WILBERT — Wildauer Bücher+E-Medien Recherche-Tool

1

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When it comes to couple(r)s, do opposites attract? (2007)

Sandall, Sharsti ; Desai, Arshad

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 790-792

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The budding yeast Dam1 complex, comprised of ten subunits, localizes to centromeres and is centrally important for chromosome–spindle microtubule interactions. Inhibition of this complex leads to extensive chromosome mis-segregation and cell lethality because replicated chromosomes cannot ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0907-790

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Losing half our scientific capacity (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 787-787

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] More women are earning PhDs in science and engineering (∼50% as of 2005). But that's where the good news ends. Women make up a small proportion of the science and engineering faculty at research universities, and they typically receive fewer resources and less support than their male ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0907-787

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3

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Chloride finds its place in the transport cycle (2007)

Amara, Susan G

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 792-794

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Neurons and glial cells accumulate neurotransmitters by a sodium-coupled transport process that is in many respects similar to systems used by other cells and organisms for concentrating amines and amino acids. By cotransporting a solute with one or more sodium ions, the energy stored in the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0907-792

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RNA polymerase II transcription in living color (2007)

Lamond, Angus I ; Swedlow, Jason R

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 788-790

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Transcription by RNA polymerase II (Pol II) is fundamental to the mechanism of gene expression and a major target of biological regulatory mechanisms. It involves many separate steps, such as RNA Pol II molecules binding promoter sequences at the 5′ regions of genes, formation of initiation ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0907-788

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5

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X chromosome exposé (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 794-794

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Drosophila melanogaster males, like males of a number of species, have only one X chromosome and thus only one copy of each X-linked gene—in contrast to females, who carry two copies of the X chromosome. In humans, one copy in the female X-chromosome pair is marked for silencing. Insects, ...

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URL: http://dx.doi.org/10.1038/nsmb0907-794

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Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 795-795

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] To the outer membrane and beyond Gram-negative bacteria, mitochondria and chloroplasts use members of the Omp85 superfamily to assemble β-barrel outer membrane proteins (OMPs) with a variety of cellular functions, including enzymes, adhesins and transporters of small molecules in or out of ...

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URL: http://dx.doi.org/10.1038/nsmb0907-795

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YY1 functions with INO80 to activate transcription (2007)

Cai, Yong ; Jin, Jingji ; Yao, Tingting ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 872-874

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1276

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In vivo dynamics of RNA polymerase II transcription (2007)

Darzacq, Xavier ; Shav-Tal, Yaron ; de Turris, Valeria ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 796-806

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] We imaged transcription in living cells using a locus-specific reporter system, which allowed precise, single-cell kinetic measurements of promoter binding, initiation and elongation. Photobleaching of fluorescent RNA polymerase II revealed several kinetically distinct populations of the enzyme ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1280

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Structural dynamics in the gating ring of cyclic nucleotide–gated ion channels (2007)

Taraska, Justin W ; Zagotta, William N

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 854-860

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] For ligand-gated ion channels, the binding of a ligand to an intracellular or extracellular domain generates changes in transmembrane pore-forming helices, which alters ion flow. The molecular mechanism for this allostery, however, remains unknown. Here we explore the structure and conformational ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1281

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The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation (2007)

Zhang, Xiaoyu ; Germann, Sophie ; Blus, Bartlomiej J ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 869-871

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation (H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID-chip method, we found that the Arabidopsis thaliana chromodomain-containing protein LHP1 colocalizes with ...

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URL: http://dx.doi.org/10.1038/nsmb1283

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MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control (2007)

Wu, Yili ; Xiao, Shujie ; Zhu, Xu-Dong

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 832-840

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Human telomeres are associated with ATM and the protein complex consisting of MRE11, RAD50 and NBS1 (MRN), which are central to maintaining genomic stability. Here we show that when targeted to telomeres, wild-type RAD50 downregulates telomeric association of TRF1, a negative regulator of telomere ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1286

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The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction (2007)

Wu, Zhiping ; Wagner, Matthew A ; Zheng, Lemin ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 861-868

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The cardioprotective function of high-density lipoprotein (HDL) is largely attributed to its ability to facilitate transport of cholesterol from peripheral tissues to the liver. However, HDL may become dysfunctional through oxidative modification, impairing cellular cholesterol efflux. Here we ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1284

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Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA (2007)

Schubert, Mario ; Lapouge, Karine ; Duss, Olivier ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 807-813

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Proteins of the RsmA/CsrA family are global translational regulators in many bacterial species. We have determined the solution structure of a complex formed between the RsmE protein, a member of this family from Pseudomonas fluorescens, and a target RNA encompassing the ribosome-binding site of ...

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URL: http://dx.doi.org/10.1038/nsmb1285

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An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis (2007)

Klinge, Sebastian ; Hirst, Judy ; Maman, Joseph D ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 875-877

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Primases synthesize the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur (Fe-S) protein. Binding of the Fe-S cluster is mediated by an evolutionarily conserved domain at the C terminus of ...

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URL: http://dx.doi.org/10.1038/nsmb1288

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Lsm proteins bind and stabilize RNAs containing 5′ poly(A) tracts (2007)

Bergman, Naomi ; Moraes, Karen C M ; Anderson, John R ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 824-831

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Many orthopoxvirus messenger RNAs have an unusual nontemplated poly(A) tract of 5 to 40 residues at the 5′ end. The precise function of this feature is unknown. Here we show that 5′ poly(A) tracts are able to repress RNA decay by inhibiting 3′-to-5′ exonucleases as well as ...

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URL: http://dx.doi.org/10.1038/nsmb1287

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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression (2007)

Mitin, Natalia ; Betts, Laurie ; Yohe, Marielle E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 814-823

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor suppressor. Here we show that binding of the armadillo repeats of APC to a 'core APC-binding' (CAB) motif within ASEF, or truncation of the SH3 domain of ASEF, relieves autoinhibition, ...

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URL: http://dx.doi.org/10.1038/nsmb1290

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Crystal structure of human DGCR8 core (2007)

Sohn, Sun Young ; Bae, Won Jin ; Kim, Jeong Joo ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 847-853

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A complex of Drosha with DGCR8 (or its homolog Pasha) cleaves primary microRNA (pri-miRNA) substrates into precursor miRNA and initiates the microRNA maturation process. Drosha provides the catalytic site for this cleavage, whereas DGCR8 or Pasha provides a frame for anchoring substrate pri-miRNAs. ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1294

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F 1 -ATPase rotates by an asymmetric, sequential mechanism using all three catalytic subunits (2007)

Muneyuki, Eiro ; Yoshida, Masasuke ; Ariga, Takayuki

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 841-846

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] F1-ATPase, the catalytic part of FoF1-ATP synthase, rotates the central γ subunit within the α3β3 cylinder in 120° steps, each step consuming a single ATP molecule. However, how the catalytic activity of each β subunit is coordinated with the other two β subunits to ...

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URL: http://dx.doi.org/10.1038/nsmb1296

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Name that gene! (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 681-681

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Certain biologists (along with club-hoppers, flip-floppers and sabermetricians) felt the glow of literary respectability earlier this year: the words apoptosis, protein kinase and primosome passed the scrutiny of the usage police (along with club-hopper, etc.) and entered that hallowed tome, the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0807-681

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Targeting the JMJD2A histone lysine demethylase (2007)

Wilson, Jon R

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 682-684

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] It is well established that chromatin structure is dynamic, and events in transcription, replication and repair are influenced by access to the DNA. The cell regulates this process by a system of post-translational modifications of selected side chains on the histone proteins, and these marks ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb0807-682

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A fork in the road for microRNAs (2007)

Bellare, Priya ; Sontheimer, Erik J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 684-686

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Several categories of small (∼20- to 30-nucleotide) RNA molecules—including short interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs)—have recently emerged as important regulators of gene expression in eukaryotes. Research into RNA silencing has led to ...

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URL: http://dx.doi.org/10.1038/nsmb0807-684

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Finding the right spot to start transcription (2007)

Cramer, Patrick

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 686-687

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In all living cells, the expression of genetic programs is governed by the dynamic transcriptome, which is established mainly by regulated transcription initiation at gene promoters. Thus, if we want to understand gene regulation, we must know the mechanism of transcription initiation. Initiation ...

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URL: http://dx.doi.org/10.1038/nsmb0807-686

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Erratum: U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 785-785

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 620–629 (2007); published online 24 June 2007; corrected after print 2 July 2007 In the version of this article initially published, the name of the second author, Sophie Bonnal, was misspelled. The error has been corrected in the HTML and PDF versions of the ...

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URL: http://dx.doi.org/10.1038/nsmb0807-785

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Research Highlights (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 688-688

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] PI3K polar patch Phosphoinositide 3-kinases (PI3Ks) regulate many cellular processes and are linked to several cancers. The PI3K catalytic subunit, p110α, dimerizes with the p85 regulatory subunit, resulting in enzyme inhibition. Some oncogenic hot spots in p110α map to the ...

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URL: http://dx.doi.org/10.1038/nsmb0807-688

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Structural basis for nick recognition by a minimal pluripotent DNA ligase (2007)

Nair, Pravin A ; Nandakumar, Jayakrishnan ; Smith, Paul ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 770-778

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular ligases. A 2.3-Å crystal structure of the Chlorella virus ligase-AMP intermediate bound ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nsmb1266

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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat (2007)

Pemble, Charles W ; Johnson, Lynnette C ; Kridel, Steven J ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 704-709

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Human fatty acid synthase (FAS) is uniquely expressed at high levels in many tumor types. Pharmacological inhibition of FAS therefore represents an important therapeutic opportunity. The drug Orlistat, which has been approved by the US Food and Drug Administration, inhibits FAS, induces tumor ...

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URL: http://dx.doi.org/10.1038/nsmb1265

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Rad54 dissociates homologous recombination intermediates by branch migration (2007)

Bugreev, Dmitry V ; Hanaoka, Fumio ; Mazin, Alexander V

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 746-753

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Double-strand DNA breaks (DSBs) cause cell death and genome instability. Homologous recombination is a major DSB repair pathway that operates by forming joint molecules with homologous DNA sequences, which are used as templates to achieve accurate repair. In eukaryotes, Rad51 protein (RecA homolog) ...

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URL: http://dx.doi.org/10.1038/nsmb1268

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Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque (2007)

Nöllmann, Marcelo ; Stone, Michael D ; Bryant, Zev ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 264-271

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] E. coli DNA gyrase uses the energy of ATP hydrolysis to introduce essential negative supercoils into the genome, thereby working against the mechanical stresses that accumulate in supercoiled DNA. Using a magnetic-tweezers assay, we demonstrate that small changes in force and torque can switch ...

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URL: http://dx.doi.org/10.1038/nsmb1213

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Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea (2007)

Fukunaga, Ryuya ; Yokoyama, Shigeyuki

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 272-279

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Cysteine is ligated to tRNACys by cysteinyl-tRNA synthetase in most organisms. However, in methanogenic archaea lacking cysteinyl-tRNA synthetase, O-phosphoserine is ligated to tRNACys by O-phosphoseryl–tRNA synthetase (SepRS), and the phosphoseryl-tRNACys is converted to cysteinyl-tRNACys. ...

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URL: http://dx.doi.org/10.1038/nsmb1219

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Potent effect of target structure on microRNA function (2007)

Long, Dang ; Lee, Rosalind ; Williams, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 287-294

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] MicroRNAs (miRNAs) are small noncoding RNAs that repress protein synthesis by binding to target messenger RNAs. We investigated the effect of target secondary structure on the efficacy of repression by miRNAs. Using structures predicted by the Sfold program, we model the interaction between an ...

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URL: http://dx.doi.org/10.1038/nsmb1226

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Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase (2007)

Couture, Jean-François ; Collazo, Evys ; Ortiz-Tello, Patricia A ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 689-695

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] JMJD2A is a JmjC histone demethylase (HDM) that catalyzes the demethylation of di- and trimethylated Lys9 and Lys36 in histone H3 (H3K9me2/3 and H3K36me2/3). Here we present the crystal structures of the JMJD2A catalytic domain in complex with H3K9me3, H3K36me2 and H3K36me3 peptides. The structures ...

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URL: http://dx.doi.org/10.1038/nsmb1273

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Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase (2007)

Liang, Gaoyang ; Klose, Robert J ; Gardner, Kathryn E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 243-245

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5′ regions of transcribed genes. Here we identify a novel budding yeast JmjC ...

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URL: http://dx.doi.org/10.1038/nsmb1204

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Erratum: Histone merry-go-round (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 351-351

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nature Structural & Molecular Biology 14, 183 (2007). In the version of this Research Highlight originally published, we printed the incorrect name as corresponding author for the paper being highlighted. The corresponding author is Michel Strubin, not Rachel Imoberdorf. We apologize for this ...

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URL: http://dx.doi.org/10.1038/nsmb0407-351a

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Erratum: Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase (2007)

Liang, Gaoyang ; Klose, Robert J ; Gardner, Kathryn E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 351-351

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nature Structural & Molecular Biology 14, 243–45 (2007); published online 18 February 2007; corrected after print 19 March 2007 In the version of this article initially published, a gel in Figure 2a is incorrectly labeled. The second gel down should be labeled H3-K4me3. The corrected ...

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URL: http://dx.doi.org/10.1038/nsmb0407-351c

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Sequence-specific dynamics modulate recognition specificity in WW domains (2007)

Peng, Tao ; Zintsmaster, John S ; Namanja, Andrew T ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 325-331

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The current canon attributes the binding specificity of protein-recognition motifs to distinctive chemical moieties in their constituent amino acid sequences. However, we show for a WW domain that the sequence crucial for specificity is an intrinsically flexible loop that partially rigidifies upon ...

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URL: http://dx.doi.org/10.1038/nsmb1207

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A toxic monomeric conformer of the polyglutamine protein (2007)

Inui, Takashi ; Popiel, H Akiko ; Fujikake, Nobuhiro ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 332-340

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Polyglutamine (polyQ) diseases are classified as conformational neurodegenerative diseases, like Alzheimer and Parkinson diseases, and they are caused by proteins with an abnormally expanded polyQ stretch. However, conformational changes of the expanded polyQ protein and the toxic conformers formed ...

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URL: http://dx.doi.org/10.1038/nsmb1215

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Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions (2007)

Ribes-Zamora, Albert ; Mihalek, Ivana ; Lichtarge, Olivier ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 301-307

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Ku heterodimer, comprised of Ku70 and Ku80 subunits, is a conserved complex involved in nonhomologous end-joining (NHEJ). However, it also functions in maintenance of telomeres, chromosome termini normally resistant to end-joining events. To elucidate the spatial organization of these ...

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Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini (2007)

Kirino, Yohei ; Mourelatos, Zissimos

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 347-348

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3′ termini of piRNAs are 2′-O-methylated; this modification may have important implications for the biogenesis and function of ...

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URL: http://dx.doi.org/10.1038/nsmb1218

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A riboswitch selective for the queuosine precursor preQ 1 contains an unusually small aptamer domain (2007)

Roth, Adam ; Winkler, Wade C ; Regulski, Elizabeth E ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 308-317

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] A previous bioinformatics-based search for riboswitches yielded several candidate motifs in eubacteria. One of these motifs commonly resides in the 5′ untranslated regions of genes involved in the biosynthesis of queuosine (Q), a hypermodified nucleoside occupying the anticodon wobble ...

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URL: http://dx.doi.org/10.1038/nsmb1224

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Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules (2007)

Mistry, Anil ; Ammirati, Mark J ; Chrunyk, Boris A ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 106-113

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Inhibition of CETP raises HDL cholesterol and may potentially be ...

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URL: http://dx.doi.org/10.1038/nsmb1197

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RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA (2007)

Jones, Hannah S ; Kawauchi, Junya ; Braglia, Priscilla ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 123-130

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] RNA polymerase (Pol) I–transcribed ribosomal genes of budding yeast exist as a tandem array (about 150 repeats) with transcription units separated by spacer sequences. Half of these rDNAs are inactivated by repressive chromatin structure, whereas the rest exist in an open conformation ...

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URL: http://dx.doi.org/10.1038/nsmb1199

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Keeping the right dosage (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 97-97

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Sex chromosomes present a gene expression dosage problem for the organisms that carry them: if the male is XY and the female XX, the female has a double dose of X chromosome genes. This has been overcome in very different ways in different organisms: whereas Drosophila melanogaster doubles gene ...

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URL: http://dx.doi.org/10.1038/nsmb0207-97

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Adenovirus type 11 binding alters the conformation of its receptor CD46 (2007)

Persson, B David ; Reiter, Dirk M ; Marttila, Marko ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 164-166

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent ...

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URL: http://dx.doi.org/10.1038/nsmb1190

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Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC (2007)

Wang, Limin ; Zhao, Yiwei ; Li, Zhong ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 169-171

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] 'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-Å resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA ...

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URL: http://dx.doi.org/10.1038/nsmb1193

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'Tis the season. . . (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1117-1117

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Despite the advent of antibiotics and vaccines, infectious diseases still account for around one-third of worldwide deaths, according to the World Health Organization. A molecular understanding of how pathogens cause disease is the object of intense research, and this issue of Nature Structural ...

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URL: http://dx.doi.org/10.1038/nsmb1207-1117

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Corrigendum: Structural insight into the substrate specificity of DNA Polymerase μ (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 680-680

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 14, 45–53 (2007); published online 10 December 2006; corrected after print 15 June 2007 In the version of this article initially published, the crystallization conditions were incorrectly reported. The correct conditions are as follows: 95 mM sodium citrate (pH 5.6), ...

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URL: http://dx.doi.org/10.1038/nsmb0707-680b

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PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs (2007)

Diem, Michael D ; Chan, Chia C ; Younis, Ihab ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1173-1179

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; however, the specific link between the EJC and the translation machinery has not been ...

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URL: http://dx.doi.org/10.1038/nsmb1321

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Structural basis for DNA duplex separation by a superfamily-2 helicase (2007)

Büttner, Katharina ; Nehring, Sebastian ; Hopfner, Karl-Peter

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 647-652

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] To reveal the mechanism of processive strand separation by superfamily-2 (SF2) 3′→5′ helicases, we determined apo and DNA-bound crystal structures of archaeal Hel308, a helicase that unwinds lagging strands and is related to human DNA polymerase θ. Our structure captures the ...

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URL: http://dx.doi.org/10.1038/nsmb1246

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A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair (2007)

Wu, Su ; Shi, Yujiang ; Mulligan, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1165-1172

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] DNA damage repair is crucial for the maintenance of genome integrity and cancer suppression. We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination. Further biochemical analyses ...

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URL: http://dx.doi.org/10.1038/nsmb1332

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The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a (2007)

Guil, Sonia ; Cáceres, Javier F

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 591-596

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] hnRNP A1 is an RNA-binding protein involved in various aspects of RNA processing. Use of an in vivo cross-linking and immunoprecipitation protocol to find hnRNP A1 RNA targets resulted in the identification of a microRNA (miRNA) precursor, pre-miR-18a. This microRNA is expressed as part of a ...

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URL: http://dx.doi.org/10.1038/nsmb1250

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Transcription and RNAi in heterochromatic gene silencing (2007)

Bühler, Marc ; Moazed, Danesh

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1041-1048

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and ...

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URL: http://dx.doi.org/10.1038/nsmb1315

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Gene regulation through nuclear organization (2007)

Sexton, Tom ; Schober, Heiko ; Fraser, Peter ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 1049-1055

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The nucleus is a highly heterogeneous structure, containing various 'landmarks' such as the nuclear envelope and regions of euchromatin or dense heterochromatin. At a morphological level, regions of the genome that are permissive or repressive to gene expression have been associated with these ...

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URL: http://dx.doi.org/10.1038/nsmb1324

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Chromatin remodeling: insights and intrigue from single-molecule studies (2007)

Cairns, Bradley R

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 989-996

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Chromatin remodelers are ATP-hydrolyzing machines specialized to restructure, mobilize or eject nucleosomes, allowing regulated exposure of DNA in chromatin. Recently, remodelers have been analyzed using single-molecule techniques in real time, revealing them to be complex DNA-pumping machines. The ...

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URL: http://dx.doi.org/10.1038/nsmb1333

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How much can SNAREs flex their muscles? (2007)

Rizo, Josep ; Dai, Han

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 880-882

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] SNARE proteins are central components of a conserved machinery that governs most types of intracellular membrane fusion in organisms ranging from yeast to mammals. Studies of the neuronal SNAREs that control neurotransmitter release, namely the synaptic vesicle protein synaptobrevin (also known as ...

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URL: http://dx.doi.org/10.1038/nsmb1007-880

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Sensing of DNA damage by XPC/Rad4: one protein for many lesions (2007)

Sugasawa, Kaoru ; Hanaoka, Fumio

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 887-888

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Xeroderma pigmentosum (XP), a human autosomal recessive disorder, is clinically characterized by cutaneous photosensitivity and a high incidence of skin cancer. So far, eight genes have been identified that are associated with XP, seven of which (XPA through XPG) are involved in nucleotide excision ...

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URL: http://dx.doi.org/10.1038/nsmb1007-887

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Structure-function relationship of CAP-Gly domains (2007)

Weisbrich, Anke ; Honnappa, Srinivas ; Jaussi, Rolf ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 959-967

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] In all eukaryotes, CAP-Gly proteins control important cellular processes. The molecular mechanisms underlying the functions of CAP-Gly domains, however, are still poorly understood. Here we use the complex formed between the CAP-Gly domain of p150glued and the C-terminal zinc knuckle of CLIP170 as ...

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URL: http://dx.doi.org/10.1038/nsmb1291

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U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 (2007)

Corsini, Lorenzo ; Bonna, Sophie ; Basquin, Jerome ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 620-629

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The U2AF-homology motif (UHM) mediates protein-protein interactions between factors involved in constitutive RNA splicing. Here we report that the splicing factor SPF45 regulates alternative splicing of the apoptosis regulatory gene FAS (also called CD95). The SPF45 UHM is necessary for this ...

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URL: http://dx.doi.org/10.1038/nsmb1260

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Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination (2007)

Zhang, Yu ; Hefferin, Melissa L ; Chen, Ling ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 639-646

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) in bacteria and eukaryotes. In Saccharomyces cerevisiae, there are pairwise physical interactions among the core complexes of the NHEJ pathway, namely Yku70–Yku80 (Ku), Dnl4–Lif1 and Mre11–Rad50–Xrs2 ...

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URL: http://dx.doi.org/10.1038/nsmb1261

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Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs (2007)

Lee, Suzanne R ; Collins, Kathleen

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 604-610

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Many classes of small RNA (sRNA) involved in RNA silencing are generated by double-stranded RNA (dsRNA) processing. Although principles of sRNA biogenesis have emerged, newly identified classes of sRNAs have features that suggest additional biogenesis mechanisms. Tetrahymena thermophila expresses ...

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URL: http://dx.doi.org/10.1038/nsmb1262

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Structural insight into the substrate specificity of DNA Polymerase μ (2007)

Moon, Andrea F ; Garcia-Diaz, Miguel ; Bebenek, Katarzyna ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 45-53

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] DNA polymerase μ (Pol μ) is a family X enzyme with unique substrate specificity that contributes to its specialized role in nonhomologous DNA end joining (NHEJ). To investigate Pol μ's unusual substrate specificity, we describe the 2.4 Å crystal structure of the polymerase domain of ...

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URL: http://dx.doi.org/10.1038/nsmb1180

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SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells (2007)

Park, Sung Wook ; Hu, Xinli ; Gupta, Pawan ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 68-75

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The Tr2 orphan nuclear receptor can be SUMOylated, resulting in the replacement of coregulators recruited to the regulatory region of its endogenous target gene, Oct4. UnSUMOylated Tr2 activates Oct4, enhancing embryonal carcinoma-cell proliferation, and is localized to the promyelocytic leukemia ...

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An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane (2007)

Moraes, Trevor F ; Bains, Manjeet ; Hancock, Robert E W ; [et al.]

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 85-87

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-Å resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from ...

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URL: http://dx.doi.org/10.1038/nsmb1189

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Corrigendum: FtsK: A groovy helicase (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 568-568

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nat. Struct. Mol. Biol. 13, 948–950 (2006). In the version of this News and Views initially published, the authors present a model to explain the low degree of positive DNA supercoiling generated during DNA translocation through the FtsK helicase. The authors' conclusion, that in a rotary ...

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URL: http://dx.doi.org/10.1038/nsmb0607-568c

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Erratum: Looking ahead with structural genomics (2007)

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 172-172

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Nature Structural & Molecular Biology 14, 1 (2007). In the version of this Editorial originally published, we incorrectly stated that the Protein Structure Initiative (PSI) represents ∼1%–3% of the total US National Institutes of Health operating budget. The PSI is funded by the US ...

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URL: http://dx.doi.org/10.1038/nsmb0207-172b

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Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease? (2007)

Hamilton, James A ; Deckelbaum, Richard J

[s.l.] : Nature Publishing Group

Nature structural & molecular biology 14 (2007), S. 95-97

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ISSN: 1545-9985

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] With the well-documented successes of statins in lowering the concentration of 'bad' cholesterol (found mainly in low-density lipoprotein, or LDL) in human plasma and in diminishing cardiovascular disease (CVD), there is increasing effort to develop drugs to raise 'good' cholesterol (in HDL). This ...

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URL: http://dx.doi.org/10.1038/nsmb0207-95

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Managing change in biotech: setbacks and failures (2007)

Rafferty, Mary Ann

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 1059-1059

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] One of the toughest challenges faced by biotech companies is having a promising lead experimental drug fall flat in the final stages of clinical trials. In the San Francisco Bay Area alone this past year, companies such as Nuvelo, Telik, Renovis, Dynavax Technologies and Threshold Pharmaceuticals ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-1059

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News in brief (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 959-960

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Biomarker group grows The public-private biomedical partnership The Biomarkers Consortium has had a substantial rise in its contributing members since its formation in October 2006. The partnership between the National Institutes of Health (NIH) and private stakeholders now boasts more than 30 ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-959

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Settling for second best? (2007)

Pitts, Peter J

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 715-716

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] To the editor: Your editorial “Probity gone nuts” (Nat. Biotechnol. 25, 483, 2007) hits the nail on the head with the statement, “The thinking behind the FDA's draft guidance on financial conflicts of interest for outside experts is deeply flawed.” But there are more nails ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-715

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The MTA—rip it up and start again? (2007)

Ku, Katharine ; Henderson, James

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 721-721

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] A material transfer agreement (MTA) is a contract allowing tangible research materials, such as cell lines, plasmids or reagents, to be transferred between research institutions. At its core, an MTA is a simple agreement that contractually defines who is making available (the provider) and who is ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-721a

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Gene patents and genetic testing in the United States (2007)

Klein, Roger D

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 989-990

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Molecular genetic testing has increasingly been incorporated into clinical medicine, and this trend is likely to accelerate in the future. However, the introduction of genetic testing into medical practice is beginning to collide head on with patents that claim ownership of correlations between ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0907-989

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Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007)

Laflamme, Michael A ; Chen, Kent Y ; Naumova, Anna V ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 1015-1024

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Cardiomyocytes derived from human embryonic stem (hES) cells potentially offer large numbers of cells to facilitate repair of the infarcted heart. However, this approach has been limited by inefficient differentiation of hES cells into cardiomyocytes, insufficient purity of cardiomyocyte ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1327

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A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments (2007)

Li, Yougen ; Drummond, D Allan ; Sawayama, Andrew M ; [et al.]

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 1051-1056

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] Thermostable enzymes combine catalytic specificity with the toughness required to withstand industrial reaction conditions. Stabilized enzymes also provide robust starting points for evolutionary improvement of other protein properties. We recently created a library of at least 2,300 new active ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt1333

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Production technologies change flu vaccine landscape (2007)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 701-701

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] The imminent approval in the European Union of the first seasonal influenza vaccine based on mammalian cell culture marks the beginning of a technology shift in the industry. However, transitioning away from the 50-year-old, egg-based manufacturing process is likely to be gradual rather than ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-701

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Human embryonic stem cells flock together (2007)

Lensch, M William ; Daley, George Q

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 748-750

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] How similar are the many human embryonic stem (hES) cell lines being studied in laboratories around the world? In the absence of standardized methods for deriving, culturing and characterizing hES cells, the International Stem Cell Initiative (ISCI) has sought to answer this question with an ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nbt0707-748

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Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 753-753

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: [Auszug] 'Murinizing' a pathogen The narrow host range of the food-borne pathogen Listeria monocytogenes prevents use of mouse models to study its pathogenesis. Now, Wollert and colleagues engineer an L. monocytogenes strain that can infect mice—a process they term 'murinization'. They accomplish ...

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URL: http://dx.doi.org/10.1038/nbt0707-753

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A green light to expression in time and space (2007)

Mango, Susan E

[s.l.] : Nature Publishing Group

Nature biotechnology 25 (2007), S. 645-646

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ISSN: 1546-1696

Source: Nature Archives 1869 - 2009