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Publication Date: 2018-05-03

Description: In-situ visualization of solute-driven phase coexistence within individual nanorods In-situ visualization of solute-driven phase coexistence within individual nanorods, Published online: 02 May 2018; doi:10.1038/s41467-018-04021-1 Compared to thin films and other geometries, nanorods can exhibit particularly high performance in solute-intercalation-based energy and information storage devices. Here, the authors use in situ electron microscopy and spectroscopy to study the hydrogenation of palladium nanorods, revealing relationships between nanorod structure and device cyclability and capacity.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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2

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Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact (2018)

Nadav Shai; Eden Yifrach; Carlo W. T. van Roermund; Nir Cohen; Chen Bibi; Lodewijk IJlst; Laetitia Cavellini; Julie Meurisse; Ramona Schuster; Lior Zada; Muriel C. Mari; Fulvio M. Reggiori; Adam L. Hughes; Mafalda Escobar-Henriques; Mickael M. Cohen; Hans R. Waterham; Ronald J. A. Wanders; Maya Schuldiner; Einat Zalckvar

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Publication Date: 2018-05-03

Description: Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact, Published online: 02 May 2018; doi:10.1038/s41467-018-03957-8 The internal organization of the cell has been enriched by the discovery that organelles establish membrane contact sites, however the entire repertoire of these contacts is still being explored. Here the authors systematically identify the landscape of cellular contact sites in yeast, discovering four potential novel contact sites and two tether proteins for the peroxisome-mitochondria contact site.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Rechargeable lithium-ion cell state of charge and defect detection by in-situ inside-out magnetic resonance imaging (2018)

Andrew J. Ilott; Mohaddese Mohammadi; Christopher M. Schauerman; Matthew J. Ganter; Alexej Jerschow

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Publication Date: 2018-05-04

Description: Rechargeable lithium-ion cell state of charge and defect detection by in-situ inside-out magnetic resonance imaging Rechargeable lithium-ion cell state of charge and defect detection by in-situ inside-out magnetic resonance imaging, Published online: 03 May 2018; doi:10.1038/s41467-018-04192-x The development of noninvasive methodology plays an important role in advancing lithium ion battery technology. Here the authors utilize the measurement of tiny magnetic field changes within a cell to assess the lithiation state of the active material, and detect defects.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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4

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Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation (2018)

Alí Alejo; M. Begoña Ruiz-Argüello; Sergio M. Pontejo; María del Mar Fernández de Marco; Margarida Saraiva; Bruno Hernáez; Antonio Alcamí

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Publication Date: 2018-05-04

Description: Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation, Published online: 03 May 2018; doi:10.1038/s41467-018-04098-8 Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemokine and cytokine driven inflammatory defenses.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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5

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Gut microbiomes of wild great apes fluctuate seasonally in response to diet (2018)

Allison L. Hicks; Kerry Jo Lee; Mara Couto-Rodriguez; Juber Patel; Rohini Sinha; Cheng Guo; Sarah H. Olson; Anton Seimon; Tracie A. Seimon; Alain U. Ondzie; William B. Karesh; Patricia Reed; Kenneth N. Cameron; W. Ian Lipkin; Brent L. Williams

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Publication Date: 2018-05-04

Description: Gut microbiomes of wild great apes fluctuate seasonally in response to diet Gut microbiomes of wild great apes fluctuate seasonally in response to diet, Published online: 03 May 2018; doi:10.1038/s41467-018-04204-w Microbiota composition fluctuates in response to changes in environmental and lifestyle factors. Here, Hicks et al. show that the faecal microbiota of wild gorillas and chimpanzees is temporally dynamic, with shifts that correlate with seasonal rainfall patterns and periods of high and low frugivory.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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6

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Reconfigurable engineered motile semiconductor microparticles (2018)

Ugonna Ohiri; C. Wyatt Shields IVKoohee Han; Talmage Tyler; Orlin D. Velev; Nan Jokerst

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Publication Date: 2018-05-04

Description: Reconfigurable engineered motile semiconductor microparticles Reconfigurable engineered motile semiconductor microparticles, Published online: 03 May 2018; doi:10.1038/s41467-018-04183-y Active particles that demonstrate life-like behavior may find use in bio-inspired technologies, but achieving on-demand reconfiguration remains challenging. Here, the authors demonstrate controllable, collective behavior in silicon microparticles, which are fabricated via conventional semiconductor methods.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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7

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Author Correction: Spin-orbit-torque-induced magnetic domain wall motion in Ta/CoFe nanowires with sloped perpendicular magnetic anisotropy (2018)

Yue Zhang; Shijiang Luo; Xiaofei Yang; Chang Yang

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Publication Date: 2018-05-03

Description: Author Correction: Spin-orbit-torque-induced magnetic domain wall motion in Ta/CoFe nanowires with sloped perpendicular magnetic anisotropy Author Correction: Spin-orbit-torque-induced magnetic domain wall motion in Ta/CoFe nanowires with sloped perpendicular magnetic anisotropy, Published online: 03 May 2018; doi:10.1038/s41598-018-25613-3 Author Correction: Spin-orbit-torque-induced magnetic domain wall motion in Ta/CoFe nanowires with sloped perpendicular magnetic anisotropy

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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8

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Author Correction: The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics (2018)

Pablo Yubero; Susanna Manrubia; Jacobo Aguirre

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Publication Date: 2018-05-03

Description: Author Correction: The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics Author Correction: The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics, Published online: 03 May 2018; doi:10.1038/s41598-018-25218-w Author Correction: The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses (2018)

Jacob D. Washburn; James C. Schnable; Gavin C. Conant; Thomas P. Brutnell; Ying Shao; Yang Zhang; Martha Ludwig; Gerrit Davidse; J. Chris Pires

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Publication Date: 2018-05-03

Description: Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses, Published online: 02 May 2018; doi:10.1038/s41598-018-25620-4 Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans (2018)

Rui Diogo; Julia L. Molnar; Campbell Rolian; Borja Esteve-Altava

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Publication Date: 2018-05-03

Description: First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans, Published online: 02 May 2018; doi:10.1038/s41598-018-25262-6 First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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11

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The stage of seed development influences iron bioavailability in pea ( Pisum sativum L.) (2018)

Katie L. Moore; Ildefonso Rodríguez-Ramiro; Eleanor R. Jones; Emily J. Jones; Jorge Rodríguez-Celma; Kirstie Halsey; Claire Domoney; Peter R. Shewry; Susan Fairweather-Tait; Janneke Balk

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Publication Date: 2018-05-03

Description: The stage of seed development influences iron bioavailability in pea ( Pisum sativum L.) The stage of seed development influences iron bioavailability in pea (〈i〉Pisum sativum〈/i〉 L.), Published online: 02 May 2018; doi:10.1038/s41598-018-25130-3 The stage of seed development influences iron bioavailability in pea ( Pisum sativum L.)

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach (2018)

Kumari Snehkant Lata; Swapnil Kumar; Vibhisha Vaghasia; Priyanka Sharma; Shivarudrappa B. Bhairappanvar; Subhash Soni; Jayashankar Das

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Publication Date: 2018-05-03

Description: Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach, Published online: 02 May 2018; doi:10.1038/s41598-018-25281-3 Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study (2018)

Merit Kullinger; Michaela Granfors; Helle Kieler; Alkistis Skalkidou

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Publication Date: 2018-05-03

Description: Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study, Published online: 02 May 2018; doi:10.1038/s41598-018-24894-y Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: a population-based register cohort study

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function (2018)

Paul Perco; Andreas Heinzel; Johannes Leierer; Stefan Schneeberger; Claudia Bösmüller; Rupert Oberhuber; Silvia Wagner; Franziska Engler; Gert Mayer

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Publication Date: 2018-05-04

Description: Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function, Published online: 03 May 2018; doi:10.1038/s41598-018-25163-8 Validation of systems biology derived molecular markers of renal donor organ status associated with long term allograft function

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Facial bone fragmentation in blind cavefish arises through two unusual ossification processes (2018)

Amanda K. Powers; Shane A. Kaplan; Tyler E. Boggs; Joshua B. Gross

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Publication Date: 2018-05-04

Description: Facial bone fragmentation in blind cavefish arises through two unusual ossification processes Facial bone fragmentation in blind cavefish arises through two unusual ossification processes, Published online: 03 May 2018; doi:10.1038/s41598-018-25107-2 Facial bone fragmentation in blind cavefish arises through two unusual ossification processes

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Synchronization by uncorrelated noise: interacting rhythms in interconnected oscillator networks (2018)

John Hongyu Meng; Hermann Riecke

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Publication Date: 2018-05-04

Description: Synchronization by uncorrelated noise: interacting rhythms in interconnected oscillator networks Synchronization by uncorrelated noise: interacting rhythms in interconnected oscillator networks, Published online: 03 May 2018; doi:10.1038/s41598-018-24670-y Synchronization by uncorrelated noise: interacting rhythms in interconnected oscillator networks

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis (2018)

Yali Li; Liang Chen; Yangyang Liu; Yong Zhang; Yunxiang Liang; Yuxia Mei

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Publication Date: 2018-04-05

Description: Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis, Published online: 04 April 2018; doi:10.1038/s41598-018-24050-6 Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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18

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Source reconstruction of airborne toxics based on acute health effects information (2018)

Christos D. Argyropoulos; Samar Elkhalifa; Eleni Fthenou; George C. Efthimiou; Spyros Andronopoulos; Alexandros Venetsanos; Ivan V. Kovalets; Konstantinos E. Kakosimos

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Publication Date: 2018-04-05

Description: Source reconstruction of airborne toxics based on acute health effects information Source reconstruction of airborne toxics based on acute health effects information, Published online: 04 April 2018; doi:10.1038/s41598-018-23767-8 Source reconstruction of airborne toxics based on acute health effects information

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells (2018)

Alexandre Janin; Delphine Bauer; Francesca Ratti; Camille Valla; Anne Bertrand; Emilie Christin; Emilie Chopin; Nathalie Streichenberger; Gisèle Bonne; Vincent Gache; Tatiana Cohen; Alexandre Méjat

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Publication Date: 2018-04-05

Description: SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells SMAD6 overexpression leads to accelerated myogenic differentiation of 〈i〉LMNA〈/i〉 mutated cells, Published online: 04 April 2018; doi:10.1038/s41598-018-23918-x SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor (2018)

Scott D. Barnett; Christina R. Smith; Craig C. Ulrich; Josh E. Baker; Iain L. O. Buxton

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Publication Date: 2018-04-05

Description: S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor, Published online: 04 April 2018; doi:10.1038/s41598-018-23371-w S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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21

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WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia (2018)

Muhannad Abu-Remaileh; Abed Khalaileh; Eli Pikarsky; Rami I. Aqeilan

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Publication Date: 2018-05-04

Description: WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia, Published online: 03 May 2018; doi:10.1038/s41419-018-0510-4 WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice (2018)

Bin Wang; Yingying Zhang; Hongli Dong; Siyi Gong; Bin Wei; Man Luo; Hongyan Wang; Xiaohui Wu; Wei Liu; Xingshun Xu; Yufang Zheng; Miao Sun

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Publication Date: 2018-05-04

Description: Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice, Published online: 03 May 2018; doi:10.1038/s41419-018-0563-4 Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells (2018)

Dongchao Xu; Ajuan Liu; Xuan Wang; Yidan Chen; Yunyun Shen; Zhou Tan; Mengsheng Qiu

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Publication Date: 2018-05-04

Description: Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells, Published online: 03 May 2018; doi:10.1038/s41419-018-0547-4 Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils (2018)

Fabian Zellweger; Patrick Buschor; Gabriel Hobi; Daniel Brigger; Clemens Andreas Dahinden; Peter Matthias Villiger; Alexander Eggel

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Publication Date: 2018-05-04

Description: IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils, Published online: 03 May 2018; doi:10.1038/s41419-018-0526-9 IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils

Electronic ISSN: 2041-4889

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Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells (2018)

Juan Guo; Youshan Zhao; Chengming Fei; Sida Zhao; Qingqing Zheng; Jiying Su; Dong Wu; Xiao Li; Chunkang Chang

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Publication Date: 2018-05-04

Description: Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells, Published online: 03 May 2018; doi:10.1038/s41419-018-0545-6 Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells

Electronic ISSN: 2041-4889

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Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway (2018)

Qingqing Zheng; Youshan Zhao; Juan Guo; Sida Zhao; Chengming Fei; Chao Xiao; Dong Wu; Lingyun Wu; Xiao Li; Chunkang Chang

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Publication Date: 2018-05-04

Description: Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway, Published online: 03 May 2018; doi:10.1038/s41419-018-0552-7 Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway

Electronic ISSN: 2041-4889

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27

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Author Correction: Surveillance of vector-borne pathogens under imperfect detection: lessons from Chagas disease risk (mis)measurement (2018)

Thaís Tâmara Castro Minuzzi-Souza; Nadjar Nitz; César Augusto Cuba Cuba; Luciana Hagström; Mariana Machado Hecht; Camila Santana; Marcelle Ribeiro; Tamires Emanuele Vital; Marcelo Santalucia; Monique Knox; Marcos Takashi Obara; Fernando Abad-Franch; Rodrigo Gurgel-Gonçalves

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Publication Date: 2018-05-04

Description: Author Correction: Surveillance of vector-borne pathogens under imperfect detection: lessons from Chagas disease risk (mis)measurement Author Correction: Surveillance of vector-borne pathogens under imperfect detection: lessons from Chagas disease risk (mis)measurement, Published online: 04 May 2018; doi:10.1038/s41598-018-24849-3 Author Correction: Surveillance of vector-borne pathogens under imperfect detection: lessons from Chagas disease risk (mis)measurement

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The acoustic adaptation hypothesis in a widely distributed South American frog: Southernmost signals propagate better (2018)

Nelson A. Velásquez; Felipe N. Moreno-Gómez; Enzo Brunetti; Mario Penna

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Publication Date: 2018-05-04

Description: The acoustic adaptation hypothesis in a widely distributed South American frog: Southernmost signals propagate better The acoustic adaptation hypothesis in a widely distributed South American frog: Southernmost signals propagate better, Published online: 03 May 2018; doi:10.1038/s41598-018-25359-y The acoustic adaptation hypothesis in a widely distributed South American frog: Southernmost signals propagate better

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Author Correction: Influence of environment on testing of hydraulic sealers (2018)

Mira Kebudi Benezra; Pierre Schembri Wismayer; Josette Camilleri

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Publication Date: 2018-05-04

Description: Author Correction: Influence of environment on testing of hydraulic sealers Author Correction: Influence of environment on testing of hydraulic sealers, Published online: 03 May 2018; doi:10.1038/s41598-018-24847-5 Author Correction: Influence of environment on testing of hydraulic sealers

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30

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Establishment and validation of the scoring system for preoperative prediction of central lymph node metastasis in papillary thyroid carcinoma (2018)

Wen Liu; Ruochuan Cheng; Yunhai Ma; Dan Wang; Yanjun Su; Chang Diao; Jianming Zhang; Jun Qian; Jin Liu

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Publication Date: 2018-05-04

Description: Establishment and validation of the scoring system for preoperative prediction of central lymph node metastasis in papillary thyroid carcinoma Establishment and validation of the scoring system for preoperative prediction of central lymph node metastasis in papillary thyroid carcinoma, Published online: 03 May 2018; doi:10.1038/s41598-018-24668-6 Establishment and validation of the scoring system for preoperative prediction of central lymph node metastasis in papillary thyroid carcinoma

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Mapping distribution of cysts of recent dinoflagellate and Cochlodinium polykrikoides using next-generation sequencing and morphological approaches in South Sea, Korea (2018)

Seung Won Jung; Donhyug Kang; Hyun-Jung Kim; Hyeon Ho Shin; Joon Sang Park; So Yun Park; Taek-Kyun Lee

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Publication Date: 2018-05-04

Description: Mapping distribution of cysts of recent dinoflagellate and Cochlodinium polykrikoides using next-generation sequencing and morphological approaches in South Sea, Korea Mapping distribution of cysts of recent dinoflagellate and 〈i〉Cochlodinium polykrikoides〈/i〉 using next-generation sequencing and morphological approaches in South Sea, Korea, Published online: 03 May 2018; doi:10.1038/s41598-018-25345-4 Mapping distribution of cysts of recent dinoflagellate and Cochlodinium polykrikoides using next-generation sequencing and morphological approaches in South Sea, Korea

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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32

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Ediacara biota flourished in oligotrophic and bacterially dominated marine environments across Baltica (2018)

Kelden Pehr; Gordon D. Love; Anton Kuznetsov; Victor Podkovyrov; Christopher K. Junium; Leonid Shumlyanskyy; Tetyana Sokur; Andrey Bekker

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Publication Date: 2018-05-05

Description: Ediacara biota flourished in oligotrophic and bacterially dominated marine environments across Baltica Ediacara biota flourished in oligotrophic and bacterially dominated marine environments across Baltica, Published online: 04 May 2018; doi:10.1038/s41467-018-04195-8 The environments and food sources that sustained Ediacara biota 575-541 million years ago remain unclear. Here, the authors perform lipid biomarker and isotopic analyses on biota fossil-containing Ediacaran strata from Baltica and propose the presence of a microbial loop bolstered by bacteria.

Electronic ISSN: 2041-1723

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33

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Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization (2018)

Emile S. Pinarbasi; Tolga Cağatay; Ho Yee Joyce Fung; Ying C. Li; Yuh Min Chook; Philip J. Thomas

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Publication Date: 2018-05-05

Description: Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization, Published online: 04 May 2018; doi:10.1038/s41598-018-25008-4 Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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34

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Chemical shift extremum of 129 Xe( aq ) reveals details of hydrophobic solvation (2018)

Petri Peuravaara; Jouni Karjalainen; Jianfeng Zhu; Jiří MarešPerttu Lantto; Juha Vaara

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Publication Date: 2018-05-05

Description: Chemical shift extremum of 129 Xe( aq ) reveals details of hydrophobic solvation Chemical shift extremum of 〈sup〉129〈/sup〉Xe(〈i〉aq〈/i〉) reveals details of hydrophobic solvation, Published online: 04 May 2018; doi:10.1038/s41598-018-25418-4 Chemical shift extremum of 129 Xe( aq ) reveals details of hydrophobic solvation

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35

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The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse (2018)

Denise K. Grosenbaugh; Brittany M. Ross; Pravin Wagley; Santina A. Zanelli

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Publication Date: 2018-05-05

Description: The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse, Published online: 04 May 2018; doi:10.1038/s41598-018-24722-3 The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse

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36

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Epidemiology is a science of high importance (2018)

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Publication Date: 2018-05-08

Description: Epidemiology is a science of high importance Epidemiology is a science of high importance, Published online: 07 May 2018; doi:10.1038/s41467-018-04243-3 Epidemiology dates back to the Age of Pericles in 5th Century B.C., but its standing as a ‘true’ science in 21st century is often questioned. This is unexpected, given that epidemiology directly impacts lives and our reliance on it will only increase in a changing world.

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37

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Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood (2018)

Pär Nyström; Teodora Gliga; Elisabeth Nilsson Jobs; Gustaf Gredebäck; Tony Charman; Mark H. Johnson; Sven Bölte; Terje Falck-Ytter

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Publication Date: 2018-05-08

Description: Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood, Published online: 07 May 2018; doi:10.1038/s41467-018-03985-4 Previous studies showed that children with autism spectrum disorder (ASD) have atypicalities in the pupillary light reflex (PLR). This study uses longitudinal monitoring of infants at risk for ASD to show that PLR magnitude at 10 months of age is associated with later ASD diagnosis and symptom severity.

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38

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Formation and radiative forcing of contrail cirrus (2018)

Bernd Kärcher

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Publication Date: 2018-05-09

Description: Formation and radiative forcing of contrail cirrus Formation and radiative forcing of contrail cirrus, Published online: 08 May 2018; doi:10.1038/s41467-018-04068-0 Condensation trails produced by jet aircraft contribute to anthropogenic climate change, yet the magnitude of their impact remains unclear. Here, the author reviews progress in understanding contrails since the last IPCC report (1999), assesses the remaining uncertainty, and identifies potential mitigating options and pathways forward.

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39

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Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo (2018)

Qi Chen; Junchao Shi; Yi Tao; Magdalena Zernicka-Goetz

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Publication Date: 2018-05-09

Description: Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo, Published online: 08 May 2018; doi:10.1038/s41467-018-04155-2 What breaks symmetry in early mammalian embryonic development has been much questioned. Here, Magdalena Zernicka-Goetz and colleagues propose that compartmentalized intracellular reactions generate micro-scale inhomogeneity, which is amplified in the developing embryo, driving pattern formation.

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40

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Designer cells programming quorum-sensing interference with microbes (2018)

Ferdinand Sedlmayer; Dennis Hell; Marius Müller; David Ausländer; Martin Fussenegger

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Publication Date: 2018-05-09

Description: Designer cells programming quorum-sensing interference with microbes Designer cells programming quorum-sensing interference with microbes, Published online: 08 May 2018; doi:10.1038/s41467-018-04223-7 Bacterial populations communicate with AI-2 signaling molecules, helping to coordinate biofilm development and other group behaviors. Here the authors design a genetic circuit for mammalian cells that allows them to sense bacterial populations and interfere with quorum communication.

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41

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Supramolecular Kandinsky circles with high antibacterial activity (2018)

Heng Wang; Xiaomin Qian; Kun Wang; Ma Su; Wei-Wei Haoyang; Xin Jiang; Robert Brzozowski; Ming Wang; Xiang Gao; Yiming Li; Bingqian Xu; Prahathees Eswara; Xin-Qi Hao; Weitao Gong; Jun-Li Hou; Jianfeng Cai; Xiaopeng Li

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Publication Date: 2018-05-09

Description: Supramolecular Kandinsky circles with high antibacterial activity Supramolecular Kandinsky circles with high antibacterial activity, Published online: 08 May 2018; doi:10.1038/s41467-018-04247-z Nested structures are common throughout nature and art, yet remain challenging synthetic targets in supramolecular chemistry. Here, the authors design multitopic terpyridine ligands that coordinate into nested concentric hexagons, and show that these discrete supramolecules display potent antimicrobial activity.

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42

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In situ coherent diffractive imaging (2018)

Yuan Hung Lo; Lingrong Zhao; Marcus Gallagher-Jones; Arjun Rana; Jared J. Lodico; Weikun Xiao; B. C. Regan; Jianwei Miao

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Publication Date: 2018-05-09

Description: In situ coherent diffractive imaging In situ coherent diffractive imaging, Published online: 08 May 2018; doi:10.1038/s41467-018-04259-9 Coherent diffractive imaging (CDI) allows for high resolution imaging without lenses. Here, Lo et al. develop in situ CDI with real-time imaging and a corresponding low-dose requirement, with expected applications in the physical and life sciences.

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43

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miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B (2018)

Feng Sun; Mengchao Yu; Jing Yu; Zhijian Liu; Xinyan Zhou; Yanqing Liu; Xiaolong Ge; Haidong Gao; Mei Li; Xiaohong Jiang; Song Liu; Xi Chen; Wenxian Guan

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Publication Date: 2018-05-10

Description: miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B, Published online: 09 May 2018; doi:10.1038/s41419-018-0611-0 miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B

Electronic ISSN: 2041-4889

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microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A (2018)

Chubin Luo; Dan Yin; Hao Zhan; Uyunbilig Borjigin; Chuanjiang Li; Zhengjun Zhou; Zhiqiang Hu; Pengcheng Wang; Qiman Sun; Jia Fan; Jian Zhou; Xin Wang; Shaolai Zhou; Xiaowu Huang

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Publication Date: 2018-05-11

Description: microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A, Published online: 10 May 2018; doi:10.1038/s41419-018-0577-y microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A

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45

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Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration (2018)

Jia-Jian Wang; Kun Shan; Bai-Hui Liu; Chang Liu; Rong-Mei Zhou; Xiu-Miao Li; Rui Dong; Shu-Jie Zhang; Sheng-Hai Zhang; Ji-Hong Wu; Biao Yan

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Publication Date: 2018-05-11

Description: Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration, Published online: 10 May 2018; doi:10.1038/s41419-018-0597-7 Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration

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46

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Fructose fuels lung adenocarcinoma through GLUT5 (2018)

Yuanyuan Weng; Jin Zhu; Zhenhong Chen; Jingqi Fu; Feng Zhang

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Publication Date: 2018-05-11

Description: Fructose fuels lung adenocarcinoma through GLUT5 Fructose fuels lung adenocarcinoma through GLUT5, Published online: 10 May 2018; doi:10.1038/s41419-018-0630-x Fructose fuels lung adenocarcinoma through GLUT5

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Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair (2018)

Chin-Chuan Chen; Chi-Yuan Chen; Shir-Hwa Ueng; Chuen Hsueh; Chau-Ting Yeh; Jar-Yi Ho; Li-Fang Chou; Tong-Hong Wang

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Publication Date: 2018-05-11

Description: Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair, Published online: 10 May 2018; doi:10.1038/s41419-018-0575-0 Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair

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48

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Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis (2018)

Rachel P. L. van Swelm; Madelon Vos; Frank Verhoeven; Frank Thévenod; Dorine W. Swinkels

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Publication Date: 2018-05-11

Description: Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis, Published online: 10 May 2018; doi:10.1038/s41419-018-0568-z Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

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Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury (2018)

Li Diao; Christopher Auger; Hisato Konoeda; Ali-Reza Sadri; Saeid Amini-Nik; Marc G. Jeschke

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Publication Date: 2018-05-11

Description: Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury, Published online: 10 May 2018; doi:10.1038/s41419-018-0531-z Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury

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PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis (2018)

Jia Cui; William J. Placzek

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Publication Date: 2018-05-11

Description: PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis PTBP1 enhances miR-101-guided AGO2 targeting to 〈i〉MCL1〈/i〉 and promotes miR-101-induced apoptosis, Published online: 10 May 2018; doi:10.1038/s41419-018-0551-8 PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis

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The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA (2018)

Ming Li; Zhongyu Xie; Peng Wang; Jinteng Li; Wenjie Liu; Su’an Tang; Zhenhua Liu; Xiaohua Wu; Yanfeng Wu; Huiyong Shen

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Publication Date: 2018-05-11

Description: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA, Published online: 10 May 2018; doi:10.1038/s41419-018-0627-5 The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

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Breaking the limitation of mode building time in an optoelectronic oscillator (2018)

Tengfei Hao; Qizhuang Cen; Yitang Dai; Jian Tang; Wei Li; Jianping Yao; Ninghua Zhu; Ming Li

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Publication Date: 2018-05-10

Description: Breaking the limitation of mode building time in an optoelectronic oscillator Breaking the limitation of mode building time in an optoelectronic oscillator, Published online: 09 May 2018; doi:10.1038/s41467-018-04240-6 In optoelectronic oscillators used to produce chirps for radar or communications, low phase noise usually comes at a cost of slow tuning due to mode-building time. The authors use Fourier-domain mode locking to break this limitation and enable fast-tunable chirp production for microwave photonics.

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Alison Roth; Steven P. Maher; Amy J. Conway; Ratawan Ubalee; Victor Chaumeau; Chiara Andolina; Stephen A. Kaba; Amélie Vantaux; Malina A. Bakowski; Richard Thomson Luque; Swamy Rakesh Adapa; Naresh Singh; Samantha J. Barnes; Caitlin A. Cooper; Mélanie Rouillier; Case W. McNamara; Sebastian A. Mikolajczak; Noah Sather; Benoît Witkowski; Brice Campo; Stefan H. I. Kappe; David E. Lanar; François Nosten; Silas Davidson; Rays H. Y. Jiang; Dennis E. Kyle; John H. Adams

53

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A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum (2018)

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Publication Date: 2018-05-10

Description: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum A comprehensive model for assessment of liver stage therapies targeting 〈i〉Plasmodium vivax〈/i〉 and 〈i〉Plasmodium falciparum〈/i〉, Published online: 09 May 2018; doi:10.1038/s41467-018-04221-9 Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.

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Gravitational clustering of cosmic relic neutrinos in the Milky Way (2018)

Jue Zhang; Xin Zhang

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Publication Date: 2018-05-10

Description: Gravitational clustering of cosmic relic neutrinos in the Milky Way Gravitational clustering of cosmic relic neutrinos in the Milky Way, Published online: 09 May 2018; doi:10.1038/s41467-018-04264-y In order to detect relic neutrinos in the vicinity of the Earth, quantitative knowledge of the gravitational clustering effects on cosmic relic neutrinos in the Milky Way is necessary. Here, the authors develop a computational method capable of yielding neutrino density profiles for different neutrino masses and phase space distributions in a single simulation.

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NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence (2018)

Aled J. Parry; Matthew Hoare; Dóra Bihary; Robert Hänsel-Hertsch; Stephen Smith; Kosuke Tomimatsu; Elizabeth Mannion; Amy Smith; Paula D’Santos; I. Alasdair Russell; Shankar Balasubramanian; Hiroshi Kimura; Shamith A. Samarajiwa; Masashi Narita

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Publication Date: 2018-05-10

Description: NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence, Published online: 09 May 2018; doi:10.1038/s41467-018-04283-9 Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

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Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis (2018)

Mugdha Sathe; Gayatri Muthukrishnan; James Rae; Andrea Disanza; Mukund Thattai; Giorgio Scita; Robert G. Parton; Satyajit Mayor

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Publication Date: 2018-05-10

Description: Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis, Published online: 09 May 2018; doi:10.1038/s41467-018-03955-w Several endocytic pathways operate simultaneously at the cell surface, including the clathrin and dynamin-independent CLIC/GEEC (CG) pathway. Here the authors show that small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin-independent endocytic vesicles.

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Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage (2018)

Gao-Qian Wang; Guo-Dong Chen; Sheng-Ying Qin; Dan Hu; Takayoshi Awakawa; Shao-Yang Li; Jian-Ming Lv; Chuan-Xi Wang; Xin-Sheng Yao; Ikuro Abe; Hao Gao

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Publication Date: 2018-05-10

Description: Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage, Published online: 09 May 2018; doi:10.1038/s41467-018-04298-2 Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.

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Ceri Shipton; Patrick Roberts; Will Archer; Simon J. Armitage; Caesar Bita; James Blinkhorn; Colin Courtney-Mustaphi; Alison Crowther; Richard Curtis; Francesco d’ Errico; Katerina Douka; Patrick Faulkner; Huw S. Groucutt; Richard Helm; Andy I. R Herries; Severinus Jembe; Nikos Kourampas; Julia Lee-Thorp; Rob Marchant; Julio Mercader; Africa Pitarch Marti; Mary E. Prendergast; Ben Rowson; Amini Tengeza; Ruth Tibesasa; Tom S. White; Michael D. Petraglia; Nicole Boivin

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78,000-year-old record of Middle and Later stone age innovation in an East African tropical forest (2018)

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Description: 78,000-year-old record of Middle and Later stone age innovation in an East African tropical forest 78,000-year-old record of Middle and Later stone age innovation in an East African tropical forest, Published online: 09 May 2018; doi:10.1038/s41467-018-04057-3 Most of the archaeological record of the Middle to Later Stone Age transition comes from southern Africa. Here, Shipton et al. describe the new site Panga ya Saidi on the coast of Kenya that covers the last 78,000 years and shows gradual cultural and technological change in the Late Pleistocene.

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59

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Regulatory protein SrpA controls phage infection and core cellular processes in Pseudomonas aeruginosa (2018)

Jiajia You; Li Sun; Xiaojing Yang; Xuewei Pan; Zhiwei Huang; Xixi Zhang; Mengxin Gong; Zheng Fan; Lingyan Li; Xiaoli Cui; Zhaoyuan Jing; Shouguang Jin; Zhiming Rao; Weihui Wu; Hongjiang Yang

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Publication Date: 2018-05-11

Description: Regulatory protein SrpA controls phage infection and core cellular processes in Pseudomonas aeruginosa Regulatory protein SrpA controls phage infection and core cellular processes in 〈i〉Pseudomonas aeruginosa〈/i〉, Published online: 10 May 2018; doi:10.1038/s41467-018-04232-6 You et al. show that SrpA, a small protein widely conserved among bacteria, controls core cellular processes in response to phage infection and environmental signals in Pseudomonas aeruginosa, including cell motility, chemotaxis, biofilm formation, and virulence.

Electronic ISSN: 2041-1723

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60

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Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling (2018)

Pragya Goel; Dion Dickman

Nature Publishing Group (NPG)

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Publication Date: 2018-05-11

Description: Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling, Published online: 10 May 2018; doi:10.1038/s41467-018-04270-0 Dual leucine zipper kinase (DLK) activates an intrinsic neuronal response to injury and is also implicated in neurodegeneration. Here, Goel and Dickman characterize how postsynaptic targets adapt to presynaptic DLK signaling through a downregulation of synaptic strength.

Electronic ISSN: 2041-1723

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61

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Diffusion in translucent media (2018)

Zhou Shi; Azriel Z. Genack

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Publication Date: 2018-05-11

Description: Diffusion in translucent media Diffusion in translucent media, Published online: 10 May 2018; doi:10.1038/s41467-018-04242-4 Despite the universal nature of diffusion, the behavior of light transport in optically thin media has remained unclear. Here the authors show that the description of this behavior in translucent media has the same form as in opaque media, even at length scales far below the mean free path.

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62

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Ultrafast probes of electron–hole transitions between two atomic layers (2018)

Xiewen Wen; Hailong Chen; Tianmin Wu; Zhihao Yu; Qirong Yang; Jingwen Deng; Zhengtang Liu; Xin Guo; Jianxin Guan; Xiang Zhang; Yongji Gong; Jiangtan Yuan; Zhuhua Zhang; Chongyue Yi; Xuefeng Guo; Pulickel M. Ajayan; Wei Zhuang; Zhirong Liu; Jun Lou; Junrong Zheng

Nature Publishing Group (NPG)

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Publication Date: 2018-05-11

Description: Ultrafast probes of electron–hole transitions between two atomic layers Ultrafast probes of electron–hole transitions between two atomic layers, Published online: 10 May 2018; doi:10.1038/s41467-018-04291-9 The investigation into the dynamical transitions of charged quasiparticles on interfaces remains technically challenging. Here, the authors use ultrafast, mid-infrared micro-spectroscopy to unveil the formation of tightly bound interlayer excitons between conducting graphene and semiconducting MoSe2.

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63

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Explaining the apparent impenetrable barrier to ultra-relativistic electrons in the outer Van Allen belt (2018)

Louis G. Ozeke; Ian R. Mann; Kyle R. Murphy; Alex W. Degeling; Seth G. Claudepierre; Harlan E. Spence

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Publication Date: 2018-05-11

Description: Explaining the apparent impenetrable barrier to ultra-relativistic electrons in the outer Van Allen belt Explaining the apparent impenetrable barrier to ultra-relativistic electrons in the outer Van Allen belt, Published online: 10 May 2018; doi:10.1038/s41467-018-04162-3 The origin of the apparent impenetrable barrier in the outer Van Allen belt is still uncertain. Here, the authors report that penetration to the barrier can occur by means of ultra-low frequency wave transport, enabling ultra-relativistic electrons to reach the location of the barrier.

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64

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Direct neurotransmitter activation of voltage-gated potassium channels (2018)

Rían W. Manville; Maria Papanikolaou; Geoffrey W. Abbott

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Publication Date: 2018-05-11

Description: Direct neurotransmitter activation of voltage-gated potassium channels Direct neurotransmitter activation of voltage-gated potassium channels, Published online: 10 May 2018; doi:10.1038/s41467-018-04266-w M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.

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Stephen J. Pettitt; Dragomir B. Krastev; Inger Brandsma; Amy Dréan; Feifei Song; Radoslav Aleksandrov; Maria I. Harrell; Malini Menon; Rachel Brough; James Campbell; Jessica Frankum; Michael Ranes; Helen N. Pemberton; Rumana Rafiq; Kerry Fenwick; Amanda Swain; Sebastian Guettler; Jung-Min Lee; Elizabeth M. Swisher; Stoyno Stoynov; Kosuke Yusa; Alan Ashworth; Christopher J. Lord

65

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance (2018)

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Publication Date: 2018-05-11

Description: Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in 〈i〉PARP1〈/i〉 causing PARP inhibitor resistance, Published online: 10 May 2018; doi:10.1038/s41467-018-03917-2 The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, suggesting alternative resistance mechanisms.

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66

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Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma (2018)

Evangelos Terpos; Ioannis Ntanasis-Stathopoulos; Dimitrios Christoulas; Tina Bagratuni; Marios Bakogeorgos; Maria Gavriatopoulou; Evangelos Eleutherakis-Papaiakovou; Nikolaos Kanellias; Efstathios Kastritis; Meletios A. Dimopoulos

Nature Publishing Group (NPG)

In: Blood Cancer Journal

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Publication Date: 2018-05-12

Description: Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma, Published online: 11 May 2018; doi:10.1038/s41408-018-0075-6 Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma

Electronic ISSN: 2044-5385

Topics: Medicine

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67

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Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1 (2018)

Zhaowei Xu; Yangyang Yang; Bowen Li; Yanan Li; Kangkai Xia; Yuxi Yang; Xiahui Li; Miao Wang; Shujing Li; Huijian Wu

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Publication Date: 2018-05-12

Description: Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1 Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1, Published online: 11 May 2018; doi:10.1038/s41419-018-0629-3 Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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68

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MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis (2018)

Weigang Zhang; Xiuli Yi; Yawen An; Sen Guo; Shuli Li; Pu Song; Yuqian Chang; Shaolong Zhang; Tianwen Gao; Gang Wang; Chunying Li

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Publication Date: 2018-05-12

Description: MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis, Published online: 11 May 2018; doi:10.1038/s41419-018-0621-y MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis

Electronic ISSN: 2041-4889

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69

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Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma (2018)

Fanglong Wu; Xueke Shi; Rui Zhang; Yuan Tian; Xiangjian Wang; Changlei Wei; Duo Li; Xiaoyu Li; Xiangli Kong; Yurong Liu; Weihua Guo; Yiqing Guo; Hongmei Zhou

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Publication Date: 2018-05-12

Description: Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma, Published online: 11 May 2018; doi:10.1038/s41419-018-0618-6 Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma

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70

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Author Correction: Fermiology and electron dynamics of trilayer nickelate La 4 Ni 3 O 10 (2018)

Haoxiang Li; Xiaoqing Zhou; Thomas Nummy; Junjie Zhang; Victor Pardo; Warren E. Pickett; J. F. Mitchell; D. S. Dessau

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Publication Date: 2018-05-12

Description: Author Correction: Fermiology and electron dynamics of trilayer nickelate La 4 Ni 3 O 10 Author Correction: Fermiology and electron dynamics of trilayer nickelate La〈sub〉4〈/sub〉Ni〈sub〉3〈/sub〉O〈sub〉10〈/sub〉, Published online: 11 May 2018; doi:10.1038/s41467-018-04105-y Author Correction: Fermiology and electron dynamics of trilayer nickelate La 4 Ni 3 O 10

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71

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Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli (2018)

Congqiang Zhang; Vui Yin Seow; Xixian Chen; Heng-Phon Too

Nature Publishing Group (NPG)

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Publication Date: 2018-05-12

Description: Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in 〈i〉Escherichia coli〈/i〉, Published online: 11 May 2018; doi:10.1038/s41467-018-04211-x Achieving high titer yield and productivity of target chemicals in industrial organism depends on multidimensional pathway optimization. Here, the authors use a refined modular method called multidimensional heuristic process to improve production of astaxanthin, nerolidol and linalool in E. coli.

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72

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Author Correction: Towards an arthritis flare-responsive drug delivery system (2018)

Nitin Joshi; Jing Yan; Seth Levy; Sachin Bhagchandani; Kai V. Slaughter; Nicholas E. Sherman; Julian Amirault; Yufeng Wang; Logan Riegel; Xueyin He; Tan Shi Rui; Michael Valic; Praveen K. Vemula; Oscar R. Miranda; Oren Levy; Ellen M. Gravallese; Antonios O. Aliprantis; Joerg Ermann; Jeffrey M. Karp

Nature Publishing Group (NPG)

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Publication Date: 2018-05-12

Description: Author Correction: Towards an arthritis flare-responsive drug delivery system Author Correction: Towards an arthritis flare-responsive drug delivery system, Published online: 11 May 2018; doi:10.1038/s41467-018-04346-x Author Correction: Towards an arthritis flare-responsive drug delivery system

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73

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Instability of the Northeast Greenland Ice Stream over the last 45,000 years (2018)

Nicolaj K. Larsen; Laura B. Levy; Anders E. Carlson; Christo Buizert; Jesper Olsen; Astrid Strunk; Anders A. Bjørk; Daniel S. Skov

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Instability of the Northeast Greenland Ice Stream over the last 45,000 years Instability of the Northeast Greenland Ice Stream over the last 45,000 years, Published online: 14 May 2018; doi:10.1038/s41467-018-04312-7 The outlet glaciers that comprise the Northeast Greenland Ice Stream (NEGIS) have experienced accelerated retreat in recent years, yet their longterm stability remains unclear. Here, via cosmogenic surface exposure and radiocarbon ages, the authors investigate the stability of the NEGIS for the past 45 kyr.

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74

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Silicon-chip-based mid-infrared dual-comb spectroscopy (2018)

Mengjie Yu; Yoshitomo Okawachi; Austin G. Griffith; Nathalie PicquéMichal Lipson; Alexander L. Gaeta

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Silicon-chip-based mid-infrared dual-comb spectroscopy Silicon-chip-based mid-infrared dual-comb spectroscopy, Published online: 14 May 2018; doi:10.1038/s41467-018-04350-1 Dual-comb spectroscopy is a powerful tool for realizing rapid spectroscopic measurements with high sensitivity and selectivity. Here, Yu et al. demonstrate silicon microresonator-based dual comb spectroscopy in the mid-infrared region, where strong vibrational resonances of many liquids exist.

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75

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Stepwise heating in Stille polycondensation toward no batch-to-batch variations in polymer solar cell performance (2018)

Sang Myeon Lee; Kwang Hyun Park; Seungon Jung; Hyesung Park; Changduk Yang

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Stepwise heating in Stille polycondensation toward no batch-to-batch variations in polymer solar cell performance Stepwise heating in Stille polycondensation toward no batch-to-batch variations in polymer solar cell performance, Published online: 14 May 2018; doi:10.1038/s41467-018-03718-7 Polymer electronics may have a bright future but the poor reproducibility limits the scaled-up manufacturing. Here Lee et al. employ a stepwise-heating protocol in the Stille polycondensation and fabricate polymer solar cells with improved performance and ignorable device-to-device variations.

Electronic ISSN: 2041-1723

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76

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Self-organizing layers from complex molecular anions (2018)

Jonas Warneke; Martin E. McBriarty; Shawn L. Riechers; Swarup China; Mark H. Engelhard; Edoardo ApràRobert P. Young; Nancy M. Washton; Carsten Jenne; Grant E. Johnson; Julia Laskin

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Self-organizing layers from complex molecular anions Self-organizing layers from complex molecular anions, Published online: 14 May 2018; doi:10.1038/s41467-018-04228-2 Using ions of one polarity to form functional layers on surfaces is usually challenging because of counter ions which are inevitably present in the condensed phase. Here the authors demonstrate accumulation of mass-selected anions and neutral molecules from the gas phase to form a self-organizing liquid-like layer on a surface.

Electronic ISSN: 2041-1723

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77

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Sculpting and fusing biomimetic vesicle networks using optical tweezers (2018)

Guido Bolognesi; Mark S. Friddin; Ali Salehi-Reyhani; Nathan E. Barlow; Nicholas J. Brooks; Oscar Ces; Yuval Elani

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Sculpting and fusing biomimetic vesicle networks using optical tweezers Sculpting and fusing biomimetic vesicle networks using optical tweezers, Published online: 14 May 2018; doi:10.1038/s41467-018-04282-w Assembly of higher-order artificial vesicles can unlock new applications. Here, the authors use optical tweezers to construct user-defined 2D and 3D architectures of chemically distinct vesicles and demonstrate inter-vesicle communication and light-enabled compartment merging.

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78

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Neural encoding and production of functional morphemes in the posterior temporal lobe (2018)

Daniel K. Lee; Evelina Fedorenko; Mirela V. Simon; William T. Curry; Brian V. Nahed; Dan P. Cahill; Ziv M. Williams

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Publication Date: 2018-05-15

Description: Neural encoding and production of functional morphemes in the posterior temporal lobe Neural encoding and production of functional morphemes in the posterior temporal lobe, Published online: 14 May 2018; doi:10.1038/s41467-018-04235-3 Functional morphemes allow us to express details about objects, events, and their relationships. Here, authors show that inhibiting a small cortical area within left posterior superior temporal lobe selectively impairs the ability to produce functional morphemes but does not impair other linguistic abilities.

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Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue (2018)

Grégory Eot-Houllier; Laura Magnaghi-Jaulin; Géraldine Fulcrand; François-Xavier Moyroud; Solange Monier; Christian Jaulin

Nature Publishing Group (NPG)

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Publication Date: 2018-05-15

Description: Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue, Published online: 14 May 2018; doi:10.1038/s41467-018-04089-9 Sustained spindle tension applied to sister centromeres during mitosis leads to loss of sister chromatid cohesion which is known as cohesion fatigue. Here the authors show that Aurora A-dependent phosphorylation of CENP-A at the inner centromeres protects bioriented chromosomes against cohesion fatigue.

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Manuel Rodrigues; Lenha Mobuchon; Alexandre Houy; Alice Fiévet; Sophie Gardrat; Raymond L. Barnhill; Tatiana Popova; Vincent Servois; Aurore Rampanou; Aurore Mouton; Stéphane Dayot; Virginie Raynal; Michèle Galut; Marc Putterman; Sarah Tick; Nathalie Cassoux; Sergio Roman-Roman; François-Clément Bidard; Olivier Lantz; Pascale Mariani; Sophie Piperno-Neumann; Marc-Henri Stern

80

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Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors (2018)

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Publication Date: 2018-05-15

Description: Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors Outlier response to anti-PD1 in uveal melanoma reveals germline 〈i〉MBD4〈/i〉 mutations in hypermutated tumors, Published online: 14 May 2018; doi:10.1038/s41467-018-04322-5 Hypermutated tumors respond more favorably to checkpoint inhibitor-based immune therapy. Here, the authors describe a new hypermutated phenotype due to germline mutations and subsequent somatic loss of heterozygosity of MBD4, and a dramatic response to the PD-1 inhibitor pembrolizumab in a patient with a MBD4-inactivated hypermutated uveal melanoma.

Electronic ISSN: 2041-1723

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Author Correction: Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis (2018)

Ramani Baddam; Narender Kumar; Lothar H. Wieler; Aditya Kumar Lankapalli; Niyaz Ahmed; Sharon J. Peacock; Torsten Semmler

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Publication Date: 2018-05-15

Description: Author Correction: Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis Author Correction: Analysis of mutations in 〈i〉pncA〈/i〉 reveals non-overlapping patterns among various lineages of 〈i〉Mycobacterium tuberculosis〈/i〉, Published online: 15 May 2018; doi:10.1038/s41598-018-25809-7 Author Correction: Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Author Correction: Adherence to diet recommendations and risk of abdominal aortic aneurysm in the Malmö Diet and Cancer Study (2018)

Sara Nordkvist; Emily Sonestedt; Stefan Acosta

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Publication Date: 2018-05-15

Description: Author Correction: Adherence to diet recommendations and risk of abdominal aortic aneurysm in the Malmö Diet and Cancer Study Author Correction: Adherence to diet recommendations and risk of abdominal aortic aneurysm in the Malmö Diet and Cancer Study, Published online: 15 May 2018; doi:10.1038/s41598-018-25616-0 Author Correction: Adherence to diet recommendations and risk of abdominal aortic aneurysm in the Malmö Diet and Cancer Study

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Author Correction: White Matter and Gray Matter Segmentation in 4D Computed Tomography (2018)

Rashindra Manniesing; Marcel T. H. Oei; Luuk J. Oostveen; Jaime Melendez; Ewoud J. Smit; Bram Platel; Clara I. Sánchez; Frederick J. A. Meijer; Mathias Prokop; Bram van Ginneken

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Publication Date: 2018-05-15

Description: Author Correction: White Matter and Gray Matter Segmentation in 4D Computed Tomography Author Correction: White Matter and Gray Matter Segmentation in 4D Computed Tomography, Published online: 15 May 2018; doi:10.1038/s41598-018-25729-6 Author Correction: White Matter and Gray Matter Segmentation in 4D Computed Tomography

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84

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Author Correction: Dynamic Changes of Genome-Wide DNA Methylation during Soybean Seed Development (2018)

Yong-qiang Charles An; Wolfgang Goettel; Qiang Han; Arthur Bartels; Zongrang Liu; Wenyan Xiao

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Publication Date: 2018-05-15

Description: Author Correction: Dynamic Changes of Genome-Wide DNA Methylation during Soybean Seed Development Author Correction: Dynamic Changes of Genome-Wide DNA Methylation during Soybean Seed Development, Published online: 15 May 2018; doi:10.1038/s41598-018-25805-x Author Correction: Dynamic Changes of Genome-Wide DNA Methylation during Soybean Seed Development

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