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  • 1
    facet.materialart.
    Unknown
    Hindawi
    Publication Date: 2018-03-05
    Description: This study investigates the acoustical and nonacoustical properties of composites using corn husk fiber (CHF) and unsaturated polyester as the sound-absorbing materials. The influence of the volume fraction of CHF on acoustic performance was experimentally investigated. In addition, the nonacoustical properties, such as air-flow resistivity, porosity, and mechanical properties of composites have been analyzed. The results show that the sound absorptions at low frequencies are determined by the number of lumens in fiber, particularly the absorption coefficient, which increases the amount of fiber. For high-frequency sound, the absorption coefficient is determined by the arrangement of fibers in the composite. An absorption coefficient is close to zero when the fibers are arranged in a conventional pattern; however, when they are arranged in a random pattern, a high absorption coefficient can be obtained. The bond interface between the fiber and resin enhances its mechanical properties, which increases the longevity of the composite panel.
    Print ISSN: 1687-6261
    Electronic ISSN: 1687-627X
    Topics: Physics
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  • 2
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    Hindawi
    Publication Date: 2018-03-05
    Description: This paper reviews the evolution of focused ultrasonic transducers of various kinds for fluid atomization and vaporization. Ultrasonic transducers used for atomization purposes in biomedical, pharmaceutical, or industrial applications, such as surface acoustic wave (SAW) transducers, array of micromachined nozzles, and Fourier horn micromachined nozzles with or without a central channel, are all presented and compared. For simplicity of manufacturing and low cost, we focus on plates and curved and corrugated structures for biomedical humidification.
    Print ISSN: 1687-6261
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  • 3
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    Hindawi
    Publication Date: 2018-03-05
    Description: Acoustical holography has been widely applied for noise sources location and sound field measurement. Performance of the microphones array directly determines the sound source recognition method. Therefore, research is very important to the performance of the microphone array, its array of applications, selection, and how to design instructive. In this paper, based on acoustic holography moving sound source identification theory, the optimization method is applied in design of the microphone array, we select the main side lobe ratio and the main lobe area as the optimization objective function and then put the optimization method use in the sound source identification based on holography, and finally we designed this paper to optimize microphone array and compare the original array of equally spaced array with optimization results; by analyzing the optimization results and objectives, we get that the array can be achieved which is optimized not only to reduce the microphone but also to change objective function results, while improving the far-field acoustic holography resolving effect. Validation experiments have showed that the optimization method is suitable for high speed trains sound source identification microphone array optimization.
    Print ISSN: 1687-6261
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  • 4
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    Hindawi
    Publication Date: 2018-03-05
    Description: In this study, the vibration and acoustic interactions between the structure and the cavity inside the freezer cabinet were investigated. Thus, a set of numerical and experimental analyses were performed. In the numerical analysis, the acoustic characteristics of the freezer cavity were solved, and the mixed finite element method was then implemented to analyse the coupled behaviour of the cavity with the air duct using the Acoustic Fluid-Structure Interaction (AFSI) technique. In the experimental analyses, an acoustic modal analysis of the freezer cavity and a structural modal analysis of the air duct were performed for the validation process. A good agreement was obtained among the results. Thus, the accuracy of the numerical model was confirmed. The validated models were used for optimizing the design. To solve the noise generation mechanism inside the freezer cabinet, the noise primarily generated by the freezer fan unit was measured under normal working conditions of the refrigerator, and the resonance frequencies were obtained. This information was compared with the normal modes of the air duct, and the overlapping frequencies were identified. To reduce the interaction between the source and the structure, a few design modifications were applied to the air duct. Thus, the structural-borne noise radiating from the air duct into the freezer cavity was reduced.
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  • 5
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    Hindawi
    Publication Date: 2018-03-05
    Description: Research has shown that the soundboard plays an increasingly important role compared to the sound hole, back plate, and the bridge at high frequencies. The frequency spectrum of investigation can be extended to 5 kHz. Design of bracings and their placements on the soundboard increase its structural stiffness as well as redistributing its deflection to nonbraced regions and affecting its loudness as well as its response at low and high frequencies. This paper attempts to present a review of the current state of the art in guitar research and to propose viable alternatives that will ultimately result in a louder and better sounding instrument. Current research is an attempt to increase the sound level with bracing designs and their placements, control of natural frequencies using scalloped braces, as well as improve the acoustic radiation of this instrument at higher frequencies by deliberately inducing asymmetric modes in the soundboard using the concept of “splitting board.” Various mathematical methods are available for analysing the soundboard based on the theory of thin plates. Discrete models of the instrument up to 4 degrees of freedom are also presented. Results from finite element analysis can be utilized for the evaluation of acoustic radiation.
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  • 6
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    Hindawi
    Publication Date: 2018-03-05
    Description: The Kaybob compressor failure of 1971 was an excellent historic example of rotordynamic instability and the design factors that affect this phenomenon. In the case of Kaybob, the use of poorly designed bearings produced unstable whirling in both the low and high pressure compressors. This required over five months of vibration troubleshooting and redesign along with over 100 million modern U.S. dollars in total costs and lost revenue. In this paper, the history of the Kaybob compressor failure is discussed in detail including a discussion of the ineffective bearing designs that were considered. Modern bearing and rotordynamic analysis tools are then employed to study both designs that were considered along with new designs for the bearings that could have ultimately restored stability to the machine. These designs include four-pad, load-between-pad bearings and squeeze film dampers with a central groove. Simple relationships based on the physics of the system are also used to show how the bearings could be tuned to produce optimum bearing stiffness and damping of the rotor vibration, producing insights which can inform the designers as they perform more comprehensive analyses of these systems.
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  • 7
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    Hindawi
    Publication Date: 2018-03-05
    Description: This research focuses on the development of a sustainable acoustic material comprising natural fibers of corn husk that were alkali modified by 1%, 2%, 5%, and 8% NaOH. The morphology and the acoustical, physical, and mechanical properties of the resulting fibers were experimentally investigated. Five different types of sample were produced in panel form, the acoustical properties of which were studied using a two-microphone impedance tube test. The porosity, tortuosity, and airflow resistivity of each panel were investigated, tensile tests were conducted, and the morphological aspects were evaluated via scanning electron microscopy. The sound absorption and tensile properties of the treated panels were better than those of raw fiber panels; the treated panels were of high airflow resistivity and had low porosity. Scanning electron micrographs of the surfaces of the corn husk fibers revealed that the different sound absorption properties of these panels were due to roughness and the lumen structures.
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  • 8
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    Hindawi
    Publication Date: 2018-03-05
    Description: Two Malaysian very virulent infectious bursal disease virus (vvIBDV) strains UPM0081 and UPM190 (also known as UPMB00/81 and UPM04/190, respectively) isolated from local IBD outbreaks were serially passaged 12 times (EP12) in specific pathogen free (SPF) chicken embryonated eggs (CEE) by chorioallantoic membrane (CAM) route. The EP12 isolate was further adapted and serially propagated in BGM-70 cell line up to 20 passages (P20). Characteristic cytopathic effects (CPEs) were subtly observed at P1 in both isolates 72 hours postinoculation (pi). The CPE became prominent at P5 with cell rounding, cytoplasmic vacuoles, granulation, and detachment from flask starting from day 3 pi, up to 7 days pi with titers of 109.50 TCID50/mL and  TCID50/mL for UPM0081 and UPM190, respectively. The CPE became subtle at P17 and disappeared by P18 and P19 for UPM0081 and UPM190, respectively. However, the presence of IBDV was confirmed by immunoperoxidase, immunofluorescence, and RT-PCR techniques. Phylogenetic analysis showed that these two isolates were of the vvIBDV. It appears that a single mutation of UPM190 and UPM0081 IBDV isolates at D279N could facilitate vvIBDV strain adaptability in CEE and BGM-70 cultures.
    Print ISSN: 1687-8639
    Electronic ISSN: 1687-8647
    Topics: Medicine
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  • 9
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    Hindawi
    Publication Date: 2018-03-05
    Description: Dengue virus is a growing public health threat that affects hundreds of million peoples every year and leave huge economic and social damage. The virus is transmitted by mosquitoes and the incidence of the disease is increasing, among other causes, due to the geographical expansion of the vector’s range and the lack of effectiveness in public health interventions in most prevalent countries. So far, no highly effective vaccine or antiviral has been developed for this virus. Here we employed phage display technology to identify peptides able to block the DENV2. A random peptide library presented in M13 phages was screened with recombinant dengue envelope and its fragment domain III. After four rounds of panning, several binding peptides were identified, synthesized, and tested against the virus. Three peptides were able to block the infectivity of the virus while not being toxic to the target cells. Blind docking simulations were done to investigate the possible mode of binding, showing that all peptides appear to bind domain III of the protein and may be mostly stabilized by hydrophobic interactions. These results are relevant to the development of novel therapeutics against this important virus.
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    Topics: Medicine
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  • 10
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    Hindawi
    Publication Date: 2018-03-05
    Description: When the coarse-resolution observations used in the first step of multiscale and multistep variational data assimilation become increasingly nonuniform and/or sparse, the error variance of the first-step analysis tends to have increasingly large spatial variations. However, the analysis error variance computed from the previously developed spectral formulations is constant and thus limited to represent only the spatially averaged error variance. To overcome this limitation, analytic formulations are constructed to efficiently estimate the spatial variation of analysis error variance and associated spatial variation in analysis error covariance. First, a suite of formulations is constructed to efficiently estimate the error variance reduction produced by analyzing the coarse-resolution observations in one- and two-dimensional spaces with increased complexity and generality (from uniformly distributed observations with periodic extension to nonuniformly distributed observations without periodic extension). Then, three different formulations are constructed for using the estimated analysis error variance to modify the analysis error covariance computed from the spectral formulations. The successively improved accuracies of these three formulations and their increasingly positive impacts on the two-step variational analysis (or multistep variational analysis in first two steps) are demonstrated by idealized experiments.
    Print ISSN: 1687-9309
    Electronic ISSN: 1687-9317
    Topics: Geosciences , Physics
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  • 11
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    Hindawi
    Publication Date: 2018-03-05
    Description: Significant accelerated warming of the Sea Surface Temperature of 0.15°C per decade (1982–2012) was recently detected, which motivated the research for the present consequences and future projections on the heat index and heat waves in the intra-Americas region. Present records every six hours are retrieved from NCEP reanalysis (1948–2015) to calculate heat waves changes. Heat index intensification has been detected in the region since 1998 and driven by surface pressure changes, sinking air enhancement, and warm/weaker cold advection. This regional warmer atmosphere leads to heat waves intensification with changes in both frequency and maximum amplitude distribution. Future projections using a multimodel ensemble mean for five global circulation models were used to project heat waves in the future under two scenarios: RCP4.5 and RCP8.5. Massive heat waves events were projected at the end of the 21st century, particularly in the RCP8.5 scenario. Consequently, the regional climate change in the current time and in the future will require special attention to mitigate the more intense and frequent heat waves impacts on human health, countries’ economies, and energy demands in the IAR.
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    Topics: Geosciences , Physics
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  • 12
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    Hindawi
    Publication Date: 2018-03-05
    Description: The Standardized Precipitation Index (SPI) was computed for October to December (OND) and January to March (JFM) summer subseasons for Free State Province, South Africa, to assess the influence of altitude on drought severity and frequency. The observed spatiotemporal heterogeneity in the SPI variability revealed that factors governing drought interannual variability varied markedly within the region for the two subseasons. Strong correlations between and 0.93 across the clusters in both subseasons were observed. Significant shift in average SPI, towards the high during the OND subseason, was detected for the far western low-lying and central regions of the province around the 1990s. An ANOVA test revealed a significant relationship between drought severity and altitude during the OND subseason only. The impact of altitude is partly manifested in the strong relationship between meridional winds and SPI extremes. When the winds are largely northerly, Free State lies predominantly in the windward side of the Drakensberg Mountains but lies in the rain shadow when the winds are mostly southerly. The relationship between ENSO and SPI indicates stronger correlations for the early summer subseason than for the late summer subseason while overall presenting a diminishing intensity with height over the province.
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  • 13
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    Hindawi
    Publication Date: 2018-03-05
    Description: Increasing summertime air temperature deteriorates human health especially in cities where the warming tendency is exacerbated by urban heat island. Human-biometeorological studies shed light on the primary role of radiation conditions in the development of summertime heat stress. However, only a limited number of field investigations have been conducted up to now. Based on a 26-hour long complex radiation measurement, this study presents the evolved differences within a medium-sized rectangular square in Szeged, Hungary. Besides assessing the impact of woody vegetation and façade orientation on the radiation heat load, different modeling software programs (ENVI-met, SOLWEIG, and RayMan) are evaluated in reproducing mean radiant temperature (). Although daytime can reach an extreme level at exposed locations (65–75°C), mature shade trees can reduce it to 30–35°C. Nevertheless, shading from buildings adjacent to sidewalks plays also an important role in mitigating pedestrian heat stress. Sidewalks facing SE, S, and SW do not benefit from the shading effect of buildings; therefore, shading them by trees or artificial shading devices is of high importance. The measurement–model comparison revealed smaller or larger discrepancies that raise awareness of the careful adaptation of any modeling software and of the relevance of fine-resolution field measurements.
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  • 14
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    Hindawi
    Publication Date: 2018-03-05
    Description: We construct metric connection associated with a first-order differential equation by means of the generator set of a Pfaffian system on a submanifold of an appropriate first-order jet bundle. We firstly show that the inviscid and viscous Burgers’ equations describe surfaces attached to an ODE of the form with certain Gaussian curvatures. In the case of PDEs, we show that the scalar curvature of a three-dimensional manifold encoding a system of first-order PDEs is determined in terms of the integrability condition and the Gaussian curvatures of the surfaces corresponding to the integral curves of the vector fields which are annihilated by the contact form. We see that an integral manifold of any PDE defines intrinsically flat and totally geodesic submanifold.
    Print ISSN: 1687-9120
    Electronic ISSN: 1687-9139
    Topics: Mathematics , Physics
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  • 15
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    Hindawi
    Publication Date: 2018-03-05
    Description: The previously obtained integral field representation in the form of double weighted Fourier transform (DWFT) describes effects of inhomogeneities with different scales. The first DWFT approximation describing the first-order effects does not account for incident wave distortions. However, in inhomogeneous media the multiscale second-order effects can also take place when large-scale inhomogeneities distort the field structure of the wave incident on small-scale inhomogeneities. The paper presents the results of the use of DWFT to derive formulas for wave statistical moments with respect to the first- and second-order effects. It is shown that, for narrow-band signals, the second-order effects do not have a significant influence on the frequency correlation. We can neglect the contribution of the second-order effects to the spatial intensity correlation when thickness of the inhomogeneous layer is small, but these effects become noticeable as the layer thickness increases. Accounting for the second-order effects enabled us to get a spatial intensity correlation function, which at large distances goes to the results obtained earlier by the path integral method. This proves that the incident wave distortion effects act on the intensity fluctuations of a wave propagating in a multiscale randomly inhomogeneous medium.
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  • 16
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    Hindawi
    Publication Date: 2018-03-05
    Description: The homotheties of spherically symmetric space-time admitting ,, and as maximal isometry groups are already known, whereas, for the space-time admitting as isometry groups, the solution in the form of differential constraints on metric coefficients requires further classification. For a class of spherically symmetric space-time admitting as maximal isometry groups without imposing any restriction on the stress-energy tensor, the metrics along with their corresponding homotheties are found. In one case, the metric is found along with its homothety vector that satisfies an additional constraint and is illustrated with the help of an example of a metric. In another case, the metric and the corresponding homothety vector are found for a subclass of spherically symmetric space-time for which the differential constraint is reduced to separable form. Stress-energy tensor and related quantities of the metrics found are given in the relevant section.
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  • 17
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    Hindawi
    Publication Date: 2018-03-05
    Description: A system with an absolute nonlinearity is studied in this work. It is noted that the system is chaotic and has an adjustable amplitude variable, which is suitable for practical uses. Circuit design of such a system has been realized without any multiplier and experimental measurements have been reported. In addition, an adaptive control has been applied to get the synchronization of the system.
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  • 18
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    Hindawi
    Publication Date: 2018-03-05
    Description: A boundary value problem for a stationary nonlinear dispersive equation of order on an interval was considered. The existence, uniqueness, and continuous dependence of a regular solution have been established.
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  • 19
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    Hindawi
    Publication Date: 2018-03-05
    Description: We focus on the following elliptic system with critical Sobolev exponents:  ; ; , where , either or , and critical Sobolev exponents and . Conditions on potential functions lead to no compact embedding. Relying on concentration-compactness principle, mountain pass lemma, and genus theory, the existence of solutions to the elliptic system with or will be established.
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  • 20
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    Hindawi
    Publication Date: 2018-03-05
    Description: We describe a mathematical link between aspects of information theory, called pairwise comparisons, and discretized gauge theories. The link is made by the notion of holonomy along the edges of a simplex. This correspondence leads to open questions in both fields.
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  • 21
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    Hindawi
    Publication Date: 2018-03-05
    Description: As a unitary quantum walk with infinitely many internal degrees of freedom, the quantum walk in terms of quantum Bernoulli noise (recently introduced by Wang and Ye) shows a rather classical asymptotic behavior, which is quite different from the case of the usual quantum walks with a finite number of internal degrees of freedom. In this paper, we further examine the structure of the walk. By using the Fourier transform on the state space of the walk, we obtain a formula that links the moments of the walk’s probability distributions directly with annihilation and creation operators on Bernoulli functionals. We also prove some other results on the structure of the walk. Finally, as an application of these results, we establish a quantum central limit theorem for the annihilation and creation operators themselves.
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  • 22
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    Hindawi
    Publication Date: 2018-03-05
    Description: The low-dimensional periodic Klein-Gordon lattices are studied for integrability. We prove that the periodic lattice with two particles and certain nonlinear potential is nonintegrable. However, in the cases of up to six particles, we prove that their Birkhoff-Gustavson normal forms are integrable, which allows us to apply KAM theory in most cases.
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  • 23
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    Hindawi
    Publication Date: 2018-03-05
    Description: We study the following generalized quasilinear Schrödinger equations with critical growth where , , is a even function, , and for all , where . Under some suitable conditions, we prove that the equation has a nontrivial solution by variational method.
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  • 24
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    Hindawi
    Publication Date: 2018-03-05
    Description: The transverse dynamic spin susceptibility is a correlation function that yields exact information about spin excitations in systems with a collinear magnetic ground state, including collective spin-wave modes. In an ab initio context, it may be calculated within many-body perturbation theory or time-dependent density-functional theory, but the quantitative accuracy is currently limited by the available functionals for exchange and correlation in dynamically evolving systems. To circumvent this limitation, the spin susceptibility is here alternatively formulated as the solution of an initial-value problem. In this way, the challenge of accurately describing exchange and correlation in many-electron systems is shifted to the stationary initial state, which is much better understood. The proposed scheme further requires the choice of an auxiliary basis set, which determines the speed of convergence but always allows systematic convergence in practical implementations.
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  • 25
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    Hindawi
    Publication Date: 2018-03-05
    Description: We consider the kinematics of the locally BPS super-Wilson loop in super-Yang-Mills with scalar coupling from a twistorial point of view. We find that the kinematics can be described either as supersymmetrized pure spinors or as a point in the product of two super-Grassmannian manifolds . In this description of the kinematics the scalar–scalar correlation function appearing in the one-loop evaluation of the super-Wilson loop can be neatly written as a sum of four superdeterminants.
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  • 26
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    Hindawi
    Publication Date: 2018-03-05
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  • 27
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    Hindawi
    Publication Date: 2018-03-05
    Description: The transition density function plays an important role in understanding and explaining the dynamics of the stochastic process. In this paper, we incorporate an ergodic process displaying fast moving fluctuation into constant volatility models to express volatility clustering over time. We obtain an analytic approximation of the transition density function under our stochastic process model. Using perturbation theory based on Lie–Trotter operator splitting method, we compute the leading-order term and the first-order correction term and then present the left and right skew scenarios through numerical study.
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  • 28
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    Hindawi
    Publication Date: 2018-03-05
    Description: A temperature index model with delay and stochastic perturbation is constructed in this paper. It explores the influence of parameters and stochastic factors on the stability and complexity of the model. Based on historical temperature data of four cities of Anhui Province in China, the temperature periodic variation trends of approximately sinusoidal curves of four cities are given, respectively. In addition, we analyze the existence conditions of the local stability of the temperature index model without stochastic term and estimate its parameters by using the same historical data of the four cities, respectively. The numerical simulation results of the four cities are basically consistent with the descriptions of their historical temperature data, which proves that the temperature index model constructed has good fitting degree. It also shows that unreasonable delay parameter can make the model lose stability and improve the complexity. Stochastic factors do not usually change the trend in temperature, but they can cause high frequency fluctuations in the process of temperature evolution. Stability control is successfully realized for unstable systems by the variable feedback control method. The trend of temperature changes in Anhui Province is deduced by analyzing four typical cities.
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  • 29
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    Hindawi
    Publication Date: 2018-03-05
    Description: In this work, we fabricated system In(O,OH)S/i-ZnO/n+-ZnO to be used as potential optical window in thin films solar cells. i-ZnO/n+-ZnO thin films were synthesized by reactive evaporation (RE) method and In(O,OH)S thin films were synthesized by chemical bath deposition (CBD) method; all thin films were deposited on soda lime glass substrates. Thin films were characterized through X-ray diffraction (XRD), atomic force microscopy (AFM), and spectral transmittance measurements. Structural results indicated that both thin films were polycrystalline; furthermore, morphological results indicated that both thin films coated uniformly soda lime glass substrate; besides, optical characterization indicated that system had more than 80% of visible radiation transmittance.
    Print ISSN: 1687-7985
    Electronic ISSN: 1687-7993
    Topics: Chemistry and Pharmacology , Physics
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  • 30
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    Hindawi
    Publication Date: 2018-03-05
    Description: In this work, we synthesized In2S3 powder through chemical bath deposition method (CBD) in acid medium; we used thioacetamide as sulphide source and InCl3 as indium ion source. X-ray diffraction, diffuse reflection, and Raman spectroscopy measurements were used for In2S3 powder physicochemical characterization. Optical analysis indicated that In2S3 was active in the visible region of electromagnetic spectrum; it had a band gap of 2.47 eV; the diffraction patterns and Raman spectroscopy suggested that powder had polycrystalline structure. Furthermore, we also studied the adsorption process of methylene blue (MB) on In2S3 powder; adsorption studies indicated that the Langmuir model describes experimental data. Finally, photocatalytic degradation of MB was studied under visible irradiation in aqueous solution; besides, pseudo-first-order model was used to obtain kinetic information about photocatalytic degradation; results indicated that the powder catalyst reduces 26% concentration of MB under visible irradiation.
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    Topics: Chemistry and Pharmacology , Physics
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  • 31
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    Hindawi
    Publication Date: 2018-03-05
    Description: (E)-N-Aryl-2-ethene-sulfonamide and its derivatives are potent anticancer agents; these compounds inhibit cancer cells proliferation. A study of quantitative structure-activity relationship (QSAR) has been applied on 40 compounds based on (E)-N-Aryl-2-ethene-sulfonamide, in order to predict their anticancer biological activity. The principal components analysis is used for minimizing the base matrix and the multiple linear regression (MLR) and multiple nonlinear regression have been used to design the relationships between the molecular descriptor and anticancer properties of the sulfonamide derivatives. The validation of the models MLR and MNLR has been done by dividing the dataset into training and test set, the external validation of multiple correlation coefficients was RpIC50 = 0.81 for MLR and RpIC50 = 0.91 for MNLR. The artificial neural network (ANN) showed a correlation coefficient close to 0.96, which concluded that this latter model is more effective and much better than the other models. This obtained model (ANN) has been confirmed by two methods of LOO cross-validation and scrambling (or Y-randomization). The high correlation between experimental and predicted activity values was observed, indicating the validation and the good quality of the derived QSAR model.
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  • 32
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    Hindawi
    Publication Date: 2018-03-05
    Description: Lawsonia inermis also known as henna was studied as a corrosion inhibitor for aluminum alloy in seawater. The inhibitor has been characterized by optical study via Fourier transform infrared spectroscopy (FTIR). The FTIR proves the existence of hydroxyl and carbonyl functional groups in Lawsonia inermis. Aluminum alloy 5083 immersed in seawater in the absence and presence of Lawsonia inermis was tested using electrochemistry method, namely, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PP). EIS and PP measurements suggest that the addition of Lawsonia inermis has caused the adsorption of inhibitor on the aluminum surface. The adsorption behavior of the inhibitor follow Langmuir adsorption model where the value of free energy of adsorption, , is less than 40 kJ/mol indicates that it is a physical adsorption. Finally, it was inferred that Lawsonia inermis has a real potential to act as a corrosion inhibitor for aluminum alloy in seawater.
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  • 33
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    Hindawi
    Publication Date: 2018-03-05
    Description: The ability of gum exudates of Azadirachta indica (GAI) to inhibit corrosion on mild steel in 1 mol L−1 HCl has been studied using mass loss, polarization, and impedence measurements. The effect of temperature (303–323 K) and immersion time of 1, 2, 4, 6, and 12 hours on corrosion behavior of mild steel was examined. Gum exudates decrease the corrosion rate up to a concentration of 80 ppm and at 323 K temperature. GAI adsorb chemically onto the surface of the mild steel while it obeys Langmuir adsorption isotherms. Polarization studies show GAI as mixed mode inhibitor. Surface studies ascertain that a shielding layer was formed on the mild steel surface.
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  • 34
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    Hindawi
    Publication Date: 2018-03-05
    Description: A homologous series of liquid crystal bearing with heterocyclic thiophene Schiff base ester with alkanoyloxy chain (CH3(CH2)nCOO–, where , 6, 8, 10, 12, 14, 16) was successfully synthesized through the modification of some reported methods. The structural information of these compounds was isolated and characterized through some spectroscopic techniques, such as FTIR, 1H, and 13C NMR and elemental analysis. Textural observation was carried out using a polarizing optical microscope (POM) over heating and cooling cycles. It was found that all synthesized compounds (3a–g) exhibited an enantiotropic nematic phase upon the heating and cooling cycle with high thermal stability. Moreover, a characteristic bar transition texture was observed for compounds 3f and 3g which have shown transition of nematic-to-smectic C phase. This has been further confirmed by obtaining relative phase transition temperature using the differential scanning calorimetry (DSC).
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  • 35
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    Hindawi
    Publication Date: 2018-03-05
    Description: Cathodic electrochemical deposition (CED) is introduced as an efficient and effective method for synthesis and surface coating of superparamagnetic iron oxide nanoparticles (SPIONs). In this way, bare Fe3O4 nanoparticles were electrosynthesized through CED method from aqueous solution Fe3+ : Fe2+ chloride (molar ratio of 2 : 1). In the next step, the surface of NPs was coated with polyethyleneimine (PEI) and polyethylene glycol (PEG) during the CED procedure, and PEG/PEI coated SPIONs were obtained. The prepared NPs were evaluated by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), vibrating sample magnetometer (VSM), and field-emission scanning electron microscopy (FE-SEM). The pure magnetite phase and nanosize (about 15 nm) of the prepared NPs were confirmed by XRD and FE-SEM. The presence of two coats (i.e., PEG and PEI) on the surface of electrosynthesized NPs was proved via FTIR results. The percentage of polymer coat (37.5%) on the NPs surface was provided by TGA analysis. The high magnetization value, negligible coercivity, and remanence measured by VSM indicate the superparamagnetic nature of both prepared NPs. The obtained results confirmed that the prepared Fe3O4 nanoparticles have suitable physicochemical and magnetic properties for biomedical applications.
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  • 36
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    Hindawi
    Publication Date: 2018-03-05
    Description: We apply density functional theory at PBE/6-311G(d) level as well as nonorthogonal tight-binding model to study the Stone-Wales transformation in C36 fullerene embedded inside the (14,0) zigzag carbon nanotube. We optimize geometries of two different isomers with the and the symmetries and the transition state dividing them. The mechanism of Stone-Wales transformation from to symmetry for the encapsulated C36 is calculated to be the same as for the isolated one. It is found that the outer carbon wall significantly stabilizes the isomer. However, carbon nanotube reduces the activation barrier of Stone-Wales rearrangement by 0.4 eV compared with the corresponding value for the isolated C36.
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  • 37
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    Hindawi
    Publication Date: 2018-03-05
    Description: A polymeric thin film modified electrode, that is, poly(niacinamide) modified carbon paste electrode (MCPE), was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. Compared to bare carbon paste electrode (BCPE), the poly(niacinamide) MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological pH 7.4. All experimental parameters were optimized. Poly(niacinamide) modified carbon paste electrode gave a linear response between concentration of CC and its anodic peak current in the range within 20.6–229.0 μM. The limit of detection (3S/M) and limit of quantification (10S/M) were 1.497 μM and 4.99 μM, respectively. From the study of scan rate variation, the electrode process was found to be adsorption-controlled. The involvement of protons and electrons in the oxidation of CC was found to be equal. The probable electropolymerisation mechanism of niacinamide was proposed. Finally, this method can be used in development of a sensor for sensitive determination of CC.
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  • 38
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    Hindawi
    Publication Date: 2018-03-05
    Description: In a search of newer and potent antileishmanial (against promastigotes and amastigotes form of parasites) drug, a series of 60 variously substituted acridines derivatives were subjected to a quantitative structure activity relationship (QSAR) analysis for studying, interpreting, and predicting activities and designing new compounds by using multiple linear regression and artificial neural network (ANN) methods. The used descriptors were computed with Gaussian 03, ACD/ChemSketch, Marvin Sketch, and ChemOffice programs. The QSAR models developed were validated according to the principles set up by the Organisation for Economic Co-operation and Development (OECD). The principal component analysis (PCA) has been used to select descriptors that show a high correlation with activities. The univariate partitioning (UP) method was used to divide the dataset into training and test sets. The multiple linear regression (MLR) method showed a correlation coefficient of 0.850 and 0.814 for antileishmanial activities against promastigotes and amastigotes forms of parasites, respectively. Internal and external validations were used to determine the statistical quality of QSAR of the two MLR models. The artificial neural network (ANN) method, considering the relevant descriptors obtained from the MLR, showed a correlation coefficient of 0.933 and 0.918 with 7-3-1 and 6-3-1 ANN models architecture for antileishmanial activities against promastigotes and amastigotes forms of parasites, respectively. The applicability domain of MLR models was investigated using simple and leverage approaches to detect outliers and outsides compounds. The effects of different descriptors in the activities were described and used to study and design new compounds with higher activities compared to the existing ones.
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  • 39
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    Hindawi
    Publication Date: 2018-03-05
    Description: The removal of toxic dye rhodamine B (RB) from aqueous solution was achieved by using Casuarina equisetifolia cone (CEC) as an adsorbent. Batch experiment method was used in order to investigate the effects of contact time, pH, temperature, ionic strength, and dye concentration on the adsorption process. Kinetics and isotherm theoretical models were applied on the experimental data and it was found that the pseudo-2nd-order kinetics and the Langmuir isotherm model best fitted into the data. The Langmuir maximum adsorption capacity for CEC was determined as 49.5 mg g−1. The adsorption of RB onto CEC is thermodynamically favourable, feasible, and endothermic in nature.
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  • 40
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    Hindawi
    Publication Date: 2018-03-05
    Description: We present explicit formula for the general Randić connectivity, general sum-connectivity, Hyper-Zagreb and Harmonic Indices, and Harmonic polynomial of some simple connected molecular graphs.
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  • 41
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    Hindawi
    Publication Date: 2018-03-05
    Description: High accuracy, high spatial resolution precipitation data is important for understanding basin-scale hydrology and the spatiotemporal distributions of regional precipitation. The objective of this study was to develop a reliable statistical downscaling algorithm to produce high quality, high spatial resolution precipitation products from Tropical Rainfall Monitoring Mission (TRMM) 3B43 data over the Yarlung Zangbo River Basin using an optimal subset regression (OSR) model combined with multiple topographical factors, the Normalized Difference Vegetation Index (NDVI), and observational data from rain gauge stations. After downscaling, the bias between TRMM 3B43 and rain gauge data decreased considerably from 0.397 to 0.109, the root-mean-square error decreased from 235.16 to 124.60 mm, and the increased from 0.54 to 0.61, indicating significant improvement in the spatial resolution and accuracy of the TRMM 3B43 data. Moreover, the spatial patterns of both precipitation rates of change and their corresponding value statistics were consistent between the downscaled results and the original TRMM 3B43 during the 2001–2014 period, which verifies that the downscaling method performed well in the Yarlung Zangbo River Basin. Its high performance in downscaling precipitation was also proven by comparing with other models. All of these findings indicate that the proposed approach greatly improved the quality and spatial resolution of TRMM 3B43 rainfall products in the Yarlung Zangbo River Basin, for which rain gauge data is limited. The potential of the post-real-time Integrated Multi-satellite Retrievals for Global Precipitation Measurement (IMERG) downscaled precipitation product was also demonstrated in this study.
    Print ISSN: 1687-9309
    Electronic ISSN: 1687-9317
    Topics: Geosciences , Physics
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  • 42
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    Hindawi
    Publication Date: 2018-03-05
    Description: Although realistic representation of the convective boundary layer (CBL) in the desert region in Northwest China is important for weather forecasts and climate simulations, evaluations of the performance of various planetary boundary layer (PBL) schemes in simulating the CBL in the region are rare. In this study, the performance of a scale-aware PBL scheme newly implemented into the Weather Research and Forecasting (WRF) model in simulating the CBL in the Taklimakan desert is evaluated based on a comparison with both the WRF-LES simulations and observations, with the focus on scale dependencies of the simulations compared to the conventional PBL scheme. A series of simulations are performed with a scale-aware PBL scheme (Shin-Hong) and the conventional PBL scheme (YSU) for a deep CBL observed at Tazhong station in the central Taklimakan on 1 July 2016. The CBL was over 5000 m deep with wider and deeper rolls than in a shallow boundary layer. The results showed that the vertical structure simulated with the Shin-Hong scheme was closer to that in both the WRF-LES (large-eddy-simulation) and observations than that simulated with the YSU. The simulation with the scale-aware scheme reproduced cellular rolls similar to those in the WRF-LES, while the conventional PBL scheme struggled to trigger intense convective cells rather than cellular rolls. The results strongly suggest that the scale-aware nonlocal PBL scheme can be used to adequately reproduce the scale and evolution of the observed rolls in the deep CBL in Taklimakan desert at subkilometer resolutions.
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  • 43
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    Hindawi
    Publication Date: 2018-03-05
    Description: As a fundamental component in material and energy circulation, precipitation with high resolution and accuracy is of great significance for hydrological, meteorological, and ecological studies. Since satellite measured precipitation is often too coarse for practical applications, it is essential to develop spatial downscaling algorithms. In this study, we investigated two downscaling algorithms based on the Multiple Linear Regression (MLR) and the Geographically Weighted Regression (GWR), respectively. They were employed to downscale annual and monthly precipitation obtained from the Global Precipitation Measurement (GPM) Mission in Hengduan Mountains, Southwestern China, from 10 km × 10 km to 1 km × 1 km. Ground observations were then used to validate the accuracy of downscaled precipitation. The results showed that GWR performed much better than MLR to regress precipitation on Normalized Difference Vegetation Index (NDVI) and Digital Elevation Model (DEM); coefficients of GWR models showed strong spatial nonstationarity, but the spatial mean standardized coefficients were very similar to standardized coefficients of MLR in terms of intra-annual patterns: generally NDVI was positively related to precipitation when monthly precipitation was under 166 mm; DEM was negatively related to precipitation, especially in wet months like July and August; contribution of DEM to precipitation was greater than that of NDVI; residuals’ correction was indispensable for the MLR-based algorithm but should be removed from the GWR-based algorithm; the GWR-based algorithm rather than the MLR-based algorithm produced more accurate precipitation than original GPM precipitation. These results indicated that GWR is a promising method in satellite precipitation downscaling researches and needed to be further studied.
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  • 44
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    Hindawi
    Publication Date: 2018-03-05
    Description: A model was developed for simulating the effects of airborne silver iodide (AgI) glaciogenic cloud seeding using the weather research and forecasting (WRF) model with a modified Morrison cloud microphysics scheme. This model was used to hindcast the weather conditions and effects of seeding for three airborne seeding experiments conducted in 2016. The spatial patterns of the simulated precipitation and liquid water path (LWP) qualitatively agreed with the observations. Considering the observed wind fields during the seeding, the simulated spatiotemporal distributions of the seeding materials, AgI, and snowfall enhancements were found to be reasonable. In the enhanced snowfall cases, the process by which cloud water and vapor were converted into ice particles after seeding was also reasonable. It was also noted that the AgI residence time (〉1 hr) above the optimum AgI concentration (105 m−3) and high LWP (〉100 g m−2) were important factors for snowfall enhancements. In the first experiment, timing of the simulated snowfall enhancement agreed with the observations, which supports the notion that the seeding of AgI resulted in enhanced snowfall in the experiment. The model developed in this study will be useful for verifying the effects of cloud seeding on precipitation.
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  • 45
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    Hindawi
    Publication Date: 2018-03-05
    Description: In order to improve the measurement of precipitation microphysical characteristics sensor (PMCS), the sampling process of raindrops by PMCS based on a particle-by-particle Monte-Carlo model was simulated to discuss the effect of different bin sizes on DSD measurement, and the optimum sampling bin sizes for PMCS were proposed based on the simulation results. The simulation results of five sampling schemes of bin sizes in four rain-rate categories show that the raw capture DSD has a significant fluctuation variation influenced by the capture probability, whereas the appropriate sampling bin size and width can reduce the impact of variation of raindrop number on DSD shape. A field measurement of a PMCS, an OTT PARSIVEL disdrometer, and a tipping bucket rain Gauge shows that the rain-rate and rainfall accumulations have good consistencies between PMCS, OTT, and Gauge; the DSD obtained by PMCS and OTT has a good agreement; the probability of ,, and Λ shows that there is a good agreement between the Gamma parameters of PMCS and OTT; the fitted and Z-R relationship measured by PMCS is close to that measured by OTT, which validates the performance of PMCS on rain-rate, rainfall accumulation, and DSD related parameters.
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  • 46
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    Hindawi
    Publication Date: 2018-03-06
    Description: Data of the physical and chemical properties of soils from three vineyards located in Vale dos Vinhedos, Bento Gonçalves, Rio Grande do Sul state, in southern Brazil, were processed. Soil mapping was performed by means of four profiles and the digital elevation model in detailed scale. Then, superficial soils (0–20 cm) were sampled according to a grid pattern. Analysis of variance (ANOVA), kriging, and unsupervised classification methods were applied on physical and chemical data of superficial soils sampled according to grid pattern. This study aimed to compare both methods, the conventional soil mapping and the map produced with superficial soil sampling, about their potential for definition of the management zones, as an approach for precision agriculture. Maps elaborated by conventional soil mapping overlapped partially with the maps derived from superficial sampling, probably due to the specific methodological differences of each case. Anyway, both methods are complementary because of the focus on vertical variability and horizontal variability, respectively. In that sense, slope appears as significant edaphic parameter, due to its control on water circulation in the profile of soil.
    Print ISSN: 1687-7667
    Electronic ISSN: 1687-7675
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
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  • 47
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    Hindawi
    Publication Date: 2018-03-06
    Description: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), also known for its significant antipyretic and analgesic properties. This chiral drug is commercialized in racemic form; however, only S-(+)-ibuprofen has clinical activities. In this paper the effect of temperature change (from 288.15 to 308.15 K) on the ibuprofen resolution was studied. A column ( mm) packed with tris(3,5-dimethylphenylcarbamate) was used to obtain the thermodynamic parameters, such as enthalpy change (), entropy change (), variation enthalpy change (), variation entropy change (), and isoenantioselective temperature (). The mobile phase was a combination of hexane (99%), isopropyl alcohol (1%), and TFA (0.1%), as an additive. The conditions led to a selectivity of 1.20 and resolution of 4.55. The first peak, R-(−)-ibuprofen, presented an enthalpy change of 7.21 kJ/mol and entropy change of 42.88 kJ/K·mol; the last peak, S-(+)-ibuprofen, has an enthalpy change of 8.76 kJ/mol and 49.40 kJ/K·mol of entropy change.
    Electronic ISSN: 2090-3510
    Topics: Chemistry and Pharmacology
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  • 48
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    Hindawi
    Publication Date: 2018-03-06
    Description: Background. Systemic sclerosis (SSc) and localized scleroderma (LoS) are two different diseases that may share some features. We evaluated the relationship between SSc and LoS in our case series of SSc patients. Methods. We analysed the clinical records of 330 SSc patients, in order to find the eventual occurrence of both the two diseases. Results. Eight (2.4%) female patients presented both the two diagnoses in their clinical histories. Six developed LoS prior to SSc; in 4/6 cases, the presence of autoantibodies was observed before SSc diagnosis. Overall, the median time interval between LoS and SSc diagnosis was 18 (range 0–156) months. Conclusions. LoS and SSc are two distinct clinical entities that may coexist. Moreover, as anecdotally reported in pediatric populations, we suggested the possible development of SSc in adult patients with LoS, particularly in presence of Raynaud’s phenomenon or antinuclear antibodies before the SSc onset.
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    Electronic ISSN: 1687-6113
    Topics: Medicine
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  • 49
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    Hindawi
    Publication Date: 2018-03-06
    Description: Several herbal remedies have been used as topical agents to cure burn wound, one of the most common injuries in worldwide. In this study, we investigated the potential use of Cleistocalyx operculatus essential oil to treat the burn wound. We identified a total of 13 bioactive compounds of essential oil, several of which exhibited the anti-inflammatory and antimicrobial activities. Furthermore, the essential oil showed the antibacterial effect against S. aureus but not with P. aeruginosa. The supportive effect of essential oil on burn wound healing process also has been proven. Among three groups of mice, wound contraction rate of essential oil treated group (100%) was significantly higher than tamanu oil treated (79%) and control mice (71%) after 20 days ( versus  cm2, resp., ). Histological studies revealed that burn wounds treated with essential oil formed a complete epidermal structure, thick and neatly arranged fibers, and scattered immune cells in burn wound. On the contrary, saline treated burn wound formed uneven epidermal layer with necrotic ulcer, infiltration of immune cells, and existence of granulation tissue. This finding demonstrated Cleistocalyx operculatus essential oil as promising topical dermatological agent to treat burn wound.
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  • 50
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    Hindawi
    Publication Date: 2018-03-06
    Description: Fusarium spp. represent 9 to 44% of onychomycoses caused by fungi other than dermatophytes. This retrospective study describes 17 cases of Fusarium onychomycosis diagnosed at the Laboratory of Parasitology and Mycology of Le Dantec University Hospital in Dakar, Senegal, from 2014 to 2016. It included all patients received in the laboratory for suspicion of onychomycosis between January 1, 2014, and December 31, 2016. Diagnosis was based on mycological examination including direct examination and culture. Mycological analysis was considered positive when direct examination and culture were positive after at least one repeat. Seventeen Fusarium onychomycosis cases representing 12.9% of all onychomycoses reported were diagnosed. There were 5 cases on the fingernails and 12 on the toenails in 6 males and 11 females, and the mean age was 44 years (range: 26–64). Onychomycoses were diagnosed in immunocompetent patients except in a diabetic patient. The mean duration of lesions was 4.9 years (range: 1–15), and distal subungual onychomycosis was predominant. Almost all patients were from suburban areas of Dakar region. The most frequent species isolated belong to Fusarium solani complex. Because of the risk of disseminated infection in immunocompromised patients, realization of susceptibility tests is necessary to ensure better therapeutic management.
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  • 51
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    Publication Date: 2018-03-06
    Description: Aim. To evaluate the efficacy and safety of endoscopic submucosal tunnel dissection (ESTD) for resection of large superficial gastric lesions (SGLs). Methods. The clinicopathological records of patients performed with ESTD or endoscopic submucosal dissection (ESD) for SGLs between January 2012 and January 2014 were retrospectively reviewed. 7 cases undergoing ESTD were enrolled to form the ESTD group. The cases were individually matched at a 1 : 1 ratio to other patients performed with ESD according to lesion location, ulcer or scar findings, resected specimen area, operation time and operators, and the matched cases constituting the ESD group. The treatment outcomes were compared between the two groups. Results. The mean specimen size was 46 mm. 10 lesions were located in the cardia and 4 lesions in the lesser curvature of the lower gastric body. En bloc resection was achieved for all lesions. The mean ESTD resection time was 69 minutes as against 87.7 minutes for the ESD (). The mean resection speed was faster for ESTD than for ESD (18.86 mm2/min versus 13.76 mm2/min, ). There were no significant differences regarding the safety and curability during the endoscopic follow-up (mean 27 months). Conclusions. ESTD is effective and safe for the removal of SGLs and appears to be an optimal option for patients with large SGLs at suitable sites.
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    Electronic ISSN: 1687-630X
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  • 52
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    Publication Date: 2018-03-06
    Description: Objectives. To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design. A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluated. The subjects were divided into a functional constipation group and a nonfunctional constipation group according to the Rome III criteria. Dietary intake data were collected using a brief-type, self-administered, diet-history questionnaire validated for Japanese preschool-aged children. Results. Of the 3595 subjects evaluated, 718 (20.0%) had functional constipation. The association between functional constipation and gender was not statistically significant (). A decrease in bowel frequency was observed in 15.9% of those with functional constipation. There was no significant difference in the proportion of participants in the constipation group by age (). Binomial logistic regression analysis indicated that only fat per 100 kcal positively correlated with functional constipation [odds ratio = 1.216, 95% confidence interval: 1.0476–1.412]. Conclusions. Functional constipation is common among children in preschool and early elementary school in urban areas of Japan. Parents should pay attention to constipation-related symptoms other than defecation frequency. A high-fat diet should be avoided to prevent functional constipation.
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  • 53
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    Hindawi
    Publication Date: 2018-03-06
    Description: Hemorrhagic chronic radiation proctopathy (CRP) is a common complication after pelvic radiotherapy in patients with prostate or gynecological cancers. This systematic review was conducted to evaluate the efficacy and safety of argon plasma coagulation (APC) in treating hemorrhagic CRP. The databases of PubMed, Embase, and Cochrane Library were searched for related studies from inception to July 2017. Finally, 33 studies were identified with a total of 821 hemorrhagic CRP patients. After APC treatment, hemoglobin levels increased from 7.7–13.4 g/L to 11–14 g/L (including 15 studies). All () studies reported an effective rate in rectal bleeding, among which five studies had a rate of 100%. Short-term complications were reported in 31 studies, while long-term complications in 33 studies and no complication in 11 studies. As for the severe complications, perforation was reported by 2 out of 33 studies, and the incidences were 3.3% (1/30) and 3.7% (1/27), respectively. As for APC setting, argon gas flow rate (median 1.5 L/min) and electric power (median 50 W) had no significant influence on complications and hemostasis. In conclusion, current literature indicated that APC therapy was an effective and safe strategy for hemorrhagic CRP, and large-scale prospective studies are needed to warrant our study.
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  • 54
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    Hindawi
    Publication Date: 2018-03-06
    Description: Background/Aims. Delayed bleeding is one of the most serious complications following gastric endoscopic submucosal dissection (ESD) under antithrombotic therapy. As a safety measure, for patients receiving antithrombotic therapy, we covered the ESD ulcer with autologous fibrin glue (prepared using autologous blood) alone or with polyglycolic acid (PGA) sheets. Methods. From July 2014 to November 2015, 20 patients with gastric neoplasms who were receiving antithrombotic therapy were enrolled in this study. After ESD, the ESD ulcers were covered with autologous fibrin glue alone or with PGA sheets. We prospectively evaluated the feasibility of this safety measure. Results. In total, 22 lesions in 20 patients were resected en bloc by ESD. The mean specimen size and tumor size were 31.5 ± 9.5 mm and 14.0 ± 8.8 mm, respectively. There were no cases of delayed bleeding or adverse events in this study. Attachment of autologous fibrin glue was observed in 81.8% (18/22) and 68.2% (15/22) of lesions at endoscopy performed 1 day and 7 days after ESD, respectively. Conclusion. No patient in this study had delayed bleeding or adverse events. This suggests that this measure may facilitate the safety of gastric ESD in patients receiving antithrombotic therapy. This trial is registered with UMIN000019386.
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  • 55
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    Hindawi
    Publication Date: 2018-03-06
    Description: Background. Vonoprazan affords more clinical benefits than proton pump inhibitors (PPIs) during the healing of gastroduodenal ulcers. However, it remains controversial whether vonoprazan is more effective than PPIs when used to heal artificial ulcers arising after endoscopic submucosal dissection (ESD). Aim. This study investigated the effects of vonoprazan compared with esomeprazole on the healing of post-ESD artificial ulcers. Methods. Sixty patients who underwent gastric ESD between May 2015 and May 2017 were randomized to treatment with vonoprazan (V group) or esomeprazole (E group) for 8 weeks. Upper endoscopy was performed at 4 and 8 weeks after ESD, and drug effects were estimated based on the ulcer healing rates and shrinkage rates. Results. Fifty-three patients were analyzed. The respective 4- and 8-week ulcer healing rates did not differ significantly between V and E groups (8.0 versus 11.5%, ; 88.9 versus 84.6%, ). Similarly, the respective 4- and 8-week ulcer shrinkage rates did not differ significantly between V and E groups (96.8 versus 97.5%, ; 100 versus 100%, ). Conclusion. The healing of artificial ulcers after ESD did not differ using vonoprazan or esomeprazole. Both vonoprazan and esomeprazole were effective when used to promote artificial ulcer healing after ESD.
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  • 56
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    Publication Date: 2018-03-06
    Description: We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 and ENO1 concentration in plasma from PDAC patients and healthy controls. We demonstrated that ENO1 overexpression is positively correlated with clinical stage, lymph node metastasis, and poor prognosis of PDAC; ENO1 may function as a hopeful candidate diagnostic marker in combination with CA19-9 in PDAC diagnosis.
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  • 57
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    Hindawi
    Publication Date: 2018-03-06
    Description: The aim of this study was to assess the efficacy of the rectal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing post-ERCP pancreatitis (PEP). We searched database for randomized controlled trials (RCTs) comparing periprocedural rectal administration of NSAIDs with placebo for the prevention of PEP. The rectal administration of NSAIDs significantly decreased the incidence of PEP in the whole patient population (odds ratio (OR): 0.44, 95% confidence interval (CI): 0.30–0.64, ), high-risk patients (OR: 0.34, 95% CI: 0.19–0.58, ), and all-risk patients (OR: 0.51, 95% CI: 0.31–0.84, ). The incidence of PEP was reduced by indomethacin (OR: 0.54, 95% CI: 0.36–0.82, ) and diclofenac (OR: 0.27, 95% CI: 0.15–0.46, ). The administration of NSAIDs before (OR: 0.42, 95% CI: 0.25–0.73, ) or after (OR: 0.39, 95% CI: 0.27–0.56, ) ERCP reduced PEP. The NSAIDs were associated with a reduction in mild PEP (OR: 0.55, 95% CI: 0.36–0.83, ) and moderate-to-severe PEP (OR: 0.47, 95% CI: 0.28–0.79, ). The rectal administration of NSAIDs reduced the incidence of PEP in high-risk and all-risk patients.
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  • 58
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    Publication Date: 2018-03-06
    Description: Introduction. Despite recent advances in surgical techniques, pancreatic fistulas are common. We aimed to determine the role of C-reactive protein in the prediction of clinically relevant fistula development. Materials and Methods. Data from patients who underwent pancreaticoduodenectomy between 2012 and 2015 is collected. Postoperative 1st, 3rd, and 5th day (POD1, POD3, and POD5) C-reactive protein (CRP) levels, postoperative pancreatic fistula (POPF) development, other complications, length of hospital stay, and mortality were recorded. Results. Of 117 patients, 43 patients (36.8%) developed complications (including fistulas). Of the patients developing fistulas, 21 (17.9%) had POPF A, 2 (1.7%) had POPF B, and 7 (6.0%) had POPF C. POD5 CRP and POD3 CRP were shown to be significantly correlated with mortality and development of clinically relevant POPF ( and , resp.) and with mortality (), respectively. The development of clinically relevant POPFs (B and C) could be predicted with 90% sensitivity and 82.2% specificity by POD5 CRP cut-off level of 19 mg/dL and with 100% sensitivity and 63.6% specificity by the difference between POD5 and POD1 CRP cut-off level of 〉2.5 mg/dL. Conclusion. CRP levels can effectively predict the development of clinically relevant pancreatic fistulas.
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  • 59
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    Publication Date: 2018-03-06
    Description: Objectives. To compare the use of an antireflux metal stent (ARMS) with that of a conventional covered self-expandable metal stent (c-CSEMS) for initial stenting of malignant distal biliary obstruction (MDBO). Materials and Methods. We retrospectively investigated 59 consecutive patients with unresectable MDBO undergoing initial endoscopic biliary drainage. ARMS was used in 32 patients and c-CSEMS in 27. Technical success, functional success, complications, causes of recurrent biliary obstruction (RBO), time to RBO (TRBO), and reintervention were compared between the groups. Results. Stent placement was technically successful in all patients. There were no significant intergroup differences in functional success (ARMS [96.9%] versus c-CSEMS [96.2%]), complications (6.2 versus 7.4%), and RBO (48.4 versus 42.3%). Food impaction was significantly less frequent for ARMS than for c-CSEMS (), but TRBO did not differ significantly between the groups (log-rank test, ). The median TRBO was 180.0 [interquartile range (IQR), 114.0–349.0] days for ARMS and 137.0 [IQR, 87.0–442.0] days for c-CSEMS. In both groups, reintervention for RBO was successfully completed in all patients thus treated. Conclusion. ARMS offers no advantage for initial stent placement, but food impaction is significantly prevented by the antireflux valve.
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  • 60
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    Publication Date: 2018-03-06
    Description: Background/Aims. Hepatic ischemia-reperfusion (I/R) injury is a serious concern during hepatic vascular occlusion. The objectives of this study were to assess effects of three techniques for hepatic vascular occlusion on I/R injury and to explore the underlying mechanisms. Methods. Liver cirrhotic rats had undertaken Pringle maneuver (PR), hemihepatic vascular occlusion (HH), or hepatic blood inflow occlusion without hemihepatic artery control (WH). Levels of tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), toll-like receptor 4 (TLR4), TIR-domain-containing adapter-inducing interferon-β (TRIF), and hemeoxygenase 1 (HMOX1) were assayed. Results. The histopathologic analysis displayed that liver harm was more prominent in the PR group, but similar in the HH and WH groups. The HH and WH groups responded to hepatic I/R inflammation similarly but better than the PR group. Mechanical studies suggested that TNF-α/NF-κB signaling and TLR4/TRIF transduction pathways were associated with the differential effects. In addition, the HH and WH groups had significantly higher levels of hepatic HMOX1 () than the PR group. Conclusions. HH and WH confer better preservation of liver function and protection than the Pringle maneuver in combating I/R injury. Upregulation of HMOX1 may lead to better protection and clinical outcomes after liver resection.
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  • 61
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    Hindawi
    Publication Date: 2018-03-06
    Description: Capsule endoscopy has been the first-line examination for small bowel diseases, yet its diagnostic yield is restricted by unsatisfactory bowel preparation. To evaluate the clinical effectiveness of different dosages of polyethylene glycol in patients undergoing capsule endoscopy, we performed a comprehensive meta-analysis of all randomized controlled trials involving polyethylene glycol in preparation for capsule endoscopy. The methodological quality of the trials was evaluated using the Cochrane Risk of Bias assessment instrument. In this study, 12 RCTs involving 2072 patients were included in this review. Our review indicated that 4 L and 2 L polyethylene (PEG) before capsule endoscopy (CE) and 500 mL PEG after CE increase the small bowel image quality, whereas 1 L PEG did not improve the small bowel image quality. PEG accelerated the gastric emptying time. There was no significant difference between the PEG group and control group in small bowel transit time, completion rates, and diagnostic yield.
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  • 62
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    Hindawi
    Publication Date: 2018-03-06
    Description: Serum α-fetoprotein- (AFP-) elevated gastric cancer is a rare tumor that has a poor prognosis due to high incidence of liver metastasis. This study sought to investigate the optimal treatment modality. A total of 319 gastric cancer patients with liver metastasis (GCLM) whose serum AFP levels were tested before treatment were enrolled in this study. They were classified as the serum AFP ≥ 20 ng/ml group () and the AFP 
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  • 63
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    Publication Date: 2018-03-06
    Description: Background. Granulocyte-monocyte apheresis has been proposed for the treatment of ulcerative colitis, although it is limited by costs and variability of results. Aim. To assess effectiveness of granulocyte-monocyte apheresis in patients with steroid-dependent, azathioprine-intolerant/resistant moderate ulcerative colitis. Methods. Consecutive patients fulfilling inclusion criteria were prospectively enrolled, treated by apheresis, and followed up for 12 months. The primary end point of the study was steroid-free clinical remission at 12 months, with no need for biologic therapy or surgery. Results. From January to December 2013, 33 patients were enrolled. After one year of follow-up, 12 (36%) patients had clinical remission, were steroid-free, and had no need for biological therapy or surgery; 3 (9%) cases showed a clinical response (but not clinical remission). Moreover, 12 (36%) patients required biologic therapy, 4 (12%) underwent colectomy, and in the other 2 (6%) a reduction, but not withdrawal, of steroid dose was achieved. Conclusions. Our study shows that a standard course of granulocyte-monocyte apheresis is associated with a 36% steroid-free clinical remission in patients with steroid-dependent, azathioprine-intolerant or resistant moderate ulcerative colitis. Apheresis might represent an alternative to biologic therapy or surgery in this specific subgroup of patients. This trial is registered with Clinicaltrial.gov NCT03189888.
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  • 64
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    Publication Date: 2018-03-05
    Description: Color variation provides the opportunity to investigate the genetic basis of evolution and selection. Reptiles are less studied than mammals. Comparative genomics approaches allow for knowledge gained in one species to be leveraged for use in another species. We describe a comparative vertebrate analysis of conserved regulatory modules in pythons aimed at assessing bioinformatics evidence that transcription factors important in mammalian pigmentation phenotypes may also be important in python pigmentation phenotypes. We identified 23 python orthologs of mammalian genes associated with variation in coat color phenotypes for which we assessed the extent of pairwise protein sequence identity between pythons and mouse, dog, horse, cow, chicken, anole lizard, and garter snake. We next identified a set of melanocyte/pigment associated transcription factors (CREB, FOXD3, LEF-1, MITF, POU3F2, and USF-1) that exhibit relatively conserved sequence similarity within their DNA binding regions across species based on orthologous alignments across multiple species. Finally, we identified 27 evolutionarily conserved clusters of transcription factor binding sites within ~200-nucleotide intervals of the 1500-nucleotide upstream regions of AIM1, DCT, MC1R, MITF, MLANA, OA1, PMEL, RAB27A, and TYR from Python bivittatus. Our results provide insight into pigment phenotypes in pythons.
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    Topics: Biology , Computer Science
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  • 65
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    Publication Date: 2018-03-05
    Description: B-cell epitopes on the envelope (E) and premembrane (prM) proteins of dengue virus (DENV) were predicted using bioinformatics tools, BepiPred, Ellipro, and SVMTriP. Predicted epitopes, 32 and 17 for E and prM proteins, respectively, were then characterized for their level of conservations. The epitopes, EP4/E (48–55), epitope number 4 of E protein at amino acids 48–55, EP9/E (165–182), EP11/E (218–233), EP20/E (322–349), EP21/E (326–353), EP23/E (356–365), and EP25/E (380–386), showed a high intraserotype conservancy with very low pan-serotype conservancy, demonstrating a potential target as serotype specific diagnostic markers. EP3 (30–41) located in domain-I and EP26/E (393–409), EP27/E (416–435), EP28/E (417–430) located in the stem region of E protein, and EP8/prM (93–112) from the prM protein have a pan-serotype conservancy higher than 70%. These epitopes indicate a potential use as universal vaccine candidates, subjected to verification of their potential in viral neutralization. EP2/E (16–21), EP5/E (62–123), EP6/E (63–89), EP19/E (310–329), and EP24/E (371–402), which have more than 50% pan-serotype conservancies, were found on E protein regions that are important in host cell attachment. Previous studies further show evidence for some of these epitopes to generate cross-reactive neutralizing antibodies, indicating their importance in antiviral strategies for DENV. This study suggests that bioinformatic approaches are attractive first line of screening for identification of linear B-cell epitopes.
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  • 66
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    Publication Date: 2018-03-06
    Description: A cyclic cohesive zone model is applied to characterize the fatigue crack growth behavior of a IN718 superalloy which is frequently used in aerospace components. In order to improve the limitation of fracture mechanics-based models, besides the predictions of the moderate fatigue crack growth rates at the Paris’ regime and the high fatigue crack growth rates at the high stress intensity factor levels, the present work is also aimed at simulating the material damage uniformly and examining the influence of the cohesive model parameters on fatigue crack growth systematically. The gradual loss of the stress-bearing ability of the material is considered through the degradation of a novel cohesive envelope. The experimental data of cracked specimens are used to validate the simulation result. Based on the reasonable estimation for the model parameters, the fatigue crack growth from moderate to high levels can be reproduced under the small-scale yielding condition, which is in fair agreement with the experimental results.
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  • 67
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    Publication Date: 2018-03-06
    Description: This study proposes deployable units driven by elastic hinges and a double-layer hoop deployable antenna composed of these units. A rational modeling method based on the energy equivalence principle is presented to develop an equivalent model of the double-layer hoop antenna in accordance with the structural characteristics of the antenna. The equivalent beam models of the rods with elastic hinges are proposed. The relationship of geometrical and material parameters is established considering the strain energy and the kinetic energy of the periodic unit, which are the same as those of the equivalent beam in the same displacement field. The equivalent model of the antenna is obtained by assembling several equivalent beam models in the circumferential direction. The precision of the equivalent model of the antenna is acceptable as found by comparing the modal analysis results obtained through equivalent model calculation, finite element simulation, and modal test.
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  • 68
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    Publication Date: 2018-03-06
    Description: We present various performance trades for multiantenna global navigation satellite system (GNSS) multisensor attitude estimation systems. In particular, attitude estimation performance sensitivity to various error sources and system configurations is assessed. This study is motivated by the need for system designers, scientists, and engineers of airborne astronomical and remote sensing platforms to better determine which system configuration is most suitable for their specific application. In order to assess performance trade-offs, the attitude estimation performance of various approaches is tested using a simulation that is based on a stratospheric balloon platform. For GNSS errors, attention is focused on multipath, receiver measurement noise, and carrier-phase breaks. For the remaining attitude sensors, different performance grades of sensors are assessed. Through a Monte Carlo simulation, it is shown that, under typical conditions, sub-0.1-degree attitude accuracy is available when using multiple antenna GNSS data only, but that this accuracy can degrade to degree level in some environments warranting the inclusion of additional attitude sensors to maintain the desired level of accuracy. Further, we show that integrating inertial sensors is more valuable whenever accurate pitch and roll estimates are critical.
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  • 69
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    Publication Date: 2018-03-06
    Description: When a carrier-based aircraft is in arrested landing on deck, the impact loads on landing gears and airframe are closely related to landing states. The distribution and extreme values of the landing loads obtained during life-cycle analysis provide an important basis for buffering parameter design and fatigue design. In this paper, the effect of the multivariate distribution was studied based on military standards and guides. By establishment of a virtual prototype, the extended Fourier amplitude sensitivity test (EFAST) method is applied on sensitivity analysis of landing variables. The results show that sinking speed and rolling angle are the main influencing factors on the landing gear’s course load and vertical load; sinking speed, rolling angle, and yawing angle are the main influencing factors on the landing gear’s lateral load; and sinking speed is the main influencing factor on the barycenter overload. The extreme values of loads show that the typical condition design in the structural strength analysis is safe. The maximum difference value of the vertical load of the main landing gear is 12.0%. This research may provide some reference for structure design of landing gears and compilation of load spectrum for carrier-based aircrafts.
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  • 70
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    Publication Date: 2018-03-06
    Description: The conception and evaluation indices of the bearing capacity of the concrete pavement field floor are analyzed in this paper. In order to get the damage process of the concrete panel, its tension and compression injury factors are derived, and a field floor structural dynamic model with concrete damage constitutive relation is built based on ABAQUS, and the influence of thickness and Young’s modulus of the concrete panel to the vehicular missile launching is comparatively analyzed.
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  • 71
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    Publication Date: 2018-03-06
    Description: In autonomous aerial refueling (AAR), the vibration of the flexible refueling hose caused by the receiver aircraft’s excessive closure speed should be suppressed once it appears. This paper proposed an active control strategy based on the permanent magnet synchronous motor (PMSM) angular control for the timely and accurate vibration suppression of the flexible refueling hose. A nonsingular fast terminal sliding-mode (NFTSM) control scheme with adaptive extended state observer (AESO) is proposed for PMSM take-up system under multiple disturbances. The states and the “total disturbance” of the PMSM system are firstly reconstituted using the AESO under the uncertainties and measurement noise. Then, a faster sliding variable with tracking error exponential term is proposed together with a special designed reaching law to enhance the global convergence speed and precision of the controller. The proposed control scheme provides a more comprehensive solution to rapidly suppress the flexible refueling hose vibration in AAR. Compared to other methods, the scheme can suppress the flexible hose vibration more fleetly and accurately even when the system is exposed to multiple disturbances and measurement noise. Simulation results show that the proposed scheme is competitive in accuracy, global rapidity, and robustness.
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  • 72
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    Publication Date: 2018-03-06
    Description: A robust nonlinear control law that achieves trajectory tracking control for unmanned aerial vehicles (UAVs) equipped with synthetic jet actuators (SJAs) is presented in this paper. A key challenge in the control design is that the dynamic characteristics of SJAs are nonlinear and contain parametric uncertainty. The challenge resulting from the uncertain SJA actuator parameters is mitigated via innovative algebraic manipulation in the tracking error system derivation along with a robust nonlinear control law employing constant SJA parameter estimates. A key contribution of the paper is a rigorous analysis of the range of SJA actuator parameter uncertainty within which asymptotic UAV trajectory tracking can be achieved. A rigorous stability analysis is carried out to prove semiglobal asymptotic trajectory tracking. Detailed simulation results are included to illustrate the effectiveness of the proposed control law in the presence of wind gusts and varying levels of SJA actuator parameter uncertainty.
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  • 73
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    Publication Date: 2018-03-06
    Description: In the event of a control failure on an axis of a spacecraft, a target attitude can be achieved by several sequential rotations around the remaining control axes. For a spacecraft actuating with wheels, the form of each submaneuver should be a pure single axis rotation since the failed axis should not be perturbed. The rotation path length in sequential submaneuvers, however, increases extremely but is short under normal conditions. In this work, it is shown that the path length is reduced dramatically by finding a proper number of sequential submaneuvers, especially for the target attitude rotation around the failed axis. A numerical optimization is suggested to obtain the shortest path length and the relevant number of maneuvers. Optimal solutions using the sequential rotation approach are confirmed by numerical simulations.
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  • 74
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    Publication Date: 2018-03-06
    Description: Calibration tests are of great importance to ensure rate-sensing accuracy of GyroWheel, an innovative attitude determination and control device. In the process of calibration tests, turntable errors are inevitable, which hinder the calibration accuracy and rate-sensing capability. Hence, error analysis for GyroWheel calibration tests is conducted, and the relationship between the calibration accuracy and the orientation error is established based on analytical derivation and numerical simulations. Subsequently, an error model of the turntable system is derived using rigid body kinematics, by which the relationship between the orientation error and turntable errors is described. According to sensitivity analysis and manufacturing capability, an error allocation method is proposed to determine the accuracy requirement of the test turntable, and the effectiveness of the proposed method is verified by repeated simulation tests. Based on the presented analysis and proposed method in this paper, the effects of various turntable errors on the calibration accuracy can be obtained quantitatively, and a theoretical basis for the determination of the turntable accuracy is provided, which are of great significance to guide the calibration tests and improve the calibration accuracy of GyroWheel.
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  • 75
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    Publication Date: 2018-03-06
    Description: Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. Equol, a major isoflavone from soybean, exhibits estrogen-like biological activity, but their effect on inflammatory response has not been well established. Here, we investigated the effect of S-equol on nitric oxide (NO) production, well-known inflammatory change in astrocytes stimulated by LPS. S-Equol attenuated LPS-induced NO production with a concomitant decrease in expression of inducible NO synthase (iNOS). S-Equol did not affect LPS-induced increase in intracellular ROS production. Intracellular ER blocker ICI 182.780 had no effect on S-equol-induced decrease in NO production. Addition of G-15, antagonist of G protein-coupled receptor 30 which is nongenomic ER and located on cell surface, partially recovered S-equol-induced attenuation of NO production. These findings suggest that attenuation of NO production by S-equol may mitigate LPS-induced neuroinflammation in astrocytes. S-Equol may exert a glioprotective effect, at least in part, via a nongenomic effect.
    Electronic ISSN: 2042-0099
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  • 76
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    Publication Date: 2018-03-06
    Description: Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and tissues (DAMPs, danger-associated molecular patterns). TLR triggering leads to the induction of proinflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. In particular, Toll-Like Receptor 4 (TLR4) has been described to be involved in the inflammatory processes observed in several pathologies (such as ischemia/reperfusion injury, neuropathic pain, neurodegenerative diseases, and cancer). Molecules obtained by natural sources have been discovered to exert an anti-inflammatory action by targeting TLR4 activation pathways. This review focuses on TLR4 antagonists obtained from bacteria, cyanobacteria, and plants.
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  • 77
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    Publication Date: 2018-03-06
    Description: Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome’s curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. Despite the expansive reports of curcucmin’s therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor. The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications. Although the polypharmacology of this extract has been considered, in mainstream medicine, to be a drawback, a perspective change reveals a comprehensive and even synergistic shaping of the NF-kB pathway, including transactivation. Much of the inconsistent research data and unreliable clinical outcomes may be due to a lack of standardization which also pervades research standard samples. The possibility of other well-known curcumin by-products contributing in the polypharmacology is also discussed. A new flowchart of crosstalk in transduction pathways that lead to shaping of nuclear NF-kB transactivation is generated and a new calibration or standardization protocol for the extract is proposed which could lead to more consistent data extraction and improved reliability in therapy.
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  • 78
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    Hindawi
    Publication Date: 2018-03-06
    Description: Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNFα () and expression of CD11b () and TLR4 () compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM () suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients.
    Electronic ISSN: 2042-0099
    Topics: Medicine
    Published by Hindawi
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  • 79
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    Unknown
    Hindawi
    Publication Date: 2018-03-06
    Description: Introduction. The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed to propose a suitable cut-off of NLR for diagnosis of CAD in Western Indians. Methods. Total 324 patients undergoing coronary angiography were enrolled and were subdivided into two groups: group 1 (; population without CAD) and group 2 (; population with CAD). Results. The results indicated significant () positive association between elevated levels of WBC, neutrophil, monocyte, NLR, hs-CRP, CPK-MB, and troponin I and disease presence. According to subgroup analysis, the association was more profound in male and older population. Among all the markers NLR showed the strongest predictive potential for CAD with highest odds ratio (1.495; 95% CI: 0.942–2.371; ). Optimum cut-off of NLR for diagnosis of CAD was 2.13 (AUC-0.823; ; sensitivity: 83.64%; specificity: 63.46%). Association of NLR with other biochemical markers such as hs-CRP, CPK-MB, and troponin I was also observed in quartile analysis. Conclusion. NLR is a simple indicator that could be effectively used for the diagnosis of CAD with a cut-off of 2.13 in Western Indian population.
    Electronic ISSN: 2042-0099
    Topics: Medicine
    Published by Hindawi
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  • 80
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    Unknown
    Hindawi
    Publication Date: 2018-03-06
    Description: Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology. Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment and recruitment could possibly contribute to disease development and progression. The present study characterizes for the first time the expression of migration related chemokine receptors and their ligands in BM-MSCs from COPD patients. CXCR4/SDF1a and CCR7/CCL19-CCL21 mRNA levels were evaluated in BM-MSCs obtained from twelve COPD patients and seven healthy donors. SDF1a protein levels in sera and BM-MSCs’ conditioned media were also evaluated. CXCR4, SDF1a, CCL19, and CCL21 mRNA levels were significantly reduced in COPD BM-MSCs while CCR7 levels were undetectable. Notably, SDF1a protein levels were marginally elevated in both patient sera and BM-MSCs’ conditioned media while the increase in SDF1a serum levels significantly correlated with disease severity in COPD. Our findings show posttranscriptional regulation of SDF1a levels in BM-MSCs of COPD patients and significant downregulation of SDF1a and CXCR4 mRNA indicating an involvement of the SDF1a signaling pathway in the disease pathophysiology.
    Electronic ISSN: 2042-0099
    Topics: Medicine
    Published by Hindawi
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  • 81
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    Unknown
    Hindawi
    Publication Date: 2018-03-06
    Description: Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient’s ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin. Nitric oxide increased significantly in cells exposed to higher doses of PMA (100 ng/ml, 150 ng/ml, and 200 ng/ml) accompanied by a loss of the characteristic cobblestone morphology with no negative effect on cell activity or viability. A significant reduction in nitric oxide production was associated with the addition of 200 pg/ml hydroxocobalamin, alongside a return to the characteristic cobblestone morphology. This study highlights the use of PMA to promote low grade inflammation in human cell lines to model gastric inflammation associated with autoimmunity; furthermore it raises questions regarding the concentration of cobalamin administered clinically to restore cell functionality, feasibly allowing the patient to receive reduced quantity of the vitamin more regularly, providing the patient with levels which are akin to dietary intake.
    Electronic ISSN: 2042-0099
    Topics: Medicine
    Published by Hindawi
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  • 82
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    Unknown
    Hindawi
    Publication Date: 2018-03-06
    Description: Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and diseases. The objective of this study was to evaluate the effect of VCO inhalation on airway remodelling in a rabbit model of allergic asthma. The effects of VCO inhalation on infiltration of airway inflammatory cells, airway structures, goblet cell hyperplasia, and cell proliferation following ovalbumin induction were evaluated. Allergic asthma was induced by a combination of ovalbumin and alum injection and/or followed by ovalbumin inhalation. The effect of VCO inhalation was then evaluated via the rescue or the preventive route. Percentage of inflammatory cells infiltration, thickness of epithelium and mucosa regions, and the numbers of goblet and proliferative cells were reduced in the rescue group but not in preventive group. Analysis using a gas chromatography-mass spectrometry found that lauric acid and capric acid were among the most abundant fatty acids present in the sample. Significant improvement was observed in rescue route in alleviating the asthma symptoms, which indicates the VCO was able to relieve asthma-related symptoms more than preventing the onset of asthma.
    Electronic ISSN: 2042-0099
    Topics: Medicine
    Published by Hindawi
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  • 83
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    Unknown
    Hindawi
    Publication Date: 2018-03-06
    Description: Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels
    Electronic ISSN: 2042-0099
    Topics: Medicine
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