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Medical genomics at Belyaev Conference – 2017 (2018)

Yuriy L. Orlov, Julio R. Fernandez-Masso, Ming Chen and Ancha V. Baranova

BioMed Central

In: BMC Medical Genomics

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Publication Date: 2018-03-06

Electronic ISSN: 1755-8794

Topics: Medicine

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3

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Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection (2018)

Na Zhang, Yun-Juan Bao, Amy Hin-Yan Tong, Scott Zuyderduyn, Gary D. Bader, J. S. Malik Peiris, Si Lok and Suki Man-Yan Lee

BioMed Central

In: BMC Medical Genomics

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Publication Date: 2018-03-06

Description: Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro and in vivo suggest that vi...

Electronic ISSN: 1755-8794

Topics: Medicine

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4

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Incidental finding of large pneumothorax on Cardiac MR scan (2018)

J. P. M. Andrews, G. McKillop and M. R. Dweck

BioMed Central

In: BMC Medical Imaging

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Publication Date: 2018-03-06

Description: We believe this is the first case report of a pneumothorax being identified using cardiac magnetic resonance imaging. This case also illustrates the haemodynamic effect a large pneumothorax can have on right v...

Electronic ISSN: 1471-2342

Topics: Biology

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5

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Systemic air embolism after percutaneous computed tomography-guided lung biopsy due to a kink in the coaxial biopsy system: a case report (2018)

Hsu-Chao Chang and Mei-Chen Yang

BioMed Central

In: BMC Medical Imaging

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Publication Date: 2018-03-06

Description: Systemic air embolism is a rare but potentially life-threatening complication of percutaneous computed tomography (CT)-guided lung biopsy. The incidence might be underestimated because of failure to diagnose t...

Electronic ISSN: 1471-2342

Topics: Biology

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6

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Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy (2018)

Zehra Hatipoglu, Ersel Gulec, Mediha Turktan, Volkan Izol, Atilla Arıdogan, Yasemin Gunes and Dilek Ozcengiz

BioMed Central

In: BMC Anesthesiology

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Publication Date: 2018-03-06

Description: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g., epidural analgesia and ...

Electronic ISSN: 1471-2253

Topics: Medicine

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7

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Characterization of sulfhydryl oxidase from Aspergillus tubingensis (2018)

Outi Nivala, Greta Faccio, Mikko Arvas, Perttu Permi, Johanna Buchert, Kristiina Kruus and Maija-Liisa Mattinen

BioMed Central

In: BMC Biochemistry

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Publication Date: 2018-03-06

Description: Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized...

Electronic ISSN: 1471-2091

Topics: Chemistry and Pharmacology

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Levonorgestrel-releasing intrauterine system for treatment of heavy menstrual bleeding in adolescents with Glanzmann’s Thrombasthenia: illustrated case series (2018)

Meiqiu Lu and Xin Yang

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Glanzmann’s Thrombasthenia (GT) is an inherited genetic disorder caused by defects in the platelet membrane glycoproteins IIb/IIIA, and is associated with heavy menstrual bleeding (HMB). HMB is a common compli...

Electronic ISSN: 1472-6874

Topics: Medicine

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9

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Predictors of cervical cancer screening intention of HIV-positive women in the central region of Ghana (2018)

Nancy Innocentia Ebu and Joseph Kwesi Ogah

BioMed Central

In: BMC Women's Health

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Publication Date: 2018-03-06

Description: Cervical cancer affects women, especially those with HIV-positive status. This study hypothesised that more HIV-positive women with high cues about cervical cancer screening, high perceived susceptibility to c...

Electronic ISSN: 1472-6874

Topics: Medicine

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10

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A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production (2018)

Christoph Geisler

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Adventitious viral contamination in cell substrates used for biologicals production is a major safety concern. A powerful new approach that can be used to identify adventitious viruses is a combination of bioi...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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DNA methylome profiling at single-base resolution through bisulfite sequencing of 5mC-immunoprecipitated DNA (2018)

Zhen Jia, Yueyi Shi, Lei Zhang, Yipeng Ren, Tong Wang, Lejun Xing, Baorong Zhang, Guolan Gao and Rongfa Bu

BioMed Central

In: BMC Biotechnology

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Publication Date: 2018-03-06

Description: Detection of DNA methylome at single-base resolution is a significant challenge but promises to shed considerable light on human disease etiology. Current technologies could not detect DNA methylation genome-w...

Electronic ISSN: 1472-6750

Topics: Process Engineering, Biotechnology, Nutrition Technology

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12

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Determinants of cancer screening awareness and participation among Indonesian women (2018)

Sumadi L. Anwar, Gindo Tampubolon, Mieke Van Hemelrijck, Susanna H. Hutajulu, Johnathan Watkins and Wahyu Wulaningsih

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Cancer screening awareness and participation may be lower in low- and middle-income countries that lack established national screening programmes compared with those that do. We evaluated potential determinant...

Electronic ISSN: 1471-2407

Topics: Medicine

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13

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Mixed response on regorafenib treatment for GIST (gastro-intestinal stromal tumor) according to 18F–FDG-PET/CT (2018)

Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere and Christophe M. Deroose

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Gastro-intestinal stromal tumors (GISTs) are very rare tumors of the gastro-intestinal tract, originating from the interstitial cells of Cajal or a common cell precursor which both express type III tyrosine ki...

Electronic ISSN: 1471-2407

Topics: Medicine

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Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma (2018)

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao and Weimin Mao

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.

Electronic ISSN: 1471-2407

Topics: Medicine

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15

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Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening (2018)

Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling and Harry J. de Koning

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Between 2003 and 2010 digital mammography (DM) gradually replaced screen-film mammography (SFM) in the Dutch breast cancer screening programme (BCSP). Previous studies showed increases in detection rate (DR) a...

Electronic ISSN: 1471-2407

Topics: Medicine

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16

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A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention (2018)

Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks and Gillian Mitchell

BioMed Central

In: BMC Cancer

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Publication Date: 2018-03-06

Description: Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (...

Electronic ISSN: 1471-2407

Topics: Medicine

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17

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A case of anterior spinal cord syndrome in a patient with unruptured thoracic aortic aneurysm with a mural thrombus (2018)

Nilukshana Yogendranathan, H. M. M. T. B. Herath, W. D. Jayamali, Anne Thushara Matthias, Aruna Pallewatte and Aruna Kulatunga

BioMed Central

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Publication Date: 2018-03-06

Description: Spinal cord infarction is an uncommon condition. Anterior cord syndrome present with paraparesis or quadriparesis with sparing of vibration and proprioceptive senses. The common causes of anterior cord syndrom...

Electronic ISSN: 1471-2261

Topics: Medicine

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CMR stress testing in a patient with morbid obesity (BMI 58 kg/m2) and suspected coronary artery disease (2018)

Lukas Stoiber, Bernhard Schnackenburg, Rolf Gebker, Hanane Hireche-Chikaoui, Burkert Pieske and Sebastian Kelle

BioMed Central

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Publication Date: 2018-03-06

Description: Severe obesity is asscociated with an increased risk of coronary artery disease (CAD) but non-invasive cardiac imaging modalities have important technical limits.

Electronic ISSN: 1471-2261

Topics: Medicine

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Percutaneous closure versus medical therapy for stroke with patent foramen Ovale: a systematic review and meta-analysis (2018)

Xin-Lin Zhang, Li-Na Kang, Lian Wang and Biao Xu

BioMed Central

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Publication Date: 2018-03-06

Description: Patent foramen ovale (PFO) closure has emerged as a secondary prevention option in patients with PFO and cryptogenic stroke. However, the comparative efficacy and safety of percutaneous closure and medical the...

Electronic ISSN: 1471-2261

Topics: Medicine

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Combined value of left ventricular ejection fraction and the Model for End-Stage Liver Disease (MELD) score for predicting mortality in patients with acute coronary syndrome who were undergoing percutaneous coronary intervention (2018)

Tuncay Kırıs, Eyüp Avcı and Aykan Çelik

BioMed Central

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Publication Date: 2018-03-06

Description: The purpose of the study was to investigate whether the addition of left ventricular ejection fraction (LVEF) to the MELD score enhances the prediction of mortality in patients with acute coronary syndrome (AC...

Electronic ISSN: 1471-2261

Topics: Medicine

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21

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MicroRNA-17-5p aggravates lipopolysaccharide-induced injury in nasal epithelial cells by targeting Smad7 (2018)

Nan Huang, Wenjing Li, Xiaolong Wang and Shanshan Qi

BioMed Central

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Publication Date: 2018-03-06

Description: Globally, rhinitis is one of the most common chronic disorders. Despite availability of drugs to manage the symptomatology of rhinitis, researchers still focus on identification of novel molecular targets for ...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Comparison of drug-eluting balloon versus drug-eluting stent for treatment of coronary artery disease: a meta-analysis of randomized controlled trials (2018)

Lulu Liu, Bin Liu, Jiajun Ren, Gang Hui, Chao Qi and Junnan Wang

BioMed Central

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Publication Date: 2018-03-06

Description: Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we co...

Electronic ISSN: 1471-2261

Topics: Medicine

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23

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Mechanically tuned 3 dimensional hydrogels support human mammary fibroblast growth and viability (2018)

Kathryn Woods, Catlyn Thigpen, Jennifer Peyling Wang, Hana Park and Abigail Hielscher

BioMed Central

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Publication Date: 2018-03-06

Description: Carcinoma associated fibroblasts (CAFs or myofibroblasts) are activated fibroblasts which participate in breast tumor growth, angiogenesis, invasion, metastasis and therapy resistance. As such, recent efforts ...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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24

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Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1 (2018)

Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe and Katalin Dobra

BioMed Central

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Publication Date: 2018-03-06

Description: The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cell cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also transloca...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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25

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A novel interaction between kinase activities in regulation of cilia formation (2018)

Nicole De; Vaul, Katerina Koloustroubis, Rong Wang and Ann O. Sperry

BioMed Central

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Publication Date: 2018-03-06

Description: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of pri...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide (2018)

Olesja Hazenbiller, Neil A. Duncan and Roman J. Krawetz

BioMed Central

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Publication Date: 2018-03-06

Description: Self-renewal and differentiation of embryonic stem cells (ESCs) is directed by biological and/or physical cues that regulate multiple signaling cascades. We have previously shown that mESCs seeded in a type I ...

Electronic ISSN: 1471-2121

Topics: Biology , Medicine

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Evaluation of SD BIOLINE H. pylori Ag rapid test against double ELISA with SD H. pylori Ag ELISA and EZ-STEP H. pylori Ag ELISA tests (2018)

Markos Negash, Afework Kassu, Bemnet Amare, Gizachew Yismaw and Beyene Moges

BioMed Central

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Publication Date: 2018-03-06

Description: Helicobacter pylori antibody titters fall very slowly even after successful treatment. Therefore, tests detecting H. pylori antibody lack specificity and sensitivity. On the other hand, H. pylori stool antigen te...

Electronic ISSN: 1472-6890

Topics: Medicine

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28

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Primary hepatic neuroendocrine carcinoma: report of two cases and literature review (2018)

Zi-Ming Zhao, Jin Wang, Ugochukwu C. Ugwuowo, Liming Wang and Jeffrey P. Townsend

BioMed Central

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Publication Date: 2018-03-06

Description: Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging—partly due to its rarity, and partly due to its lack of unique clinical features. Available treatm...

Electronic ISSN: 1472-6890

Topics: Medicine

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29

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The expression of MDM2 in gastrointestinal stromal tumors: immunohistochemical analysis of 35 cases (2018)

Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi and Laila Chbani

BioMed Central

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Publication Date: 2018-03-06

Description: Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there a...

Electronic ISSN: 1472-6890

Topics: Medicine

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Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse (2018)

Alain Stricker-Krongrad, Catherine Shoemake, Miao Zhong, Jason Liu and Guy Bouchard

BioMed Central

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Publication Date: 2018-03-06

Description: Measuring expression profiles of inflammatory biomarkers is important in monitoring the polarization of immune responses; therefore, results should be independent of quantitation methods if they are to be acce...

Electronic ISSN: 1472-6890

Topics: Medicine

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Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer (2018)

Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford and Emma J. Crosbie

BioMed Central

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Publication Date: 2018-03-06

Description: Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered...

Electronic ISSN: 1472-6890

Topics: Medicine

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Rhaponticum acaule (L) DC essential oil: chemical composition, in vitro antioxidant and enzyme inhibition properties (2018)

Habib Mosbah, Hassiba Chahdoura, Jannet Kammoun, Malek Besbes Hlila, Hanen Louati, Saoussen Hammami, Guido Flamini, Lotfi Achour and Boulbaba Selmi

BioMed Central

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Publication Date: 2018-03-06

Description: α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that cataly...

Electronic ISSN: 1472-6882

Topics: Medicine

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Water extract of Semecarpus parvifolia Thw. leaves inhibits cell proliferation and induces apoptosis on HEp-2 cells (2018)

Preethi Soysa, Panchima Jayarthne and Imali Ranathunga

BioMed Central

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Publication Date: 2018-03-06

Description: Semecarpus parvifolia Thw is used as an ingredient of poly herbal decoctions to treat cancer in traditional medicine. The present study aims to investigate the antiproliferative activity on HEp 2 cells by the wat...

Electronic ISSN: 1472-6882

Topics: Medicine

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Immune-enhancing activity of C. militaris fermented with Pediococcus pentosaceus (GRC-ON89A) in CY-induced immunosuppressed model (2018)

Ha-Kyoung Kwon, Woo-Ri Jo and Hye-Jin Park

BioMed Central

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Publication Date: 2018-03-06

Description: Cordyceps militaris (C. militaris) is reported to exert various immune-activities. To enhance its activity, we fermented C.militaris with Pediococcus pentosaceus ON89A (GRC-ON89A). In this study, we investigated ...

Electronic ISSN: 1472-6882

Topics: Medicine

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Phytochemical profiling and in vitro screening for anticholinesterase, antioxidant, antiglucosidase and neuroprotective effect of three traditional medicinal plants for Alzheimer’s Disease and Diabetes Mellitus dual therapy (2018)

Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Suresh Kumar Reddy Mallepalli, Ramakrishna Vadde and Damu Gangaiah Amooru

BioMed Central

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Publication Date: 2018-03-06

Description: Extensive epidemiological and clinical studies revealed that Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2D) are most likely to appear simultaneously in aged people as T2D is a major risk factor fo...

Electronic ISSN: 1472-6882

Topics: Medicine

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Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity (2018)

Shasha Xu, Shaoang Tu, Jinlong Gao, Jia Liu, Zhirui Guo, Jinming Zhang, Xingdang Liu, Jianhui Liang, Yiyun Huang and Mei Han

BioMed Central

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Publication Date: 2018-03-06

Description: Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the...

Electronic ISSN: 1472-6882

Topics: Medicine

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Reliability and validity study of Sino-nasal outcome test 22 (Thai version) in chronic rhinosinusitis (2018)

Jate Lumyongsatien, Waralak Yangsakul, Chaweewan Bunnag, Claire Hopkins and Pongsakorn Tantilipikorn

BioMed Central

In: BMC Ear, Nose and Throat Disorders

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Publication Date: 2018-03-06

Description: Chronic rhinosinusitis (CRS) is one of common health conditions that affects patients’ health-related quality of life. Our purpose is to assess the reliability and validity of Thai-version of Sino-Nasal Outcom...

Electronic ISSN: 1472-6815

Topics: Medicine

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High inter-observer agreement of observer-perceived pain assessment in the emergency department (2018)

Martin Høhrmann Hangaard, Brian Malling and Christian Backer Mogensen

BioMed Central

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Publication Date: 2018-03-06

Description: Triage is used to prioritize the patients in the emergency department. The majority of the triage systems include the patients’ pain score to assess their level of acuity by using a combination of patient repo...

Electronic ISSN: 1471-227X

Topics: Medicine

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Ambulance use is not associated with patient acuity after road traffic collisions: a cross-sectional study from Addis Ababa, Ethiopia (2018)

Yonas Abebe, Tolesa Dida, Engida Yisma and David M. Silvestri

BioMed Central

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Publication Date: 2018-03-06

Description: Africa accounts for one sixth of global road traffic deaths—most in the pre-hospital setting. Ambulance transport is expensive relative to other modes of pre-hospital transport, but has advantages in time-sens...

Electronic ISSN: 1471-227X

Topics: Medicine

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Correction to: Systematic reporting to improve the emergency medical response to major incidents: a pilot study (2018)

Sophie Hardy, Sabina Fattah, Torben Wisborg, Lasse Raatiniemi, Trine Staff and Marius Rehn

BioMed Central

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Publication Date: 2018-03-06

Description: The original article [1] contains an error whereby all authors’ names were mistakenly interchanged. The original article has now been corrected to present the authors’ names correctly.

Electronic ISSN: 1471-227X

Topics: Medicine

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41

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Ultrasound-guided identification of the cricothyroid membrane in a patient with a difficult airway: a case report (2018)

Hiromu Okano, Kohji Uzawa, Kunitaro Watanabe, Akira Motoyasu, Joho Tokumine, Alan Kawarai Lefor and Tomoko Yorozu

BioMed Central

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Publication Date: 2018-03-06

Description: Surgical cricothyroidotomy is considered to be the last resort for management of the difficult airway. A major point for a successful surgical cricothyroidotomy is to identify the location of the cricothyroid ...

Electronic ISSN: 1471-227X

Topics: Medicine

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42

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Systematic reporting to improve the emergency medical response to major incidents: a pilot study (2018)

Sophie Hardy, Sabina Fattah, Torben Wisborg, Lasse Raatiniemi, Trine Staff and Marius Rehn

BioMed Central

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Publication Date: 2018-03-06

Description: Major incidents affect us globally, and are occurring with increasing frequency. There is still no evidence-based standard regarding the best medical emergency response to major incidents. Currently, reports o...

Electronic ISSN: 1471-227X

Topics: Medicine

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43

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Prevalence of metabolic syndrome in Saudi Arabia - a cross sectional study (2018)

Khalid Al-Rubeaan, Nahla Bawazeer, Yousuf Al Farsi, Amira M. Youssef, Abdulrahman A. Al-Yahya, Hamid Al; Qumaidi, Basim M. Al-Malki, Khalid A. Naji, Khalid Al-Shehri and Fahd I. Al Rumaih

BioMed Central

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Publication Date: 2018-03-06

Description: The evaluation of metabolic syndrome in a society predisposed to the diabetes mellitus epidemic opens a new avenue to understanding this rapidly growing global metabolic problem. Although Saudi Arabia reports ...

Electronic ISSN: 1472-6823

Topics: Medicine

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44

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Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment (2018)

Tao Tao, Peihong Wu, Yuying Wang and Wei Liu

BioMed Central

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Publication Date: 2018-03-06

Description: Impaired insulin activity in women with polycystic ovary syndrome might differ from that seen in type 2 diabetes mellitus without polycystic ovary syndrome. This study was designed to compare the effects of tr...

Electronic ISSN: 1472-6823

Topics: Medicine

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45

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The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population (2018)

Jainagul Isakova, Elnura Talaibekova, Denis Vinnikov, Nazira Aldasheva, Erkin Mirrakhimov and Almaz Aldashev

BioMed Central

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Publication Date: 2018-03-06

Description: The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population.

Electronic ISSN: 1472-6823

Topics: Medicine

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46

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Patients’ and caregivers’ experiences of using continuous glucose monitoring to support diabetes self-management: qualitative study (2018)

J. Lawton, M. Blackburn, J. Allen, F. Campbell, D. Elleri, L. Leelarathna, D. Rankin, M. Tauschmann, H. Thabit and R. Hovorka

BioMed Central

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Publication Date: 2018-03-06

Description: Continuous glucose monitoring (CGM) enables users to view real-time interstitial glucose readings and provides information on the direction and rate of change of blood glucose levels. Users can also access his...

Electronic ISSN: 1472-6823

Topics: Medicine

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47

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A single-center retrospective study of factors related to the effects of intravenous glucocorticoid therapy in moderate-to-severe and active thyroid-associated ophthalmopathy (2018)

Yang Wang, Shuo Zhang, Yidan Zhang, Xingtong Liu, Hao Gu, Sisi Zhong, Yazhuo Huang, Sijie Fang, Jing Sun, Huifang Zhou and Xianqun Fan

BioMed Central

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Publication Date: 2018-03-06

Description: Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. Th...

Electronic ISSN: 1472-6823

Topics: Medicine

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48

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Complete mitochondrial genomes of Nanorana taihangnica and N. yunnanensis (Anura: Dicroglossidae) with novel gene arrangements and phylogenetic relationship of Dicroglossidae (2018)

Jia-Yong Zhang, Le-Ping Zhang, Dan-Na Yu, Kenneth B. Storey and Rong-Quan Zheng

BioMed Central

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Publication Date: 2018-03-06

Description: Complete mitochondrial (mt) genomes have been used extensively to test hypotheses about microevolution and to study population structure, phylogeography, and phylogenetic relationships of Anura at various taxo...

Electronic ISSN: 1471-2148

Topics: Biology

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49

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Phylogeny with introgression in Habronattus jumping spiders (Araneae: Salticidae) (2018)

Geneviève Leduc-Robert and Wayne P. Maddison

BioMed Central

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Publication Date: 2018-03-06

Description: Habronattus is a diverse clade of jumping spiders with complex courtship displays and repeated evolution of Y chromosomes. A well-resolved species phylogeny would provide an important framework to study these tra...

Electronic ISSN: 1471-2148

Topics: Biology

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50

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Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules (2018)

Unni Grimholt

BioMed Central

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Publication Date: 2018-03-06

Description: In sharks, chickens, rats, frogs, medaka and zebrafish there is haplotypic variation in MHC class I and closely linked genes involved in antigen processing, peptide translocation and peptide loading. At least ...

Electronic ISSN: 1471-2148

Topics: Biology

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51

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Elucidation of cross-species proteomic effects in human and hominin bone proteome identification through a bioinformatics experiment (2018)

F. Welker

BioMed Central

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Publication Date: 2018-03-06

Description: The study of ancient protein sequences is increasingly focused on the analysis of older samples, including those of ancient hominins. The analysis of such ancient proteomes thereby potentially suffers from “cr...

Electronic ISSN: 1471-2148

Topics: Biology

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52

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The role of facial pattern variation for species recognition in red-fronted lemurs (Eulemur rufifrons) (2018)

Hanitriniaina Rakotonirina, Peter M. Kappeler and Claudia Fichtel

BioMed Central

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Publication Date: 2018-03-06

Description: Species recognition, i.e., the ability to distinguish conspecifics from heterospecifics, plays an essential role in reproduction. The role of facial cues for species recognition has been investigated in severa...

Electronic ISSN: 1471-2148

Topics: Biology

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53

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How well do general practitioners know their elderly patients’ social relations and feelings of loneliness? (2018)

Tina Drud Due, Håkon Sandholdt, Volkert Dirk Siersma and Frans Boch Waldorff

BioMed Central

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Publication Date: 2018-03-06

Description: Social relationships are important to people and affect their quality of life, morbidity and mortality. The aim of this study was to examine the correlation between elderly patients’ descriptions of their soci...

Electronic ISSN: 1471-2296

Topics: Medicine

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54

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Disentangling the effect of illness perceptions on health status in people with type 2 diabetes after an acute coronary event (2018)

Rimke Cathelijne Vos, Marise Jeannine Kasteleyn, Monique Johanna Heijmans, Elke de Leeuw, François Georges Schellevis, Mieke Rijken and Guy Emile Rutten

BioMed Central

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Publication Date: 2018-03-06

Description: Chronically ill patients such as people with type 2 diabetes develop perceptions of their illness, which will influence their coping behaviour. Perceptions are formed once a health threat has been recognised. ...

Electronic ISSN: 1471-2296

Topics: Medicine

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55

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Prevalence, aetiologies and prognosis of the symptom dizziness in primary care – a systematic review (2018)

Stefan Bösner, Sonja Schwarm, Paula Grevenrath, Laura Schmidt, Kaja Hörner, Dominik Beidatsch, Milena Bergmann, Annika Viniol, Annette Becker and Jörg Haasenritter

BioMed Central

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Publication Date: 2018-03-06

Description: Dizziness is a common reason for consulting a general practitioner and there is a broad range of possible underlying aetiologies. There are few evidence-based data about prevalence, aetiology and prognosis in ...

Electronic ISSN: 1471-2296

Topics: Medicine

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The increasing importance of a continence nurse specialist to improve outcomes and save costs of urinary incontinence care: an analysis of future policy scenarios (2018)

Margreet G Franken, Isaac Corro Ramos, Jeanine Los and Maiwenn J Al

BioMed Central

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Publication Date: 2018-03-06

Description: In an ageing population, it is inevitable to improve the management of care for community-dwelling elderly with incontinence. A previous study showed that implementation of the Optimum Continence Service Speci...

Electronic ISSN: 1471-2296

Topics: Medicine

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57

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Perceptions about screening for prostate cancer using genetic lifetime risk assessment: a qualitative study (2018)

Pia Kirkegaard, Adrian Edwards, Trine Laura Overgaard Nielsen, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Michael Borre and Flemming Bro

BioMed Central

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Publication Date: 2018-03-06

Description: Most health authorities do not recommend screening for prostate cancer with PSA tests in asymptomatic patients who are not at increased risk. However, opportunistic screening for prostate cancer is still wante...

Electronic ISSN: 1471-2296

Topics: Medicine

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58

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Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients (2018)

Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

BioMed Central

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Publication Date: 2018-03-06

Description: Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

Electronic ISSN: 1471-230X

Topics: Medicine

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Correction to: Rate and determinants of non-adherence to a gluten-free diet and nutritional status assessment in children and adolescents with celiac disease in a tertiary Brazilian referral center: a cross-sectional and retrospective study (2018)

Maraci Rodrigues, Glauce Hiromi Yonamine and Carla Aline Fernandes Satiro

BioMed Central

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Publication Date: 2018-03-06

Description: Unfortunately, after publication of this article [1], it was noticed that the names of the second and third authors were incorrectly displayed, respectively, as Glauce Hiromi Yonaminez and Carla Aline Satiro. ...

Electronic ISSN: 1471-230X

Topics: Medicine

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60

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Functional gastrointestinal diseases and psychological maladjustment, personality traits and quality of life (2018)

Nishadi Ranasinghe, Niranga Manjuri Devanarayana, Shaman Rajindrajith, Madusanka S. Perera, Samudu Nishanthinie, Tania Warnakulasuriya and Piyanjali Thamesha de Zoysa

BioMed Central

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Publication Date: 2018-03-06

Description: Chronic abdominal pain is a common worldwide problem and known to be associated with psychological problems. This study evaluated the association between abdominal pain-predominant functional gastrointestinal ...

Electronic ISSN: 1471-230X

Topics: Medicine

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61

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Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice (2018)

Takemasa Senoo, Ryu Sasaki, Yuko Akazawa, Tatsuki Ichikawa, Satoshi Miuma, Hisamitsu Miyaaki, Naota Taura and Kazuhiko Nakao

BioMed Central

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Publication Date: 2018-03-06

Description: Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate ...

Electronic ISSN: 1471-230X

Topics: Medicine

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62

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Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle (2018)

Paula Nicolini, Rocío Amorín, Yi Han and Francisco Peñagaricano

BioMed Central

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Publication Date: 2018-03-06

Description: Service sire has a considerable impact on reproductive success in dairy cattle. Most gene mapping studies for bull fertility have focused on additive effects, while non-additive effects have been largely ignor...

Electronic ISSN: 1471-2156

Topics: Biology

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63

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Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis (2018)

Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

BioMed Central

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Publication Date: 2018-03-06

Description: Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancer. A new multi-functional ESD device was developed to achieve complete ESD with a single device. A metal plate attached to ...

Electronic ISSN: 1471-230X

Topics: Medicine

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Correction to: High density marker panels, SNPs prioritizing and accuracy of genomic selection (2018)

Ling-Yun Chang, Sajjad Toghiani, Ashley Ling, Sammy E. Aggrey and Romdhane Rekaya

BioMed Central

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Publication Date: 2018-03-06

Description: The original version of this article [1], published on 5 January 2018, contained 3 formatting errors. In this Correction the affected parts of the article are shown. The original article has been updated.

Electronic ISSN: 1471-2156

Topics: Biology

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Genetic diversity and ex situ conservation of Loropetalum subcordatum, an endangered species endemic to China (2018)

Bai-Jun Li, Jie-Yu Wang, Zhong-Jian Liu, Xue-Ying Zhuang and Jiu-Xiang Huang

BioMed Central

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Publication Date: 2018-03-06

Description: Loropetalum subcordatum is an endangered species endemic to China that is characterized by narrow distribution, small population size, and delayed fertilization. However, the genetic diversity of the entire extan...

Electronic ISSN: 1471-2156

Topics: Biology

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66

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Diversity of plant defense elicitor peptides within the Rosaceae (2018)

Cristina Ruiz, Anna Nadal, Laura Foix, Laura Montesinos, Emilio Montesinos and Maria Pla

BioMed Central

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Publication Date: 2018-03-06

Description: Plant elicitor peptides (Peps) are endogenous molecules that induce and amplify the first line of inducible plant defense, known as pattern-triggered immunity, contributing to protect plants against attack by ...

Electronic ISSN: 1471-2156

Topics: Biology

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Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus (2018)

Ujjwal Maulik, Sagnik Sen, Saurav Mallik and Sanghamitra Bandyopadhyay

BioMed Central

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Publication Date: 2018-03-06

Description: Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on ...

Electronic ISSN: 1471-2156

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68

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Successful use of whole genome amplified DNA from multiple source types for high-density Illumina SNP microarrays (2018)

Casey L. Dagnall, Lindsay M. Morton, Belynda D. Hicks, Shengchao Li, Weiyin Zhou, Eric Karlins, Kedest Teshome, Salma Chowdhury, Kerrie S. Lashley, Joshua N. Sampson, Leslie L. Robison, Gregory T. Armstrong, Smita Bhatia, Gretchen A. Radloff, Stella M. Davies, Margaret A. Tucker…

BioMed Central

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Publication Date: 2018-03-06

Description: The recommended genomic DNA input requirements for whole genome single nucleotide polymorphism microarrays can limit the scope of molecular epidemiological studies. We performed a large-scale evaluation of who...

Electronic ISSN: 1471-2164

Topics: Biology

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Characterization of the human RFX transcription factor family by regulatory and target gene analysis (2018)

Debora Sugiaman-Trapman, Morana Vitezic, Eeva-Mari Jouhilahti, Anthony Mathelier, Gilbert Lauter, Sougat Misra, Carsten O. Daub, Juha Kere and Peter Swoboda

BioMed Central

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Publication Date: 2018-03-06

Description: Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal differentiation. H...

Electronic ISSN: 1471-2164

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Summarizing performance for genome scale measurement of miRNA: reference samples and metrics (2018)

P. Scott Pine, Steven P. Lund, Jerod R. Parsons, Lindsay K. Vang, Ashish A. Mahabal, Luca Cinquini, Sean C. Kelly, Heather Kincaid, Daniel J. Crichton, Avrum Spira, Gang Liu, Adam C. Gower, Harvey I. Pass, Chandra Goparaju, Steven M. Dubinett, Kostyantyn Krysan…

BioMed Central

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Publication Date: 2018-03-06

Description: The potential utility of microRNA as biomarkers for early detection of cancer and other diseases is being investigated with genome-scale profiling of differentially expressed microRNA. Processes for measuremen...

Electronic ISSN: 1471-2164

Topics: Biology

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AmpuBase: a transcriptome database for eight species of apple snails (Gastropoda: Ampullariidae) (2018)

Jack C. H. Ip, Huawei Mu, Qian Chen, Jin Sun, Santiago Ituarte, Horacio Heras, Bert Van Bocxlaer, Monthon Ganmanee, Xin Huang and Jian-Wen Qiu

BioMed Central

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Publication Date: 2018-03-06

Description: Gastropoda, with approximately 80,000 living species, is the largest class of Mollusca. Among gastropods, apple snails (family Ampullariidae) are globally distributed in tropical and subtropical freshwater eco...

Electronic ISSN: 1471-2164

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Analysis of MAPK and MAPKK gene families in wheat and related Triticeae species (2018)

Ravinder K. Goyal, Dan Tulpan, Nora Chomistek, Dianevys González-Peña Fundora, Connor West, Brian E. Ellis, Michele Frick, André Laroche and Nora A. Foroud

BioMed Central

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Publication Date: 2018-03-06

Description: The mitogen-activated protein kinase (MAPK) family is involved in signal transduction networks that underpin many different biological processes in plants, ranging from development to biotic and abiotic stress...

Electronic ISSN: 1471-2164

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Does sarcopenia predict change in mobility after hip fracture? a multicenter observational study with one-year follow-up (2018)

Ole Martin Steihaug, Clara Gram Gjesdal, Bård Bogen, Målfrid Holen Kristoffersen, Gunhild Lien, Karl Ove Hufthammer and Anette Hylen Ranhoff

BioMed Central

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Publication Date: 2018-03-06

Description: Patients with hip fracture frequently have sarcopenia and are at great risk of loss of mobility. We have investigated if sarcopenia predicts change in mobility after hip fracture.

Electronic ISSN: 1471-2318

Topics: Medicine

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Video-calls to reduce loneliness and social isolation within care environments for older people: an implementation study using collaborative action research (2018)

Sonam Zamir, Catherine Hagan Hennessy, Adrian H Taylor and Ray B Jones

BioMed Central

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Publication Date: 2018-03-06

Description: Older people in care may be lonely with insufficient contact if families are unable to visit. Face-to-face contact through video-calls may help reduce loneliness, but little is known about the processes of eng...

Electronic ISSN: 1471-2318

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Are physiotherapists employing person-centred care for people with dementia? An exploratory qualitative study examining the experiences of people with dementia and their carers (2018)

Abigail J. Hall, Lisa Burrows, Iain A. Lang, Ruth Endacott and Victoria A. Goodwin

BioMed Central

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Publication Date: 2018-03-06

Description: People with dementia may receive physiotherapy for a variety of reasons. This may be for musculoskeletal conditions or as a result of falls, fractures or mobility difficulties. While previous studies have soug...

Electronic ISSN: 1471-2318

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Polypharmacy in the oldest old (≥80 years of age) patients in China: a cross-sectional study (2018)

Xiaoxing Lai, Hongwei Zhu, Xiaopeng Huo and Zheng Li

BioMed Central

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Publication Date: 2018-03-06

Description: The oldest old generally have worse health and more comorbidities than the general population of older adults, and they are more likely to be exposed to polypharmacy. Reliable investigation of polypharmacy amo...

Electronic ISSN: 1471-2318

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Access to primary care and computed tomography use in the emergency department (2018)

M. Fernanda Bellolio, Shawna D. Bellew, Lindsey R. Sangaralingham, Ronna L. Campbell, Daniel Cabrera, Molly M. Jeffery, Nilay D. Shah and Erik P. Hess

BioMed Central

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Publication Date: 2018-03-06

Description: The decision to obtain a computed tomography CT scan in the emergency department (ED) is complex, including a consideration of the risk posed by the test itself weighed against the importance of obtaining the ...

Electronic ISSN: 1472-6963

Topics: Medicine

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Development of a complex intervention to improve participation of nursing home residents with joint contractures: a mixed-method study (2018)

Susanne Saal, Gabriele Meyer, Katrin Beutner, Hanna Klingshirn, Ralf Strobl, Eva Grill, Eva Mann, Sascha Köpke, Michel H. C. Bleijlevens, Gabriele Bartoszek, Anna-Janina Stephan, Julian Hirt and Martin Müller

BioMed Central

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Publication Date: 2018-03-06

Description: Joint contractures in nursing home residents limit the capacity to perform daily activities and restrict social participation. The purpose of this study was to develop a complex intervention to improve partici...

Electronic ISSN: 1471-2318

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The effects of continuity of care on hospital utilization in patients with knee osteoarthritis: analysis of Nationwide insurance data (2018)

Boyoung Jung, Kyoung Hee Cho, Dong Hyun Lee and Soyoon Kim

BioMed Central

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Publication Date: 2018-03-06

Description: Korea’s rapidly aging population has led to a rise in the prevalence of knee osteoarthritis (which reached upwards of 21.3% in 2017) in elderly people aged 65 years and over. Most patients with knee osteoarthr...

Electronic ISSN: 1472-6963

Topics: Medicine

Published by BioMed Central

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80

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Sustainability in Health care by Allocating Resources Effectively (SHARE) 8: developing, implementing and evaluating an evidence dissemination service in a local healthcare setting (2018)

Claire Harris, Marie Garrubba, Angela Melder, Catherine Voutier, Cara Waller, Richard King and Wayne Ramsey

BioMed Central

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Publication Date: 2018-03-06

Description: This is the eighth in a series of papers reporting Sustainability in Health care by Allocating Resources Effectively (SHARE) in a local healthcare setting. The SHARE Program was a systematic, integrated, evide...

Electronic ISSN: 1472-6963

Topics: Medicine

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81

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Community mobilization and maternal Care of Women Living with HIV in poor settings: the case of Mfuwe, Zambia (2018)

Choolwe Muzyamba, Wim Groot, Sonila Tomini and Milena Pavlova

BioMed Central

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Publication Date: 2018-03-06

Description: Research has shown that community mobilization is a useful strategy in promoting maternal care of HIV negative women in resource poor settings; however, similar evidence for women living with HIV is missing. T...

Electronic ISSN: 1472-6963

Topics: Medicine

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82

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Selling my sheep to pay for medicines – household priorities and coping strategies in a setting without universal health coverage (2018)

Onarheim Kristine Husøy, Sisay Mitike Molla, Gizaw Muluken, Moland Karen Marie, Norheim Ole Frithof and Miljeteig Ingrid

BioMed Central

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Publication Date: 2018-03-06

Description: The first month of life is the period with the highest risk of dying. Despite knowledge of effective interventions, newborn mortality is high and utilization of health care services remains low in Ethiopia. In...

Electronic ISSN: 1472-6963

Topics: Medicine

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83

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A rare case of avascular necrosis in sickle cell trait: a case report (2018)

William J. Sanders

BioMed Central

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Publication Date: 2018-03-06

Description: Sickle cell trait is usually an asymptomatic presentation of a patient with slightly different hemoglobin molecule makeup than normal. It is similar to a more serious disease, sickle cell disease, in which a p...

Electronic ISSN: 1471-2326

Topics: Medicine

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84

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More is less, less is more, or does it really matter? The curious case of impact of azacitidine administration schedules on outcomes in patients with myelodysplastic syndromes (2018)

Rory M. Shallis and Amer M. Zeidan

BioMed Central

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Publication Date: 2018-03-06

Description: Myelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progressio...

Electronic ISSN: 1471-2326

Topics: Medicine

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85

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Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia (2018)

Roman M. Shapiro and Alejandro Lazo-Langner

BioMed Central

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Publication Date: 2018-03-06

Description: 5-Azacitidine administered as a 7-day dosing regimen (7–0-0) is approved in high risk IPSS myelodysplastic syndrome (MDS) patients. Alternative regimens such as a 5-day (5–0-0) or 7-day with a weekend break (5...

Electronic ISSN: 1471-2326

Topics: Medicine

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86

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Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia (2018)

Berhanu Elfu Feleke and Teferi Elfu Feleke

BioMed Central

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Publication Date: 2018-03-06

Description: Information on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother.

Electronic ISSN: 1471-2326

Topics: Medicine

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87

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Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease (2018)

Fekri Samarah and Mahmoud A. Srour

BioMed Central

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Publication Date: 2018-03-06

Description: Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to investigate the prevalence and clinical impact of factor V Leiden G1691A (FVL) and prothrombin G2...

Electronic ISSN: 1471-2326

Topics: Medicine

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88

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Utility of dominant epitopes derived from cell-wall protein LppZ for immunodiagnostic of pulmonary tuberculosis (2018)

Jinjing Tan, Xiaoguang Wu, Suting Chen, Meng Gu, Hairong Huang and Wentao Yue

BioMed Central

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Publication Date: 2018-03-06

Description: Serological antibodies tests for tuberculosis (TB) are widely used in developing countries. They appear to have some advantages- faster, simple and could be used for extrapulmonary TB. However, most of current...

Electronic ISSN: 1471-2172

Topics: Medicine

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89

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Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised (2018)

Kari J. Dugger, Taylor Chrisman, Sarah L. Sayner, Parker Chastain, Kacie Watson and Robert Estes

BioMed Central

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Publication Date: 2018-03-06

Description: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven al...

Electronic ISSN: 1471-2172

Topics: Medicine

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90

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Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ (2018)

Tammy Oth, Thomas H. P. M. Habets, Wilfred T. V. Germeraad, Marijke I. Zonneveld, Gerard M. J. Bos and Joris Vanderlocht

BioMed Central

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Publication Date: 2018-03-06

Description: Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk betwe...

Electronic ISSN: 1471-2172

Topics: Medicine

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91

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Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation (2018)

Sumera Y. Younis, Christophe Barnier-Quer, Simon Heuking, Vinod Sommandas, Livia Brunner, Nicole vd.Werff, Patrice Dubois, Martin Friede, Clemens Kocken, Nicolas Collin and Ed Remarque

BioMed Central

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Publication Date: 2018-03-06

Description: The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a me...

Electronic ISSN: 1471-2172

Topics: Medicine

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92

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Establishment of malignantly transformed dendritic cell line SU3-ihDCTC induced by Glioma stem cells and study on its sensitivity to resveratrol (2018)

Xifeng Fei, Anqi Wang, Delin Wang, Xan Meng, Jiawei Ma, Lei Hong, Ruwei Qin, Aidong Wang, Jun Dong, Qiang Huang and Zhimin Wang

BioMed Central

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Publication Date: 2018-03-06

Description: As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely be...

Electronic ISSN: 1471-2172

Topics: Medicine

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93

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Impact of a vaccination programme in children vaccinated with ProQuad, and ProQuad-specific effectiveness against varicella in the Veneto region of Italy (2018)

Carlo Giaquinto, Giovanni Gabutti, Vincenzo Baldo, Marco Villa, Lara Tramontan, Nadia Raccanello, Francesca Russo, Chiara Poma, Antonio Scamarcia, Luigi Cantarutti, Rebecca Lundin, Emilia Perinetti, Xavier Cornen, Stéphane Thomas, Céline Ballandras, Audrey Souverain…

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadri...

Electronic ISSN: 1471-2334

Topics: Medicine

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Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia (2018)

Natasha E. Holmes, J. Owen Robinson, Sebastiaan J. van Hal, Wendy J. Munckhof, Eugene Athan, Tony M. Korman, Allen C. Cheng, John D. Turnidge, Paul D. R. Johnson and Benjamin P. Howden

BioMed Central

In: BMC Infectious Diseases

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Publication Date: 2018-03-06

Description: Various studies have identified numerous factors associated with poor clinical outcomes in patients with Staphylococcus aureus bacteraemia (SAB). A new study was created to provide deeper insight into in-hospital...

Electronic ISSN: 1471-2334

Topics: Medicine

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