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  • 1
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    Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-02
    Description: Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community, Published online: 02 August 2018; doi:10.1038/s41598-018-30164-8 Author Correction: Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 2
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    Publisher Correction: Deletion of DDB1- and CUL4- associated factor-17 ( Dcaf17 ) gene causes spermatogenesis defects and male infertility in mice (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-02
    Description: Publisher Correction: Deletion of DDB1- and CUL4- associated factor-17 ( Dcaf17 ) gene causes spermatogenesis defects and male infertility in mice Publisher Correction: Deletion of DDB1- and CUL4- associated factor-17 (〈i〉Dcaf17〈/i〉) gene causes spermatogenesis defects and male infertility in mice, Published online: 01 August 2018; doi:10.1038/s41598-018-29836-2 Publisher Correction: Deletion of DDB1- and CUL4- associated factor-17 ( Dcaf17 ) gene causes spermatogenesis defects and male infertility in mice
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 3
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    Structural elucidation of Tsukamurella pulmonis neutral polysaccharide and its visualization in infected mouse tissues by specific monoclonal antibodies (2018)
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    Publication Date: 2018-08-02
    Description: Structural elucidation of Tsukamurella pulmonis neutral polysaccharide and its visualization in infected mouse tissues by specific monoclonal antibodies Structural elucidation of 〈i〉Tsukamurella pulmonis〈/i〉 neutral polysaccharide and its visualization in infected mouse tissues by specific monoclonal antibodies, Published online: 01 August 2018; doi:10.1038/s41598-018-29864-y Structural elucidation of Tsukamurella pulmonis neutral polysaccharide and its visualization in infected mouse tissues by specific monoclonal antibodies
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 4
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    Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum (2018)
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    Publication Date: 2018-07-04
    Description: Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum, Published online: 03 July 2018; doi:10.1038/s41598-018-28398-7 Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 5
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    Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis (2018)
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    Publication Date: 2018-08-03
    Description: Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis, Published online: 02 August 2018; doi:10.1038/s41467-018-05466-0 Engineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E. coli.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 6
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    Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics (2018)
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    Publication Date: 2018-08-02
    Description: Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics, Published online: 01 August 2018; doi:10.1038/s41398-018-0174-y Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics
    Electronic ISSN: 2158-3188
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 7
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    Male increase in brain gene expression variability is linked to genetic risk for schizophrenia (2018)
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    Publication Date: 2018-08-02
    Description: Male increase in brain gene expression variability is linked to genetic risk for schizophrenia Male increase in brain gene expression variability is linked to genetic risk for schizophrenia, Published online: 01 August 2018; doi:10.1038/s41398-018-0200-0 Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
    Electronic ISSN: 2158-3188
    Topics: Medicine
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  • 8
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    Reciprocal Perspective for Improved Protein-Protein Interaction Prediction (2018)
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    Publication Date: 2018-08-04
    Description: Reciprocal Perspective for Improved Protein-Protein Interaction Prediction Reciprocal Perspective for Improved Protein-Protein Interaction Prediction, Published online: 03 August 2018; doi:10.1038/s41598-018-30044-1 Reciprocal Perspective for Improved Protein-Protein Interaction Prediction
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 9
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    Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons (2018)
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    Publication Date: 2018-08-04
    Description: Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons, Published online: 03 August 2018; doi:10.1038/s41598-018-29862-0 Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 10
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    Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies (2018)
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    Publication Date: 2018-08-03
    Description: Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies, Published online: 02 August 2018; doi:10.1038/s41398-018-0202-y Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies
    Electronic ISSN: 2158-3188
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 11
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    Automated single-molecule imaging in living cells (2018)
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    Publication Date: 2018-08-04
    Description: Automated single-molecule imaging in living cells Automated single-molecule imaging in living cells, Published online: 03 August 2018; doi:10.1038/s41467-018-05524-7 Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EGFR dynamics in response to various stimuli.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 12
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    In situ formation of catalytically active graphene in ethylene photo-epoxidation (2018)
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    Publication Date: 2018-08-04
    Description: In situ formation of catalytically active graphene in ethylene photo-epoxidation In situ formation of catalytically active graphene in ethylene photo-epoxidation, Published online: 03 August 2018; doi:10.1038/s41467-018-05352-9 In situ studies under working conditions are important in atomic-level elucidation, design, and optimization of industrially relevant catalysts. Here, the authors report an in situ study of an Ag ethylene photo-epoxidation catalyst using surface enhanced Raman scattering, which uncovers an unconventional mechanism.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 13
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    Uniaxial stress flips the natural quantization axis of a quantum dot for integrated quantum photonics (2018)
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    Publication Date: 2018-08-04
    Description: Uniaxial stress flips the natural quantization axis of a quantum dot for integrated quantum photonics Uniaxial stress flips the natural quantization axis of a quantum dot for integrated quantum photonics, Published online: 03 August 2018; doi:10.1038/s41467-018-05499-5 The natural quantization axis in quantum dots, which is usually parallel to the growth direction, is not ideal for planar photonic circuits. Here Yuan et al. show that for gallium arsenide dots, the quantization axis can be flipped to lie in the growth plane via moderate in-plane uniaxial stress.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 14
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    Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology (2018)
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    Publication Date: 2018-07-06
    Description: Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology, Published online: 05 July 2018; doi:10.1038/s41598-018-28393-y Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 15
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    Association of meteorological factors and air NO 2 and O 3 concentrations with acute exacerbation of elderly chronic obstructive pulmonary disease (2018)
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    Publication Date: 2018-07-06
    Description: Association of meteorological factors and air NO 2 and O 3 concentrations with acute exacerbation of elderly chronic obstructive pulmonary disease Association of meteorological factors and air NO〈sub〉2〈/sub〉 and O〈sub〉3〈/sub〉 concentrations with acute exacerbation of elderly chronic obstructive pulmonary disease, Published online: 05 July 2018; doi:10.1038/s41598-018-28532-5 Association of meteorological factors and air NO 2 and O 3 concentrations with acute exacerbation of elderly chronic obstructive pulmonary disease
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 16
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    Metastable phase formation of Pt-X (X = Ir, Au) thin films (2018)
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    Publication Date: 2018-07-06
    Description: Metastable phase formation of Pt-X (X = Ir, Au) thin films Metastable phase formation of Pt-X (X = Ir, Au) thin films, Published online: 05 July 2018; doi:10.1038/s41598-018-28452-4 Metastable phase formation of Pt-X (X = Ir, Au) thin films
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 17
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    Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-04
    Description: Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus Full-length transcriptome of 〈i〉Misgurnus anguillicaudatus〈/i〉 provides insights into evolution of genus 〈i〉Misgurnus〈/i〉, Published online: 03 August 2018; doi:10.1038/s41598-018-29991-6 Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 18
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    Zeroth Law investigation on the logarithmic thermostat (2018)
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    Publication Date: 2018-08-04
    Description: Zeroth Law investigation on the logarithmic thermostat Zeroth Law investigation on the logarithmic thermostat, Published online: 03 August 2018; doi:10.1038/s41598-018-30129-x Zeroth Law investigation on the logarithmic thermostat
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 19
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    Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-04
    Description: Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation, Published online: 03 August 2018; doi:10.1038/s41598-018-30051-2 Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 20
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    The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-07
    Description: The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4, Published online: 06 August 2018; doi:10.1038/s41419-018-0841-1 The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 21
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    Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway (2018)
    Nature Publishing Group (NPG)
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    Publication Date: 2018-08-07
    Description: Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway, Published online: 06 August 2018; doi:10.1038/s41419-018-0857-6 Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 22
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    DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer (2018)
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    Publication Date: 2018-08-07
    Description: DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer, Published online: 06 August 2018; doi:10.1038/s41419-018-0899-9 DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 23
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    An atmospheric chronology for the glacial-deglacial Eastern Equatorial Pacific (2018)
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    Publication Date: 2018-08-07
    Description: An atmospheric chronology for the glacial-deglacial Eastern Equatorial Pacific An atmospheric chronology for the glacial-deglacial Eastern Equatorial Pacific, Published online: 06 August 2018; doi:10.1038/s41467-018-05574-x Chronological assumptions in marine sediment records can result in uncertainties in paleoenvironmental reconstructions. Here, using computed tomography to identify in situ woody debris, the authors construct a robust 14C chronology and reassess ventilation ages in the Eastern Equatorial Pacific during the LGM.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 24
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    Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis (2018)
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    Publication Date: 2018-08-08
    Description: Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis, Published online: 07 August 2018; doi:10.1038/s41467-018-05491-z Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation in macrophages can ameliorate PAP in both humans and mice.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 25
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    Tunable inverse spin Hall effect in nanometer-thick platinum films by ionic gating (2018)
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    Publication Date: 2018-08-08
    Description: Tunable inverse spin Hall effect in nanometer-thick platinum films by ionic gating Tunable inverse spin Hall effect in nanometer-thick platinum films by ionic gating, Published online: 07 August 2018; doi:10.1038/s41467-018-05611-9 The ability to electrically control spintronic materials significantly widens their potential for integration into devices, but it is difficult to achieve in metals with high carrier densities. Here the authors demonstrate ionic liquid gated control of the inverse spin Hall effect in platinum.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 26
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    Persistent structures in a three-dimensional dynamical system with flowing and non-flowing regions (2018)
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    Publication Date: 2018-08-08
    Description: Persistent structures in a three-dimensional dynamical system with flowing and non-flowing regions Persistent structures in a three-dimensional dynamical system with flowing and non-flowing regions, Published online: 07 August 2018; doi:10.1038/s41467-018-05508-7 Understanding mixing in yield stress materials, such as paint and sand, is complicated due to the coexistence of solid-like and fluid-like regimes. Zaman et al. examine mixing in a granular material in three dimensions and find persistent complex non-mixing structures within the chaotic flowing regime.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 27
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    Identifying individuals with attention deficit hyperactivity disorder based on temporal variability of dynamic functional connectivity (2018)
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    Publication Date: 2018-08-08
    Description: Identifying individuals with attention deficit hyperactivity disorder based on temporal variability of dynamic functional connectivity Identifying individuals with attention deficit hyperactivity disorder based on temporal variability of dynamic functional connectivity, Published online: 07 August 2018; doi:10.1038/s41598-018-30308-w Identifying individuals with attention deficit hyperactivity disorder based on temporal variability of dynamic functional connectivity
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 28
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    Following laser induced changes of plant phenylpropanoids by Raman microscopy (2018)
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    Publication Date: 2018-08-08
    Description: Following laser induced changes of plant phenylpropanoids by Raman microscopy Following laser induced changes of plant phenylpropanoids by Raman microscopy, Published online: 07 August 2018; doi:10.1038/s41598-018-30096-3 Following laser induced changes of plant phenylpropanoids by Raman microscopy
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 29
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    Course and characteristics of work disability 3 years before and after lumbar spine decompression surgery– a national population-based study (2018)
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    Publication Date: 2018-08-08
    Description: Course and characteristics of work disability 3 years before and after lumbar spine decompression surgery– a national population-based study Course and characteristics of work disability 3 years before and after lumbar spine decompression surgery– a national population-based study, Published online: 07 August 2018; doi:10.1038/s41598-018-30211-4 Course and characteristics of work disability 3 years before and after lumbar spine decompression surgery– a national population-based study
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 30
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    γδ T cells control humoral immune response by inducing T follicular helper cell differentiation (2018)
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    Publication Date: 2018-08-09
    Description: γδ T cells control humoral immune response by inducing T follicular helper cell differentiation γδ T cells control humoral immune response by inducing T follicular helper cell differentiation, Published online: 08 August 2018; doi:10.1038/s41467-018-05487-9 Many immune functions have been reported for γδ T cells, including the regulation of antibody responses. Here the authors show that CXCR5+ γδ T cells release Wnt ligands to initiate the T follicular helper cell differentiation program and promote antibody production.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Author Correction: Interfacial photochemistry at the ocean surface is a global source of organic vapors and aerosols (2018)
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    Publication Date: 2018-08-09
    Description: Author Correction: Interfacial photochemistry at the ocean surface is a global source of organic vapors and aerosols Author Correction: Interfacial photochemistry at the ocean surface is a global source of organic vapors and aerosols, Published online: 08 August 2018; doi:10.1038/s41467-018-05687-3 Author Correction: Interfacial photochemistry at the ocean surface is a global source of organic vapors and aerosols
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer (2018)
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    Publication Date: 2018-08-09
    Description: Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer, Published online: 08 August 2018; doi:10.1038/s41467-018-05550-5 Changes in the DNA methylation status are commonly observed in cancer but their impact on cancer development is unclear. Here, combining DNA methylation and expression profiles from a murine model of hepatocellular carcinoma with those from human samples, the authors report an epigenetic reprogramming process ensuring increased dosage of an “oncogene module”.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions (2018)
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    Publication Date: 2018-08-09
    Description: Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions, Published online: 08 August 2018; doi:10.1038/s41467-018-05633-3 The populous global land monsoon region has been suffering from extreme precipitation. Here, the authors show that limiting global warming to 1.5 °C instead of 2 °C could reduce areal and population exposures to baseline once-in-20-year rainfall extremes by 25% (18–41%) and 36% (22–46%), respectively.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Crystalline polymeric carbon dioxide stable at megabar pressures (2018)
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    Publication Date: 2018-08-09
    Description: Crystalline polymeric carbon dioxide stable at megabar pressures Crystalline polymeric carbon dioxide stable at megabar pressures, Published online: 08 August 2018; doi:10.1038/s41467-018-05593-8 The nature and stability of carbon dioxide under extreme conditions relevant to the Earth’s mantle is still under debate, in view of its possible role within the deep carbon cycle. Here, the authors perform high-pressure experiments providing evidence that polymeric crystalline CO2 is stable under megabaric conditions.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Exceptional electrocatalytic oxygen evolution via tunable charge transfer interactions in La 0.5 Sr 1.5 Ni 1−x Fe x O 4±δ Ruddlesden-Popper oxides (2018)
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    Publication Date: 2018-08-09
    Description: Exceptional electrocatalytic oxygen evolution via tunable charge transfer interactions in La 0.5 Sr 1.5 Ni 1−x Fe x O 4±δ Ruddlesden-Popper oxides Exceptional electrocatalytic oxygen evolution via tunable charge transfer interactions in La〈sub〉0.5〈/sub〉Sr〈sub〉1.5〈/sub〉Ni〈sub〉1−x〈/sub〉Fe〈sub〉x〈/sub〉O〈sub〉4±δ〈/sub〉 Ruddlesden-Popper oxides, Published online: 08 August 2018; doi:10.1038/s41467-018-05600-y Water electrolysis provides a potential means to large-scale renewable fuel generation, although sluggish oxygen evolution kinetics challenges progress. Here, authors report on Ruddlesden–Popper oxides as active oxygen evolution electrocatalysts that provide impetus for overcoming kinetic barriers.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Forcing the reversibility of a mechanochemical reaction (2018)
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    Publication Date: 2018-08-09
    Description: Forcing the reversibility of a mechanochemical reaction Forcing the reversibility of a mechanochemical reaction, Published online: 08 August 2018; doi:10.1038/s41467-018-05115-6 Mechanical force can facilitate thermodynamically unfavourable reactions. Here, the authors found that a stretching force can promote the SN2 cleavage of a protein disulfide bond by weak nucleophilic thiols, and that removing this force reverses the reaction yielding the original disulfide bond.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine (2018)
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    Publication Date: 2018-08-09
    Description: Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine, Published online: 08 August 2018; doi:10.1038/s41467-018-05657-9 While making up a small percentage of neurons in the nucleus accumbens, somatostatin interneurons may have important function in dopamine- and addiction-related behavior. Here, Ribeiro and colleagues show that somatostatin interneurons regulate behavioral responses to cocaine with physiological and transcriptomic changes.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Author Correction: Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction (2018)
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    Publication Date: 2018-08-10
    Description: Author Correction: Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction Author Correction: Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction, Published online: 10 August 2018; doi:10.1038/s41598-018-28914-9 Author Correction: Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Functional near-infrared spectroscopy for monitoring macaque cerebral motor activity during voluntary movements without head fixation (2018)
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    Publication Date: 2018-08-10
    Description: Functional near-infrared spectroscopy for monitoring macaque cerebral motor activity during voluntary movements without head fixation Functional near-infrared spectroscopy for monitoring macaque cerebral motor activity during voluntary movements without head fixation, Published online: 09 August 2018; doi:10.1038/s41598-018-30416-7 Functional near-infrared spectroscopy for monitoring macaque cerebral motor activity during voluntary movements without head fixation
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Feasibility of autologous plasma gel for tonsil-derived stem cell therapeutics in hypoparathyroidism (2018)
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    Publication Date: 2018-08-10
    Description: Feasibility of autologous plasma gel for tonsil-derived stem cell therapeutics in hypoparathyroidism Feasibility of autologous plasma gel for tonsil-derived stem cell therapeutics in hypoparathyroidism, Published online: 09 August 2018; doi:10.1038/s41598-018-30454-1 Feasibility of autologous plasma gel for tonsil-derived stem cell therapeutics in hypoparathyroidism
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity (2018)
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    Publication Date: 2018-08-10
    Description: MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity, Published online: 09 August 2018; doi:10.1038/s41598-018-30355-3 MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells (2018)
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    Publication Date: 2018-08-10
    Description: Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells, Published online: 09 August 2018; doi:10.1038/s41598-018-29817-5 Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    A single N 1 -methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes (2018)
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    Publication Date: 2018-08-10
    Description: A single N 1 -methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes A single N〈sup〉1〈/sup〉-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes, Published online: 09 August 2018; doi:10.1038/s41598-018-30383-z A single N 1 -methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Low temperature a / b nanotwins in Ni 50 Mn 25+x Ga 25−x Heusler alloys (2018)
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    Publication Date: 2018-08-10
    Description: Low temperature a / b nanotwins in Ni 50 Mn 25+x Ga 25−x Heusler alloys Low temperature 〈i〉a〈/i〉/〈i〉b〈/i〉 nanotwins in Ni〈sub〉50〈/sub〉Mn〈sub〉25+x〈/sub〉Ga〈sub〉25−x〈/sub〉 Heusler alloys, Published online: 09 August 2018; doi:10.1038/s41598-018-30388-8 Low temperature a / b nanotwins in Ni 50 Mn 25+x Ga 25−x Heusler alloys
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins (2018)
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    Publication Date: 2018-08-09
    Description: Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins, Published online: 08 August 2018; doi:10.1038/s41398-018-0195-6 Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins
    Electronic ISSN: 2158-3188
    Topics: Medicine
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    The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome (2018)
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    Publication Date: 2018-08-14
    Description: The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome, Published online: 13 August 2018; doi:10.1038/s41408-018-0115-2 The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome
    Electronic ISSN: 2044-5385
    Topics: Medicine
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    How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells? (2018)
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    Publication Date: 2018-08-14
    Description: How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells? How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?, Published online: 13 August 2018; doi:10.1038/s41419-018-0516-y How PERK kinase conveys stress signals to nuclear factor-κB to mediate estrogen-induced apoptosis in breast cancer cells?
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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    Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease (2018)
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    Publication Date: 2018-08-15
    Description: Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease, Published online: 14 August 2018; doi:10.1038/s41398-018-0201-z Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
    Electronic ISSN: 2158-3188
    Topics: Medicine
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    PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD (2018)
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    Publication Date: 2018-08-15
    Description: PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD, Published online: 14 August 2018; doi:10.1038/s41398-018-0208-5 PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD
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    Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population (2018)
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    Publication Date: 2018-08-15
    Description: Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population Association study and mutation sequencing of genes on chromosome 15q11-q13 identified 〈i〉GABRG3〈/i〉 as a susceptibility gene for autism in Chinese Han population, Published online: 14 August 2018; doi:10.1038/s41398-018-0197-4 Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population
    Electronic ISSN: 2158-3188
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    Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders (2018)
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    Publication Date: 2018-08-15
    Description: Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders, Published online: 14 August 2018; doi:10.1038/s41398-018-0199-2 Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders
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    Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation (2018)
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    Publication Date: 2018-08-11
    Description: Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation, Published online: 10 August 2018; doi:10.1038/s41598-018-30435-4 Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation
    Electronic ISSN: 2045-2322
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    Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma (2018)
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    Publication Date: 2018-08-11
    Description: Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma, Published online: 10 August 2018; doi:10.1038/s41598-018-30442-5 Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma
    Electronic ISSN: 2045-2322
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    Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata (2018)
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    Publication Date: 2018-08-11
    Description: Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata Hairy root induction and benzylisoquinoline alkaloid production in 〈i〉Macleaya cordata〈/i〉, Published online: 10 August 2018; doi:10.1038/s41598-018-30560-0 Hairy root induction and benzylisoquinoline alkaloid production in Macleaya cordata
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    Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation (2018)
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    Publication Date: 2018-08-11
    Description: Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation, Published online: 10 August 2018; doi:10.1038/s41598-018-30461-2 Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation
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    BCS thermal vacuum of fermionic superfluids and its perturbation theory (2018)
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    Publication Date: 2018-08-11
    Description: BCS thermal vacuum of fermionic superfluids and its perturbation theory BCS thermal vacuum of fermionic superfluids and its perturbation theory, Published online: 10 August 2018; doi:10.1038/s41598-018-30438-1 BCS thermal vacuum of fermionic superfluids and its perturbation theory
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    Author Correction: Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training (2018)
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    Publication Date: 2018-08-11
    Description: Author Correction: Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training Author Correction: Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training, Published online: 10 August 2018; doi:10.1038/s41598-018-30574-8 Author Correction: Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training
    Electronic ISSN: 2045-2322
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    Temperature-dependent excitonic superuid plasma frequency evolution in an excitonic insulator, Ta 2 NiSe 5 (2018)
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    Publication Date: 2018-08-11
    Description: Temperature-dependent excitonic superuid plasma frequency evolution in an excitonic insulator, Ta 2 NiSe 5 Temperature-dependent excitonic superuid plasma frequency evolution in an excitonic insulator, Ta〈sub〉2〈/sub〉NiSe〈sub〉5〈/sub〉, Published online: 10 August 2018; doi:10.1038/s41598-018-30430-9 Temperature-dependent excitonic superuid plasma frequency evolution in an excitonic insulator, Ta 2 NiSe 5
    Electronic ISSN: 2045-2322
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    A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum (2018)
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    Publication Date: 2018-08-11
    Description: A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum A superfolder variant of pH-sensitive pHluorin for 〈i〉in vivo〈/i〉 pH measurements in the endoplasmic reticulum, Published online: 10 August 2018; doi:10.1038/s41598-018-30367-z A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum
    Electronic ISSN: 2045-2322
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    Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism (2018)
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    Publication Date: 2018-08-11
    Description: Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism, Published online: 10 August 2018; doi:10.1038/s41398-018-0214-7 Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism
    Electronic ISSN: 2158-3188
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    Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder (2018)
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    Publication Date: 2018-08-11
    Description: Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder, Published online: 10 August 2018; doi:10.1038/s41398-018-0213-8 Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder
    Electronic ISSN: 2158-3188
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    Confined small-sized cobalt catalysts stimulate carbon-chain growth reversely by modifying ASF law of Fischer–Tropsch synthesis (2018)
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    Publication Date: 2018-08-15
    Description: Confined small-sized cobalt catalysts stimulate carbon-chain growth reversely by modifying ASF law of Fischer–Tropsch synthesis Confined small-sized cobalt catalysts stimulate carbon-chain growth reversely by modifying ASF law of Fischer–Tropsch synthesis, Published online: 14 August 2018; doi:10.1038/s41467-018-05755-8 Fischer–Tropsch synthesis (FTS) is theoretically limited by Anderson–Schulz–Flory (ASF) law. Here, the authors successfully tune the selectivity of products from diesel-range hydrocarbons to gasoline-range hydrocarbons in FTS by controlling the crystallite sizes of confined cobalt, and modify the ASF law.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Publisher Correction: Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes (2018)
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    Publication Date: 2018-08-15
    Description: Publisher Correction: Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes Publisher Correction: Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes, Published online: 14 August 2018; doi:10.1038/s41467-018-05447-3 Publisher Correction: Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Engineering the spin couplings in atomically crafted spin chains on an elemental superconductor (2018)
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    Publication Date: 2018-08-15
    Description: Engineering the spin couplings in atomically crafted spin chains on an elemental superconductor Engineering the spin couplings in atomically crafted spin chains on an elemental superconductor, Published online: 14 August 2018; doi:10.1038/s41467-018-05701-8 Magnetic atomic chains assembled on the surface of superconductors are a potential platform for engineering topological superconducting phases. Here the authors step towards this by manipulating magnetic atoms at interstitial sites to tune interatomic interactions and control the Yu-Shiba-Rusinov states that form.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Revealing circadian mechanisms of integration and resilience by visualizing clock proteins working in real time (2018)
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    Publication Date: 2018-08-15
    Description: Revealing circadian mechanisms of integration and resilience by visualizing clock proteins working in real time Revealing circadian mechanisms of integration and resilience by visualizing clock proteins working in real time, Published online: 14 August 2018; doi:10.1038/s41467-018-05438-4 The circadian clock proteins KaiA, KaiB, and KaiC reconstitute a circa-24 h oscillation of KaiC phosphorylation in vitro. Here the authors use high-speed atomic force microscopy to visualize in real time and quantify the dynamic interactions of KaiA with KaiC on the sub-second timescale to discover mechanisms of oscillatory resilience.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis (2018)
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    Publication Date: 2018-08-15
    Description: The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis, Published online: 14 August 2018; doi:10.1038/s41467-018-05768-3 Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation and exerts potent anti-fibrotic effects.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Multi-marker metabarcoding approach to study mesozooplankton at basin scale (2018)
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    Publication Date: 2018-08-15
    Description: Multi-marker metabarcoding approach to study mesozooplankton at basin scale Multi-marker metabarcoding approach to study mesozooplankton at basin scale, Published online: 14 August 2018; doi:10.1038/s41598-018-30157-7 Multi-marker metabarcoding approach to study mesozooplankton at basin scale
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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    PyMT-1099, a versatile murine cell model for EMT in breast cancer (2018)
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    Publication Date: 2018-08-15
    Description: PyMT-1099, a versatile murine cell model for EMT in breast cancer PyMT-1099, a versatile murine cell model for EMT in breast cancer, Published online: 14 August 2018; doi:10.1038/s41598-018-30640-1 PyMT-1099, a versatile murine cell model for EMT in breast cancer
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    Topics: Natural Sciences in General
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    Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production (2018)
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    Publication Date: 2018-08-15
    Description: Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production, Published online: 14 August 2018; doi:10.1038/s41598-018-30522-6 Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production
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    Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro (2018)
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    Publication Date: 2018-08-15
    Description: Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro, Published online: 14 August 2018; doi:10.1038/s41598-018-30626-z Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro
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    Room-temperature mechanocaloric effects in lithium-based superionic materials (2018)
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    Publication Date: 2018-08-21
    Description: Room-temperature mechanocaloric effects in lithium-based superionic materials Room-temperature mechanocaloric effects in lithium-based superionic materials, Published online: 20 August 2018; doi:10.1038/s41467-018-05835-9 Large mechanocaloric effects are disclosed in lithium-ion superionic conductors at room temperature. These occur in the absence of any structural phase transition, which is beneficial from a practical point of view, and are related to stress-induced variations in the ionic conductivity.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors (2018)
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    Publication Date: 2018-08-21
    Description: Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors, Published online: 20 August 2018; doi:10.1038/s41467-018-05798-x Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Evidence for auto-catalytic mineral dissolution from surface-specific vibrational spectroscopy (2018)
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    Publication Date: 2018-08-21
    Description: Evidence for auto-catalytic mineral dissolution from surface-specific vibrational spectroscopy Evidence for auto-catalytic mineral dissolution from surface-specific vibrational spectroscopy, Published online: 20 August 2018; doi:10.1038/s41467-018-05762-9 Although it is well known that silica can dissolve in water, the precise mechanism is unclear. Here, the authors employ sum frequency generation spectroscopy to probe the interfacial water structure reporting directly on the underlying dissolution mechanism, which appears to be auto-catalytic.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation (2018)
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    Publication Date: 2018-08-21
    Description: Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation, Published online: 20 August 2018; doi:10.1038/s41467-018-05649-9 The Late Chalcolithic material culture in the southern Levant has unique attributes that suggest spread of people or culture. Here, the authors use genome-wide ancient DNA data from 22 individuals from a Chalcolithic site and show evidence of complex population movements and turnovers.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction (2018)
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    Publication Date: 2018-08-21
    Description: A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction, Published online: 20 August 2018; doi:10.1038/s41467-018-05725-0 How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.
    Electronic ISSN: 2041-1723
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    The influence of Arctic amplification on mid-latitude summer circulation (2018)
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    Publication Date: 2018-08-21
    Description: The influence of Arctic amplification on mid-latitude summer circulation The influence of Arctic amplification on mid-latitude summer circulation, Published online: 20 August 2018; doi:10.1038/s41467-018-05256-8 Accelerated global warming in the Arctic might have profound impacts on mid-latitude weather particularly in winter, although the evidence for an effect also in summer is also growing. Here Coumou et al. show that these interactions could lead to more persistent hot-dry extremes in mid-latitudes.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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    Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection (2018)
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    Publication Date: 2018-08-21
    Description: Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection, Published online: 20 August 2018; doi:10.1038/s41467-018-05746-9 SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.
    Electronic ISSN: 2041-1723
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    Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA (2018)
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    Publication Date: 2018-08-18
    Description: Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA, Published online: 17 August 2018; doi:10.1038/s41598-018-30784-0 Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA
    Electronic ISSN: 2045-2322
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    Local structure in deeply supercooled liquids exhibits growing lengthscales and dynamical correlations (2018)
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    Publication Date: 2018-08-17
    Description: Local structure in deeply supercooled liquids exhibits growing lengthscales and dynamical correlations Local structure in deeply supercooled liquids exhibits growing lengthscales and dynamical correlations, Published online: 16 August 2018; doi:10.1038/s41467-018-05371-6 The glass transition remains an unsolved problem due to the scarcity of particle-resolved data over a large dynamic range. Hallett et al. probe an unprecedented time window and show a strong correlation between local structure and slow dynamics in a deeply supercooled liquid of colloids.
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    Size control in mammalian cells involves modulation of both growth rate and cell cycle duration (2018)
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    Publication Date: 2018-08-17
    Description: Size control in mammalian cells involves modulation of both growth rate and cell cycle duration Size control in mammalian cells involves modulation of both growth rate and cell cycle duration, Published online: 16 August 2018; doi:10.1038/s41467-018-05393-0 The size of cells fluctuates but there are limited experimental methods to measure live mammalian cell sizes. Here, the authors track single cell volume (FXm) over the cell cycle and generate a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells.
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    Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses (2018)
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    Publication Date: 2018-08-17
    Description: Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses, Published online: 16 August 2018; doi:10.1038/s41467-018-05720-5 Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses
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    The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation (2018)
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    Publication Date: 2018-08-17
    Description: The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation, Published online: 16 August 2018; doi:10.1038/s41598-018-30006-7 The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation
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    Author Correction: Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis (2018)
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    Publication Date: 2018-08-17
    Description: Author Correction: Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis Author Correction: Structural and functional studies on 〈i〉Pseudomonas aeruginosa〈/i〉 DspI: implications for its role in DSF biosynthesis, Published online: 17 August 2018; doi:10.1038/s41598-018-30920-w Author Correction: Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis
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    Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach (2018)
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    Publication Date: 2018-08-17
    Description: Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach, Published online: 16 August 2018; doi:10.1038/s41598-018-30209-y Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach
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    HbA 1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes (2018)
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    Publication Date: 2018-08-17
    Description: HbA 1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes HbA〈sub〉1c〈/sub〉 Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes, Published online: 16 August 2018; doi:10.1038/s41598-018-30833-8 HbA 1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes
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    Region-specific and state-dependent action of striatal GABAergic interneurons (2018)
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    Publication Date: 2018-08-22
    Description: Region-specific and state-dependent action of striatal GABAergic interneurons Region-specific and state-dependent action of striatal GABAergic interneurons, Published online: 21 August 2018; doi:10.1038/s41467-018-05847-5 Striatal GABAergic interneurons regulate the influence of cortical inputs on striatal projection neurons through feedforward inhibition. Here, the authors report that this inhibition is mediated mainly by PV interneurons in the dorsolateral striatum and SOM interneurons in the dorsomedial striatum.
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