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  • Nature Publishing Group  (15,104)
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  • 2000-2004  (17,339)
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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 800-802 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Cells use elaborate transcriptional and translational mechanisms to control the timing and fidelity of protein synthesis. It is becoming increasingly apparent that intricate mechanisms also control how and when specific proteins are removed by degradation. Energy-dependent proteolytic machines ...
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  • 2
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 811-811 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nuclear fallout When confronted with damaged DNA, cells respond either by arresting the cell cycle and repairing the damage, or by undergoing apoptosis. The PI3-like protein kinase ATM is one DNA damage sensor that activates DNA repair and cell cycle arrest. ATM is mutated in ataxia telangiectasia ...
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  • 3
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 894-900 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The superfamily of plant and bacterial type III polyketide synthases (PKSs) produces diverse metabolites with distinct biological functions. PKS18, a type III PKS from Mycobacterium tuberculosis, displays an unusual broad specificity for aliphatic long-chain acyl-coenzyme A (acyl-CoA) starter units ...
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  • 4
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 816-821 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Cells respond to changes in environmental conditions via orchestrated modifications in gene expression. For example, in response to heat shock, cells execute a program of gene-specific transcriptional activation and repression. Although the activation of genes upon heat shock has been widely ...
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  • 5
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 844-849 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The neuronal protein synaptotagmin 1 functions as a Ca2+ sensor in exocytosis via two Ca2+-binding C2 domains. The very similar synaptotagmin 4, which includes all the predicted Ca2+-binding residues in the C2B domain but not in the C2A domain, is also thought to function as a neuronal Ca2+ sensor. ...
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  • 6
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 679-679 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The subject of peer review, its shortcomings and ways to solve them, are a perennial source of discussion among scientists and editors. Virtually all scientists have anecdotes of how their papers have been rejected due to what they perceive as biased or vindictive refereeing. Meanwhile high profile ...
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  • 7
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 682-685 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] This was a FEBS Lecture Course on Cellular Signaling, as well as the 4th Dubrovnik Signaling Conference, held in Croatia*. As its title suggests, the meeting covered a great deal of ground—much of it reflecting work that had only recently been published. Tony Hunter (Salk Institute, La ...
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  • 8
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 696-696 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Gene silencing without RNAi RNA interference (RNAi) is a phenomenon in which double-stranded RNAs are processed into small interfering RNAs that degrade homologous mRNAs. While RNAi has generally been thought to act post- transcriptionally it can also act at the transcriptional level. For example, ...
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  • 9
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 706-713 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled receptors such as metabotropic glutamate (mGlu) receptors that have large extracellular domains (ECDs) where agonists bind. How agonist binding in dimeric ECDs activates ...
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  • 10
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 738-746 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor is an obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner by targeting the ...
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  • 11
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 678-678 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nat. Struct. Biol. 10, 781–788 (2003). Two mistakes are found in the final version of this manuscript. The first is on page 784 (second column, line 19 from the bottom); the correct sentence should read: “... in which the base U33 forms hydrogen bonds with the main chain amide and ...
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  • 12
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 632-636 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] DNA polymerase requires two processing factors, sliding clamps and clamp loaders, to direct rapid and accurate duplication of genomic DNA. In eukaryotes, proliferating cell nuclear antigen (PCNA), the ring-shaped sliding clamp, encircles double-stranded DNA within its central hole and tethers the ...
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  • 13
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 501-501 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] What specifies that a cell will become an antenna and not a leg? For fruit flies, cell fate is determined early in the cytoplasm of the egg. Here, maternal mRNAs and proteins are localized to different regions of the egg chamber creating gradients of macromolecules throughout the cell. The ...
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  • 14
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 544-550 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The σ70 subunit of RNA polymerase plays an essential role in transcription initiation. In addition, σ70 has a critical regulatory role during transcription elongation at the bacteriophage λ late promoter, λPR′. At this promoter, σ70 mediates a pause in early ...
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  • 15
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 693-695 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] There are two main types of tumor suppressor genes (TSGs): 'gatekeepers' that encode proteins that provide direct protection from tumorigenesis, and 'caretakers' that encode proteins necessary for maintaining genome stability and consequently guard against somatic mutations arising in oncogenes and ...
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  • 16
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 697-705 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Cholesterol-dependent cytolysins are bacterial protein toxins that bind to cholesterol-containing membranes, form oligomeric complexes and insert into the bilayer to create large aqueous pores. Membrane-dependent structural rearrangements required to initiate the oligomerization of perfringolysin O ...
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  • 17
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 429-434 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor ...
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  • 18
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 435-442 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] HIV-1 deleted for the vif accessory gene encapsidates the cellular cytidine deaminase APOBEC3G. Upon infection, the encapsidated APOBEC3G induces G→A mutations in the viral reverse transcripts. The G→A mutations result either from C→U deamination of the minus strand or deamination of ...
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  • 19
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 469-474 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Tenofovir, also known as PMPA, R-9-(2-(phosphonomethoxypropyl)adenine, is a nucleotide reverse transcriptase (RT) inhibitor. We have determined the crystal structures of two related complexes of HIV-1 RT with template primer and tenofovir: (i) a ternary complex at a resolution of 3.0 Å of RT ...
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  • 20
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 394-403 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Advances in structure determination of the bacterial and eukaryotic transcription machinery have led to a marked increase in the understanding of the mechanism of transcription. Models for the specific assembly of the RNA polymerase II transcription machinery at a promoter, conformational changes ...
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  • 21
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 443-449 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We present a structural analysis of the folding transition states of three SH3 domains. Our results reveal that the secondary structure is not yet fully formed at this stage of folding and that the solvent is only partially excluded from the interior of the protein. Comparison of the members of the ...
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  • 22
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 293-295 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In the January issue of Nature Structural & Molecular Biology, Stephen Harrison accurately communicates in a commentary the need to expand the length and timescale at which we study biological systems at atomic resolution. Expanding the number of systems being studied will certainly benefit our ...
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  • 23
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 300-300 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Two classes of small RNAs influence a wide variety of biological processes by silencing gene expression. MicroRNAs (miRNAs) are produced from stem-loop RNA precursors encoded in the genome and are incorporated into miRNA-induced silencing complexes (miRISCs). These complexes appear to silence gene ...
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  • 24
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 307-307 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A new partner for telomerase protein Cancerous cells can rapidly divide and have the potential to live indefinitely. The survival of such cells through cycles of cell division critically depends on their ability to maintain chromosome ends—or telomeres—by a multisubunit enzyme called ...
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  • 25
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 305-306 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The nonsense-mediated decay (NMD) pathway degrades abnormal mRNAs that contain premature translation termination codons (PTCs; reviewed in refs. 1–4). Three interacting proteins, Upf1, Upf2 and Upf3, are essential for NMD (Fig. 1). However, the mechanism by which Upf proteins help detect and ...
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  • 26
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 365-370 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] SCFFbs1 is a ubiquitin ligase that functions in the endoplasmic reticulum (ER)-associated degradation pathway. Fbs1/Fbx2, a member of the F-box proteins, recognizes high-mannose oligosaccharides. Efficient binding to an N-glycan requires di-N-acetylchitobiose (chitobiose). Here we report the ...
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  • 27
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 308-315 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The transcriptional coactivator p300 is a histone acetyltransferase (HAT) whose function is critical for regulating gene expression in mammalian cells. However, the molecular events that regulate p300 HAT activity are poorly understood. We evaluated autoacetylation of the p300 HAT protein domain to ...
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  • 28
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 519-525 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The BRCT repeats in BRCA1 are essential for its tumor suppressor activity and interact with phosphorylated protein targets containing the sequence pSer-X-X-Phe, where X indicates any residue. The structure of the tandem BRCA1 BRCT repeats bound to an optimized phosphopeptide reveals that the ...
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  • 29
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 284-289 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The counterion, a negatively charged amino acid residue that stabilizes a positive charge on the retinylidene chromophore, is essential for rhodopsin to receive visible light. The counterion in vertebrate rhodopsins, Glu113 in the third transmembrane helix, has an additional role as an ...
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  • 30
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    Nature structural & molecular biology 11 (2004), S. 219-225 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sodium channels initiate the electrical cascade responsible for cardiac rhythm, and certain life-threatening arrhythmias arise from Na+ channel dysfunction. We propose a novel mechanism for modulation of Na+ channel function whereby calcium ions bind directly to the human cardiac Na+ channel (hH1) ...
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  • 31
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 257-264 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The tandem zinc finger (TZF) domain of the protein TIS11d binds to the class II AU-rich element (ARE) in the 3′ untranslated region (3′ UTR) of target mRNAs and promotes their deadenylation and degradation. The NMR structure of the TIS11d TZF domain bound to the RNA sequence ...
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  • 32
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 275-283 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We report a novel chromatin-modulating factor, nuclear FK506-binding protein (FKBP). It is a member of the peptidyl prolyl cis-trans isomerase (PPIase) family, whose members were originally identified as enzymes that assist in the proper folding of polypeptides. The endogenous FKBP gene is required ...
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  • 33
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 291-291 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] “What do you do with my manuscript once I've submitted it to your office?” This is one of the most commonly asked questions we get from authors. We understand the anxiety behind the question since we publish only about one out of every six papers submitted to the journal. No doubt some ...
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  • 34
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    Nature structural & molecular biology 11 (2004), S. 112-112 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Plants use small interfering RNAs (siRNAs), in a process called RNA silencing, to mediate sequence-specific degradation of viral RNAs and thereby defend against attack. Viruses have developed a counter-defense. Their genomes encode proteins that specifically suppress siRNA-mediated degradation. The ...
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  • 35
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    Nature structural & molecular biology 11 (2004), S. 120-120 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Shine a light on me Researchers at the University of Hawaii at Manoa and UCLA have identified a set of unusual proteins in the reflective tissues of the Hawaiian bobtail squid. Reflectivity involves the redirection of natural sunlight or bioluminescence, and it's a strategy that is widely ...
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  • 36
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    Nature structural & molecular biology 11 (2004), S. 163-170 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sialic acid terminates oligosaccharide chains on mammalian and microbial cell surfaces, playing critical roles in recognition and adherence. The enzymes that transfer the sialic acid moiety from cytidine-5′-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to the terminal positions of these ...
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  • 37
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    Nature structural & molecular biology 11 (2004), S. 1156-1157 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genes have informational borders but no physical boundaries. This poses restrictions to the ways RNA polymerases use to initiate and terminate transcription accurately. The simplest strategy is the recognition of specific DNA or nascent RNA sequences by the RNA polymerase, either directly or ...
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  • 38
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1163-1164 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Many bacterial pathogens produce protein toxins that contribute to their virulence. The largest class of toxins is composed by pore-forming toxins (PFTs) (∼25% of all toxins), which all share a similar mode of action (Fig. 1a). The toxin is secreted into the medium as a water-soluble protein ...
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  • 39
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1253-1253 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nat. Struct. Mol. Biol. 11, 412–419 (2004). Some of the enzymatic activity data for paraoxonase (PON1) reported in this article were biased by two factors. First, the gene encoding the H115Q mutant contained an additional H177R mutation introduced during PCR amplification. Although His177 is ...
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  • 40
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1179-1185 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The Escherichia coli OxyR transcription factor is activated by cellular hydrogen peroxide through the oxidation of reactive cysteines. Although there is substantial evidence for specific disulfide bond formation in the oxidative activation of OxyR, the presence of the disulfide bond has remained ...
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  • 41
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    Nature structural & molecular biology 11 (2004), S. 1206-1214 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The bacterial Sm-like protein Hfq facilitates RNA-RNA interactions involved in post-transcriptional regulation of the stress response. Specifically, Hfq helps pair noncoding RNAs (ncRNAs) with complementary regions of target mRNAs. To probe the mechanism of this pairing, we generated a series of ...
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  • 42
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    Nature structural & molecular biology 11 (2004), S. 1237-1242 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis ...
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  • 43
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1251-1252 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Here we report the crystal structures of I·C and I·A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I·A base pair is of an Ianti·Aanti conformation, as predicted by Crick. Additionally, the structures enable the observation of ...
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  • 44
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1028-1030 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Infection by viral or bacterial pathogens is one of the great stresses in the life of a cell. How the invading pathogen is initially recognized and how the host cell responds within the first minutes to hours can dictate the subsequent development of immune protection, with far-reaching ...
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  • 45
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    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 11 (2004), S. 1114-1121 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nuclear foci containing the promyelocytic leukemia protein (PML bodies), which occur in most cells, play a role in tumor suppression. Here, we demonstrate that CHFR, a mitotic checkpoint protein frequently inactivated in human cancers, is a dynamic component of PML bodies. Intermolecular ...
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  • 46
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    Nature structural & molecular biology 11 (2004), S. 1101-1106 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The ribosome accelerates the rate of peptide bond formation by at least 107-fold, but the catalytic mechanism remains controversial. Here we report evidence that a functional group on one of the tRNA substrates plays an essential catalytic role in the reaction. Substitution of the P-site tRNA A76 ...
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    Nature structural & molecular biology 11 (2004), S. 1134-1141 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The crystal structure of Escherichia coli cysteinyl-tRNA synthetase (CysRS) bound to tRNACys at a resolution of 2.3 Å reveals base-specific and shape-selective interactions across an extensive protein-RNA recognition interface. The complex contains a mixed α/β C-terminal domain, ...
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    Nature structural & molecular biology 11 (2004), S. 1049-1053 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence ...
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    Nature structural & molecular biology 11 (2004), S. 912-913 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The role of conformational dynamics in enzyme catalysis has fascinated biologists for decades. Motions at the active site—and within the protein scaffold surrounding it—may affect the overall rate constant of the catalyzed reaction in several ways. On page 945 of this issue of Nature ...
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    Nature structural & molecular biology 11 (2004), S. 917-917 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Setting boundaries Pattern development in plants and animals begins with the division of groups of cells into distinct domains. The cells within each group acquire different developmental fates as a result of precise gene expression patterns. MicroRNAS (miRNAs), which are involved in regulation of ...
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    Nature structural & molecular biology 11 (2004), S. 992-1000 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nonsense-mediated mRNA decay (NMD) in mammalian cells targets cap-binding protein 80 (CBP80)-bound mRNA during or after a pioneer round of translation. It is unknown whether eukaryotic translation initiation factor 4G (eIF4G) functions in the pioneer round. We show that baculovirus-produced CBP80 ...
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    Nature structural & molecular biology 11 (2004), S. 1008-1014 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Using single-molecule methods we observed the stepwise movement of aminoacyl-tRNA (aa-tRNA) into the ribosome during selection and kinetic proofreading using single-molecule fluorescence resonance energy transfer (smFRET). Intermediate states in the pathway of tRNA delivery were observed using ...
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    Nature structural & molecular biology 11 (2004), S. 1021-1022 
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 ...
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Restricted access During protein synthesis, some polypeptides go through a channel known as the translocon to cross the endoplasmic reticulum membrane in eukaryotes and the plasma membrane in prokaryotes. van den Berg et al. report a long-awaited high-resolution crystal structure of this channel, ...
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    Topics: Biology , Medicine
    Notes: [Auszug] I have no question that students who learn, not professors who perform, is what teaching is all about: students who learn are the finest fruit of teachers who teach.... I am also clear that... teachers possess the power to create conditions that can help students learn a great deal—or keep ...
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    Notes: [Auszug] Unveiling the human genome, with the finding that it encodes a relatively modest number of genes, has highlighted the importance of post-transcriptional modifications in generating biological complexity. Alternative pre-mRNA splicing is considered to be one important source of protein diversity in ...
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    Notes: [Auszug] Genomic integrity is essential to the survival of any organism, and DNA double-strand breaks (DSBs) are a dangerous threat to this integrity. Although it is well known that exogenous agents such as ionizing radiation can induce DSBs, problems encountered during replication are probably the most ...
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    Nature biotechnology 22 (2004), S. 507-507 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Your editorial in the February issue (Nat. Biotechnol. 22, 13, 2004) expressed concerns about the use of conventional crops, mainly maize, for the production of biopharmaceuticals. With the current capacity crunch for production of biopharmaceuticals by current-day technologies, and ...
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    Nature biotechnology 22 (2004), S. 509-510 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Though the reports produced by the US President's Council on Bioethics have not yet had a dramatic effect on public debates in the United States, the Council itself is back in the limelight following the departures of Elizabeth Blackburn and William F. May and the additions of Benjamin Carson, ...
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    Nature biotechnology 22 (2004), S. 533-533 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Wood chips Genome-wide expression analysis in plants has largely been carried out in model organisms whose genomes have been sequenced, such as Arabidopsis thaliana (thale cress) and Oryza sativa (rice), rather than in perennial, woody plants. To develop tools for studying perennials and processes ...
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    Nature biotechnology 22 (2004), S. 609-609 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Anthony J. Cavalieri has joined the board of directors of Chromatin (Chicago). He spent more than 20 years at Pioneer Hi-Bred International, a subsidiary of DuPont, and recently retired as vice president in charge of trait and technology development. Affymax (Palo Alto, CA, USA) has added to its ...
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    Nature biotechnology 22 (2004), S. 633-635 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What are the structural similarities and differences between European and US biotech research centers? How do they perform? What is their impact? These were the basic questions underlying a study launched by the European Commission's Directorate General for Research in 2000. A UK-German-US research ...
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    Nature biotechnology 22 (2004), S. 560-567 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In adults and children over two years of age, large cranial defects do not reossify successfully, posing a substantial biomedical burden. The osteogenic potential of bone marrow stromal (BMS) cells has been documented. This study investigates the in vivo osteogenic capability of adipose-derived ...
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    Nature biotechnology 22 (2004), S. 491-492 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Coming off a year that brought biotech investment back up near 2000 boom levels, the first quarter of 2004 (1Q04) registered continued high investor confidence. But industry observers see a potential dark cloud looming in the shape of hype and a leaderless US Food and Drug Administration (FDA; ...
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    Nature biotechnology 22 (2004), S. 493-494 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Ten countries from central and eastern Europe (CEE) will join the European Union (EU) on May 1, bringing the total number of member states to 25. Industry observers believe the creation of a wider—albeit not yet harmonized—European market could bring opportunities to biotech companies ...
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    Nature biotechnology 22 (2004), S. 513-519 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Protein structure information has traditionally played only a supporting role in many pharmaceutical drug discovery programs. With huge investments in 'high-throughput' screening and combinatorial chemistry technologies, many pharmaceutical companies aren't willing to put structural information ...
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    Nature biotechnology 22 (2004), S. 508-508 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Your editorial “Drugs in crops—the unpalatable truth” (Nat. Biotechnol., 22, 133, 2004) points out that the use of nonfood crops for the production of pharmaceuticals, preferably under contained (greenhouse) conditions, would add an extra dimension of safety to ...
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    Nature biotechnology 22 (2004), S. 526-527 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The high cost and technical difficulty of removing many noxious and toxic organic compounds (xenobiotics) from the environment has provided impetus to studies in which plants are used as an inexpensive means of environmental cleanup (phytoremediation). In this issue, Barac et al. describe a new ...
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    Nature biotechnology 22 (2004), S. 529-531 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The laboratory rat is the most widely used animal species for studying physiology, nutrition and metabolism. Last month, a large collaborative effort, the rat genome sequencing project consortium (RGSPC), succeeded in decoding the complete genome sequence of this higher eukaryotic species. With ...
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    Nature biotechnology 22 (2004), S. 601-601 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 21, 1473–1479 (2003) In this article, we concluded that inserting HCDR3 sequences derived from antibodies into a particular stable form of GFP created intrinsically fluorescent affinity reagents, which we termed 'fluorobodies.' We have recently realized that the strategy ...
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    Nature biotechnology 22 (2004), S. 603-605 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A trademark is a signifier that identifies goods and services, and can be a valuable intellectual property (IP) asset for biotechnology and pharmaceutical companies. Trademarks can induce purchase or avoidance of a product or service. In fact, trademark law has been explained on the hypothesis that ...
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    Nature biotechnology 22 (2004), S. 613-614 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The fundamental tenet of scientific publication is that the results of any study have to be open to independent validation or refutation. Consequently, few would argue with the value, or necessity, of releasing DNA sequence data in support of a publication. As genome sequencing has evolved, the ...
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    Nature biotechnology 22 (2004), S. 459-459 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nat. Biotechnol. 21, 1208–1214 (2003) In the author list, the name of author Seong-il Lee was misspelled as Sung-Il ...
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    Nature biotechnology 22 (2004), S. 467-467 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Novacea (S. San Francisco, CA, USA) has announced the appointment of Edward C. Albini as vice president and CFO. Mr. Albini joins the company from Lynx Therapeutics, where he served as CFO. Previously, he worked at Genentech in various senior financial management positions, including director of ...
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    Nature biotechnology 22 (2004), S. 487-488 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Growing biotechnology companies are in constant turmoil as they balance the three legs of their corporate stool: their offerings (e.g., technology, products or services), the money they have (or don't have) to bring their offerings forward and the managers who are leading the company toward some ...
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    Nature biotechnology 22 (2004), S. 427-433 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Freezing injury is a major environmental limitation on the productivity and geographical distribution of plants. Here we show that freezing tolerance can be manipulated in Arabidopsis thaliana by genetic alteration of the gene encoding phospholipase Dδ (PLDδ), which is involved in ...
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