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Publication Date: 2018-12-20

Description: Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V, Published online: 19 December 2018; doi:10.1038/s41467-018-07797-4 How DNA repair proteins locate their target sites on DNA is still a matter of debate. Here the authors characterize by single-molecule fluorescence imaging the modes of scanning adopted by bacterial endonuclease V as it moves along linear DNA tracks.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Integrin CD11b activation drives anti-tumor innate immunity (2018)

Michael C. Schmid; Samia Q. Khan; Megan M. Kaneda; Paulina Pathria; Ryan Shepard; Tiani L. Louis; Sudarshan Anand; Gyunghwi Woo; Chris Leem; M. Hafeez Faridi; Terese Geraghty; Anugraha Rajagopalan; Seema Gupta; Mansoor Ahmed; Roberto I. Vazquez-Padron; David A. Cheresh; Vineet Gupta; Judith A. Varner

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Publication Date: 2018-12-20

Description: Integrin CD11b activation drives anti-tumor innate immunity Integrin CD11b activation drives anti-tumor innate immunity, Published online: 19 December 2018; doi:10.1038/s41467-018-07387-4 Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Konstantinos Tzelepis; Etienne De Braekeleer; Demetrios Aspris; Isaia Barbieri; M. S. Vijayabaskar; Wen-Hsin Liu; Malgorzata Gozdecka; Emmanouil Metzakopian; Hamish D. Toop; Monika Dudek; Samuel C. Robson; Francisco Hermida-Prado; Yu Hsuen Yang; Roya Babaei-Jadidi; Dimitrios A. Garyfallos; Hannes Ponstingl; Joao M. L. Dias; Paolo Gallipoli; Michael Seiler; Silvia Buonamici; Binje Vick; Andrew J. Bannister; Roland Rad; Rab K. Prinjha; John C. Marioni; Brian Huntly; Jennifer Batson; Jonathan C. Morris; Cristina Pina; Allan Bradley; Irmela Jeremias; David O. Bates; Kosuke Yusa; Tony Kouzarides; George S. Vassiliou

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 (2018)

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Publication Date: 2018-12-20

Description: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4, Published online: 19 December 2018; doi:10.1038/s41467-018-07620-0 SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance (2018)

Congcong Du; Shenbao Jin; Yuan Fang; Jin Li; Shenyang Hu; Tingting Yang; Ying Zhang; Jianyu Huang; Gang Sha; Yugang Wang; Zhongxia Shang; Xinghang Zhang; Baoru Sun; Shengwei Xin; Tongde Shen

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Publication Date: 2018-12-20

Description: Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance, Published online: 19 December 2018; doi:10.1038/s41467-018-07712-x Weaker ferritic/matensitic steels rather than stronger austenitic steels are usually candidates for nuclear reactors since they do not easily swell under irradiation. Here, the authors make an ultrastrong lanthanum-doped nanocrystalline austenitic steel that is thermally stable and radiation-tolerant.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes (2018)

Lukas Brüning; Philipp Hackert; Roman Martin; Jimena Davila Gallesio; Gerald Ryan R. Aquino; Henning Urlaub; Katherine E. Sloan; Markus T. Bohnsack

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Publication Date: 2018-12-20

Description: RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes, Published online: 19 December 2018; doi:10.1038/s41467-018-07783-w Pre-ribosomes undergo numerous structural rearrangements during their assembly. Here the authors identify the binding sites of three essential RNA helicases on pre-ribosomal particles, enabling them to provide insights into the structural and compositional changes that occur during biogenesis of the large ribosomal subunit.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Emerging negative impact of warming on summer carbon uptake in northern ecosystems (2018)

Tao Wang; Dan Liu; Shilong Piao; Yilong Wang; Xiaoyi Wang; Hui Guo; Xu Lian; John F Burkhart; Philippe Ciais; Mengtian Huang; Ivan Janssens; Yue Li; Yongwen Liu; Josep Peñuelas; Shushi Peng; Hui Yang; Yitong Yao; Yi Yin; Yutong Zhao

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Publication Date: 2018-12-20

Description: Emerging negative impact of warming on summer carbon uptake in northern ecosystems Emerging negative impact of warming on summer carbon uptake in northern ecosystems, Published online: 19 December 2018; doi:10.1038/s41467-018-07813-7 The impacts of climate change on summer carbon cycling in the northern hemisphere remain poorly resolved. Here the authors use atmospheric CO2 records from Point Barrow (Alaska) to show that summer CO2 drawdown is significantly negatively correlated with terrestrial temperature north of 50°N between 1979–2012.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Closure of the Bering Strait caused Mid-Pleistocene Transition cooling (2018)

Sev Kender; Ana Christina Ravelo; Savannah Worne; George E. A. Swann; Melanie J. Leng; Hirofumi Asahi; Julia Becker; Henrieka Detlef; Ivano W. Aiello; Dyke Andreasen; Ian R. Hall

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Publication Date: 2018-12-20

Description: Closure of the Bering Strait caused Mid-Pleistocene Transition cooling Closure of the Bering Strait caused Mid-Pleistocene Transition cooling, Published online: 19 December 2018; doi:10.1038/s41467-018-07828-0 The causes of Mid-Pleistocene Transition global cooling 1 million years ago are still unknown. Here, the authors find the subarctic North Pacific became stratified during these glaciations due to closure of the Bering Strait, which would have removed CO2 from the atmosphere and caused global cooling.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Concurrent influence of top-down and bottom-up inputs on correlated activity of Macaque extrastriate neurons (2018)

Yaser Merrikhi; Kelsey Clark; Behrad Noudoost

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Publication Date: 2018-12-20

Description: Concurrent influence of top-down and bottom-up inputs on correlated activity of Macaque extrastriate neurons Concurrent influence of top-down and bottom-up inputs on correlated activity of Macaque extrastriate neurons, Published online: 19 December 2018; doi:10.1038/s41467-018-07816-4 Changes in correlated activity of neurons are believed to influence their information coding capacity. Here, the authors show how top-down and bottom-up inputs and their interaction differentially alter the correlated activity of neurons in extrastriate cortex

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems (2018)

Anna B. Solovieva; Valeria V. Kardumian; Nadezhda A. Aksenova; Lyudmila V. Belovolova; Mikhail V. Glushkov; Evgeny A. Bezrukov; Roman B. Sukhanov; Svetlana L. Kotova; Peter S. Timashev

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Publication Date: 2018-12-20

Description: Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems, Published online: 20 December 2018; doi:10.1038/s41598-018-37181-7 Author Correction: Optimization of Photosensitized Tryptophan Oxidation in the Presence of Dimegin-Polyvinylpyrrolidone-Chitosan Systems

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule (2018)

Fernanda C. Lessa; Jennifer Milucky; Nadine G. Rouphael; Nancy M. Bennett; H. Keipp Talbot; Lee H. Harrison; Monica M. Farley; Jeremy Walston; Fabiana Pimenta; Robert E. Gertz; Gowrisankar Rajam; Maria da Gloria Carvalho; Bernard Beall; Cynthia G. Whitney

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Publication Date: 2018-12-20

Description: Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule 〈i〉Streptococcus mitis〈/i〉 Expressing Pneumococcal Serotype 1 Capsule, Published online: 19 December 2018; doi:10.1038/s41598-018-35921-3 Streptococcus mitis Expressing Pneumococcal Serotype 1 Capsule

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Visual capture of gait during redirected walking (2018)

Yannick Rothacher; Anh Nguyen; Bigna Lenggenhager; Andreas Kunz; Peter Brugger

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Publication Date: 2018-12-20

Description: Visual capture of gait during redirected walking Visual capture of gait during redirected walking, Published online: 19 December 2018; doi:10.1038/s41598-018-36035-6 Visual capture of gait during redirected walking

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation (2018)

Ding-yang Li; Wen-tao Liu; Guang-yi Wang; Xiao-ju Shi

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Publication Date: 2018-12-20

Description: Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation, Published online: 19 December 2018; doi:10.1038/s41598-018-36365-5 Impact of combined ischemic preconditioning and remote ischemic perconditioning on ischemia-reperfusion injury after liver transplantation

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans (2018)

Emilio J. Poveda-Pagán; Sergio Hernández-Sánchez; Luis Rhys-Jones-López; Antonio Palazón-Bru; Carlos Lozano-Quijada

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Publication Date: 2018-12-20

Description: Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans, Published online: 19 December 2018; doi:10.1038/s41598-018-36417-w Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer (2018)

Saba Choudhary; Poornema Ramasundaram; Eugenia Dziopa; Ciaran Mannion; Yair Kissin; Lucas Tricoli; Christopher Albanese; Woo Lee; Jenny Zilberberg

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Publication Date: 2018-12-20

Description: Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer, Published online: 19 December 2018; doi:10.1038/s41598-018-36424-x Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy (2018)

Anna Mandziak; Juan de la Figuera; Sandra Ruiz-Gómez; Guiomar D. Soria; Lucas Pérez; Pilar Prieto; Adrian Quesada; Michael Foerster; Lucía Aballe

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Publication Date: 2018-12-20

Description: Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy, Published online: 19 December 2018; doi:10.1038/s41598-018-36356-6 Structure and magnetism of ultrathin nickel-iron oxides grown on Ru(0001) by high-temperature oxygen-assisted molecular beam epitaxy

Electronic ISSN: 2045-2322

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Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking (2018)

Rafaela Takako Ribeiro de Almeida; Rodolpho Martin do Prado; Carla Porto; Geraldo Tadeu dos Santos; Sharon Ann Huws; Eduardo Jorge Pilau

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Publication Date: 2018-12-20

Description: Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking, Published online: 19 December 2018; doi:10.1038/s41598-018-36196-4 Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Author Correction: The bHLH transcription factor CgbHLH001 is a potential interaction partner of CDPK in halophyte Chenopodium glaucum (2018)

Juan Wang; Gang Cheng; Cui Wang; Zhuanzhuan He; Xinxin Lan; Shiyue Zhang; Haiyan Lan

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Publication Date: 2018-12-21

Description: Author Correction: The bHLH transcription factor CgbHLH001 is a potential interaction partner of CDPK in halophyte Chenopodium glaucum Author Correction: The bHLH transcription factor CgbHLH001 is a potential interaction partner of CDPK in halophyte 〈i〉Chenopodium glaucum〈/i〉, Published online: 21 December 2018; doi:10.1038/s41598-018-37592-6 Author Correction: The bHLH transcription factor CgbHLH001 is a potential interaction partner of CDPK in halophyte Chenopodium glaucum

Electronic ISSN: 2045-2322

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Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques (2018)

Yaoguang Jiang; Michael L. Platt

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Publication Date: 2018-12-21

Description: Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques, Published online: 20 December 2018; doi:10.1038/s41598-018-36332-0 Oxytocin and vasopressin increase male-directed threats and vocalizations in female macaques

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Neural coding of intended and executed grasp force in macaque areas AIP, F5, and M1 (2018)

Rijk W. Intveld; Benjamin Dann; Jonathan A. Michaels; Hansjörg Scherberger

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Publication Date: 2018-12-21

Description: Neural coding of intended and executed grasp force in macaque areas AIP, F5, and M1 Neural coding of intended and executed grasp force in macaque areas AIP, F5, and M1, Published online: 20 December 2018; doi:10.1038/s41598-018-35488-z Neural coding of intended and executed grasp force in macaque areas AIP, F5, and M1

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Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients: A Descriptive Sub-study of the PermiT Randomized Controlled Trial (2018)

Yaseen M. Arabi; Mohammed Al-Balwi; Ali H. Hajeer; Dunia Jawdat; Musharaf Sadat; Hasan M. Al-Dorzi; Hani Tamim; Lara Afesh; Walid Almashaqbeh; Haitham Alkadi; Deemah Alwadaani; G. K. Udaya; Raja; Ibrahim B. Al Abdulkareem; Abdulaziz Al-Dawood

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Publication Date: 2018-12-21

Description: Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients: A Descriptive Sub-study of the PermiT Randomized Controlled Trial Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients: A Descriptive Sub-study of the PermiT Randomized Controlled Trial, Published online: 20 December 2018; doi:10.1038/s41598-018-36007-w Differential Gene Expression in Peripheral White Blood Cells with Permissive Underfeeding and Standard Feeding in Critically Ill Patients: A Descriptive Sub-study of the PermiT Randomized Controlled Trial

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin (2018)

Eileen McNeill; Elena Stylianou; Mark J. Crabtree; Rachel Harrington-Kandt; Anna-Lena Kolb; Marina Diotallevi; Ashley B. Hale; Paulo Bettencourt; Rachel Tanner; Matthew K. O’Shea; Magali Matsumiya; Helen Lockstone; Julius Müller; Helen A. Fletcher; David R. Greaves; Helen McShane; Keith M. Channon

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Publication Date: 2018-12-21

Description: Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin Regulation of mycobacterial infection by macrophage 〈i〉Gch1〈/i〉 and tetrahydrobiopterin, Published online: 20 December 2018; doi:10.1038/s41467-018-07714-9 Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate NO-independent control of Mycobacterial infection.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy (2018)

Byungjun Kang; Jisoo Shin; Hyun-Ji Park; Chanryeol Rhyou; Donyoung Kang; Shin-Jeong Lee; Young-sup Yoon; Seung-Woo Cho; Hyungsuk Lee

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Publication Date: 2018-12-21

Description: High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy, Published online: 20 December 2018; doi:10.1038/s41467-018-07823-5 Engineering 3D tissues faces the challenge of adequate vascularisation for nutrient delivery and gas exchange deep inside the construct. Here the authors use surface acoustic waves to create an aligned array of blood vessels in a hyaluronic acid hydrogel and use it to improve function in a mouse hindlimb ischemia model.

Electronic ISSN: 2041-1723

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Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus (2018)

Erik R. Nöldeke; Lena M. Muckenfuss; Volker Niemann; Anna Müller; Elena Störk; Georg Zocher; Tanja Schneider; Thilo Stehle

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Publication Date: 2018-12-21

Description: Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of 〈i〉Staphylococcus aureus〈/i〉, Published online: 21 December 2018; doi:10.1038/s41598-018-37082-9 Author Correction: Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus

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The Enzymatic Activity of APOBE3G Multimers (2018)

Yangang Pan; Karen Zagorski; Luda S. Shlyakhtenko; Yuri L. Lyubchenko

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Publication Date: 2018-12-19

Description: The Enzymatic Activity of APOBE3G Multimers The Enzymatic Activity of APOBE3G Multimers, Published online: 18 December 2018; doi:10.1038/s41598-018-36372-6 The Enzymatic Activity of APOBE3G Multimers

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Environmental factors influencing mucilage accumulation of the endangered Brasenia schreberi in China (2018)

Chun Xie; Jiafeng Li; Fan Pan; Junjie Fu; Wenzong Zhou; Shan Lu; Pengfu Li; Changfang Zhou

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Publication Date: 2018-12-19

Description: Environmental factors influencing mucilage accumulation of the endangered Brasenia schreberi in China Environmental factors influencing mucilage accumulation of the endangered 〈i〉Brasenia schreberi〈/i〉 in China, Published online: 18 December 2018; doi:10.1038/s41598-018-36448-3 Environmental factors influencing mucilage accumulation of the endangered Brasenia schreberi in China

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Activation of the motivation-related ventral striatum during delusional experience (2018)

Tuukka T. Raij; Tapani J. J. Riekki; Eva Rikandi; Teemu MäntyläTuula KieseppäJaana Suvisaari

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Publication Date: 2018-12-19

Description: Activation of the motivation-related ventral striatum during delusional experience Activation of the motivation-related ventral striatum during delusional experience, Published online: 18 December 2018; doi:10.1038/s41398-018-0347-8 Activation of the motivation-related ventral striatum during delusional experience

Electronic ISSN: 2158-3188

Topics: Medicine

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A case–control genome-wide association study of ADHD discovers a novel association with the tenascin R ( TNR ) gene (2018)

Ziarih Hawi; Hannah Yates; Ari Pinar; Aurina Arnatkeviciute; Beth Johnson; Janette Tong; Kealan Pugsley; Callum Dark; Marc Pauper; Marieke Klein; Helen S. Heussler; Harriet Hiscock; Alex Fornito; Jeggan Tiego; Amy Finlay; Alasdair Vance; Michael Gill; Lindsey Kent; Mark A. Bellgrove

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Publication Date: 2018-12-19

Description: A case–control genome-wide association study of ADHD discovers a novel association with the tenascin R ( TNR ) gene A case–control genome-wide association study of ADHD discovers a novel association with the tenascin R (〈i〉TNR〈/i〉) gene, Published online: 18 December 2018; doi:10.1038/s41398-018-0329-x A case–control genome-wide association study of ADHD discovers a novel association with the tenascin R ( TNR ) gene

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Author Correction: Distinct effects of social motivation on face evaluations in adolescents with and without autism (2018)

Lou Safra; Christina Ioannou; Frédérique Amsellem; Richard Delorme; Coralie Chevallier

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Description: Author Correction: Distinct effects of social motivation on face evaluations in adolescents with and without autism Author Correction: Distinct effects of social motivation on face evaluations in adolescents with and without autism, Published online: 21 December 2018; doi:10.1038/s41598-018-37593-5 Author Correction: Distinct effects of social motivation on face evaluations in adolescents with and without autism

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Tanja Wagner; Denise Traxler; Elisabeth Simader; Lucian Beer; Marie-Sophie Narzt; Florian Gruber; Sibylle Madlener; Maria Laggner; Michael Erb; Vera Vorstandlechner; Alfred Gugerell; Christine Radtke; Massimiliano Gnecchi; Anja Peterbauer; Maria Gschwandtner; Erwin Tschachler; Claudia Keibl; Paul Slezak; Hendrik J. Ankersmit; Michael Mildner

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Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions (2018)

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Description: Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions, Published online: 20 December 2018; doi:10.1038/s41598-018-36928-6 Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions

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Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats (2018)

Junji Saruwatari; Chao Dong; Teruo Utsumi; Masatake Tanaka; Matthew McConnell; Yasuko Iwakiri

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Description: Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats, Published online: 20 December 2018; doi:10.1038/s41598-018-36297-0 Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats

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Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites (2018)

Michel Nuevo; George Cooper; Scott A. Sandford

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Description: Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice analogues and comparison to meteorites, Published online: 18 December 2018; doi:10.1038/s41467-018-07693-x Sugars are known to form from the UV photoprocessing of ices under astrophysical conditions. Here, the authors report the detection of deoxyribose, the sugar of DNA, and other deoxysugars from the UV photoprocessing of H2O:CH3OH ice mixtures, which are compared with materials from carbonaceous meteorites.

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Source-device-independent heterodyne-based quantum random number generator at 17 Gbps (2018)

Marco Avesani; Davide G. Marangon; Giuseppe Vallone; Paolo Villoresi

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Description: Source-device-independent heterodyne-based quantum random number generator at 17 Gbps Source-device-independent heterodyne-based quantum random number generator at 17 Gbps, Published online: 18 December 2018; doi:10.1038/s41467-018-07585-0 For many applications, quantum random number generation should be fast and independent from assumptions on the apparatus. Here, the authors devise and implement an approach which assumes a trusted detector but not a trusted source, and allows random bit generations at ~17 Gbps using off-the-shelf components.

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Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018)

Antoine Bergel; Thomas Deffieux; Charlie DemenéMickaël Tanter; Ivan Cohen

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Description: Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep, Published online: 18 December 2018; doi:10.1038/s41467-018-07752-3 Neural activity during REM sleep is similar to the waking state. Here, the authors measure blood volume with neurofunctional ultrasound imaging together with hippocampal neural activity during REM sleep and report that fast gamma oscillations are coupled to a brain-wide upregulation of vascular flow.

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Ultimate limit in size and performance of WSe 2 vertical diodes (2018)

Ghazanfar Nazir; Hakseong Kim; Jihwan Kim; Kyoung Soo Kim; Dong Hoon Shin; Muhammad Farooq Khan; Dong Su Lee; Jun Yeon Hwang; Chanyong Hwang; Junho Suh; Jonghwa Eom; Suyong Jung

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Description: Ultimate limit in size and performance of WSe 2 vertical diodes Ultimate limit in size and performance of WSe〈sub〉2〈/sub〉 vertical diodes, Published online: 18 December 2018; doi:10.1038/s41467-018-07820-8 Vertical charge transport through homogeneous WSe2 layers can be effectively tuned by the layer number and contacting metals deposited. Here, the authors report WSe2 vertical diodes with superior device performance characteristics based on variable WSe2 thickness and gadolinium and platinum contact metals.

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Nicole Scherr; Raphael Bieri; Sangeeta S. Thomas; Aurélie Chauffour; Nitin Pal Kalia; Paul Schneide; Marie-Thérèse Ruf; Araceli Lamelas; Malathy S. S. Manimekalai; Gerhard Grüber; Norihisa Ishii; Koichi Suzuki; Marcel Tanner; Garrett C. Moraski; Marvin J. Miller; Matthias Witschel; Vincent Jarlier; Gerd Pluschke; Kevin Pethe

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Targeting the Mycobacterium ulcerans cytochrome bc 1 : aa 3 for the treatment of Buruli ulcer (2018)

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Description: Targeting the Mycobacterium ulcerans cytochrome bc 1 : aa 3 for the treatment of Buruli ulcer Targeting the 〈i〉Mycobacterium ulcerans〈/i〉 cytochrome 〈i〉bc〈/i〉〈sub〉1〈/sub〉:〈i〉aa〈/i〉〈sub〉3〈/sub〉 for the treatment of Buruli ulcer, Published online: 18 December 2018; doi:10.1038/s41467-018-07804-8 Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effective at killing M. ulcerans and is a promising therapeutic candidate for BU.

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Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages (2018)

Shaon Chakrabarti; Andrew L. Paek; Jose Reyes; Kathleen A. Lasick; Galit Lahav; Franziska Michor

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Description: Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages, Published online: 18 December 2018; doi:10.1038/s41467-018-07788-5 The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures.

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HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity (2018)

Jie Zheng; Chen Wang; Mi Ra Chang; Swapnil C. Devarkar; Brandon Schweibenz; Gogce C. Crynen; Ruben D. Garcia-Ordonez; Bruce D. Pascal; Scott J. Novick; Smita S. Patel; Joseph Marcotrigiano; Patrick R. Griffin

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Description: HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity, Published online: 18 December 2018; doi:10.1038/s41467-018-07780-z RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.

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Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity (2018)

Zhihai Li; Shuo Song; Maozhou He; Daning Wang; Jingjie Shi; Xinlin Liu; Yunbing Li; Xin Chi; Shuangping Wei; Yurou Yang; Zhiping Wang; Jinjin Li; Huilian Qian; Hai Yu; Qingbing Zheng; Xiaodong Yan; Qinjian Zhao; Jun Zhang; Ying Gu; Shaowei Li; Ningshao Xia

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Publication Date: 2018-12-19

Description: Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Published online: 18 December 2018; doi:10.1038/s41467-018-07199-6 More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

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Chemistry of resistivity changes in TiTe/Al 2 O 3 conductive-bridge memories (2018)

M. Kazar Mendes; E. Martinez; J. M. Ablett; M. Veillerot; R. Gassilloud; M. Bernard; O. Renault; J. P. Rueff; N. Barrett

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Description: Chemistry of resistivity changes in TiTe/Al 2 O 3 conductive-bridge memories Chemistry of resistivity changes in TiTe/Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉 conductive-bridge memories, Published online: 18 December 2018; doi:10.1038/s41598-018-36131-7 Chemistry of resistivity changes in TiTe/Al 2 O 3 conductive-bridge memories

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A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines (2018)

Jiho Song; Agnès Miermont; Chwee Teck Lim; Roger D. Kamm

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Description: A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines, Published online: 18 December 2018; doi:10.1038/s41598-018-36381-5 A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines

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The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment (2018)

Boris JovanovićNikola JovanovićVladimir J. CvetkovićSanja MatićSnežana StanićElizabeth M. Whitley; Tatjana Lj. Mitrović

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Description: The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment The effects of a human food additive, titanium dioxide nanoparticles E171, on 〈i〉Drosophila melanogaster〈/i〉 - a 20 generation dietary exposure experiment, Published online: 18 December 2018; doi:10.1038/s41598-018-36174-w The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

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Hartman effect for spin waves in exchange regime (2018)

Jarosław W. Kłos; Yuliya S. Dadoenkova; Justyna Rychły; Nataliya N. Dadoenkova; Igor L. Lyubchanskii; Józef Barnaś

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Description: Hartman effect for spin waves in exchange regime Hartman effect for spin waves in exchange regime, Published online: 18 December 2018; doi:10.1038/s41598-018-35761-1 Hartman effect for spin waves in exchange regime

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Temporal and spatial distribution of under-five mortality and factors associated with multiple cases of under-five deaths within a family in the rural area of Khuzestan, Southern Iran (2018)

Tofigh Anafcheh; Mahmoud Yaghoubi Doust; Mehdi Mojadam; Roksana Mirkazemi; Morteza Abdullatif Khafaie

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Description: Temporal and spatial distribution of under-five mortality and factors associated with multiple cases of under-five deaths within a family in the rural area of Khuzestan, Southern Iran Temporal and spatial distribution of under-five mortality and factors associated with multiple cases of under-five deaths within a family in the rural area of Khuzestan, Southern Iran, Published online: 18 December 2018; doi:10.1038/s41598-018-36438-5 Temporal and spatial distribution of under-five mortality and factors associated with multiple cases of under-five deaths within a family in the rural area of Khuzestan, Southern Iran

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HAI Peptide and Backbone Analogs—Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles (2018)

Pol Arranz-Gibert; Roger Prades; Bernat Guixer; Simón Guerrero; Eyleen Araya; Sonia Ciudad; Marcelo J. Kogan; Ernest Giralt; Meritxell Teixidó

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Description: HAI Peptide and Backbone Analogs—Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles HAI Peptide and Backbone Analogs—Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles, Published online: 18 December 2018; doi:10.1038/s41598-018-35938-8 HAI Peptide and Backbone Analogs—Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles

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Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia (2018)

Xiao-E Lang; Daomin Zhu; Guangya Zhang; Xiangdong Du; Qiufang Jia; Guangzhong Yin; Dachun Chen; Meihong Xiu; Bo Cao; Li Wang; Xiaosi Li; Jair C. Soares; Xiang Yang Zhang

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Description: Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia, Published online: 18 December 2018; doi:10.1038/s41398-018-0346-9 Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia

Electronic ISSN: 2158-3188

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Regional tau pathology and loneliness in cognitively normal older adults (2018)

Federico d’Oleire Uquillas; Heidi I. L. Jacobs; Kelsey D. Biddle; Michael Properzi; Bernard Hanseeuw; Aaron P. Schultz; Dorene M. Rentz; Keith A. Johnson; Reisa A. Sperling; Nancy J. Donovan

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Description: Regional tau pathology and loneliness in cognitively normal older adults Regional tau pathology and loneliness in cognitively normal older adults, Published online: 18 December 2018; doi:10.1038/s41398-018-0345-x Regional tau pathology and loneliness in cognitively normal older adults

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IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses (2018)

Olga Babaev; Hugo Cruces-Solis; Carolina Piletti Chatain; Matthieu Hammer; Sally Wenger; Heba Ali; Nikolaos Karalis; Livia de Hoz; Oliver M. Schlüter; Yuchio Yanagawa; Hannelore Ehrenreich; Holger Taschenberger; Nils Brose; Dilja Krueger-Burg

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Publication Date: 2018-12-21

Description: IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses, Published online: 20 December 2018; doi:10.1038/s41467-018-07762-1 IgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.

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Electrical appliances moderate households’ water demand response to heat (2018)

Alberto Salvo

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Description: Electrical appliances moderate households’ water demand response to heat Electrical appliances moderate households’ water demand response to heat, Published online: 20 December 2018; doi:10.1038/s41467-018-07833-3 Better understanding of the determinants of residential water demand is important for Tropical Asian countries. Here the author studied how Singapore household electricity use from appliances modify weather-induced water demand and found that residential water and electricity demand respond differently to heat across different income groups.

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Genome re-sequencing reveals the evolutionary history of peach fruit edibility (2018)

Yang Yu; Jun Fu; Yaoguang Xu; Jiewei Zhang; Fei Ren; Hongwei Zhao; Shilin Tian; Wei Guo; Xiaolong Tu; Jing Zhao; Dawei Jiang; Jianbo Zhao; Weiying Wu; Gaochao Wang; Rongcai Ma; Quan Jiang; Jianhua Wei; Hua Xie

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Description: Genome re-sequencing reveals the evolutionary history of peach fruit edibility Genome re-sequencing reveals the evolutionary history of peach fruit edibility, Published online: 20 December 2018; doi:10.1038/s41467-018-07744-3 Peach is an economically important fruit crop. Here, the authors carry out a large-scale population genomics analysis of peach, describing its demographic history as well as genes associated with domestication and edibility traits.

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Dissection of genetic variation and evidence for pleiotropy in male pattern baldness (2018)

Chloe X. Yap; Julia Sidorenko; Yang Wu; Kathryn E. Kemper; Jian Yang; Naomi R. Wray; Matthew R. Robinson; Peter M. Visscher

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Description: Dissection of genetic variation and evidence for pleiotropy in male pattern baldness Dissection of genetic variation and evidence for pleiotropy in male pattern baldness, Published online: 20 December 2018; doi:10.1038/s41467-018-07862-y Male pattern baldness (MPB) is a polygenic trait that affects the majority of European men. Here, Yap et al. estimate heritability, partitioned by autosomes and the X-chromosome, of MPB in the UK Biobank cohort, perform GWAS for MPB and find genetic correlation with other sex-specific traits.

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Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs (2018)

Miguel Ganuza; Ashley Chabot; Xing Tang; Wenjian Bi; Sivaraman Natarajan; Robert Carter; Charles Gawad; Guolian Kang; Yong Cheng; Shannon McKinney-Freeman

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Publication Date: 2018-12-21

Description: Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs, Published online: 20 December 2018; doi:10.1038/s41467-018-07769-8 The source of where definitive hematopoietic stem cells (dHSCs) develop in the mouse embyro has been much debated. Here, the authors identify that dHSCs arise from the intra-embyronic region by using murine embryonic explant transplantation but not from the yolk sac.

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Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells (2018)

Hilal Taymaz-Nikerel; Muhammed Erkan Karabekmez; Serpil Eraslan; Betül Kırdar

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Publication Date: 2018-09-13

Description: Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells, Published online: 12 September 2018; doi:10.1038/s41598-018-31939-9 Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

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Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling (2018)

Ignacio R. Ipharraguerre; Jose J. Pastor; Aleix Gavaldà-Navarro; Francesc Villarroya; Alessandro Mereu

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Publication Date: 2018-09-13

Description: Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling, Published online: 12 September 2018; doi:10.1038/s41598-018-32107-9 Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling

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Growth tradeoffs produce complex microbial communities on a single limiting resource (2018)

Michael Manhart; Eugene I. Shakhnovich

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Publication Date: 2018-08-11

Description: Growth tradeoffs produce complex microbial communities on a single limiting resource Growth tradeoffs produce complex microbial communities on a single limiting resource, Published online: 10 August 2018; doi:10.1038/s41467-018-05703-6 Higher-order interactions occur when one species mediates the interaction between two others. Here, the authors model microbial growth and competition to show that higher-order interactions can arise from tradeoffs in growth traits, leading to neutral coexistence and other complex dynamics.

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Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation (2018)

Cornelius Krull; Marina Castelli; Prokop Hapala; Dhaneesh Kumar; Anton Tadich; Martina Capsoni; Mark T. Edmonds; Jack Hellerstedt; Sarah A. Burke; Pavel Jelinek; Agustin Schiffrin

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Publication Date: 2018-08-11

Description: Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation, Published online: 10 August 2018; doi:10.1038/s41467-018-05543-4 Polynuclear metal-organic coordination complexes are often inaccessible by traditional synthetic chemistry methods. Here, the authors use on-surface supramolecular chemistry to form a planar trinuclear Fe complex, in which an accumulation of electrons around the positive mixed-valence polynuclear centre suggests a catalytically active core.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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N 2 activation on a molybdenum–titanium–sulfur cluster (2018)

Yasuhiro Ohki; Keisuke Uchida; Mizuki Tada; Roger E. Cramer; Takashi Ogura; Takehiro Ohta

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Publication Date: 2018-08-11

Description: N 2 activation on a molybdenum–titanium–sulfur cluster N〈sub〉2〈/sub〉 activation on a molybdenum–titanium–sulfur cluster, Published online: 10 August 2018; doi:10.1038/s41467-018-05630-6 Nitrogenase—whose cofactor consists of a metal–sulfur cluster—catalyzes the production of NH3 from N2, but designing metal–sulfur complexes capable of promoting this conversion remains challenging. Here, the authors report on the activation of N2 by a metal–sulfur cluster containing [Mo3S4Ti] cubes, demonstrating NH3 and N2H4 production.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Rajeswara Rao Arasada; Konstantin Shilo; Tadaaki Yamada; Jianying Zhang; Seiji Yano; Rashelle Ghanem; Walter Wang; Shinji Takeuchi; Koji Fukuda; Nobuyuki Katakami; Keisuke Tomii; Fumitaka Ogushi; Yasuhiko Nishioka; Tiffany Talabere; Shrilekha Misra; Wenrui Duan; Paolo Fadda; Mohammad A. Rahman; Patrick Nana-Sinkam; Jason Evans; Joseph Amann; Elena E. Tchekneva; Mikhail M. Dikov; David P. Carbone

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Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC (2018)

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Publication Date: 2018-08-11

Description: Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC, Published online: 10 August 2018; doi:10.1038/s41467-018-05626-2 Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs. In this study, the authors discover a non-canonical activation of β-catenin signaling through Notch3 as a mechanism of adaptation to and resistance to EGFR TKI treatment in NSCLC.

Electronic ISSN: 2041-1723

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Elongator mutation in mice induces neurodegeneration and ataxia-like behavior (2018)

Marija Kojic; Monika Gaik; Bence Kiska; Anna Salerno-Kochan; Sarah Hunt; Angelo Tedoldi; Sergey Mureev; Alun Jones; Belinda Whittle; Laura A. Genovesi; Christelle Adolphe; Darren L. Brown; Jennifer L. Stow; Kirill Alexandrov; Pankaj Sah; Sebastian Glatt; Brandon J. Wainwright

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Publication Date: 2018-08-11

Description: Elongator mutation in mice induces neurodegeneration and ataxia-like behavior Elongator mutation in mice induces neurodegeneration and ataxia-like behavior, Published online: 10 August 2018; doi:10.1038/s41467-018-05765-6 Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

Electronic ISSN: 2041-1723

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Programmed cell removal by calreticulin in tissue homeostasis and cancer (2018)

Mingye Feng; Kristopher D. Marjon; Fangfang Zhu; Rachel Weissman-Tsukamoto; Aaron Levett; Katie Sullivan; Kevin S. Kao; Maxim Markovic; Paul A. Bump; Hannah M. Jackson; Timothy S. Choi; Jing Chen; Allison M. Banuelos; Jie Liu; Phung Gip; Lei Cheng; Denong Wang; Irving L. Weissman

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Publication Date: 2018-08-11

Description: Programmed cell removal by calreticulin in tissue homeostasis and cancer Programmed cell removal by calreticulin in tissue homeostasis and cancer, Published online: 10 August 2018; doi:10.1038/s41467-018-05211-7 Macrophage-mediated programmed cell removal (PrCR) allows clearance of living cells. Here the authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on cancer cells, determining in both cases clearance by PrCR.

Electronic ISSN: 2041-1723

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A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers (2018)

S. N. Gettinger; J. Choi; N. Mani; M. F. Sanmamed; I. Datar; Ryan Sowell; Victor Y. Du; E. Kaftan; S. Goldberg; W. Dong; D. Zelterman; K. Politi; P. Kavathas; S. Kaech; X. Yu; H. Zhao; J. Schlessinger; R. Lifton; D. L. Rimm; L. Chen; R. S. Herbst; K. A. Schalper

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Publication Date: 2018-08-11

Description: A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers, Published online: 10 August 2018; doi:10.1038/s41467-018-05032-8 Immune checkpoint blockade (ICB) only induces tumour response in a subset of non-small cell lung carcinomas (NSCLC). Here the authors do whole genome sequencing and multiplexed quantitative immunofluorescence on patient samples and identify a “dormant” T-cell signature associated with sensitivity to ICB.

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How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells? (2018)

Ping Fan; V. Craig Jordan

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In: Cell Death & Disease

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Publication Date: 2018-08-14

Description: How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells? How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?, Published online: 13 August 2018; doi:10.1038/s41419-018-0516-y How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure (2018)

Christiaan A. de Leeuw; Sven Stringer; Ilona A. Dekkers; Tom Heskes; Danielle Posthuma

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Publication Date: 2018-09-15

Description: Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure, Published online: 14 September 2018; doi:10.1038/s41467-018-06022-6 Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.

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Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization (2018)

Chih-Chan Lee; Jiunn-Chang Lin; Wei-Lun Hwang; Ying-Ju Kuo; Hung-Kai Chen; Shyh-Kuan Tai; Chun-Chi Lin; Muh-Hwa Yang

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Publication Date: 2018-09-15

Description: Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization, Published online: 14 September 2018; doi:10.1038/s41467-018-06268-0 Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.

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Genome-wide association study of seasonal affective disorder (2018)

Kwo Wei David Ho; Shizhong Han; Jakob V. Nielsen; Dubravka Jancic; Benjamin Hing; Jess Fiedorowicz; Myrna M. Weissman; Douglas F. Levinson; James B. Potash

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Publication Date: 2018-09-15

Description: Genome-wide association study of seasonal affective disorder Genome-wide association study of seasonal affective disorder, Published online: 14 September 2018; doi:10.1038/s41398-018-0246-z Genome-wide association study of seasonal affective disorder

Electronic ISSN: 2158-3188

Topics: Medicine

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Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression (2018)

Lingdi Zhang; Hengbo Zhou; Xueni Li; Rebecca L. Vartuli; Michael Rowse; Yongna Xing; Pratyaydipta Rudra; Debashis Ghosh; Rui Zhao; Heide L. Ford

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Publication Date: 2018-09-18

Description: Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression, Published online: 17 September 2018; doi:10.1038/s41467-018-06265-3 Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

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Three-dimensional X-ray diffraction imaging of dislocations in polycrystalline metals under tensile loading (2018)

Mathew J. Cherukara; Reeju Pokharel; Timothy S. O’Leary; J. Kevin Baldwin; Evan Maxey; Wonsuk Cha; Jorg Maser; Ross J. Harder; Saryu J. Fensin; Richard L. Sandberg

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Publication Date: 2018-09-18

Description: Three-dimensional X-ray diffraction imaging of dislocations in polycrystalline metals under tensile loading Three-dimensional X-ray diffraction imaging of dislocations in polycrystalline metals under tensile loading, Published online: 17 September 2018; doi:10.1038/s41467-018-06166-5 Identifying atomic defects during deformation is crucial to understand material response but remains challenging in three dimensions. Here, the authors couple X-ray Bragg coherent diffraction imaging and atomistic simulations to correlate a strain field to a screw dislocation in a single copper grain.

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A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis (2018)

Jinbo Shen; Qiong Zhao; Xiangfeng Wang; Caiji Gao; Ying Zhu; Yonglun Zeng; Liwen Jiang

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Publication Date: 2018-09-18

Description: A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis, Published online: 17 September 2018; doi:10.1038/s41467-018-05913-y The ESCRT complex contributes to selective vacuolar degradation of membrane proteins. Here, the authors show that the plant-specific BRAF protein negatively regulates intraluminal vesicle formation and membrane protein degradation by preventing FREE1 binding to the ESCRT-I complex protein Vps23.

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Leticia Peris; Mariano Bisbal; José Martinez-Hernandez; Yasmina Saoudi; Julie Jonckheere; Marta Rolland; Muriel Sebastien; Jacques Brocard; Eric Denarier; Christophe Bosc; Christophe Guerin; Sylvie Gory-FauréJean Christophe Deloulme; Fabien LantéIsabelle Arnal; Alain Buisson; Yves Goldberg; Laurent Blanchoin; Christian Delphin; Annie Andrieux

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A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines (2018)

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Publication Date: 2018-09-18

Description: A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines, Published online: 17 September 2018; doi:10.1038/s41467-018-05869-z Microtubule-associated protein 6 (MAP6) is known to be important for synaptic plasticity and cognition, supposedly via interaction with microtubules. Here, the authors found that MAP6 is crucial for the stabilisation of enlarged synapses through its association with a different cytoskeletal element, actin.

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Author Correction: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1 (2018)

Wen-Sheng Wu; Ren-In You; Chuan-Chu Cheng; Ming-Che Lee; Teng-Yi Lin; Chi-Tan Hu

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Publication Date: 2018-09-18

Description: Author Correction: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1 Author Correction: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1, Published online: 18 September 2018; doi:10.1038/s41598-018-28913-w Author Correction: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Large-scale mass wasting on small volcanic islands revealed by the study of Flores Island (Azores) (2018)

A. Hildenbrand; F. O. Marques; J. Catalão

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Publication Date: 2018-09-18

Description: Large-scale mass wasting on small volcanic islands revealed by the study of Flores Island (Azores) Large-scale mass wasting on small volcanic islands revealed by the study of Flores Island (Azores), Published online: 17 September 2018; doi:10.1038/s41598-018-32253-0 Large-scale mass wasting on small volcanic islands revealed by the study of Flores Island (Azores)

Electronic ISSN: 2045-2322

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Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles (2018)

Eric K. Johnson; Scot J. Matkovich; Jeanne M. Nerbonne

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Publication Date: 2018-09-18

Description: Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles, Published online: 17 September 2018; doi:10.1038/s41598-018-32154-2 Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles

Electronic ISSN: 2045-2322

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Dominance of cropland reduces the pollen deposition from bumble bees (2018)

Sonja C. Pfister; Philipp W. Eckerter; Julius Krebs; James E. Cresswell; Jens Schirmel; Martin H. Entling

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Publication Date: 2018-09-18

Description: Dominance of cropland reduces the pollen deposition from bumble bees Dominance of cropland reduces the pollen deposition from bumble bees, Published online: 17 September 2018; doi:10.1038/s41598-018-31826-3 Dominance of cropland reduces the pollen deposition from bumble bees

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Effective Radiative Properties of Tilted Metallic Nanorod Arrays Considering Polarization Coupling (2018)

Dustin M. Lattery; Mingeon Kim; Jongin Choi; Bong Jae Lee; Xiaojia Wang

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Publication Date: 2018-09-18

Description: Effective Radiative Properties of Tilted Metallic Nanorod Arrays Considering Polarization Coupling Effective Radiative Properties of Tilted Metallic Nanorod Arrays Considering Polarization Coupling, Published online: 17 September 2018; doi:10.1038/s41598-018-32265-w Effective Radiative Properties of Tilted Metallic Nanorod Arrays Considering Polarization Coupling

Electronic ISSN: 2045-2322

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Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus (2018)

Johanna Berg; Thomas Hiller; Maya S. Kissner; Taimoor H. Qazi; Georg N. Duda; Andreas C. Hocke; Stefan Hippenstiel; Laura Elomaa; Marie Weinhart; Christoph Fahrenson; Jens Kurreck

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Publication Date: 2018-09-18

Description: Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus, Published online: 17 September 2018; doi:10.1038/s41598-018-31880-x Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus

Electronic ISSN: 2045-2322

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A new Eocene anagalid (Mammalia: Euarchontoglires) from Mongolia and its implications for the group’s phylogeny and dispersal (2018)

Sergi López-TorresŁucja Fostowicz-Frelik

Nature Publishing Group (NPG)

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Publication Date: 2018-09-18

Description: A new Eocene anagalid (Mammalia: Euarchontoglires) from Mongolia and its implications for the group’s phylogeny and dispersal A new Eocene anagalid (Mammalia: Euarchontoglires) from Mongolia and its implications for the group’s phylogeny and dispersal, Published online: 17 September 2018; doi:10.1038/s41598-018-32086-x A new Eocene anagalid (Mammalia: Euarchontoglires) from Mongolia and its implications for the group’s phylogeny and dispersal

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Neural Signatures of the Configural Superiority Effect and Fundamental Emergent Features in Human Vision (2018)

Thiago Leiros Costa; Kimberley Orsten-Hooge; Gabriel Gaudêncio Rêgo; Johan Wagemans; James R Pomerantz; Paulo Sérgio Boggio

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Publication Date: 2018-09-18

Description: Neural Signatures of the Configural Superiority Effect and Fundamental Emergent Features in Human Vision Neural Signatures of the Configural Superiority Effect and Fundamental Emergent Features in Human Vision, Published online: 17 September 2018; doi:10.1038/s41598-018-32289-2 Neural Signatures of the Configural Superiority Effect and Fundamental Emergent Features in Human Vision

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Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules (2018)

Yang Yang; Jie Liang; Fei Pan; Zhen Wang; Jianqi Zhang; Kamran Amin; Jin Fang; Wenjun Zou; Yuli Chen; Xinghua Shi; Zhixiang Wei

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Publication Date: 2018-09-19

Description: Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules, Published online: 18 September 2018; doi:10.1038/s41467-018-06239-5 Chirality transfer by chemical self-assembly has been studied intensively for years but chirality transfers along the same path remains elusive. Here the authors use a multiscale chemo-mechanical model to elucidate the mechanism underlying the chirality transfer via self-assembly in hierarchical camphorsulfonic acid doped polyaniline.

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Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers (2018)

Marjory Koller; Si-Qi Qiu; Matthijs D. Linssen; Liesbeth Jansen; Wendy Kelder; Jakob de Vries; Inge Kruithof; Guo-Jun Zhang; Dominic J. Robinson; Wouter B. Nagengast; Annelies Jorritsma-Smit; Bert van der Vegt; Gooitzen M. van Dam

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Publication Date: 2018-09-19

Description: Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers, Published online: 18 September 2018; doi:10.1038/s41467-018-05727-y Fluorescent tracers are being tested in clinical trials to improve detection of tumor margins, but procedures are not standardised. Here, the authors develop an analytical framework that is compatible with the workflow in the operating theatre, and show that it leads to an 88% increase in intraoperative detection of tumor margins in patients with breast cancer.

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Quantum theory cannot consistently describe the use of itself (2018)

Daniela Frauchiger; Renato Renner

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Publication Date: 2018-09-19

Description: Quantum theory cannot consistently describe the use of itself Quantum theory cannot consistently describe the use of itself, Published online: 18 September 2018; doi:10.1038/s41467-018-05739-8 Quantum mechanics is expected to provide a consistent description of reality, even when recursively describing systems contained in each other. Here, the authors develop a variant of Wigner’s friend Gedankenexperiment where each of the current interpretations of QM fails in giving a consistent description.

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Solvatochromic covalent organic frameworks (2018)

Laura Ascherl; Emrys W. Evans; Matthias Hennemann; Daniele Di Nuzzo; Alexander G. Hufnagel; Michael Beetz; Richard H. Friend; Timothy Clark; Thomas Bein; Florian Auras

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Publication Date: 2018-09-19

Description: Solvatochromic covalent organic frameworks Solvatochromic covalent organic frameworks, Published online: 18 September 2018; doi:10.1038/s41467-018-06161-w Covalent organic frameworks (COFs) find increasing application as sensor material, but fast switching solvatochromism was not realized. Here the authors demonstrate that combination of electron-rich and -deficient building blocks leads to COFs which fast and reversibly change of their electronic structure depending on the surrounding atmosphere.

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Water printing of ferroelectric polarization (2018)

Yu Tian; Lanying Wei; Qinghua Zhang; Houbing Huang; Yuelin Zhang; Hua Zhou; Fengjie Ma; Lin Gu; Sheng Meng; Long-Qing Chen; Ce-Wen Nan; Jinxing Zhang

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Publication Date: 2018-09-19

Description: Water printing of ferroelectric polarization Water printing of ferroelectric polarization, Published online: 18 September 2018; doi:10.1038/s41467-018-06369-w Controlling ferroelectric polarization is conventionally achieved by applying electric fields, mechanical force or similar. Here reversible switching of the bulk polarization of a BiFeO3 thin film is demonstrated by pattering aqueous solution on to the surface enabling large-scale switching.

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The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration (2018)

Claudia Dollt; Julia Michel; Loreen Kloss; Susanne Melchers; Kai Schledzewski; Kathrin Becker; Andrea Sauer; Andreas Krewer; Franziska Koll; Astrid Schmieder

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In: Cell Death & Disease

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Publication Date: 2018-09-20

Description: The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration, Published online: 19 September 2018; doi:10.1038/s41419-018-1011-1 The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

Published by Nature Publishing Group (NPG)

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Mechano-regulated metal–organic framework nanofilm for ultrasensitive and anti-jamming strain sensing (2018)

Liang Pan; Gang Liu; Wenxiong Shi; Jie Shang; Wan Ru Leow; Yaqing Liu; Ying Jiang; Shuzhou Li; Xiaodong Chen; Run-Wei Li

Nature Publishing Group (NPG)

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Publication Date: 2018-09-20

Description: Mechano-regulated metal–organic framework nanofilm for ultrasensitive and anti-jamming strain sensing Mechano-regulated metal–organic framework nanofilm for ultrasensitive and anti-jamming strain sensing, Published online: 19 September 2018; doi:10.1038/s41467-018-06079-3 High performance flexible strain sensors with accurate signal detection and noise screening are key to the development of smart sensing systems. Here, the authors demonstrate metal–organic framework based strain sensors that are ultrasensitive, robust, and non-responsive to environmental noise.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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Green microalgae in marine coastal waters: The Ocean Sampling Day (OSD) dataset (2018)

Margot Tragin; Daniel Vaulot

Nature Publishing Group (NPG)