia (2018)

Roman M. Shapiro and Alejandro Lazo-Langner

BioMed Central

In: BMC Hematology

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Publication Date: 2018-03-06

Description: 5-Azacitidine administered as a 7-day dosing regimen (7–0-0) is approved in high risk IPSS myelodysplastic syndrome (MDS) patients. Alternative regimens such as a 5-day (5–0-0) or 7-day with a weekend break (5...

Electronic ISSN: 1471-2326

Topics: Medicine

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7

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Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease (2018)

Fekri Samarah and Mahmoud A. Srour

BioMed Central

In: BMC Hematology

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Publication Date: 2018-03-06

Description: Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to investigate the prevalence and clinical impact of factor V Leiden G1691A (FVL) and prothrombin G2...

Electronic ISSN: 1471-2326

Topics: Medicine

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8

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Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia (2018)

Berhanu Elfu Feleke and Teferi Elfu Feleke

BioMed Central

In: BMC Hematology

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Publication Date: 2018-03-06

Description: Information on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother.

Electronic ISSN: 1471-2326

Topics: Medicine

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9

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Utility of dominant epitopes derived from cell-wall protein LppZ for immunodiagnostic of pulmonary tuberculosis (2018)

Jinjing Tan, Xiaoguang Wu, Suting Chen, Meng Gu, Hairong Huang and Wentao Yue

BioMed Central

In: BMC Immunology

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Publication Date: 2018-03-06

Description: Serological antibodies tests for tuberculosis (TB) are widely used in developing countries. They appear to have some advantages- faster, simple and could be used for extrapulmonary TB. However, most of current...

Electronic ISSN: 1471-2172

Topics: Medicine

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10

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Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised (2018)

Kari J. Dugger, Taylor Chrisman, Sarah L. Sayner, Parker Chastain, Kacie Watson and Robert Estes

BioMed Central

In: BMC Immunology

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Publication Date: 2018-03-06

Description: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven al...

Electronic ISSN: 1471-2172

Topics: Medicine

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11

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Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ (2018)

Tammy Oth, Thomas H. P. M. Habets, Wilfred T. V. Germeraad, Marijke I. Zonneveld, Gerard M. J. Bos and Joris Vanderlocht

BioMed Central

In: BMC Immunology

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Publication Date: 2018-03-06

Description: Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk betwe...

Electronic ISSN: 1471-2172

Topics: Medicine

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12

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Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia (2018)

Natasha E. Holmes, J. Owen Robinson, Sebastiaan J. van Hal, Wendy J. Munckhof, Eugene Athan, Tony M. Korman, Allen C. Cheng, John D. Turnidge, Paul D. R. Johnson and Benjamin P. Howden

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Various studies have identified numerous factors associated with poor clinical outcomes in patients with Staphylococcus aureus bacteraemia (SAB). A new study was created to provide deeper insight into in-hospital...

Electronic ISSN: 1471-2334

Topics: Medicine

Published by BioMed Central

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13

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Establishment of malignantly transformed dendritic cell line SU3-ihDCTC induced by Glioma stem cells and study on its sensitivity to resveratrol (2018)

Xifeng Fei, Anqi Wang, Delin Wang, Xan Meng, Jiawei Ma, Lei Hong, Ruwei Qin, Aidong Wang, Jun Dong, Qiang Huang and Zhimin Wang

BioMed Central

In: BMC Immunology

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Publication Date: 2018-03-06

Description: As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely be...

Electronic ISSN: 1471-2172

Topics: Medicine

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14

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Impact of a vaccination programme in children vaccinated with ProQuad, and ProQuad-specific effectiveness against varicella in the Veneto region of Italy (2018)

Carlo Giaquinto, Giovanni Gabutti, Vincenzo Baldo, Marco Villa, Lara Tramontan, Nadia Raccanello, Francesca Russo, Chiara Poma, Antonio Scamarcia, Luigi Cantarutti, Rebecca Lundin, Emilia Perinetti, Xavier Cornen, Stéphane Thomas, Céline Ballandras, Audrey Souverain…

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadri...

Electronic ISSN: 1471-2334

Topics: Medicine

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15

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Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation (2018)

Sumera Y. Younis, Christophe Barnier-Quer, Simon Heuking, Vinod Sommandas, Livia Brunner, Nicole vd.Werff, Patrice Dubois, Martin Friede, Clemens Kocken, Nicolas Collin and Ed Remarque

BioMed Central

In: BMC Immunology

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Publication Date: 2018-03-06

Description: The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a me...

Electronic ISSN: 1471-2172

Topics: Medicine

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16

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Treatment outcomes and factors affecting unsuccessful outcome among new pulmonary smear positive and negative tuberculosis patients in Anqing, China: a retrospective study (2018)

Yufeng Wen, Zhiping Zhang, Xianxiang Li, Dan Xia, Jun Ma, Yuanyuan Dong and Xinwei Zhang

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Monitoring the treatment outcomes of tuberculosis and determining the specific factors associated with unsuccessful treatment outcome are essential to evaluate the effectiveness of tuberculosis control program...

Electronic ISSN: 1471-2334

Topics: Medicine

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17

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Household contact non-attendance of clinical evaluation for tuberculosis: a pilot study in a high burden district in South Africa (2018)

Gladys Kigozi, Michelle Engelbrecht, Christo Heunis and André Janse van Rensburg

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: In 2012, the World Health Organization launched guidelines for systematically investigating contacts of persons with infectious tuberculosis (TB) in low- and middle-income countries. As such, it is necessary t...

Electronic ISSN: 1471-2334

Topics: Medicine

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18

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Lymphnode tuberculosis in a 4-year-old boy with relapsed ganglioneuroblastoma: a case report (2018)

Karoline van de Loo, Stefan Balzer, Colin R. Mac; Kenzie, Thomas M. Boemers, Monika Ortmann, Jörg Schaper, Arndt Borkhardt, Hans-Jürgen Laws and Michaela Kuhlen

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Mycobacterium tuberculosis (M. tuberculosis) disease is a generally well-known problem among immunocompromised adults and children. In pediatric oncology, only few cases of M. tuberculosis disease are reported so...

Electronic ISSN: 1471-2334

Topics: Medicine

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19

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Socioeconomic and environmental determinants of under-five mortality in Gamo Gofa Zone, Southern Ethiopia: a matched case control study (2018)

Girma Temam Shifa, Ahmed Ali Ahmed and Alemayehu Worku Yalew

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: Despite global declaration of the right to life as a fundamental human right and substantial progress in reducing childhood mortality, unacceptably high number of children still die before their fifth birthday...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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20

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Care-‘less’: exploring the interface between child care and parental control in the context of child rights for workers in children’s homes in Ghana (2018)

Ernest Darkwah, Marguerite Daniel and Joana Salifu Yendork

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: This study explored how employed caregivers experience the interface between child care, parental control and child rights in the context of Children’s Homes in Ghana. The focus was on investigating caregiver ...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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21

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Small scale migration along the interoceanic highway in Madre de Dios, Peru: an exploration of community perceptions and dynamics due to migration (2018)

Kelly E Jensen, Nehal N. Naik, Christina O’Neal, Gabriela Salmón-Mulanovich, Amy R. Riley-Powell, Gwenyth O. Lee, Stella M. Hartinger, Daniel G. Bausch and Valerie A. Paz-Soldan

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: Madre de Dios, a southern state in the Peruvian Amazon basin, has experienced rapid development as well as an influx of migrants since the construction of the Interoceanic Highway (IOH) connecting Brazil, Boli...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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22

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Does the Stockholm Syndrome affect female sex workers? The case for a “Sonagachi Syndrome” (2018)

Abraar Karan and Nathan Hansen

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: Female sex workers are subjected to intense physical, sexual, and mental abuses that are well documented in the medical and public health literature. However, less well-studied are the mental coping mechanisms...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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23

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Assessing refugee healthcare needs in Europe and implementing educational interventions in primary care: a focus on methods (2018)

Christos Lionis, Elena Petelos, Enkeleint-Aggelos Mechili, Dimitra Sifaki-Pistolla, Vasiliki-Eirini Chatzea, Agapi Angelaki, Imre Rurik, Danica Rotar Pavlic, Christopher Dowrick, Michel Dückers, Dean Ajdukovic, Helena Bakic, Elena Jirovsky, Elisabeth Sophie Mayrhuber, Maria van den Muijsenbergh and Kathryn Hoffmann

BioMed Central

In: BMC International Health and Human Rights

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Publication Date: 2018-03-06

Description: The current political crisis, conflicts and riots in many Middle Eastern and African countries have led to massive migration waves towards Europe. European countries, receiving these migratory waves as first p...

Electronic ISSN: 1472-698X

Topics: Medicine , Law

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24

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What do medical students know about e-cigarettes? A cross-sectional survey from one U.S. medical school (2018)

Katie Hinderaker, David V. Power, Sharon Allen, Ellen Parker and Kolawole Okuyemi

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Although electronic cigarette (e-cigarette) use has rapidly increased, there is little data about what United States medical students know or are taught about them. This study examined medical students’ experi...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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25

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Effects of a work-based critical reflection program for novice nurses (2018)

Yeon Hee Kim, Ja Min, Soon Hee Kim and Sujin Shin

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Critical reflection is effective in improving students’ communication abilities and confidence. The aim of this study was to evaluate the effectiveness of a work-based critical reflection program to enhance no...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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26

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A searchable database of medical education objectives – creating a comparable gold standard (2018)

Sam Brooks, Namita Biala and Sage Arbor

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Medical school curricula strives to teach as much material as can be retained in a limited amount of time. A common “gold standard” resource used building curricula are medical objectives suggested by national...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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27

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Perceived stress, reasons for and sources of stress among medical students at Rabigh Medical College, King Abdulaziz University, Jeddah, Saudi Arabia (2018)

Zohair Jamil Gazzaz, Mukhtiar Baig, Bader Salem Mana Al Alhendi, Mohammed Mahdi Owiad Al Suliman, Awshaemah Salem Al Alhendi, Mana Saleh Hadi Al-Grad and Mohammed Abdullah Ali Qurayshah

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Medical students have high levels of stress that could be due to the daily life stressors and the extra stress of academic burden. The present study investigated the perceived stress level as well as the reaso...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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28

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Correction to: An audit of clinical training exposure amongst junior doctors working in Trauma & Orthopaedic Surgery in 101 hospitals in the United Kingdom (2018)

Mustafa S. Rashid

BioMed Central

In: BMC Medical Education

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Publication Date: 2018-03-06

Description: Following publication of the original article [1], the corresponding author wrote to say that he had missed the names of some of the collaborators in the list he sent to the typesetters. In addition, there was...

Electronic ISSN: 1472-6920

Topics: Medicine , Education

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29

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Euthanasia and assisted suicide for people with an intellectual disability and/or autism spectrum disorder: an examination of nine relevant euthanasia cases in the Netherlands (2012–2016) (2018)

Irene Tuffrey-Wijne, Leopold Curfs, Ilora Finlay and Sheila Hollins

BioMed Central

In: BMC Medical Ethics

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Publication Date: 2018-03-06

Description: Euthanasia and assisted suicide (EAS) have been legally possible in the Netherlands since 2001, provided that statutory due care criteria are met, including: (a) voluntary and well-considered request; (b) unbe...

Electronic ISSN: 1472-6939

Topics: Medicine , Philosophy

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30

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Presentation of laboratory test results in patient portals: influence of interface design on risk interpretation and visual search behaviour (2018)

Paolo Fraccaro, Markel Vigo, Panagiotis Balatsoukas, Sabine N. van der Veer, Lamiece Hassan, Richard Williams, Grahame Wood, Smeeta Sinha, Iain Buchan and Niels Peek

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: Patient portals are considered valuable instruments for self-management of long term conditions, however, there are concerns over how patients might interpret and act on the clinical information they access. W...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

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31

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Developing a tablet computer-based application (‘App’) to measure self-reported alcohol consumption in Indigenous Australians (2018)

KS Kylie Lee, Scott Wilson, Jimmy Perry, Robin Room, Sarah Callinan, Robert Assan, Noel Hayman, Tanya Chikritzhs, Dennis Gray, Edward Wilkes, Peter Jack Grad; Dip; Indig; H and Katherine M. Conigrave

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: The challenges of assessing alcohol consumption can be greater in Indigenous communities where there may be culturally distinct approaches to communication, sharing of drinking containers and episodic patterns...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

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32

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Combining information from a clinical data warehouse and a pharmaceutical database to generate a framework to detect comorbidities in electronic health records (2018)

Emmanuelle Sylvestre, Guillaume Bouzillé, Emmanuel Chazard, Cécil His-Mahier, Christine Riou and Marc Cuggia

BioMed Central

In: BMC Medical Informatics and Decision Making

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Publication Date: 2018-03-06

Description: Medical coding is used for a variety of activities, from observational studies to hospital billing. However, comorbidities tend to be under-reported by medical coders. The aim of this study was to develop an a...

Electronic ISSN: 1472-6947

Topics: Computer Science , Medicine

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33

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DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network (2018)

Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang and Yuval Kluger

BioMed Central

In: BMC Medical Research Methodology

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Publication Date: 2018-03-06

Description: Medical practitioners use survival models to explore and understand the relationships between patients’ covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Stand...

Electronic ISSN: 1471-2288

Topics: Medicine

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34

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Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer (2018)

G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann and L. C. de Wreede

BioMed Central

In: BMC Medical Research Methodology

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Publication Date: 2018-03-06

Description: Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data w...

Electronic ISSN: 1471-2288

Topics: Medicine

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35

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The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline (2018)

Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley and Stuart R Dalziel

BioMed Central

In: BMC Medical Research Methodology

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Publication Date: 2018-03-06

Description: Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation i...

Electronic ISSN: 1471-2288

Topics: Medicine

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36

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Pre-anesthetic assessment with three core questions for the detection of obstructive sleep apnea in childhood: An observational study (2018)

Joerg Schnoor, Thilo Busch, Nazar Turemuratov and Andreas Merkenschlager

BioMed Central

In: BMC Anesthesiology

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Publication Date: 2018-03-06

Description: Children with obstructive sleep apnea are at high risk for perioperative airway obstruction. Many “at risk” children may remain unrecognized. The aim of this study is to find a clinically practicable test to i...

Electronic ISSN: 1471-2253

Topics: Medicine

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37

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Characterization of sulfhydryl oxidase from Aspergillus tubingensis (2018)

Outi Nivala, Greta Faccio, Mikko Arvas, Perttu Permi, Johanna Buchert, Kristiina Kruus and Maija-Liisa Mattinen

BioMed Central

In: BMC Biochemistry

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Publication Date: 2018-03-06

Description: Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized...

Electronic ISSN: 1471-2091

Topics: Chemistry and Pharmacology

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38

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Feruloyl esterase immobilization in mesoporous silica particles and characterization in hydrolysis and transesterification (2018)

Cyrielle Bonzom, Laura Schild, Hanna Gustafsson and Lisbeth Olsson

BioMed Central

In: BMC Biochemistry

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Publication Date: 2018-03-06

Description: Enzymes display high reactivity and selectivity under natural conditions, but may suffer from decreased efficiency in industrial applications. A strategy to address this limitation is to immobilize the enzyme....

Electronic ISSN: 1471-2091

Topics: Chemistry and Pharmacology

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39

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The relationship between under-five child death and maternal mental distress in Gamo Gofa Zone, Southern Ethiopia: a community based comparative cross-sectional study (2018)

Girma Temam Shifa, Ahmed Ali Ahmed and Alemayehu Worku Yalew

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Knowledge of the association between child death and maternal mental distress may help to understand the indirect impact of reduction of under-five mortality on maternal mental wellbeing. This will further hav...

Electronic ISSN: 1472-6874

Topics: Medicine

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40

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Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013 (2018)

Stephanie Ann Grilo, Xiaoyu Song, Tom Lutalo, Margo Mullinax, Sanyukta Mathur and John Santelli

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Unintended pregnancy is a persistent and global issue with consequences for the health and well-being of mothers and babies. The aim of this paper is to examine unintended pregnancy over time in the context of...

Electronic ISSN: 1472-6874

Topics: Medicine

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41

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Levonorgestrel-releasing intrauterine system for treatment of heavy menstrual bleeding in adolescents with Glanzmann’s Thrombasthenia: illustrated case series (2018)

Meiqiu Lu and Xin Yang

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Glanzmann’s Thrombasthenia (GT) is an inherited genetic disorder caused by defects in the platelet membrane glycoproteins IIb/IIIA, and is associated with heavy menstrual bleeding (HMB). HMB is a common compli...

Electronic ISSN: 1472-6874

Topics: Medicine

Published by BioMed Central

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42

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Predictors of cervical cancer screening intention of HIV-positive women in the central region of Ghana (2018)

Nancy Innocentia Ebu and Joseph Kwesi Ogah

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Cervical cancer affects women, especially those with HIV-positive status. This study hypothesised that more HIV-positive women with high cues about cervical cancer screening, high perceived susceptibility to c...

Electronic ISSN: 1472-6874

Topics: Medicine

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43

Unknown

An adaptable chromosome preparation methodology for use in invertebrate research organisms (2018)

Longhua Guo, Alice Accorsi, Shuonan He, Carlos Guerrero-Hernández, Shamilene Sivagnanam, Sean McKinney, Matthew Gibson and Alejandro Sánchez Alvarado

BioMed Central

In: BMC Biology

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Publication Date: 2018-03-06

Description: The ability to efficiently visualize and manipulate chromosomes is fundamental to understanding the genome architecture of organisms. Conventional chromosome preparation protocols developed for mammalian cells...

Electronic ISSN: 1741-7007

Topics: Biology

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44

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Synaptic neuron-astrocyte communication is supported by an order of magnitude analysis of inositol tris-phosphate diffusion at the nanoscale in a model of peri-synaptic astrocyte projection (2018)

Pavel Montes de Oca Balderas and Horacio Montes de Oca Balderas

BioMed Central

In: BMC Biophysics

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Publication Date: 2018-03-06

Description: Astrocytes were conceived for decades only as supporting cells of the brain. However, the observation of Ca2+ waves in astrocyte synctitia, their neurotransmitter receptor expression and gliotransmitter secret...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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45

Unknown

Human S100A5 binds Ca2+ and Cu2+ independently (2018)

Lucas C. Wheeler and Michael J. Harms

BioMed Central

In: BMC Biophysics

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Publication Date: 2018-03-06

Description: S100A5 is a calcium binding protein found in a small subset of amniote tissues. Little is known about the biological roles of S100A5, but it may be involved in inflammation and olfactory signaling. Previous wo...

Electronic ISSN: 2046-1682

Topics: Biology , Physics

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46

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Agrobacterium-mediated and electroporation-mediated transformation of Chlamydomonas reinhardtii: a comparative study (2018)

Paola Mini, Olivia Costantina Demurtas, Silvia Valentini, Patrizia Pallara, Giuseppe Aprea, Paola Ferrante and Giovanni Giuliano

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Chlamydomonas reinhardtii is an unicellular green alga used for functional genomics studies and heterologous protein expression. A major hindrance in these studies is the low level and instability of expression o...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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47

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Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics (2018)

D. A. Doronin, N. V. Barykina, O. M. Subach, V. P. Sotskov, V. V. Plusnin, O. A. Ivleva, E. A. Isaakova, A. M. Varizhuk, G. E. Pozmogova, A. Y. Malyshev, I. V. Smirnov, K. D. Piatkevich, K. V. Anokhin, G. N. Enikolopov and F. V. Subach

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: The recently developed genetically encoded calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca2+-binding moiety inserted into the mNeonGr...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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48

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A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production (2018)

Christoph Geisler

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Adventitious viral contamination in cell substrates used for biologicals production is a major safety concern. A powerful new approach that can be used to identify adventitious viruses is a combination of bioi...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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49

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DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA (2018)

Zhen Jia, Yueyi Shi, Lei Zhang, Yipeng Ren, Tong Wang, Lejun Xing, Baorong Zhang, Guolan Gao and Rongfa Bu

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-w...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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50

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Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma (2018)

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

Electronic ISSN: 1471-2407

Topics: Medicine

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51

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A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention (2018)

Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks and Gillian Mitchell

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (...

Electronic ISSN: 1471-2407

Topics: Medicine

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52

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CMR stress testing in a patient with morbid obesity (BMI 58 kg/m2) and suspected coronary artery disease (2018)

Lukas Stoiber, Bernhard Schnackenburg, Rolf Gebker, Hanane Hireche-Chikaoui, Burkert Pieske and Sebastian Kelle

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: Severe obesity is asscociated with an increased risk of coronary artery disease (CAD) but non-invasive cardiac imaging modalities have important technical limits.

Electronic ISSN: 1471-2261

Topics: Medicine

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53

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Percutaneous closure versus medical therapy for stroke with patent foramen Ovale: a systematic review and meta-analysis (2018)

Xin-Lin Zhang, Li-Na Kang, Lian Wang and Biao Xu

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: Patent foramen ovale (PFO) closure has emerged as a secondary prevention option in patients with PFO and cryptogenic stroke. However, the comparative efficacy and safety of percutaneous closure and medical the...

Electronic ISSN: 1471-2261

Topics: Medicine

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54

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Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials (2018)

Lulu Liu, Bin Liu, Jiajun Ren, Gang Hui, Chao Qi and Junnan Wang

BioMed Central

In: BMC Cardiovascular Disorders

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Publication Date: 2018-03-06

Description: Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we co...

Electronic ISSN: 1471-2261

Topics: Medicine

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55

Unknown

Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1 (2018)

Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe and Katalin Dobra

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-06

Description: The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also transloca...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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56

Unknown

A novel interaction between kinase activities in regulation of cilia formation (2018)

Nicole De; Vaul, Katerina Koloustroubis, Rong Wang and Ann O. Sperry

BioMed Central

In: BMC Cell Biology

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Publication Date: 2018-03-06

Description: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of pri...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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57

Unknown

Evaluation of SD BIOLINE H. pylori Ag rapid test against double ELISA with SD H. pylori Ag ELISA and EZ-STEP H. pylori Ag ELISA tests (2018)

Markos Negash, Afework Kassu, Bemnet Amare, Gizachew Yismaw and Beyene Moges

BioMed Central

In: BMC Clinical Pathology

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Publication Date: 2018-03-06

Description: Helicobacter pylori antibody titters fall very slowly even after successful treatment. Therefore, tests detecting H. pylori antibody lack specificity and sensitivity. On the other hand, H. pylori stool antigen te...

Electronic ISSN: 1472-6890

Topics: Medicine

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58

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The expression of MDM2 in gastrointestinal stromal tumors: immunohistochemical analysis of 35 cases (2018)

Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi and Laila Chbani

BioMed Central

In: BMC Clinical Pathology

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Publication Date: 2018-03-06

Description: Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there a...

Electronic ISSN: 1472-6890

Topics: Medicine

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59

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Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer (2018)

Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford and Emma J. Crosbie

BioMed Central

In: BMC Clinical Pathology

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Publication Date: 2018-03-06

Description: Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered...

Electronic ISSN: 1472-6890

Topics: Medicine

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60

Unknown

Water extract of Semecarpus parvifolia Thw. leaves inhibits cell proliferation and induces apoptosis on HEp-2 cells (2018)

Preethi Soysa, Panchima Jayarthne and Imali Ranathunga

BioMed Central

In: BMC Complementary and Alternative Medicine

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Publication Date: 2018-03-06

Description: Semecarpus parvifolia Thw is used as an ingredient of poly herbal decoctions to treat cancer in traditional medicine. The present study aims to investigate the antiproliferative activity on HEp 2 cells by the wat...

Electronic ISSN: 1472-6882

Topics: Medicine

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61

Unknown

Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial (2018)

Mathias Tiedemann Svendsen, Flemming Andersen, Kirsten Hammond Andersen and Klaus Ejner Andersen

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low ...

Electronic ISSN: 1471-5945

Topics: Medicine

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62

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Phytochemical profiling and in vitro screening for anticholinesterase, antioxidant, antiglucosidase and neuroprotective effect of three traditional medicinal plants for Alzheimer’s Disease and Diabetes Mellitus dual therapy (2018)

Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Suresh Kumar Reddy Mallepalli, Ramakrishna Vadde and Damu Gangaiah Amooru

BioMed Central

In: BMC Complementary and Alternative Medicine

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Publication Date: 2018-03-06

Description: Extensive epidemiological and clinical studies revealed that Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2D) are most likely to appear simultaneously in aged people as T2D is a major risk factor fo...

Electronic ISSN: 1472-6882

Topics: Medicine

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63

Unknown

Composite hemangioendothelioma of the forehead and right eye; a case report (2018)

Ghasem Rahmatpour Rokni, Fatemeh Montazer, Mahnaz Sharifian and Mohamad Goldust

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Hemangioendothelioma includes several types of vascular neoplasms, as well as both benign and malignant growth.

Electronic ISSN: 1471-5945

Topics: Medicine

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64

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A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? (2018)

Denis Miyashiro, Ana Paula Vieira, Maria Angela Bianconcini Trindade, João Avancini, José Antonio Sanches and Gil Benard

BioMed Central

In: BMC Dermatology

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Publication Date: 2018-03-06

Description: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis...

Electronic ISSN: 1471-5945

Topics: Medicine

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65

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Evidence for a centrosome-attracting body like structure in germ-soma segregation during early development, in the urochordate Oikopleura dioica (2018)

Lisbeth Charlotte Olsen, Ioannis Kourtesis, Henriette Busengdal, Marit Flo Jensen, Harald Hausen and Daniel Chourrout

BioMed Central

In: BMC Developmental Biology

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Publication Date: 2018-03-06

Description: Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells ...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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66

Unknown

Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells (2018)

Anna Mantsoki, Guillaume Devailly and Anagha Joshi

BioMed Central

In: BMC Developmental Biology

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Publication Date: 2018-03-06

Description: Mammalian embryonic stem cells display a unique epigenetic and transcriptional state to facilitate pluripotency by maintaining lineage-specification genes in a poised state. Two epigenetic and transcription pr...

Electronic ISSN: 1471-213X

Topics: Biology , Medicine

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67

Unknown

The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review (2018)

Jostein Førsvoll and Knut Øymar

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome. ...

Electronic ISSN: 1472-6815

Topics: Medicine

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68

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Generic quality of life in persons with hearing loss: a systematic literature review (2018)

Øyvind Nordvik, Peder O. Laugen Heggdal, Jonas Brännström, Flemming Vassbotn, Anne Kari Aarstad and Hans Jørgen Aarstad

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: To the best of our knowledge, no empirically based consensus has been reached as to if, and to what extent, persons with hearing loss (HL) have reduced generic Quality of life (QoL). There seems to be limited ...

Electronic ISSN: 1472-6815

Topics: Medicine

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69

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Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease (2018)

Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet…

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary dise...

Electronic ISSN: 1741-7015

Topics: Medicine

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70

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Hospital Mortality – a neglected but rich source of information supporting the transition to higher quality health systems in low and middle income countries (2018)

Mike English, Paul Mwaniki, Thomas Julius, Mercy Chepkirui, David Gathara, Paul O. Ouma, Peter Cherutich, Emelda A. Okiro and Robert W. Snow

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: There is increasing focus on the strength of primary health care systems in low and middle-income countries (LMIC). There are important roles for higher quality district hospital care within these systems. The...

Electronic ISSN: 1741-7015

Topics: Medicine

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71

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Adaptive designs in clinical trials: why use them, and how to run and report them (2018)

Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap and Thomas Jaki

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules. Trials with an adaptive design are of...

Electronic ISSN: 1741-7015

Topics: Medicine

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72

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Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers (2018)

José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí…

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our und...

Electronic ISSN: 1741-7015

Topics: Medicine

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73

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The Cambridge Prognostic Groups for improved prediction of disease mortality at diagnosis in primary non-metastatic prostate cancer: a validation study (2018)

V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin and A. Lophatananon

BioMed Central

In: BMC Medicine

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Publication Date: 2018-03-06

Description: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer.

Electronic ISSN: 1741-7015

Topics: Medicine

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74

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Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages (2018)

Lucy Cheng, Laura J. Marinelli, Noël Grosset, Sorel T. Fitz-Gibbon, Charles A. Bowman, Brian Q. Dang, Daniel A. Russell, Deborah Jacobs-Sera, Baochen Shi, Matteo Pellegrini, Jeff F. Miller, Michel Gautier, Graham F. Hatfull and Robert L. Modlin

BioMed Central

In: BMC Microbiology

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Publication Date: 2018-03-06

Description: A remarkable exception to the large genetic diversity often observed for bacteriophages infecting a specific bacterial host was found for the Cutibacterium acnes (formerly Propionibacterium acnes) phages, which a...

Electronic ISSN: 1471-2180

Topics: Biology

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75

Unknown

The PhyR homolog RSP_1274 of Rhodobacter sphaeroides is involved in defense of membrane stress and has a moderate effect on RpoE (RSP_1092) activity (2018)

Qingfeng Li, Tao Peng and Gabriele Klug

BioMed Central

In: BMC Microbiology

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Publication Date: 2018-03-06

Description: A major role of the PhyR-NepR-σ(EcfG) cascade in the general stress response was demonstrated for some bacterial species and considered as conserved in Alphaproteobacteria. The σ(EcfG) factor activates its tar...

Electronic ISSN: 1471-2180

Topics: Biology

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76

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Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis (2018)

Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede and Bård Reiakvam Kittang

BioMed Central

In: BMC Microbiology

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Publication Date: 2018-03-06

Description: During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manif...

Electronic ISSN: 1471-2180

Topics: Biology

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77

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Distinct fermentation and antibiotic sensitivity profiles exist in salmonellae of canine and human origin (2018)

Corrin V. Wallis, Preena Lowden, Zoe V. Marshall-Jones and Anthony C. Hilton

BioMed Central

In: BMC Microbiology

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Publication Date: 2018-03-06

Description: Salmonella enterica is a recognised cause of diarrhoea in dogs and humans, yet the potential for transfer of salmonellosis between dogs and their owners is unclear, with reported evidence both for and against Sal...

Electronic ISSN: 1471-2180

Topics: Biology

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78

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Porphyromonas gingivalis ATCC 33277 promotes intercellular adhesion molecule-1 expression in endothelial cells and monocyte-endothelial cell adhesion through macrophage migration inhibitory factor (2018)

Wanyue Xu, Yaping Pan, Qiufang Xu, Yun Wu, Jiayu Pan, Jingya Hou, Li Lin, Xiaolin Tang, Chen Li, Jingbo Liu and Dongmei Zhang

BioMed Central

In: BMC Microbiology

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Publication Date: 2018-03-06

Description: Porphyromonas gingivalis (P. gingivalis), one of the main pathogenic bacteria involved in periodontitis, induces the expression of intercellular adhesion molecule − 1 (ICAM-1) and monocyte-endothelial cell adhesi...

Electronic ISSN: 1471-2180

Topics: Biology

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79

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Nutrient depletion and TOR inhibition induce 18S and 25S ribosomal RNAs resistant to a 5′-phosphate-dependent exonuclease in Candida albicans and other yeasts (2018)

Jacob Fleischmann and Miguel A. Rocha

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Messenger RNA (mRNA) represents a small percentage of RNAs in a cell, with ribosomal RNA (rRNA) making up the bulk of it. To isolate mRNA from eukaryotes, typically poly-A selection is carried out. Recently, a...

Electronic ISSN: 1471-2199

Topics: Biology

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80

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Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939 (2018)

Jun Yang, Yan Liu, Bing Wang, Hongzhen Lan, Ying Liu, Fei Chen, Ju Zhang and Jian Luo

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and poor response to conventional therapies. Previously, we found that p27kip1 nuclear-cytoplasmic translocation confers proliferation ...

Electronic ISSN: 1471-2199

Topics: Biology

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81

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An optimized rapid bisulfite conversion method with high recovery of cell-free DNA (2018)

Shaohua Yi, Fei Long, Juanbo Cheng and Daixin Huang

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Methylation analysis of cell-free DNA is a encouraging tool for tumor diagnosis, monitoring and prognosis. Sensitivity of methylation analysis is a very important matter due to the tiny amounts of cell-free DN...

Electronic ISSN: 1471-2199

Topics: Biology

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82

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An optimised protocol for isolation of RNA from small sections of laser-capture microdissected FFPE tissue amenable for next-generation sequencing (2018)

Parisa Amini, Julia Ettlin, Lennart Opitz, Elena Clementi, Alexandra Malbon and Enni Markkanen

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: Formalin-fixed paraffin embedded (FFPE) tissue constitutes a vast treasury of samples for biomedical research. Thus far however, extraction of RNA from FFPE tissue has proved challenging due to chemical RNA–pr...

Electronic ISSN: 1471-2199

Topics: Biology

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83

Unknown

Nanotechnology in orthopedics: a clinically oriented review (2018)

Walter Ryan Smith, Parke William Hudson, Brent Andrew Ponce and Sakthivel Rajan Rajaram Manoharan

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: The utility of nanotechnology in medicine, specifically within the field of orthopedics, is a topic of extensive research. Our review provides a unique comprehensive overview of the current and potential futur...

Electronic ISSN: 1471-2474

Topics: Medicine

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84

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Physical shearing imparts biological activity to DNA and ability to transmit itself horizontally across species and kingdom boundaries (2018)

Gorantla Venkata Raghuram, Deepika Gupta, Siddharth Subramaniam, Ashwini Gaikwad, Naveen Kumar Khare, Malcolm Nobre, Naveen Kumar Nair and Indraneel Mittra

BioMed Central

In: BMC Molecular Biology

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Publication Date: 2018-03-06

Description: We have recently reported that cell-free DNA (cfDNA) fragments derived from dying cells that circulate in blood are biologically active molecules and can readily enter into healthy cells to activate DNA damage...

Electronic ISSN: 1471-2199

Topics: Biology

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85

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The influence of preoperative determinants on quality of life, functioning and pain after total knee and hip replacement: a pooled analysis of Dutch cohorts (2018)

Stefanie N. Hofstede, Maaike G. J. Gademan, Theo Stijnen, Rob G. H. H. Nelissen and Perla J. Marang- van de Mheen

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: Previous research has identified preoperative determinants that predict health related quality of life (HRQoL), functioning and pain after total knee or hip arthroplasty (TKA/THA), but these differed between s...

Electronic ISSN: 1471-2474

Topics: Medicine

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86

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A case of bilateral revision total knee arthroplasty using distal femoral allograft–prosthesis composite and femoral head allografting at the tibial site with a varus-valgus constrained prosthesis: ten-year follow up (2018)

Sung-Hyun Lee, Sung-Hyun Noh, Keun-Churl Chun, Joung-Kyue Han and Churl-Hong Chun

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: We report the successful use of allograft–prosthesis composite (APC) and structural femoral head allografting in the bilateral reconstruction of large femoral and tibial uncontained defects during revision tot...

Electronic ISSN: 1471-2474

Topics: Medicine

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87

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Incidence of distal radius fracture surgery in Finns aged 50 years or more between 1998 and 2016 – too many patients are yet operated on? (2018)

Teemu P. Hevonkorpi, Antti P. Launonen, Tuomas T. Huttunen, Pekka Kannus, Seppo Niemi and Ville M. Mattila

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: Although optimal treatment of distal radius fractures is controversial, surgery has gained popularity. The purpose of this study was to evaluate recent trends in the surgical treatment of distal radius fractur...

Electronic ISSN: 1471-2474

Topics: Medicine

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88

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What factors impact on the implementation of clubfoot treatment services in low and middle-income countries?: a narrative synthesis of existing qualitative studies (2018)

Sarah Drew, Rachael Gooberman-Hill and Christopher Lavy

BioMed Central

In: BMC Musculoskeletal Disorders

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Publication Date: 2018-03-06

Description: Around 100,000 children are born annually with clubfoot worldwide and 80% live in low and middle-income counties (LMICs). Clubfoot is a condition in which children are born with one or both feet twisted inward...

Electronic ISSN: 1471-2474

Topics: Medicine

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89

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The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study (2018)

Hyo Jin Kim, Eunjeong Kang, Yun Kyu Oh, Yeong Hoon Kim, Seung Hyeok Han, Tae Hyun Yoo, Dong-Wan Chae, Joongyub Lee, Curie Ahn and Kook-Hwan Oh

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The prese...

Electronic ISSN: 1471-2369

Topics: Medicine

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90

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Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA nephropathy: a case report (2018)

Hisato Shima, Manabu Tashiro, Satoshi Yamada, Motokazu Matsuura, Kazuyoshi Okada, Toshio Doi, Jun Minakuchi and Shu Kawashima

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: Cilostazol is an antiplatelet drug that is widely prescribed for the prevention of secondary stroke. Adverse reactions to cilostazol include headaches, palpitations, and diarrhea. Little is known about the nep...

Electronic ISSN: 1471-2369

Topics: Medicine

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91

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Increased circulating bioactive C-type natriuretic peptide is associated with reduced heart rate variability in patients with chronic kidney disease (2018)

Lulu Wang, Wenjin Liu, Yanting Yu, Lei Jiang and Junwei Yang

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family and have been implicated to be involved in maintaining vascular homeostasis and acting as a cardiac chronotropic agent in experime...

Electronic ISSN: 1471-2369

Topics: Medicine

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92

Unknown

Quality of life in hemodialysis diabetic patients: a multicenter cross-sectional study from Palestine (2018)

Sohaib T. Khatib, Mohammad K. Hemadneh, Samer A. Hasan, Emad Khazneh and Sa’ed H. Zyoud

BioMed Central

In: BMC Nephrology

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Publication Date: 2018-03-06

Description: Both diabetes and hemodialysis can seriously impair patients’ health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in he...

Electronic ISSN: 1471-2369

Topics: Medicine

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