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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 294 (1992), S. 466-478 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 317 (1993), S. 474-484 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
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    Elsevier
    Publication Date: 2018-01-04
    Description: Publication date: 2 January 2018 Source: Cell Reports, Volume 22, Issue 1 Author(s): Ze-Lin Wang, Bin Li, Yu-Xia Luo, Qiao Lin, Shu-Rong Liu, Xiao-Qin Zhang, Hui Zhou, Jian-Hua Yang, Liang-Hu Qu RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about the dysregulation of RBPs at the genomic level in human cancers. Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), and mutation profiles of 1,542 RBPs in ∼7,000 clinical specimens across 15 cancer types. We identified markedly dysregulated RBPs and found that downregulation was a predominant pattern in cancer. Combined with recurrent SCNA data, we identified 76 RBPs as potential drivers. We also discovered a set of 139 RBPs that were significantly mutated in cancers. We confirmed the oncogenic property of six RBPs in colorectal and liver cancer cell lines by using in vitro functional experiments. Our study highlights the potential roles of RBPs in carcinogenesis and lays the groundwork to better understand the functions and mechanisms of RBPs in cancer. Graphical abstract Teaser Wang et al. characterize transcriptional and genomic alterations in the landscape of RNA-binding proteins (RBPs) in ∼7,000 clinical samples across 15 human cancer types and experimentally validate the effects of several cancer-related RBPs on cell viability.
    Electronic ISSN: 2211-1247
    Topics: Biology
    Published by Elsevier on behalf of Cell Press.
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  • 4
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    Elsevier
    Publication Date: 2018-01-04
    Description: Publication date: 2 January 2018 Source: Cell Reports, Volume 22, Issue 1 Author(s): Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, R248Q, and R273H hotspot mutants of the tumor suppressor p53. These antibodies recognize their intended specific alterations without any cross-reactivity against wild-type (WT) p53 or other p53 mutants, including at the same position (as exemplified by anti-R248Q antibody, which does not recognize the R248W mutation), evaluated by direct immunoblotting, immunoprecipitation, and immunofluorescence methods on transfected and endogenous proteins. Moreover, their clinical utility to diagnose the presence of specific p53 mutants in human tumor microarrays by immunohistochemistry is also shown. Together, the data demonstrate that antibodies against specific single-amino-acid alterations can be generated reproducibly and highlight their utility, which could potentially be extended to therapeutic settings. Graphical abstract Teaser Hwang et al. generate mutation-specific monoclonal antibodies with high sensitivity and specificity against three of the most common p53 hotspot mutations. These reagents represent the next generation of antibodies against single-amino-acid alterations, which could have potential in the diagnosis and therapeutic targeting of the many alterations found in disease states.
    Electronic ISSN: 2211-1247
    Topics: Biology
    Published by Elsevier on behalf of Cell Press.
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  • 5
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: Available online 3 January 2018 Source: Geoscience Frontiers Author(s): Manish Tiwari, Siddhesh Nagoji, Vikash Kumar, Shubham Tripathi, Padmasini Behera The global warming leads to a large freshwater influx into the Arctic Ocean, which has adverse implications to the sea-ice dynamics, ocean circulation, and acidification. The relationship between oxygen isotope ratio ( δ 18 O) and salinity (S) is helpful in exploring various hydrographic processes related to the freshwater influx and is also required to accurately determine past salinity variability using oxygen isotope ratio of the carbonates. In view of this, systematic measurements of δ 18 O and salinity of water from an Arctic fjord (Kongsfjorden) were carried out during the summer season of 2013. Until now, the relationships between δ 18 O and salinity from such fjords were based on a limited number of samples collected during a very short span of time and thus may not accurately represent the long-term conditions prevailing in the Fjord. The present study determines a more representative δ 18 O-salinity relationship as water samples from different depths and location over a long period were systematically collected. The water samples were collected from four different locations at different depths along the axis of the fjord representing the inner and the outer fjord. The inner stations (I-8 and I-6) exhibit lower δ 18 O values than the outer stations (I-1 and I-3), which indicate the higher influence of freshwater from glacial melting in the inner stations. The δ 18 O-salinity relationship from the inner and outer fjords yield a slope of 0.54 ( r 2 =0.67, n =56) and 0.39 ( r 2 =0.66, n =68), respectively. The δ 18 O of freshwater influx in the fjord is estimated at – 18.4‰, which is close to the widely accepted freshwater- δ 18 O value of the Arctic basin. The δ 18 O of glacial discharge, which is the largest source of freshwater influx to the fjord, is estimated at ca. – 21.0‰, which will be useful for future freshwater budget calculations. Graphical abstract
    Print ISSN: 1674-9871
    Topics: Geosciences
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  • 6
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    Elsevier
    Publication Date: 2018-01-04
    Description: Publication date: Available online 3 January 2018 Source: Fuzzy Sets and Systems Author(s): J.J. Arias-García, R. Mesiar, E.P. Klement, S. Saminger-Platz, B. De Baets In this paper we study the smallest and the greatest M -Lipschitz continuous n -ary aggregation functions with a given diagonal section. We show that several properties that were studied for the smallest and the greatest 1-Lipschitz continuous binary aggregation functions with a given diagonal section extend naturally to higher dimensions while considering different Lipschitz constants. Just as in the binary case, we show that the smallest n -quasi-copula with a given diagonal section coincides with the smallest 1-Lipschitz n -ary aggregation function with that diagonal section. Additionally, we show that the smallest n -quasi-copula with a given diagonal section, called the Bertino n -quasi-copula, is supermodular for any n ≥ 2 .
    Print ISSN: 0165-0114
    Electronic ISSN: 1872-6801
    Topics: Mathematics
    Published by Elsevier
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  • 7
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: Available online 4 January 2018 Source: Geoscience Frontiers Author(s): James W. Hall, Stijn Glorie, Anthony Reid, Samuel C. Boone, Alan S. Collins, Andrew Gleadow Apatite U–Pb thermochronology was applied to granitoid basement samples across the northern Gawler Craton to unravel the Proterozoic, post-orogenic, cooling history and to examine the role of major fault zones during cooling. Our observations indicate that cooling following the ∼2500 Ma Sleaford Orogeny and ∼1700 Ma Kimban Orogeny is restricted to the Christie and Wilgena Domains of the central northern Gawler Craton. The northern Gawler Craton mainly records post-Hiltaba Event (∼1590 Ma) U–Pb cooling ages. Cooling following the ∼1560 Ma Kararan Orogeny is preserved within the Coober Pedy Ridge, Nawa Domain and along major shear zones within the south-western Fowler Domain. The Nawa Domain samples preserve U–Pb cooling ages that are >150 Ma younger than the samples within the Coober Pedy Ridge and Fowler Domain, indicating that later (∼1300 Ma) fault movement within the Nawa Domain facilitated cooling of these samples, caused by arc collision in the Madura Province of eastern Western Australia. When compared to 40 Ar/ 39 Ar from muscovite, biotite and hornblende, our new apatite U–Pb ages correlate well, particularly in regions of higher data density. Our data also preserve a progressive younging of U–Pb ages from the nucleus of the craton to the periphery with a stark contrast in U–Pb ages across major structures such as the Karari Shear Zone and the Southern Overthrust, which indicates the timing of reactivation of these major crustal structures. Although this interpolation was based solely on thermochronological data and did not take into account structural or other geological data, these maps are consistent with the structural architecture of the Gawler Craton and reveal the thermal footprint of known tectonic and magmatic events in the Gawler Craton. Graphical abstract
    Print ISSN: 1674-9871
    Topics: Geosciences
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  • 8
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: 1 March 2018 Source: Fuzzy Sets and Systems, Volume 334 Author(s): Dragan Jočić, Ivana Štajner-Papuga The issue of conditional distributivity, or how it is also called, restricted distributivity, which is a form of relaxed distributivity on the restricted domain, is crucial for many different areas such as utility theory and integration theory. The focus of this paper is on this specific form of distributivity for a continuous semi-t-operator with respect to a continuous t-conorm and for a continuous semi-t-operator with respect to a uninorm of the form U min or U max with continuous underlying t-norm and t-conorm.
    Print ISSN: 0165-0114
    Electronic ISSN: 1872-6801
    Topics: Mathematics
    Published by Elsevier
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  • 9
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: Available online 3 January 2018 Source: Protein Expression and Purification Author(s): Prachi Pathak, Ashu Kumar, Prabhu Prasad Sarangi, Sameer Bhagyawant, Duraipandian Thavaselvam Brucellosis is a zoonotic disease caused by various species of the genus Brucella . The control of disease mainly depends on its accurate and early diagnosis. Culture methods employed for diagnosis are time consuming and require well equipped biosafety level 3 laboratories and hence serological tests are favored alternative for brucellosis diagnosis. At present serological diagnosis is based on LPS (lipopolysaccharide) which is less specific as the LPS antigen of Brucella species shows cross reactivity with other gram-negative bacteria. There is a need to develop serological diagnostic assay based on purified recombinant antigen of Brucella. T4SS (Type IV Secretion System) is an important virulent factor of Brucella and required for infection suggesting their expression in vivo and can be targeted as serological marker for infection . To test this concept, the present study is designed to clone, express and purify virB10 gene of Brucella T4SS under denaturing conditions and to evaluate its use as serological marker of Brucella infection. The immunoreactivity of this recombinant antigen was checked with antisera collected after experimental infection in Balb/C mice with B. melitensis 16M, BR31 (human clinical isolate) and Y. enterocolitica O:9 . The recombinant protein was also tested against a panel of 46 bovine sera samples collected from Leh, India. Antibody response against VirB10 was detected in experimental and natural host suggesting that it can be explored as potential target for serodiagnosis of Brucella infection.
    Print ISSN: 1046-5928
    Electronic ISSN: 1096-0279
    Topics: Biology , Medicine
    Published by Elsevier
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  • 10
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: Available online 4 January 2018 Source: SoftwareX Author(s): Paul Bauer, Alexandre Barrozo, Miha Purg, Beat Anton Amrein, Mauricio Esguerra, Philippe Barrie Wilson, Dan Thomas Major, Johan Åqvist, Shina Caroline Lynn Kamerlin Atomistic simulations have become one of the main approaches to study the chemistry and dynamics of biomolecular systems in solution. Chemical modelling is a powerful way to understand biochemistry, with a number of different programs available to perform specialized calculations. We present here Q6, a new version of the Q software package, which is a generalized package for empirical valence bond, linear interaction energy, and other free energy calculations. In addition to general technical improvements, Q6 extends the reach of the EVB implementation to fast approximations of quantum effects, extended solvent descriptions and quick estimation of the contributions of individual residues to changes in the activation free energy of reactions.
    Electronic ISSN: 2352-7110
    Topics: Computer Science
    Published by Elsevier
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  • 11
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: February 2018 Source: Transportation Research Part B: Methodological, Volume 108 Author(s): Chuan-Yao Li, Hai-Jun Huang The flow congestion model provides a realistic form of depicting congestion by considering the spatial dynamic characteristics of traffic flow. For reducing the complication of analysis, previous studies adopted the α − β − γ preference of travel time, arrival early and late penalties. This handling method destroys the continuity of user equilibrium (UE) inflow rate as pointed out by Li and Huang (2017). In this paper, we investigate the single-entry traffic corridor with continuous scheduling preference (CSP) and develop a customized method to find the computational solution of UE flow pattern. Analytical and numerical results show that the introduction of CSP lets inflow rate of early arrivals first increase then decrease. This extends the knowledge given by classical bottleneck model and flow congestion model with α − β − γ preference. Another finding is that, even though the introduction of CSP can smooth inflow rate at departure time of the punctual commuter and make the UE flow pattern more stable, a series of shock waves still exist.
    Print ISSN: 0191-2615
    Electronic ISSN: 1879-2367
    Topics: Architecture, Civil Engineering, Surveying , Economics
    Published by Elsevier
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  • 12
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: February 2018 Source: Transportation Research Part B: Methodological, Volume 108 Author(s): Qinglong Yan, Zhe Sun, Qijian Gan, Wen-Long Jin The existence of stationary states during peak periods has been an underlying assumption of many studies on analysis, operations, control, and management of transportation networks. In Cassidy (1998), a method was proposed to manually identify near-stationary states by visually inspecting transformed curves of cumulative total vehicle counts and occupancies. Such near-stationary states are important for calibrating fundamental diagrams, identifying active bottlenecks and incidents, and quantifying capacity drop magnitudes. To the best of our knowledge, however, there lacks an automatic method that can be applied to efficiently identify near-stationary states from a large amount of data. In this study, we attempt to fill this gap. We start with definitions of steady, stationary, and equilibrium states and discuss their relations. Then we present a novel four-step method for automatically identifying near-stationary states from raw loop-detector data: first, the raw data are pre-processed to obtain healthy datasets, fill in missing values, and normalize averaged vehicle counts and occupancies to the same scale; second, daily time series are partitioned into multiple candidate intervals based on the pruned exact linear time (PELT) changepoint detection method; third, the characteristics of the candidate intervals are calculated; and finally, near-stationary states are selected based on modified Cassidy’s gap and duration criteria. We further close the loop by presenting an algorithm to automatically determine the penalty threshold in the second step and the gap threshold in fourth step to ensure the quantity as well as the quality of identified near-stationary states. In a case study, we apply the proposed method to identify near-stationary states from a large set of 30-s raw loop-detector data at a freeway mainline station. We verify the validity of identified near-stationary states both directly and indirectly. The results show that the identified near-stationary states are valid with high quality and the calibrated triangular fundamental diagram is well-fitted and physically meaningful. We finally conclude by discussing some future improvements and potential applications.
    Print ISSN: 0191-2615
    Electronic ISSN: 1879-2367
    Topics: Architecture, Civil Engineering, Surveying , Economics
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  • 13
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    Elsevier
    Publication Date: 2018-01-06
    Description: Publication date: May 2018 Source: Applied Mathematics Letters, Volume 79 Author(s): Jitsuro Sugie, Kazuki Ishibashi The purpose of this paper is to provide an oscillation theorem that can be applied to half-linear differential equations with time-varying coefficients. A parametric curve by the coefficients is focused in order to obtain our theorem. This parametric curve is a generalization of the curve given by the characteristic equation of the second-order linear differential equation with constant coefficients. The obtained theorem is proved by transforming the half-linear differential equation to a standard polar coordinates system and using phase plane analysis carefully.
    Print ISSN: 0893-9659
    Electronic ISSN: 1873-5452
    Topics: Mathematics
    Published by Elsevier
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  • 14
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    Elsevier
    Publication Date: 2018-01-06
    Description: Publication date: May 2018 Source: Applied Mathematics Letters, Volume 79 Author(s): Duanmei Zhou, Guoliang Chen, Gaohang Yu, Jian Zhong We study the commuting solutions of the Yang–Baxter matrix equation A X A = X A X when A is an arbitrary square matrix. By characterizing its commuting solutions based on projection matrices, we show that projections can be determined by using the generalized eigenspaces corresponding to the eigenvalues of A . Therefore, commuting solutions can be constructed explicitly. Our results are more general than those obtained recently by Dong (2017), Ding and Zhang (2014), and Ding and Rhee (2013).
    Print ISSN: 0893-9659
    Electronic ISSN: 1873-5452
    Topics: Mathematics
    Published by Elsevier
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  • 15
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    Elsevier
    Publication Date: 2018-01-06
    Description: Publication date: May 2018 Source: Ecological Economics, Volume 147 Author(s): Fatemeh Bakhtiari, Jette Bredahl Jacobsen, Bo Jellesmark Thorsen, Thomas Hedemark Lundhede, Niels Strange, Mattias Boman
    Print ISSN: 0921-8009
    Electronic ISSN: 1873-6106
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 16
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    Elsevier
    Publication Date: 2018-01-06
    Description: Publication date: May 2018 Source: Ecological Economics, Volume 147 Author(s): Jérôme Ballet, Lucile Marchand, Jérôme Pelenc, Robin Vos The capability approach and the ecosystem services approach have experienced a rapprochement in recent years, evidenced in particular by the publication of several papers in Ecological Economics . Our article advances this rapprochement by embedding the concepts of identity and aspirations. First, we argue that a further set of components should be integrated into the framework: the aspirations set. Second, we argue that a new component within this set i.e. a personal identity conversion factor, must be added to the capability approach so that an integrated analysis framework can be developed. This component derives from the personal identity capability and the aspirations window, both of which are related to cultural ecosystem services. Our analytical framework then highlights all the ambiguity associated with this conversion factor, which can either be a negative or a positive factor in environmental protection.
    Print ISSN: 0921-8009
    Electronic ISSN: 1873-6106
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 17
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    Elsevier
    Publication Date: 2018-01-06
    Description: Publication date: May 2018 Source: Ecological Economics, Volume 147 Author(s): Mairi-Jane V. Fox, Jon D. Erickson The Genuine Progress Indicator (GPI) was designed to reveal the economic, social, and environmental trade-offs associated with conventional economic growth as traditionally measured by Gross Domestic Product (GDP). Although originally designed for use at the national scale, an interest has developed in the United States in a state-level uptake of the GPI to inform and guide policy. This study presents the first fifty-state estimate for U.S. GPI in order to address questions over its design, implementation, and ultimate potential as a tool to guide state-level economic policy. Following a review of the current state of analysis and critique of GPI, we provide an overview of methodology and database development. Results are then presented, including discussion of lessons learned through a fifty-state application. The paper concludes with suggestions for further research and next steps to consolidating a consistent methodology.
    Print ISSN: 0921-8009
    Electronic ISSN: 1873-6106
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 18
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: Available online 3 January 2018 Source: Technological Forecasting and Social Change Author(s): Abdul-Nasser El-Kassar, Sanjay Kumar Singh Faced with internal and external pressure to adapt and implement environmental friendly business activities, it is becoming crucial for firms to identify practices that enhance their competitive advantage, economic, and environmental performance. Green innovation, green technologies, and the implementation of green supply chain management are examples of such practices. Green innovation and the adoption of the combination of green product innovation and green process innovation involve reduction in consumption of energy and pollution emission, recycling of wastes, sustainable utilization of resources, and green product designs. Although the extent research in this area is substantial, research on the importance of considering corporate environmental ethics, stakeholders view of green product, and demand for green products as drivers of green innovation must be conducted. Moreover, the role of large scale data, management commitment, and human resource practices play to overcome the technological challenges, achieve competitive advantage, and enhance the economic and environmental performance have yet to be addressed. This paper develops and tests a holistic model that depicts and examines the relationships among green innovation, its drivers, as well as factors that help overcome the technological challenges and influence the performance and competitive advantage of the firm. This paper is among the first works to deal with such a complex framework which considers the interrelationships among numerous constructs and their effects on competitive advantage as well as overall organizational performance. A questionnaire was designed to measure the influence of green innovation adoption/implementation and its drivers on performance and competitive advantage while taking into consideration the impact of management commitment and HR practices, as well as the use of large data on these relationships. Data collected from a sample of 215 respondents working in Middle East and North Africa (MENA) region and Golf-Cooperation Countries (GCC) were used to test the proposed relationships. The proposed model proved to be fit. The hypotheses were supported, and implications were discussed.
    Print ISSN: 0040-1625
    Electronic ISSN: 1873-5509
    Topics: Sociology , Technology
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  • 19
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    Elsevier
    Publication Date: 2018-01-05
    Description: Publication date: February 2018 Source: Transportation Research Part B: Methodological, Volume 108 Author(s): Daniel Hörcher, Daniel J. Graham This paper investigates multi-period public transport supply, i.e. networks in which capacity cannot be differentiated between links and time periods facing independent but nonidentical demand conditions. This setting is particularly relevant in public transport, as earlier findings on multi-period road supply cannot be applied when the user cost function, defined as the sum of waiting time and crowding costs, is nonhomogeneous. The presence of temporal, spatial and directional demand imbalances is unavoidable in a public transport network. It is not obvious, however, how the magnitude of demand imbalances may affect its economic and financial performance. We show in a simple back-haul setting with elastic demand, controlling for total willingness to pay in the network, that asymmetries in market size reduce the attainable social surplus of a service, while variety in maximum willingness to pay leads to higher aggregate social surplus and lower subsidy under efficient pricing. The analysis of multi-period supply sheds light on the relationship between urban structure, daily activity patterns, and public transport performance.
    Print ISSN: 0191-2615
    Electronic ISSN: 1879-2367
    Topics: Architecture, Civil Engineering, Surveying , Economics
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  • 20
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    Elsevier
    Publication Date: 2018-01-07
    Description: Publication date: May 2018 Source: Ecological Economics, Volume 147 Author(s): John K. Pattison-Williams, John W. Pomeroy, Pascal Badiou, Shane Gabor This paper applies a social return on investment (SROI) analysis to the issue of flood control and wetland conservation in the Smith Creek basin of southeastern Saskatchewan, Canada. Basin hydrological modeling applied to wetland loss and restoration scenarios in the study area provides local estimates of the ecosystem service (ES) provision related to flood control and nutrient removal. Locally appropriate monetary values are applied to these services to gauge the cost effectiveness of wetland conservation funding at two levels: flood control capacity alone and then incorporating a suite of ES. SROI ratios for flood control alone provide ratios between 3.17 (retention) and 0.80 (full restoration) over 30 years; when other ES are included, the ratios increase, ranging from 7.70 (retention) to 2.98 (full restoration) over 30 years. Retention of existing wetlands provides the highest SROI and therefore we argue that government policy should focus on preventing further loss of wetlands as a strategic investment opportunity. Overall, these results indicate that wetland retention is an economically viable solution to limit the financial, social and environmental damages of flooding in Saskatchewan specifically and the Prairie Pothole Region (PPR) generally.
    Print ISSN: 0921-8009
    Electronic ISSN: 1873-6106
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 21
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    Elsevier
    Publication Date: 2018-01-07
    Description: Publication date: April 2018 Source: Energy Policy, Volume 115 Author(s): Fateh Belaïd, Salomé Bakaloglou, David Roubaud Energy policymakers are increasingly concerned about energy efficiency improvements, as such improvements are considered to be a key strategy in reducing energy demand in the residential sector. However, energy efficiency investments may not yield the expected energy-savings due to the rebound effect concept, which leads to lower savings than expected when energy-efficiency increases. Using the standard OLS regression and autoregressive distributed lag cointegration (ARDL) approach, this paper provides estimates of the magnitude of the rebound effect for residential gas consumption in France. Using 1983–2015 annual time-series data, the methodology is based on estimates of the gas demand elasticity with respect to service price. The empirical findings indicate that the variables used in the model are cointegrated and suggest the presence of an obvious rebound effect in residential gas use. More specifically, estimates of the direct rebound effect in residential gas demand are approximately 53% in the short-run and approximately 60% in the long-run. Our findings reject the hypothesis of a backfire effect regarding residential gas use in France and hence suggest incorporating carbon taxation, energy efficiency and alternative energy in the formulation of an energy-saving policy to facilitate the transition towards a low-carbon economy in France.
    Print ISSN: 0301-4215
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Political Science
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  • 22
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    Elsevier
    Publication Date: 2018-01-07
    Description: Publication date: April 2018 Source: Energy Policy, Volume 115 Author(s): M. Safari It is getting increasingly crucial for policymakers to acquire reliable price forecasts for battery electric vehicles (BEVs) to make choices and set priorities. Here, we examine the prospects for the wide deployment of BEVs, following an ex-post analysis of their learning rate and an ex-ante forecast of their price up to 2040. We make a clear distinction between the mainstream of BEVs and a hypothetical group of BEVs that are technically on a par with internal combustion vehicles (ICVs). To do so, we introduce a new index, in which the driving range and max-speed of a vehicle are coupled together, i.e., the Mobility-Diffusion coefficient. We highlight different shares of battery packs (i.e., 19 ± 1%), and the ensemble of electrification components (e.g., battery pack, electric motor, power electronics), i.e., electrification cost (52 ± 2%), in the price of a BEV. Our price projections suggest that there is no prospect of breakeven between BEVs and ICVs before 2040 for both groups of BEVs, because the current learning rates of 9 ± 2% and 15 ± 1% for the price and electrification costs, respectively, of BEVs. Strong and long-term support from policymakers is required to ensure competitiveness of BEVs with ICVs in the near future.
    Print ISSN: 0301-4215
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Political Science
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  • 23
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    Elsevier
    Publication Date: 2018-01-07
    Description: Publication date: March 2018 Source: International Journal of Production Economics, Volume 197 Author(s): Fen Lu, He Xu, Pengyu Chen, Stuart X. Zhu We consider a firm who supplies two types of products: high-end and low-end. Because of the uncertainty in the production process, the yield rate of the high-end products is uncertain. The substandard high-end products caused by the yield uncertainty can be transformed into the low-end products with a certain cost. We characterize the optimal pricing and production decisions and develop an algorithm to compute the optimal solution. We also investigate the impact of the yield uncertainty on the firm's performance, and explore how stability of market demand, emergent fulfillment costs, and downconversion cost influence this effect. We find that (i) the profit of the firm deteriorates when the risk of the yield uncertainty is high. In the face of yield uncertainty, the firm prefers to decrease (increase) the production quantity of the high-end (low-end) products; (ii) when the market demands are quite unstable, the emergent fulfillment costs are low, or the downconversion cost is high, the firm has a low incentive to eliminate the yield uncertainty.
    Print ISSN: 0925-5273
    Electronic ISSN: 1873-7579
    Topics: Technology , Economics
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  • 24
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    Elsevier
    Publication Date: 2018-01-07
    Description: Publication date: Available online 6 January 2018 Source: International Journal of Production Economics Author(s): Gopalakrishnan Narayanamurthy, Anand Gurumurthy, Nachiappan Subramanian, Roger Moser We develop a lean readiness framework and an assessment methodology to quantify the readiness of healthcare institutions for implementing lean. We use stakeholder theory and work with a lean implementation team responsible for process improvement in a healthcare group to develop the framework. The framework uses fuzzy based input derived from the stakeholders of the healthcare institution to generate an overall ranking through ideal solution technique. The assessment method derives input from the readiness scores shared by various stakeholders. The ranking suggests future improvement areas to prepare the healthcare institution for a lean implementation project. We provide an alternative perspective of assessing the lean readiness of healthcare institutions before beginning a lean implementation project for both researchers and practitioners. Our research is the first to develop a lean readiness framework for healthcare institutions and demonstrate it using an assessment technique.
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    Electronic ISSN: 1873-7579
    Topics: Technology , Economics
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Data in Brief, Volume 16 Author(s): Michele A. De Santis, Ondrej Kosik, Diana Passmore, Zina Flagella, Peter R. Shewry, Alison Lovegrove The data presented are related to the research article entitled “Comparison of the dietary fibre composition of old and modern durum wheat ( Triticum turgidum spp. durum ) genotypes” (De Santis et al., 2018) [1] . This article provides details of the structures of the major dietary fibre components, arabinoxylan and β-glucan, in semolina and wholemeal flour of old and modern Italian durum wheat genotypes grown in two seasons, determined by enzyme digestion followed by high-performance anion-exchange chromatography (enzyme fingerprinting).
    Print ISSN: 2352-3409
    Topics: Biology
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  • 26
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    Publication Date: 2018-01-07
    Description: Publication date: Available online 6 January 2018 Source: Journal of the Franklin Institute Author(s): Shiqi Zheng, Wenjie Li This paper concentrates on computing the stabilizing region of PD μ controller for fractional order system with general interval uncertainties and an interval delay . The stabilizing region means the complete/approximate set of PD μ controllers that stabilize the given closed-loop control system. General interval uncertainties refer to both coefficients and orders of the fractional system suffer from interval uncertainties. Interval delay indicates that the delay also vary in a specified interval. Firstly, a method is presented to calculate the stabilizing region for general interval fractional system with an interval time-constant delay . Based on a novel mapping function and the concept of critical controller parameters, the stabilizing region can be determined numerically. Secondly, the stabilizing region computation problem for general interval fractional system with an interval time-varyingdelay is considered. By applying a revised small-gain theorem, the stabilizing region can be calculated like the time-constant delay case. Thirdly, two alternative methods are proposed to improve the computational efficiency of stabilizing region calculation. Both methods can reduce the number of polynomials which are used to determine the stabilizing region. Examples are followed to illustrate the proposed results.
    Print ISSN: 0016-0032
    Electronic ISSN: 1879-2693
    Topics: Mathematics , Technology
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    Publication Date: 2018-01-07
    Description: Publication date: Available online 6 January 2018 Source: Journal of the Franklin Institute Author(s): Xueyan Yang, Xiaodi Li, Jinde Cao The problem of robust finite-time stability (RFTS) for singular nonlinear systems with interval time-varying delay is studied in this paper. Some delay-dependent sufficient conditions of RFTS are derived in the form of the linear matrix inequalities (LMIs) by using Lyapunov-Krasovskii functional (LKF) method and singular analysis technique. Two examples are provided to show the applications of the proposed criteria.
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    Topics: Mathematics , Technology
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  • 28
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Jie Tang, Dian Jiao, Lei Zhang, Xuezhen Zhang, Xiaoxia Xu, Cong Yao, Jihuai Wu, Zhang Lan NiO is an important hole-transporting material for preparing inverted planar perovskite solar cells (PSCs). Apart from some complicated preparation methodologies such as doping routes, pulsed laser deposition, atomic layer deposition and high temperature spray pyrolysis, the simpler solution-processed method can also achieve high-quality NiO hole-transporting layers for efficient inverted planar PSCs. One of the prerequisites for solution-processed high-quality NiO hole-transporting layers is pre-synthesized highly crystalline NiO nanocrystals (NCs). Here, we use the sophisticated solvothermal method to synthesize highly crystalline NiO NCs. The oleylamine ligands are used to well control the nucleation and growth of NiO NCs and achieve good colloidal stability in toluene, which make for high-quality NiO hole-transporting layers by solution process. The related measurements and analysises reveal that the as-prepared NiO hole-transporting layer shows faster hole extraction, more effectively suppressed recombination and fewer surface trap states than the typical poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonic acid) hole-transporting layer, finally contributing to superior photovoltaic performance of the corresponding device. This work highlights the feasibility of colloidal chemical synthetic route for pre-synthesizing highly crystalline and well dispersed semiconductor NCs suitable for preparing efficient PSCs by the simple solution-processed protocol.
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 29
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Mansour Alramlawi, Aouss Gabash, Erfan Mohagheghi, Pu Li In many developing countries where the energy supply capacity is less than the demand, energy companies distribute the available power according to a specific time schedule, leading to grid scheduled blackouts (GSBs) for the costumers. A suitable way to solve this problem for residential loads is to install a combined photovoltaic (PV) and battery storage system as a replacement of the grid during the blackout periods. However, it is well-known that the lifetime of battery storage will be considerably shortened, if it is not operated appropriately. This paper explores the potential benefits of applying economic model predictive control (EMPC) to optimize the operation of a hybrid PV-battery system to address the GSB problem. The aim of our control strategy is to cover the load as much as possible and meanwhile minimize the total cost of the energy consumed from the grid. In particular, the battery is operated in such a way that its lifetime will be prolonged. A comparison between different operation strategies for the system considering the seasonal variation in the load and the PV power generation is made. The results show that the proposed approach leads to a significant reduction of the total energy consumed from the grid while decreasing the curtailment of the generated power from the PV-array, and maximizing the battery lifetime. Graphical abstract
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 30
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Tingting Zhang, Jinke Bai, Peizhi Yang, Feng Li, Xiao Jin, Qin Zhang, Qinghua Li Bifacial solar cells that can generate electricity from either front or rear side are regarded as advanced photovoltaics for markedly increased photoelectric conversion efficiency. We present here the fabrication of transparent RuSe counter electrodes by an alternating electrodeposition method for bifacial dye-sensitized solar cells (DSSCs). The catalytic and photovoltaics performances are maximized by tuning stoichiometric Ru/Se ratio and bilayer number. Upon irradiation by AM1.5 (100 mW cm −2 ), the device yields a maximized front efficiency of 8.72% and a rear efficiency of 5.9%, arising from the >80%-transparency of RuSe electrode in visible light region. This strategy provides new opportunities for fabricating high-performance DSSCs.
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 31
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Z. Abdin, C.J. Webb, E.MacA. Gray Large photovoltaic arrays are becoming common as the world moves to replace fossil-fuelled electricity generators. As the array size and project cost increase, it becomes increasingly important to know accurately what the array’s performance will be before it is built. Large arrays inevitably contain modules with a spread of performance characteristics such as short-circuit current and open-circuit voltage, and suffer from temperature differences between modules. In this first study of these problems, a model has been developed that accurately predicts the behaviour of a photovoltaic array subject to variability between modules and inhomogeneity of cell temperature across the array. The model was applied to a real rooftop array consisting of 912 modules (298 kW nominal peak power). Based on measured string currents, the predicted average string temperature was compared the temperature measured by a radiometric survey using a drone-mounted IR camera and matched very well. The five-parameter model of cell I - V characteristics was fitted to manufacturer’s data, with highest weighting given to the region around the maximum-power point (MPP) where a real array should operate via active MPP tracking. The model was used to explore separately the effects of a spread in module characteristics arising in the manufacturing process and of temperature inhomogeneity across the array. The current in each module of a string was constrained to be the same, and the voltage of every parallel-connected string was also constrained to be the same. These constraints lead to greater power loss than is predicted based on an average module at an average temperature. Compared to a hypothetical array assembled from identical average modules at the same average temperature, variability caused a loss of power of about 2%, depending on the detailed form of the distribution function chosen to represent the spread of characteristics in the manufacturer’s tolerance band. As a rule of thumb, de-rating the maximum power to the lower end of the manufacturer’s tolerance band is recommended to account for module variability during the design phase. The effect of temperature inhomogeneity is more serious, because temperature affects V oc strongly, causing parallel-connected strings to be pulled away from their ideal operating points to obey the constraint of equal voltage. A modest 10 °C temperature gradient across the studied array was predicted to cause about a 4% loss of power at the MPP. Much higher real temperature differences could be expected in summer and were observed. The study confirmed that temperature inhomogeneity poses a serious design problem for large arrays, requiring careful thermal design to achieve not only acceptably low average array temperature, but also the least possible temperature spread.
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  • 32
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Ting-Chun Wang, Hsin-Ying Lee, Ching-Ting Lee, Yu-Chin Cheng, Hung-Wei Chen In this work, the textured surface of the multi-crystalline silicon (mc-Si) wafers sliced by the diamond wire sawing (DWS) technique was formed using the X-Y axis micro-pressure sandblast treatment and the acidic texturing process. From the scanning electron microscopy (SEM) images, the X-Y axis micro-pressure sandblast treated DWS-sliced mc-Si wafers could effectively remove the saw marks caused by the fixed diamond abrasives. Furthermore, the textured surface of the acidic-textured DWS-sliced mc-Si wafers was also observed in the SEM images. Besides, using the X-Y axis micro-pressure sandblast treatment, the average reflectivity of the DWS-sliced mc-Si wafers was reduced from 28.94% to 22.28%. Consequently, the short-circuit current of 8.70 A and the power conversion efficiency of 17.92% for the DWS-sliced mc-Si solar cells with micro-pressure sandblast treatment were respectively better than 8.59 A and 17.35% in comparison with the DWS-sliced mc-Si solar cells without micro-pressure sandblast treatment.
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Omid Farhangian Marandi, Mohammad Ameri, Behrouz Adelshahian In this manuscript, a solar cavity packed with hybrid PV-TEG modules has been designed, fabricated and investigated experimentally. Reducing the re-radiation loss of solar radiative power in a cavity receiver has led to an increase in module temperature. TEG modules convert directly heat into electricity using Seebeck effect induced by a temperature difference between them. They were utilized to decrease the PV module temperature and generate extra power. The device was subjected to a simulated solar radiation of 1000 W/m 2 over its aperture in a laboratory environment. It was also tested under solar irradiance which varied during daily hours. The efficiency of the hybrid system reached a peak of 21.9% at the start of production in the morning when the system was under real sunlight exposure. The significant part of power produced by the PV panels which was strongly affected by the temperature increase, and it consequently caused the efficiency drop despite the solar irradiance and ambient temperature enhancement. However, during the afternoon, as the ambient temperature and solar irradiance decreased, the efficiency increased to 20%. The measurements of the current and voltage of the system have revealed that the hybrid PV-TEG power generation is three times greater than a flat PV-TEG system power production. The hybrid cavity PV-TEG efficiency improvement has been 18.9% in comparison with the conventional system, whereas the economic analysis of the cavity system has shown that the levelized cost of energy (LCOE) is 9.432 US $/kWh which is 67% greater than the PV-TEG flat plate LCOE.
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Shilpi Shital, Sanjay Kumar Swami, Piers Barnes, Viresh Dutta Bifacial dye sensitized solar cells (DSSCs) show potential for use in diffuse and low light environments, but their photoanode light scattering properties have not been optimised. We examine DSSC photoanodes composed of a mixed scattering layer (made by blend of 18NR-T and WER2-O pastes), sandwiched between nanostructured TiO 2 layers (made by 18NR-T paste). WER2-O paste was chossen after accessing scattering properties: scattering coefficient (S), forward scattering ratio (FSR) and forward path length enhancement (FPLE) of the solid TiO 2 particles of different shapes and sizes. Monte Carlo simulations of light harvesting indicate the optimal volume fraction of scattering particles ( f vsca ) in the sandwiched layer to be 5–30%. The proposed photoanode absorbs light effectively and the DSSC with scattering layer made by blend of 60% of 18NR-T and 40% of WER2-O paste showed the power conversion efficiency (PEC) of 8.54% and 5.26%, when illuminated from photoanode (PA) and counter electrode (CE) side, respectively. The effective sorting criteria and optimization routine used in this work can also be used for other devices like perovskite solar cells. Graphical abstract
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  • 35
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    Publication Date: 2018-01-07
    Description: Publication date: February 2018 Source: Solar Energy, Volume 161 Author(s): Kalpana Galappaththi, Piyasiri Ekanayake, Mohammad Iskandar Petra We have computationally designed and characterized a series of new organic D−π−A architected dyes that have originated from cyanidin, which is vastly available in nature, for effective sensitization of DSSCs with absorption spectra extending up to near infrared region. Cyanidin acts as the donor group while cyanoacrylic acid and thieno [3, 2-b] thiophene are employed as the acceptor and π-spacer, respectively. Sensitization performance, depending on the substituted position of the π-spacer-acceptor (π-A) combination on cyanidin molecule, is examined by the results of density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. The calculated data of free energy change driving force ( Δ G inject ), electron regeneration driving force ( Δ G regen ), open circuit potential eV OC and light harvesting efficiency (LHE) suggest two preferred substitutions of π-A combination to cyanidin molecule that leads to an efficient DSSC. At LUMO the designed sensitizers have denser electron cloud towards acceptor group that leads to an efficient electron injection process. All π-A substitutions resulted a broader absorption spectrum with a redshift up to 2500 nm which is a significant improvement compared to the vast majority of reported sensitizers. Graphical abstract
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 36
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    Publication Date: 2018-01-08
    Description: Publication date: February 2018 Source: Transportation Research Part B: Methodological, Volume 108 Author(s): Pablo C. Guedes, Denis Borenstein The multiple-depot vehicle type rescheduling problem (MDVTRSP) is a dynamic extension of the classic multiple-depot vehicle scheduling problem (MDVSP), where a heterogeneous fleet is considered. The MDVTRSP consists of finding a new schedule given that a severe disruption occurred in previously scheduled trips very quickly, simultaneously minimizing the transportation costs and the deviations from the original plan. Although several mathematical formulations and solution methods have been developed for the robust MDVTRSP, the real time MDVTRSP is still unexplored. In this paper, we introduce a formulation of the problem and develop a heuristic solution method, employing time-space network, truncated column generation, and preprocessing procedures. The solution method has been implemented in several algorithm variants, combining different developed preprocessing methods. Computational experiments on randomly generated instances were performed to evaluate the performance of the developed algorithms. The best solutions concerning efficiency and efficacy were obtained by the variants considering state space reductions to accelerate the convergence process of the column generation. Solutions were obtained very quickly (in less than 150 seconds for large instances, considering up to 2500 trips, eight depots, and one breakdown. The developed heuristics also presented a good behavior for several simultaneous disruptions, solving the problem with a little increase (less than 8.5%, on average) in the required CPU time. A case study using data from a real-life small instance in Brazil also demonstrated the efficiency and efficacy of the approach when compared with manual planning strategies.
    Print ISSN: 0191-2615
    Electronic ISSN: 1879-2367
    Topics: Architecture, Civil Engineering, Surveying , Economics
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    Publication Date: 2018-01-08
    Description: Publication date: February 2018 Source: Transportation Research Part F: Traffic Psychology and Behaviour, Volume 53 Author(s): Predrag Stanojević, Timo Lajunen, Dragan Jovanović, Paul Sârbescu, Svilen Kostadinov Using data from three samples and more than 1000 participants, this study have examined the psychometric properties of the Driver Behaviour Questionnaire (DBQ) in three countries from South-East Europe. Differences in driving behaviour between countries were also investigated. Exploratory factor analysis results supported the distinction between errors and violations in all three countries. Furthermore, the positive associations of both errors and violations with self-reported traffic accidents were also consistent in all three samples. In terms of differences in driving behaviour, Romanian drivers scored higher on many error and violation items in comparison to the other two countries. Also, speeding violations were the most common violations in all three countries. Overall, our results provide further support for using the DBQ to measure aberrant (i.e. errors and violations) driver behaviour.
    Print ISSN: 1369-8478
    Electronic ISSN: 1873-5517
    Topics: Psychology
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    Publication Date: 2018-01-09
    Description: Publication date: March 2018 Source: International Journal of Production Economics, Volume 197 Author(s): Navid Sahebjamnia, S. Ali Torabi, S. Afshin Mansouri The increasing number of natural and man-made hazards is forcing organizations to build resilience against numerous types of disruptions that threaten continuity of their business processes. This paper presents an integrated business continuity and disaster recovery planning (IBCDRP) model to build organizational resilience that can respond to multiple disruptive incidents, which may occur simultaneously or sequentially. This problem involves multiple objectives and accounts for inherent epistemic uncertainty in input data. A multi-objective mixed-integer robust possibilistic programming model is formulated, which accounts for sensitivity and feasibility robustness. The model aims to plan both internal and external resources with minimal resumption time, restoration time, and loss in the operating level of critical functions by making tradeoffs between required resources for continuity plans, recovery time, and the recovery point. A real case study in a furniture manufacturing company is conducted to demonstrate the performance and applicability of the proposed IBCDRP model. The results confirm the capability of the proposed model to improve organizational resilience. In addition, the proposed model demonstrates the interaction between the organizational resilience and required resources, particularly in respect to the total budget and external resources, which is necessary for developing continuity and recovery strategies.
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    Topics: Technology , Economics
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    Publication Date: 2018-01-09
    Description: Publication date: Available online 8 January 2018 Source: Journal of the Franklin Institute Author(s): Jian-Chen Liu Based on the generalized probability-interval-decomposition approach, the delay-dependent stability analysis for a class of T-S fuzzy systems with stochastic delays is investigated. The information of the probability distribution of stochastic delay is fully exploited and a series of sufficient stability criteria are obtained. A rigorous mathematical proof is provided that the conservatism of the proposed stability criteria can be reduced progressively by increasing the number of the probability interval. Based on this, a novel hierarchy of LMI conditions is established. It is rigorously proved that with the same decomposition of probability interval, the conservatism of the proposed stability criteria is less than the one obtained by time-varying delay decomposition approach. The computation burden of the proposed method is analyzed and compared with the one of the time-varying delay decomposition approach. Finally, a numerical example is given to illustrate the validness and effectiveness of the proposed approach.
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    Topics: Mathematics , Technology
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Applied Mathematics Letters, Volume 79 Author(s): Won-Kwang Park Various studies have confirmed the possibility of identifying the location of a set of small inhomogeneities via a direct sampling method; however, when their permeability differs from that of the background, their location cannot be satisfactorily identified. However, no theoretical explanation for this phenomenon has been verified. In this study, we demonstrate that the indicator function of the direct sampling method can be expressed by the Bessel function of order one of the first kind and explain why the exact locations of inhomogeneities cannot be identified. Numerical results with noisy data are exhibited to support our examination.
    Print ISSN: 0893-9659
    Electronic ISSN: 1873-5452
    Topics: Mathematics
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Applied Mathematics Letters, Volume 79 Author(s): Klemens Fellner, Michael Kniely We consider a Shockley–Read–Hall recombination–drift–diffusion model coupled to Poisson’s equation and subject to boundary conditions, which imply conservation of the total charge. As main result, we derive an explicit functional inequality between relative entropy and entropy production rate, which implies exponential convergence to equilibrium with explicit constant and rate. We report that the key entropy–entropy production inequality ought rather not to be formulated on the states space of the parabolic–elliptic system, but on the reduced states space of the associated nonlocal drift–diffusion problem, where the Poisson equation is replaced by the corresponding Green function.
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Applied Mathematics Letters, Volume 79 Author(s): Chein-Shan Liu, Fajie Wang, Yan Gu The inverse Cauchy problem of Laplace equation is hard to solve numerically, since it is highly ill-posed in the Hadamard sense. With this in mind, we propose a natural regularization technique to overcome the difficulty. In the linear space of the Trefftz bases for solving the Laplace equation, we introduce a novel concept to construct the Trefftz energy bases used in the numerical solution for the inverse Cauchy problem of the Laplace equation in arbitrary star plane domain. The Trefftz energy bases not only satisfy the Laplace equation but also preserve the energy, whose performance is better than the original Trefftz bases. We test the new method by two numerical examples.
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Ecological Economics, Volume 147 Author(s): Jayash Paudel This paper evaluates the role of use of community-managed forests as a means of improving economic well-being of rural Nepalese households. It utilizes a nationwide survey consisting of detailed questionnaires related to household welfare and employs instrumental variable (IV) approach to investigate the linkage between community-managed forests and food consumption in Nepal. Results show that households that use community-managed forests for firewood spend significantly more on food consumption than those dependent on government-managed forests. The study further finds that community-managed forest users appear to be more participatory and are more likely to find their food consumption adequate. Together, these results provide compelling evidence that community-managed forests can be an effective means of addressing food insecurity in a developing country setting.
    Print ISSN: 0921-8009
    Electronic ISSN: 1873-6106
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: Energy Economics Author(s): Catherine Hausman Since 2000, around half of US nuclear power plants have changed ownership and entered competitive electricity generation markets. In past work I analyzed the impact of these changes on nuclear power plant safety. A recent replication study by Zhen Lei and Chen-Hao Tsai raises several issues, which I address in this comment.
    Print ISSN: 0140-9883
    Electronic ISSN: 1873-6181
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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    Publication Date: 2018-01-10
    Description: Publication date: April 2018 Source: Energy Policy, Volume 115 Author(s): Zongwei Liu, Han Hao, Xiang Cheng, Fuquan Zhao Energy efficient and new energy vehicles are key measures in addressing China's energy and environment problems. In terms of the prospect of different technologies, the industrial and academic circles have not reached a consensus yet. In this study, the current situation and future development of main technology pathways in China are discussed. Specifically, internal combustion engines will be simpler in the future as a result of electric motor coupling. Battery electric vehicles are faced with a certain challenges currently and should be adopted in smaller vehicles at first. Hybrid technologies should be considered a significant development stage and should be applied before 2018. Plug-in hybrid electric vehicles and extended range electric vehicles are different in essence and should be applied based on their original intentions. Fuel cell vehicles are confronted with multiple challenges currently and will probably popularize after 2025.
    Print ISSN: 0301-4215
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Political Science
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    Publication Date: 2018-01-10
    Description: Publication date: October 2017 Source: Global Ecology and Conservation, Volume 12
    Print ISSN: 2351-9894
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: International Journal of Production Economics Author(s): Andrew S. Manikas, James R. Kroes, Thomas F. Gattiker Lean is one of the most pervasive and powerful paradigms in Operations and Supply Chain Management. As a theory, lean has been well tested in manufacturing. Lean in retail has received less attention. There is good reason to think that seminal constructs from lean, such as inventory slack reduction and capacity slack reduction, may explain a great deal of the variance in retail firm performance. Therefore this paper tests lean-based propositions pertaining to the relationships between inventory slack, capacity slack, market instability and firm market performance. Using retail firm data from a 35 year period, we find that lean thinking in its basic unadorned form helps explain retail performance remarkably well. From both a snapshot and quarterly difference perspective and regardless of whether we look at capacity slack or inventory slack, lean produces superior, lasting returns for retailers.
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    Topics: Technology , Economics
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    Elsevier
    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: International Journal of Production Economics Author(s): Kanchan Das Lean based systems include several practices and tools that have the potential to facilitate an organization to be economically, environmentally, and socially sustainable. The objective of this research is to integrate applications of lean systems in the design and planning model of a supply chain to improve sustainability performances of the overall business. The study defines and identifies antecedents, enablers, and ingredients of sustainable supply chain based on the literature. It also identifies practices and outcomes of Lean based systems that may be applied to supply chain functions in the perspectives of established sustainability criteria. Such practices and outcomes of lean based systems are then incorporated in the design of a sustainable supply chain to become enabler, antecedents or ingredients of sustainability to improve overall business performances. A numerical example illustrates the applicability of the approach.
    Print ISSN: 0925-5273
    Electronic ISSN: 1873-7579
    Topics: Technology , Economics
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Journal of Pure and Applied Algebra, Volume 222, Issue 5 Author(s): Fares Maalouf We show that if k is an infinite field, then there exists a subspace W ⊂ k N of dimension | k | ℵ 0 , such that no nonzero member of W has infinitely many zeros. This generalizes a result from a paper by Bergman and Nahlus, and partly answers another question from the same paper.
    Print ISSN: 0022-4049
    Electronic ISSN: 1873-1376
    Topics: Mathematics
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  • 50
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Journal of Pure and Applied Algebra, Volume 222, Issue 5 Author(s): Mauricio Medina-Bárcenas, Lorena Morales-Callejas, Martha Lizbeth Shaid Sandoval-Miranda, Ángel Zaldívar-Corichi In this paper we study some frames associated to an R -module M . We define semiprimitive submodules and we prove that they form an spatial frame canonically isomorphic to the topology of Max ( M ) . We characterize the soberness of Max ( M ) in terms of the point space of that frame. Beside of this, we study the regularity of an spatial frame associated to M given by annihilator conditions.
    Print ISSN: 0022-4049
    Electronic ISSN: 1873-1376
    Topics: Mathematics
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  • 51
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    Publication Date: 2018-01-10
    Description: Publication date: May 2018 Source: Journal of Pure and Applied Algebra, Volume 222, Issue 5 Author(s): Lucas Reis Let F q be the finite field with q elements, p = char ( F q ) . The group GL 2 ( F q ) acts naturally in the set of irreducible polynomials over F q of degree at least 2. In this paper we are interested in the characterization and number of the irreducible polynomials that are fixed by the elements of a subgroup H of GL 2 ( F q ) . We make a complete characterization of the fixed polynomials in the case when H has only elements of the form ( 1 b 0 1 ) , corresponding to translations x ↦ x + b and, as a consequence, the case when H is a p -subgroup of GL 2 ( F q ) . This paper also contains alternative solutions for the cases when H is generated by an element of the form ( a 0 0 1 ) , obtained by Garefalakis (2010) and H = PGL 2 ( F q ) , obtained by Stichtenoth and Topuzoglu (2011).
    Print ISSN: 0022-4049
    Electronic ISSN: 1873-1376
    Topics: Mathematics
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  • 52
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 8 January 2018 Source: Journal of Rock Mechanics and Geotechnical Engineering Author(s): Vitthal M. Khatik, Arup Kr. Nandi Rock Mass Classification (RMC) is a backbone of support design and installation in applications like mining, tunneling and other underground excavations. Although a number of techniques available in this regards, there is an uncertainty in application to complex grounds. Keeping this issue in mind, in the present work, a Generic Rock Mass Rating (GRMR) system has been formulated. The proposed GRMR system refers to most commonly used techniques, and it can be effective for a variety of complex rock masses available on the earth. Two rock load equations are suggested in terms of GRMR, which are based on the fact that whether or not all the rock parameters considered by the system have an influence or only few of them are influencing. The GRMR method has been validated with the data obtained from three underground coal mines in India. Subsequently a semi-empirical model has been developed for the GRMR method using Artificial Neural Network (ANN), and validated based on a comparative analysis of ANN model results with that found by analytical GRMR method.
    Print ISSN: 1674-7755
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
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  • 53
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: Journal of the Franklin Institute Author(s): Jinling Wang, Jinling Liang, Lan Wang In this paper, the Takagi-Sugeno fuzzy positive system is analyzed under the switched mechanisms, which is described by the discrete-time Fornasini-Marchesini Second model. By utilizing the co-positive Lyapunov function and the novel average dwell time method, sufficient conditions are derived under which the proposed system is positive, exponentially stable and has l 1 -gain bound. Furthermore, the criteria obtained are presented in the form of matrix inequalities which can be solved by the standard software. Finally, a numerical example is given to demonstrate the effectiveness of the approach outlined in the paper.
    Print ISSN: 0016-0032
    Electronic ISSN: 1879-2693
    Topics: Mathematics , Technology
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  • 54
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: Journal of the Franklin Institute Author(s): L. Giarré, F. Argenti In this paper, the problem of detrending a time series and/or estimating a wandering baseline is addressed. We propose a new methodology that adaptively minimizes different regularized cost functions by introducing an ARMA model of the underlying trend. Mixed ℓ 1 /ℓ 2 -norm penalty functions are taken into consideration and novel RLS and LMS solutions are derived for the model parameters estimation. The proposed methods are applied to typical trend estimation/removal problems that can be found in the analysis of economic time series or biomedical signal acquisition. Comparisons with standard noncausal filtering techniques are also presented.
    Print ISSN: 0016-0032
    Electronic ISSN: 1879-2693
    Topics: Mathematics , Technology
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  • 55
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    Publication Date: 2018-01-10
    Description: Publication date: 15 April 2018 Source: Linear Algebra and its Applications, Volume 543 Author(s): M. Revan Özkale, Özge Kuran In this article, we propose the principal components regression and r-k class predictors, which combine the techniques of the ridge and principal components regressions in the linear mixed models. We demonstrate that the Henderson's predictors, the ridge predictors and the principal components regression predictors are special cases of the r-k class predictors. We also research assumption that the variance parameters are not known and get estimators of variance parameters. The necessary and sufficient conditions for the superiorities of the r-k class predictors over each of these three predictors are obtained by the criterion of mean square error matrix. Furthermore, we suggest tests to approve if these conditions are indeed satisfied. Finally, real data analysis and a simulation study are used to illustrate the findings.
    Print ISSN: 0024-3795
    Electronic ISSN: 1873-1856
    Topics: Mathematics
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  • 56
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 9 January 2018 Source: Long Range Planning Author(s): Rakesh Kumar Pati, M.K. Nandakumar, Abby Ghobadian, R. Duane Ireland, Nicholas O'Regan We examined Business Model (BM) designs – performance relationship and the moderating effects of firm age and external environment on this relationship. Furthermore, we investigated the impact of simultaneously operating dual BM designs (i.e. novelty and efficiency) on firm performance and contingent effect of firm age on this relationship. Based on data from 241 Indian SMEs, our findings highlighted that BM novelty was of greater benefit to younger SMEs compared to mature SMEs, while BM efficiency was of greater benefit to more mature SMEs. The environmental dynamism positively moderated the relationship between BM novelty and performance but it negatively moderated the relationship between BM efficiency and performance. We also found that BM efficiency is more beneficial in a low, rather than a high, munificent environment but we found environmental munificence did not moderate the BM novelty and SME performance relationship. Finally, we found simultaneous deployment of BM novelty and BM efficiency resulted in an enhancement of performance among mature SMEs compared to younger SMEs. Our study not only adds to the limited literature on BMs in SMEs but also helps practicing managers and entrepreneurs to make informed choices about their BMs.
    Print ISSN: 0024-6301
    Electronic ISSN: 1873-1872
    Topics: Economics
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  • 57
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 8 January 2018 Source: Molecular Immunology Author(s): Simon R. Corrie, Magdalena Plebanski Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.
    Print ISSN: 0161-5890
    Electronic ISSN: 1872-9142
    Topics: Medicine
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    Publication Date: 2018-01-10
    Description: Publication date: February 2018 Source: Molecular Immunology, Volume 94 Author(s): Amir Ghasemi, Nazanin Mohammad, Josef Mautner, Mehrnaz Taghipour Karsabet, Abolfazl Ardjmand, Rezvan Moniri Nearly half of the world’s population is infected with Helicobacter pylori. Clinical manifestations of this infection range from gastritis and peptic ulcers to gastric adenocarcinoma and lymphoma. Due to the emerging of antibiotic resistant strains and poor patient compliance of the antibiotic therapy, there is increasing interest in the development of a protective vaccine against H. pylori infection. The bacterial protein FliD forms a capping structure on the end of each flagellum which is critical to prevent depolymerization and structural degradation. In this study, the potential of FliD as a prospective H. pylori subunit vaccine was assessed. For this purpose, immunogenicity and protective efficacy of recombinant FliD (rFliD) from H. pylori was evaluated in C57BL/6 mice. Purified rFliD was formulated with different adjuvants and administered via subcutaneous or oral route. Subcutaneous immunization with rFliD elicited predominantly mixed Th1 and Th17 immune responses, with high titers of specific IgG 1 and IgG 2a . Splenocytes of immunized mice exhibited strong antigen-specific memory responses, resulting in the secretion of high amounts of IFN-γ and IL-17, and low levels of IL-4. Immunization with rFliD caused a significant reduction in H. pylori bacterial load relative to naïve control mice (p 〈 0.001), demonstrating a robust protective effect. Taken together, these results suggest that subcutaneous vaccination with rFliD formulated with CpG or Addavax could be considered as a potential candidate for the development of a subunit vaccine against H. pylori infection.
    Print ISSN: 0161-5890
    Electronic ISSN: 1872-9142
    Topics: Medicine
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 8 January 2018 Source: Oceanologia Author(s): Sudheeshan Sushama Shaju, Raghunadha Rao Akula, Thajudeen Jabir The red Noctiluca scintillans bloom was observed off Cochin in the South Eastern Arabian Sea (SEAS), affecting a very large area during July–August 2016. The surface water samples from the bloom region were collected to study the physical, biological and light absorption characteristics. The bloom affects the food chain by their voracious predation on the species of both first and second trophic levels. The N. scintillans cell density during the bloom was estimated at 4.73 × 10 5 cells l −1 . In the phytoplankton absorption coefficient spectra, the accessory pigments displayed peaks in the 488–558 nm regions, which represent the characteristic carotenoid pigment (red colored pigment) for the bloom of red Noctiluca . Signature of the coastal upwelling was found from the salinity and temperature distribution, which was measured prior to the bloom occurrence. From the sea surface temperature (SST), it is also confirmed the presence of fresh water from the Cochin estuary. Increased productivity near coastal region, along with episodic events of strengthening of the upwelling, favors the proliferation of smaller diatoms. The plankton succession from smaller diatoms to larger diatoms and dinoflagellates, favors the proliferation of the red Noctiluca . The occurrence of blooms of red N. scintillans , which feed on phytoplankton, mainly diatoms, and other dinoflagellates, could be a threat to larvae of oil sardine during the upwelling period, and may negatively impact on the commercially important fishery of oil sardine, in this region.
    Print ISSN: 0078-3234
    Topics: Biology , Geosciences , Physics
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    Publication Date: 2018-01-10
    Description: Publication date: March 2018 Source: Transportation Research Part E: Logistics and Transportation Review, Volume 111 Author(s): Ioannis Mallidis, Eleftherios Iakovou, Rommert Dekker, Dimitrios Vlachos We propose an analytical modeling methodology for quantifying the impact of slow steaming on the carrier’s voyage cost and on the shipper’s total landed logistics costs. The developed methodology can be employed by a carrier and a shipper in their contract negotiations, in order for the two parties to determine how they could divide between them the savings resulted from slow steaming. We demonstrate that the impact of slow steaming and speed adjustment policies on the shippers’ total landed logistics costs tend to increase as the vessel travels towards the end of its voyage.
    Print ISSN: 1366-5545
    Electronic ISSN: 1878-5794
    Topics: Architecture, Civil Engineering, Surveying , Economics
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 8 January 2018 Source: Sustainable Environment Research Author(s): Pappula Bridjesh, Pitchaipillai Periyasamy, Arani Vijayarao Krishna Chaitanya, Narayanan Kannaiyan Geetha Waste plastic oil (WPO) is a standout amongst the most promising alternative fuels for diesel in view of most of its properties similar to diesel. The challenges of waste management and increasing fuel crisis can be addressed while with the production of fuel from plastic wastes. This experimental investigation is an endeavour to supplant diesel at least by 50% with waste plastic oil alongside 2-methoxy ethyl acetate (MEA) and diethyl ether (DEE) as additives. Test fuels considered in this study are WPO, 50D50W (50%Diesel + 50%WPO), 50D40W10MEA (50%Diesel + 40%WPO + 10%MEA) and 50D40W10DEE (50%Diesel + 40%WPO + 10%DEE). The test results are compared with diesel. An increase in brake thermal efficiency and abatement in brake specific fuel consumption are seen with 50D40W10MEA, as well as reduction in hydro carbon, carbon monoxide and smoke emissions. 50D40W10DEE showed reduced NO x emission whereas 50D40W10MEA has almost no impact. Engine performance and emission characteristics under different loads for different test fuels are discussed.
    Print ISSN: 1022-7636
    Electronic ISSN: 2468-2039
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Publication Date: 2018-01-10
    Description: Publication date: 1 March 2018 Source: Topology and its Applications, Volume 236 Author(s): Christopher R. Cornwell Dehn surgery on a knot determines a dual knot in the surgered manifold, the core of the filling torus. We consider duals of knots in S 3 that have a lens space surgery. Each dual supports a contact structure. We show that if a universally tight contact structure is supported, then the dual is in the same homology class as the dual of a torus knot.
    Print ISSN: 0166-8641
    Electronic ISSN: 1879-3207
    Topics: Mathematics
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  • 63
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    Publication Date: 2018-01-10
    Description: Publication date: Available online 8 January 2018 Source: Technological Forecasting and Social Change Author(s): Fjalar J. de Haan, Jan Rotmans In this opinion piece we suggest a number of theoretical innovations related to the representation and conceptualisation of actors and agency in transitions studies. The research field has gained significant academic and policy popularity and reached a degree of maturity that belies its youth. Despite the ongoing advances and sophistications however, we argue that major lacunae remain regarding actors and agency. Because transitions are reaching advanced stages with more prominent roles for actors, addressing this issue is a prerequisite for progress in transition research – something which is widely acknowledged in the field. Rather than the archetypical way of conceptualising a transition as some kind of systemic fight between alternative systems (niches) and dominant systems (the regime), we present a transition as a fluid unfolding of network activities by diverse actors aligned with a particular stream, resulting in a transformed system. We emphasize that our framework is a proposition – to stimulate debate and suggest avenues of further research. The ideas in this framework have yet to prove themselves, empirically and theoretically as regards their merits for transitions research, but at least they provide a different conceptualisation of transitions with a central role for actors and agency.
    Print ISSN: 0040-1625
    Electronic ISSN: 1873-5509
    Topics: Sociology , Technology
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  • 64
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    Publication Date: 2018-01-10
    Description: Publication date: February 2018 Source: Transportation Research Part E: Logistics and Transportation Review, Volume 110 Author(s): Woosuk Yang We consider a maximal coverage problem for locating congested fast charging stations and deploying chargers in a stochastic environment. A user-choice behaviour considering various factors is modelled. A user-choice model fully reflecting it and system-choice models partially reflecting it are derived. A case study shows the decisions by the system-choice models may result in huge congestion from the user-choice behaviour, and it gives the following main managerial implications for the user-choice model. The model seems to make robust location decisions for different settings of budget and utility function parameters, and it may give less coverage when allowing a long detour.
    Print ISSN: 1366-5545
    Electronic ISSN: 1878-5794
    Topics: Architecture, Civil Engineering, Surveying , Economics
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    Publication Date: 2018-01-10
    Description: Publication date: March 2018 Source: Transportation Research Part D: Transport and Environment, Volume 59 Author(s): Casey Visintin, Nick Golding, Rodney van der Ree, Michael A. McCarthy Understanding wildlife-vehicle collision risk is critical to mitigating its negative impacts on wildlife conservation, human health and economy. Research often focuses on collisions between wildlife and road vehicles, but collision risk factors for other types of vehicles, less examined in the literature, may also be informative. We studied spatial and temporal variation in wildlife-train collision risk in the State of Victoria, Australia. We quantified train movements in space and time, and mapped species occurrence likelihood, across the railway network. Using spatially- and temporally-resolved collision data, we fitted a model to analyse collisions between trains and kangaroos; accounting for time of day, train frequency and speed, and kangaroo occurrence. We then predicted collision rates on the passenger railway network under three management scenarios relating to train speed and occurrence of kangaroos near the railway lines. Temporal variation in animal activity was the strongest predictor of collision risk. Train speed was the second most influential variable, followed by spatial variation in likelihood of species occurrence. Reducing speeds in areas of high predicted species occurrence and during periods of peak animal activity (early morning and evening for kangaroos) was predicted to reduce collision risk the most. Our results suggest mechanisms that might improve existing wildlife-transport collision analyses. The model can help managers decide where, when and how best to mitigate collisions between animals and transport. It can also be used to predict high-risk locations or times for (a) timetable/schedule changes (b) proposals for new routes or (c) disused routes considered for re-opening.
    Print ISSN: 1361-9209
    Electronic ISSN: 1879-2340
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering
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    Publication Date: 2018-01-11
    Description: Publication date: April 2018 Source: Energy Policy, Volume 115 Author(s): José Carlos Romero, Pedro Linares, Xiral López The methodologies and indicators that have been proposed in the literature to measure energy poverty are quite diverse. Some are subjective approaches based on personal or third parties’ perceptions of affordable warmth at home; whereas others calculate objective indicators. Although these different proposals have already been theoretically compared, an empirical comparative analysis that measures in a real case study the practical impact of the theoretical limitations detected for the different indicators was still pending. The goal of this paper is thus to contribute to this debate by comparing critically the different approaches used to measure energy poverty in a real case (Spain in 2015), and to propose a new methodology that might be able to overcome some of the major problems that affect current methods.
    Print ISSN: 0301-4215
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Political Science
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    Publication Date: 2018-01-11
    Description: Publication date: 9 January 2018 Source: Cell Reports, Volume 22, Issue 2 Author(s): Md Fakruddin, Fan-Yan Wei, Takeo Suzuki, Kana Asano, Takashi Kaieda, Akiko Omori, Ryoma Izumi, Atsushi Fujimura, Taku Kaitsuka, Keishi Miyata, Kimi Araki, Yuichi Oike, Luca Scorrano, Tsutomu Suzuki, Kazuhito Tomizawa A subset of mitochondrial tRNAs (mt-tRNAs) contains taurine-derived modifications at 34U of the anticodon. Loss of taurine modification has been linked to the development of mitochondrial diseases, but the molecular mechanism is still unclear. Here, we showed that taurine modification is catalyzed by mitochondrial optimization 1 (Mto1) in mammals. Mto1 deficiency severely impaired mitochondrial translation and respiratory activity. Moreover, Mto1 -deficient cells exhibited abnormal mitochondrial morphology owing to aberrant trafficking of nuclear DNA-encoded mitochondrial proteins, including Opa1. The mistargeted proteins were aggregated and misfolded in the cytoplasm, which induced cytotoxic unfolded protein response. Importantly, application of chemical chaperones successfully suppressed cytotoxicity by reducing protein misfolding and increasing functional mitochondrial proteins in Mto1-deficient cells and mice. Thus, our results demonstrate the essential role of taurine modification in mitochondrial translation and reveal an intrinsic protein homeostasis network between the mitochondria and cytosol, which has therapeutic potential for mitochondrial diseases. Graphical abstract Teaser Taurine modification of mitochondrial tRNA is associated with mitochondrial disease. Fakruddin et al. find that taurine modification is indispensable for mitochondrial protein translation. The authors also find that deficiency of taurine modification impairs a mitochondrial-cytosolic proteostatic network through an Opa1-dependent mechanism and demonstrate the therapeutic potential of chemical chaperones.
    Electronic ISSN: 2211-1247
    Topics: Biology
    Published by Elsevier on behalf of Cell Press.
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    Publication Date: 2018-01-11
    Description: Publication date: 9 January 2018 Source: Cell Reports, Volume 22, Issue 2 Author(s): Susan J. Gelman, Fuad Naser, Nathaniel G. Mahieu, Lisa D. McKenzie, Gavin P. Dunn, Milan G. Chheda, Gary J. Patti Gain-of-function mutations in isocitrate dehydrogenase 1 ( IDH1 ) occur in multiple types of human cancer. Here, we show that these mutations significantly disrupt NADPH homeostasis by consuming NADPH for 2-hydroxyglutarate (2-HG) synthesis. Cells respond to 2-HG synthesis, but not exogenous administration of 2-HG, by increasing pentose phosphate pathway (PPP) flux. We show that 2-HG production competes with reductive biosynthesis and the buffering of oxidative stress, processes that also require NADPH. IDH1 mutants have a decreased capacity to synthesize palmitate and an increased sensitivity to oxidative stress. Our results demonstrate that, even when NADPH is limiting, IDH1 mutants continue to synthesize 2-HG at the expense of other NADPH-requiring pathways that are essential for cell viability. Thus, rather than attempting to decrease 2-HG synthesis in the clinic, the consumption of NADPH by mutant IDH1 may be exploited as a metabolic weakness that sensitizes tumor cells to ionizing radiation, a commonly used anti-cancer therapy. Graphical abstract Teaser Using liquid chromatography/mass spectrometry (LC/MS) and stable isotope tracing, Gelman et al. find that 2-HG production in cells with IDH1 mutations leads to increased pentose phosphate pathway activity to generate NADPH. Production of 2-HG competes with other NADPH-dependent pathways and sensitizes cells to redox stress.
    Electronic ISSN: 2211-1247
    Topics: Biology
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    Publication Date: 2018-01-11
    Description: Publication date: 9 January 2018 Source: Cell Reports, Volume 22, Issue 2 Author(s): Arif Luqman, Mulugeta Nega, Minh-Thu Nguyen, Patrick Ebner, Friedrich Götz A subgroup of biogenic amines, the so-called trace amines (TAs), are produced by mammals and bacteria and can act as neuromodulators. In the genus Staphylococcus , certain species are capable of producing TAs through the activity of staphylococcal aromatic amino acid decarboxylase (SadA). SadA decarboxylates aromatic amino acids to produce TAs, as well as dihydroxy phenylalanine and 5-hydroxytryptophan to thus produce the neurotransmitters dopamine and serotonin. SadA-expressing staphylococci were prevalent in the gut of most probands, where they are part of the human intestinal microflora. Furthermore, sadA -expressing staphylococci showed increased adherence to HT-29 cells and 2- to 3-fold increased internalization. Internalization and adherence was also increased in a sadA mutant in the presence of tryptamine. The α2-adrenergic receptor is required for enhanced adherence and internalization. Thus, staphylococci in the gut might contribute to gut activity and intestinal colonization. Graphical abstract Teaser Luqman et al. examine the sadA gene and argue that it contributes to TAs. They found that neuromodulator-producing staphylococci were present in the gut of most probands. The produced neuromodulators enhanced the adherence and internalization of staphylococci to cells in culture.
    Electronic ISSN: 2211-1247
    Topics: Biology
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    In: Omega
    Publication Date: 2018-01-11
    Description: Publication date: Available online 9 January 2018 Source: Omega Author(s): Kaiying Cao, Xiaoyan Xu, Yiwen Bian, Yanhong Sun B2C platforms are increasingly implementing trade-in programs to boost sales. Most of these platforms have adopted dual-format retailing model including both self-run stores and third-party stores. Under trade-in program framework, B2C platforms will determine the optimal trade-in rebate, and whether to offer the rebate to consumers with gift card (GC) or cash coupon (CC). GC can only be used in self-run stores, while CC can be used in both stores. To entice more consumers to trade-in products, platforms may launch trade-in efforts in the market. To address such decision-making challenges, we consider a B2C platform who owns a self-run store and hosts a third-party store, and examine the optimal trade-in strategy for the platform by developing four theoretical models. We first present two models without considering trade-in efforts, i.e., one model regarding GC payment, and one model regarding CC payment, and then extend them by taking trade-in efforts into consideration. Some interesting finding and insights are achieved. In particular, we find that both GC and CC do not always benefit the platform. Interestingly, offering high quality and low selling price for products in both the self-run store and the third-party store are also not always beneficial to the platform. So is the competition between both stores. Launching trade-in efforts may lead to a lower trade-in rebate but a higher profit for the platform. A counterintuitive finding is obtained that a higher gift card redemption rate is not beneficial to the platform, and vice versa.
    Print ISSN: 0305-0483
    Topics: Economics
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: Available online 9 January 2018 Source: Technological Forecasting and Social Change Author(s): Siqing Shan, Yingwei Jia, Xianrong Zheng, Xiaobo Xu As a driver of global economic growth, the development of emerging economies has been a highly significant trend over the past decade. China has adopted technological entrepreneurship as a national strategy for future economic development. In this paper, we applied a statistical description, contribution rate, gray absolute correlation, and elastic coefficient analysis to assess contributions of technological entrepreneurship to national development. We found that: (1) The number of technology enterprises has been growing and their contributions to the country's output value, exports, employment, and tax are increasing; (2) From 2010 to 2014, the industrial output value of technological entrepreneurship accounted for 41.49% of the average GDP growth. There is a high correlation between technological entrepreneurship and economic growth with a gray correlation coefficient of 0.8296. (3) Technological entrepreneurship has made a significant contribution to the promotion of technological progress and foreign trade. Invention patents created by entrepreneurs accounted for approximately 71% of domestic invention patents. The total export value of high-tech products accounted for approximately 22.6%. (4) Technological entrepreneurship didn't have a clear impact on employment with an employment elasticity of only 2.79%. (5) The contribution rate of technological entrepreneurship to state tax revenue was approximately 8.49%. We considered the paper as the first endeavor to study technological entrepreneurship in China from macro perspectives which have both theoretical value and practical significance for socio-economic development.
    Print ISSN: 0040-1625
    Electronic ISSN: 1873-5509
    Topics: Sociology , Technology
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  • 72
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: February 2018 Source: Transportation Research Part C: Emerging Technologies, Volume 87 Author(s): Azalden Alsger, Ahmad Tavassoli, Mahmoud Mesbah, Luis Ferreira, Mark Hickman Although smart card fare data has recently become more prevalent as a rich, comprehensive and continuous source of information, there is still some missing information which inhibits its capability in the research field. One key missing piece of information is the passengers’ trip purpose. This paper investigates the potential of the smart card data to infer passengers’ trip purpose, thereby reducing the use of the expensive and time-consuming Household Travel Surveys (HTS). On this basis, an improved model has been proposed, calibrated and validated for trip purpose inference by integrating different data sources, namely: HTS, a land use database, the South East Queensland Strategic Transport Model (SEQSTM), the General Transit Feed Specification (GTFS) data, O-D survey data, and most importantly the unique smart card fare data from Brisbane, Queensland. As smart card fare data does not record passengers’ trip purpose, the calibration and validation procedures are performed on HTS data. Based on the validation results, the proposed methodology shows a strong capability to predict trip purpose at a high level of accuracy. The results show an overall 67% correct inference after applying spatial attributes, but the correct inference increases to 78% after applying temporal attributes. Different trip purposes show different sensitivities to the applied spatial and temporal attributes. Work and home trips have the highest correct inference results, at 92% and 96%, respectively. Furthermore, the results of correct inference for shopping and education trips improved after applying the temporal attributes.
    Print ISSN: 0968-090X
    Electronic ISSN: 1879-2359
    Topics: Architecture, Civil Engineering, Surveying
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  • 73
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: February 2018 Source: Transportation Research Part F: Traffic Psychology and Behaviour, Volume 53 Author(s): Jasper S. Wijnands, Jason Thompson, Gideon D.P.A. Aschwanden, Mark Stevenson Globally, motor vehicle crashes account for over 1.2 million fatalities per year and are the leading cause of death for people aged 15–29 years. The majority of road crashes are caused by human error, with risk heightened among young and novice drivers learning to negotiate the complexities of the road environment. Direct feedback has been shown to have a positive impact on driving behaviour. Methods that could detect behavioural changes and therefore, positively reinforce safer driving during the early stages of driver licensing could have considerable road safety benefit. A new methodology is presented combining in-vehicle telematics technology, providing measurements forming a personalised driver profile, with neural networks to identify changes in driving behaviour. Using Long Short-Term Memory (LSTM) recurrent neural networks, individual drivers are identified based on their pattern of acceleration, deceleration and exceeding the speed limit. After model calibration, new, real-time data of the driver is supplied to the LSTM and, by monitoring prediction performance, one can assess whether a (positive or negative) change in driving behaviour is occurring over time. The paper highlights that the approach is robust to different neural network structures, data selections, calibration settings, and methodologies to select benchmarks for safe and unsafe driving. Presented case studies show additional model applications for investigating changes in driving behaviour among individuals following or during specific events (e.g., receipt of insurance renewal letters) and time periods (e.g., driving during holiday periods). The application of the presented methodology shows potential to form the basis of timely provision of direct feedback to drivers by telematics-based insurers. Such feedback may prevent internalisation of new, risky driving habits contributing to crash risk, potentially reducing deaths and injuries among young drivers as a result.
    Print ISSN: 1369-8478
    Electronic ISSN: 1873-5517
    Topics: Psychology
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  • 74
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: Available online 9 January 2018 Source: Transportation Research Part F: Traffic Psychology and Behaviour Author(s): Moatz Saad, Mohamed Abdel-Aty, Jaeyoung Lee Drivers are required to make many rapid decisions at expressway toll plazas, which could result in drivers’ confusion, speed variation, and sudden lane change maneuvers. Thus, toll plazas are considered one of the most dangerous segments on expressways. Nevertheless, only a limited number of studies have explored the factors that affect driving behavior and safety at toll plazas. This study assessed driving behavior at a section, including a hybrid toll plaza, on one of the main expressways in Central Florida using a driving simulator. The details of the section and the plaza were accurately replicated in the simulator. Overall, 72 participants were recruited and each driver performed three different scenarios out of a total of 24 scenarios. Subsequently, four behavioral variables were extracted from the experimental data (i.e., average speed, speed variation, standard deviation of lane deviation, and standard deviation of acceleration) to explore risky driving behaviors with various paths, signs, pavement markings, segment lengths, and traffic conditions. In addition, the effects of drivers’ individual characteristics on driving behavior were investigated. A series of linear mixed models with random effects to account for multiple observations from the same participant were developed to reveal the contributing factors for driving behavior at toll plazas. The results uncovered that drivers experiencing the open road tolling (ORT) have safer driving behavior than those who use the tollbooth. Also, providing dynamic message sign (DMS) on the ramp before the toll plaza has a significant effect on reducing sudden lane change maneuvers. Adjustment of the locations of overhead signs was also recommended in this study. Moreover, the existence of arrow pavement marking before and after the toll plaza is important for reducing unsafe driving behavior before and after the toll plaza.
    Print ISSN: 1369-8478
    Electronic ISSN: 1873-5517
    Topics: Psychology
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  • 75
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: 15 April 2018 Source: Linear Algebra and its Applications, Volume 543 Author(s): Alberto Seeger This work concerns the spectral analysis of connected graphs from a non-traditional point of view. Instead of the usual eigenvalues of the adjacency matrix A G of a graph G under consideration, we compute and analyze the complementarity eigenvalues of A G . The complementarity eigenvalues of a general square matrix are defined in terms of a certain complementarity system relative to the componentwise ordering. The complementarity eigenvalues of A G form the so-called complementarity spectrum of G . In general, the structure of a connected graph is better discriminated in terms of its complementarity spectrum than in terms of its usual spectrum. This observation is one of the leading motivation behind our work.
    Print ISSN: 0024-3795
    Electronic ISSN: 1873-1856
    Topics: Mathematics
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  • 76
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: February 2018 Source: Molecular Immunology, Volume 94 Author(s): Fengbo Zhang, Shaoyu Li, Yuejie Zhu, Chuntao Zhang, Yujiao Li, Haimei Ma, Nannan Pang, Mengting An, Hongying Wang, Jianbing Ding Aims This study is to predict and purify the T-B combined epitopes of egG1Y162 antigen in Echinococcus granulosus , and to evaluate their immunogenicity in mice. Methods The bioinformatics software was used to predict the T-B combined epitopes of egG1Y162 antigen. Recombinant egG1Y161/2 peptides were constructed, expressed and purified. Mice were immunized with egG1Y161/2 peptides. The serum and spleen cells were isolated. The isolated spleen cells were stimulated with egG1Y161/2 peptides in vitro and the culture supernatant was collected. The levels of IgG in serum and levels of IL-4 and IFN-γ in the culture supernatant were measured by ELISA. The weight and number of the fresh hydatid cysts were evaluated. The serum ptotoscolicidal activity was measured by the complement dependent cytotoxicity assay. Results Peptides of 6–19aa, 64–82aa, 106–119aa were predicted as T-B combined epitopes of egG1Y162 antigen. And, recombinant protein egG1Y162-1 or egG1Y162-2, which contained T-B combined epitope(s) of the 6–19aa, or the 64–82aa and the 106–119aa in egG1Y162 antigen, respectively, was successfully expressed and purified. Serum IgG levels of mice immunized with egG1Y162-1/2 were significantly increased during the immune response to Echinococcus granulosus . The levels of IFN-γ, IL-4 and the ratio of IFN-γ/IL-4 after egG1Y162-1/2 immunization were significantly higher. Weight and number of the fresh hydatid cysts in egG1Y162-1/2 immunized mice was significantly decreased. And, the serum protoscolicidal activity after egG1Y162-1/2 immunization was enhanced. Conclusions The egG1Y162-1/2 induces production of serum IgG levels and Th1 cell immune response, which enhances the protective immunity in Echinococcus granulosus challenged mice and thus may be used as a potential vaccine candidate.
    Print ISSN: 0161-5890
    Electronic ISSN: 1872-9142
    Topics: Medicine
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  • 77
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: Available online 9 January 2018 Source: Metabolic Engineering Author(s): Mara Reifenrath, Eckhard Boles Mandelic acid (MA) and 4-hydroxymandelic acid (HMA) are valuable specialty chemicals used as precursors for flavors as well as for cosmetic and pharmaceutical purposes. Today they are mainly synthesized chemically. Their synthesis through microbial fermentation would allow for environmentally sustainable production. In this work, we engineered the yeast Saccharomyces cerevisiae for high-level production of MA and HMA. Expressing the hydroxymandelate synthase from Amycolatopsis orientalis in a yeast wild type strain resulted in the production of 119 mg/L HMA from glucose. As the enzyme also accepts phenylpyruvate as a substrate aside from its native substrate 4-hydroxyphenylpyruvate, 0.7 mg/L MA was also produced. Preventing binding of 4-hydroxyphenylpyruvate to the hydroxymandelate synthase by introducing a S201V replacement in its substrate binding site nearly completely prevented HMA production but increased MA production only 3.5-fold. To further increase HMA and MA production, the aromatic amino acid pathway was engineered. We increased the precursor supply by introducing modifications in the shikimic acid pathway ( ARO1 ↑, ARO3 K222L ↑, ARO4 K220L ↑) and reducing flux into the Ehrlich pathway ( aro10Δ ), and thereby enhanced the HMA titer to 465 mg/L and the MA titer to 2.9 mg/L. A further increase in HMA and MA titers was achieved by replacing the hydroxymandelate synthase from A. orientalis with the corresponding enzyme from Nocardia uniformis . Subsequently, we introduced additional deletions to block the competing tryptophan branch ( trp2Δ ), to further decrease flux into the Ehrlich pathway ( pdc5Δ ) and to avoid transamination of phenylpyruvate and 4-hydroxyphenylpyruvate ( aro8Δ , aro9Δ ). We achieved more than 1 g/L 4-hydroxymandelate when additionally preventing formation of phenylpyruvate by deleting PHA2 . When deleting TYR1 to prevent formation of 4-hydroxyphenylpyruvate instead, an MA titer of 236 mg/L was achieved. This is a more than 200-fold increase in MA production compared to the wild type strain expressing the hydroxymandelate synthase from A. orientalis . Finally, we showed that S. cerevisiae tolerates HMA and MA to concentrations as high as 3 g/L and 7.5 g/L, respectively. Our results demonstrate that S. cerevisiae is a promising host for sustainable MA and HMA production. Graphical abstract
    Print ISSN: 1096-7176
    Electronic ISSN: 1096-7184
    Topics: Medicine , Process Engineering, Biotechnology, Nutrition Technology
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  • 78
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: Available online 9 January 2018 Source: Oceanologia Author(s): Nebil Yucel Spatial and temporal variations in size-fractionated primary production (PP) and chl a , in relation to ambient physicochemical parameters, were studied in the three distinct ecosystems of northeastern Levantine Basin namely eutrophic Mersin Bay, mesotrophic Rhodes Gyre, and oligotrophic offshore waters. These ecosystems were visited in July and September 2012 and March and May 2013. Total primary production (TPP) rates ranged between 0.22 and 17.8 mg C m −3 h −1 within the euphotic zone, whereas depth-integrated TPP rates were in the range 21.5–348.8 mg C m −2 h −1 (mean: 105.5 ± 88 mg C m −2 h −1 ), with the lowest rates recorded for offshore waters. Similar spatio-temporal variations were observed in chl a concentrations, ranging from 2.3 to 117.9 mg m −2 (mean: 28.9 ± 24.9 mg m −2 ) in the study area. The Mersin Bay TPP rates have exceeded almost 8–12 times those measured in the offshore waters and the Rhodes Gyre; however, the chl a concentrations measured in coastal waters (0.343 mg m −3 ) and the Rhodes Gyre (0.308 mg m −3 ) were only threefold larger than the offshore values. PP and chl a were dominated by picoplankton in the study area whereas small nanoplankton, being the most active, displayed the highest assimilation ratio in offshore waters (6.8) and the Rhodes Gyre (2.8). In the upper-layer waters depleted of P (0.02–0.03 μM) of the northeastern Mediterranean, a positive correlation was observed between NO 3 + NO 2 and PP (and thus, chl a ), which strongly suggests that reactive P and inorganic nitrogen are co-limiting factors in the production and biomass distribution of the phytoplankton community in both shelf and offshore waters.
    Print ISSN: 0078-3234
    Topics: Biology , Geosciences , Physics
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  • 79
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: 15 January 2018 Source: Solar Energy, Volume 160
    Print ISSN: 0038-092X
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 80
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    Elsevier
    Publication Date: 2018-01-11
    Description: Publication date: February 2018 Source: Sustainable Energy Technologies and Assessments, Volume 25 Author(s): A. Khosravi, R.N.N. Koury, L. Machado, J.J.G. Pabon In this study, three models of machine learning algorithms are implemented to predict wind speed, wind direction and output power of a wind turbine. The first model is multilayer feed-forward neural network (MLFFNN) that is trained with different data training algorithms. The second model is support vector regression with a radial basis function (SVR-RBF). The third model is adaptive neuro-fuzzy inference system (ANFIS) that is optimized with a partial swarm optimization algorithm (ANFIS-PSO). Temperature, pressure, relative humidity and local time are considered as input variables of the models. A large set of wind speed and wind direction data measured at 5-min, 10-min, 30-min and 1-h intervals are utilized to accurately predict wind speed and its direction for Bushehr. Energy and exergy analysis of wind energy for a wind turbine (E-44, 900 kW) is done. Also, the developed models are used to predict the output power of the wind turbine. Comparison of the statistical indices for the predicted and actual data indicate that the SVR-RBF model outperforms the MLFFNN and ANFIS-PSO models. Also, the current energy and exergy analysis presents an average of 32% energy efficiency and approximately 25% exergy efficiency of the wind turbine in the study region.
    Print ISSN: 2213-1388
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 81
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    Elsevier
    Publication Date: 2018-01-12
    Description: Publication date: March 2018 Source: Transportation Research Part D: Transport and Environment, Volume 59 Author(s): Yassine Charabi, Sabah Abdul-Wahab, Ghazi Al-Rawas, Malik Al-Wardy, Sulaiman Fadlallah The paper concentrates on utilizing CALPUFF to model and investigate the impact of the monsoon season on the dispersion of carbon monoxide (CO), carbon dioxide (CO 2 ), and nitrogen oxides (NO x ) emitted from vehicles. During monsoon season, traffic jams have become an important issue in Salalah, Oman, due to a rapid increase in visitors to Salalah at that time of the year. Therefore, the main aim of the current work is to evaluate the region’s concentrations of CO, CO 2 , and NO x during monsoon season and compare them with non-monsoon season levels. The CALPUFF simulation analysis was based on selected modeling days for both monsoon and non-monsoon seasons. The modeling periods' meteorological conditions were multifarious. Thus, as a result, concentration levels, as well as the coordinates where concentrations exceeded the criterion limits, differed. Seasonal comparisons revealed that concentration levels of CO, CO 2 , and NO x during the monsoon season were greater than the levels associated with the modeling days during the non-monsoon season. Graphical abstract
    Print ISSN: 1361-9209
    Electronic ISSN: 1879-2340
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering
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  • 82
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    Elsevier
    Publication Date: 2018-01-13
    Description: Publication date: Available online 12 January 2018 Source: Energy Economics Author(s): Elisa Lanzi, Rob Dellink, Jean Chateau This paper provides an assessment of the costs of inaction of outdoor air pollution in the coming decades, focusing on the market impacts relative to additional health expenditures, changes in labour productivity and crop yield losses. The results show that the global economic costs of outdoor air pollution gradually increase to 1% of global GDP by 2060, with highest GDP losses in China, the Caspian region and Eastern Europe. These economic consequences stem from a combination of exposure to high concentrations, ageing population and relatively high pollution-related health expenditures that crowd out other consumption and savings. While the direct costs of these market impacts grow more or less at the same pace as total economic activity, the indirect economic costs induced by these impacts become increasingly significant over time. Numerical results are more sensitive to the specification of the feedbacks to the economic model than to the parameter values used in calibrating the impacts; the most optimistic specifications lead to significantly lower costs of air pollution, but qualitative conclusions on the sign of effects and ordering of regional consequences are robust. Non-market damages, especially the welfare losses from premature deaths, are potentially an order of magnitude larger than the market damages that this paper focuses on, but those do not directly affect the economy. These findings on the costs of inaction of outdoor air pollution underline the need for policy action that would reduce the health and environmental impacts as well as lead to economic benefits.
    Print ISSN: 0140-9883
    Electronic ISSN: 1873-6181
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 83
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    Elsevier
    Publication Date: 2018-01-13
    Description: Publication date: Available online 11 January 2018 Source: Energy Economics Author(s): Chi-Chuan Lee, Chien-Chiang Lee This paper contributes to the existing literature by investigating the impacts of oil prices on bank performance through a broad array of CAMEL (Capital adequacy, Asset quality, Management, Earnings, and Liquidity) indicators in China over the period 2000–2014. To gain further insights into this issue, we also discuss whether the correlations change with different dimensions of country risk, i.e., economic, financial, and political, which extant studies ignored. The results reveal that oil prices have a significant impact on banking performance, as their increase triggers a reduction in banking performance in terms of capitalization, management efficiency, earning power, and liquidity. However, these adverse effects are mitigated by country stability, especially economic stability and political stability. These results are important for policy makers who should be cautious when formulating a strategy for macroeconomic stability. From the managerial perspective, bank managers should consider establishing early warning and response mechanisms on the back of oil price shocks in order to operate under better performance.
    Print ISSN: 0140-9883
    Electronic ISSN: 1873-6181
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
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  • 84
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    Elsevier
    Publication Date: 2018-01-13
    Description: Publication date: April 2018 Source: Energy Policy, Volume 115 Author(s): Agne Toleikyte, Lukas Kranzl, Andreas Müller This paper aims to calculate potential energy savings for space heating and hot water by 2030 for the Lithuanian building sector by implementing energy efficiency solutions. Policy recommendations are derived by showing which buildings and energy efficiency measures should be addressed in order to determine the full energy saving potential in the most effective way. Different cost curves for energy savings potential are applied, and these curves show the investor perspective and overall economic perspective. Final energy demand can be reduced by 56% by year 2030 if the least-cost energy efficiency solutions for each building type are selected. Energy performance class A implementation for the apartment buildings built before 1990 and supplied by district heating is the most cost-effective measure. If we consider the overall economic perspective, energy performance class A++ (deep renovation) for the same buildings is the most cost-effective measure. The results call for (I) policies to support building renovation that address buildings with low energy performance instead of subsidising energy prices and (II) policies promoting deep renovation (A+, A++) in order to avoid lock-in effects and ensure the transition of the Lithuanian building stock towards nearly zero-energy buildings (nZEBs).
    Print ISSN: 0301-4215
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Political Science
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    Elsevier
    Publication Date: 2018-01-13
    Description: Publication date: April 2018 Source