WILBERT — Wildauer Bücher+E-Medien Recherche-Tool

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Development and validation of a new rating scale for perimenopausal depression—the Meno-D (2018)

Jayashri Kulkarni; Emorfia Gavrilidis; Abdul-Rahman Hudaib; Caitlin Bleeker; Roisin Worsley; Caroline Gurvich

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-06-29

Description: Development and validation of a new rating scale for perimenopausal depression—the Meno-D Development and validation of a new rating scale for perimenopausal depression—the Meno-D, Published online: 28 June 2018; doi:10.1038/s41398-018-0172-0 Development and validation of a new rating scale for perimenopausal depression—the Meno-D

Electronic ISSN: 2158-3188

Topics: Medicine

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Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis (2018)

Chao Liang; Songlin Peng; Jie Li; Jun Lu; Daogang Guan; Feng Jiang; Cheng Lu; Fangfei Li; Xiaojuan He; Hailong Zhu; D. W. T. Au; Dazhi Yang; Bao-Ting Zhang; Aiping Lu; Ge Zhang

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis, Published online: 24 August 2018; doi:10.1038/s41467-018-05974-z BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated bone formation in mice.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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3

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High entropy oxides for reversible energy storage (2018)

Abhishek Sarkar; Leonardo Velasco; Di Wang; Qingsong Wang; Gopichand Talasila; Lea de Biasi; Christian Kübel; Torsten Brezesinski; Subramshu S. Bhattacharya; Horst Hahn; Ben Breitung

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: High entropy oxides for reversible energy storage High entropy oxides for reversible energy storage, Published online: 24 August 2018; doi:10.1038/s41467-018-05774-5 High entropy oxides provide a new strategy toward materials design by stabilizing single-phase crystal structures composed of multiple cations. Here, the authors apply this concept to the development of conversion-type electrode materials for lithium-ion storage and show the underlying mechanism.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes (2018)

Lien Van Hoecke; Sandra Van Lint; Kenny Roose; Alexander Van Parys; Peter Vandenabeele; Johan Grooten; Jan Tavernier; Stefaan De Koker; Xavier Saelens

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes, Published online: 24 August 2018; doi:10.1038/s41467-018-05979-8 Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth and lung metastasis.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Peritectic titanium alloys for 3D printing (2018)

Pere Barriobero-Vila; Joachim Gussone; Andreas Stark; Norbert Schell; Jan Haubrich; Guillermo Requena

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Peritectic titanium alloys for 3D printing Peritectic titanium alloys for 3D printing, Published online: 24 August 2018; doi:10.1038/s41467-018-05819-9 3D printing of titanium alloys today is based on known alloy compositions that result in anisotropic structural properties. Here, the authors add lanthanum to commercially pure titanium and exploit a solidification path that reduces texture and anisotropy.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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6

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Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects (2018)

Qin Zhang; Baoling Bai; Xinyu Mei; Chunlei Wan; Haiyan Cao Dan Li; Shan Wang; Min Zhang; Zhigang Wang; Jianxin Wu; Hongyan Wang; Junsheng Huo; Gangqiang Ding; Jianyuan Zhao; Qiu Xie; Li Wang; Zhiyong Qiu; Shiming Zhao; Ting Zhang

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects, Published online: 24 August 2018; doi:10.1038/s41467-018-05451-7 Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi (2018)

Javier Emperador-Melero; Vincent Huson; Jan van Weering; Christian Bollmann; Gabriele Fischer von Mollard; Ruud F. Toonen; Matthijs Verhage

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi, Published online: 24 August 2018; doi:10.1038/s41467-018-05699-z Vti1a and Vti1b are SNARE proteins implicated in regulated secretion. Here the authors show that Vti1a and Vti1b control protein sorting at the Golgi, and targeting to the axon, and thereby indirectly control regulated secretion at the synapse.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Morphology and structure of ZIF-8 during crystallisation measured by dynamic angle-resolved second harmonic scattering (2018)

Stijn Van Cleuvenbergen; Zachary J. Smith; Olivier Deschaume; Carmen Bartic; Sebastian Wachsmann-Hogiu; Thierry Verbiest; Monique A. van der Veen

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Morphology and structure of ZIF-8 during crystallisation measured by dynamic angle-resolved second harmonic scattering Morphology and structure of ZIF-8 during crystallisation measured by dynamic angle-resolved second harmonic scattering, Published online: 24 August 2018; doi:10.1038/s41467-018-05713-4 Angle-resolved monitoring of structure parameters during crystal growth is often slow owing to mechanical movements. Here, the authors use second harmonic scattering and Fourier-plane imaging to dynamically monitor size, shape and concentration of ZIF-8 in situ during the growth process.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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9

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Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures (2018)

Maria J. Sarmento; Michele Oneto; Simone Pelicci; Luca Pesce; Lorenzo Scipioni; Mario Faretta; Laura Furia; Gaetano Ivan Dellino; Pier Giuseppe Pelicci; Paolo Bianchini; Alberto Diaspro; Luca Lanzanò

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-25

Description: Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures, Published online: 24 August 2018; doi:10.1038/s41467-018-05963-2 A known limitation of super-resolution STED microscopy is the need of high laser power which can cause photobleaching and phototoxicity. Here the authors further optimize this method and show that modulating STED intensity during acquisition results in an enhanced resolution and reduced background.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores (2018)

Hannah Stocker; Tobias Möllers; Laura Perna; Hermann Brenner

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-08-25

Description: The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores The genetic risk of Alzheimer’s disease beyond 〈i〉APOE ε4:〈/i〉 systematic review of Alzheimer’s genetic risk scores, Published online: 24 August 2018; doi:10.1038/s41398-018-0221-8 The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores

Electronic ISSN: 2158-3188

Topics: Medicine

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11

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Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer (2018)

Su Jin Kim; Tae Hwan Noh; Sujin Son; Do Hyun Kim; Wooseong Kim; Yunna Lee; Jieun Choo; Gwangbeom Heo; Min Jae Kim; Hae Young Chung; Yunjin Jung; Jee Hyung Jung; Hyung Ryong Moon; Eunok Im

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-08-30

Description: Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer, Published online: 29 August 2018; doi:10.1038/s41419-018-0942-x Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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12

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Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel (2018)

Yue Yuan; Jing Zhao; Yongtai Gong; Dingyu Wang; Xiaoyu Wang; Fengxiang Yun; Zhaorui Liu; Song Zhang; Wenpeng Li; Xinbo Zhao; Li Sun; Li Sheng; Zhenwei Pan; Yue Li

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-08-30

Description: Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel, Published online: 29 August 2018; doi:10.1038/s41419-018-0860-y Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer (2018)

Julien Baruteau; Dany P. Perocheau; Joanna Hanley; Maëlle Lorvellec; Eridan Rocha-Ferreira; Rajvinder Karda; Joanne Ng; Natalie Suff; Juan Antinao Diaz; Ahad A. Rahim; Michael P. Hughes; Blerida Banushi; Helen Prunty; Mariya Hristova; Deborah A. Ridout; Alex Virasami; Simon Heales; Stewen J. Howe; Suzanne M. K. Buckley; Philippa B. Mills; Paul Gissen; Simon N. Waddington

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-30

Description: Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by 〈i〉Asl〈/i〉 gene transfer, Published online: 29 August 2018; doi:10.1038/s41467-018-05972-1 Patients with mutations in the ASL gene present with argininosuccinic aciduria characterised by hyperammonaemia and cognitive impairment. Here, the authors show that cerebral disease involves neuronal nitrosative/oxidative stress that is not induced by hyperammonaemia, and that it can be reversed using AAV-ASL directed to liver and brain in mice.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming (2018)

David Olagnier; Aske M. Brandtoft; Camilla Gunderstofte; Nikolaj L. Villadsen; Christian Krapp; Anne L. Thielke; Anders Laustsen; Suraj Peri; Anne Louise Hansen; Lene Bonefeld; Jacob Thyrsted; Victor Bruun; Marie B. Iversen; Lin Lin; Virginia M. Artegoitia; Chenhe Su; Long Yang; Rongtuan Lin; Siddharth Balachandran; Yonglun Luo; Mette Nyegaard; Bernadette Marrero; Raphaela Goldbach-Mansky; Mona Motwani; Dylan G. Ryan; Katherine A. Fitzgerald; Luke A. O’Neill; Anne K. Hollensen; Christian K. Damgaard; Frank v. de Paoli; Hanne C. Bertram; Martin R. Jakobsen; Thomas B. Poulsen; Christian K. Holm

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-30

Description: Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming, Published online: 29 August 2018; doi:10.1038/s41467-018-05861-7 Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Role of hydrogen bonding in hysteresis observed in sorption-induced swelling of soft nanoporous polymers (2018)

Mingyang Chen; Benoit Coasne; Robert Guyer; Dominique Derome; Jan Carmeliet

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-08-30

Description: Role of hydrogen bonding in hysteresis observed in sorption-induced swelling of soft nanoporous polymers Role of hydrogen bonding in hysteresis observed in sorption-induced swelling of soft nanoporous polymers, Published online: 29 August 2018; doi:10.1038/s41467-018-05897-9 Water uptake of natural polymers is accompanied by swelling and changes in the internal structure of the polymeric system but the exact mechanism of water-uptake and swelling remained unknown. Here the authors use atom-scale simulations to identify a molecular mechanism which is responsible for hysteresis in sorption-induced swelling in natural polymers.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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16

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Correction: Abolishing Tau cleavage by caspases at Aspartate 421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations (2018)

F. Biundo; C. d’Abramo; M. D. Tambini; H. Zhang; D. Del Prete; F. Vitale; L. Giliberto; O. Arancio; L. D’Adamio

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-01

Description: Correction: Abolishing Tau cleavage by caspases at Aspartate 421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations Correction: Abolishing Tau cleavage by caspases at Aspartate〈sup〉421〈/sup〉 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations, Published online: 31 August 2018; doi:10.1038/s41398-018-0188-5 Correction: Abolishing Tau cleavage by caspases at Aspartate 421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

Electronic ISSN: 2158-3188

Topics: Medicine

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Correction: Regulation of dopaminergic function: an [ 18 F]-DOPA PET apomorphine challenge study in humans (2018)

S. Jauhar; M. Veronese; M. Rogdaki; M. Bloomfield; S. Natesan; F. Turkheimer; S. Kapur; O. D. Howes

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-01

Description: Correction: Regulation of dopaminergic function: an [ 18 F]-DOPA PET apomorphine challenge study in humans Correction: Regulation of dopaminergic function: an [〈sup〉18〈/sup〉F]-DOPA PET apomorphine challenge study in humans, Published online: 31 August 2018; doi:10.1038/s41398-018-0187-6 Correction: Regulation of dopaminergic function: an [ 18 F]-DOPA PET apomorphine challenge study in humans

Electronic ISSN: 2158-3188

Topics: Medicine

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MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence (2018)

Judit Cabana-Domínguez; Concepció Arenas; Bru Cormand; Noèlia Fernàndez-Castillo

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-08-31

Description: MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence, Published online: 30 August 2018; doi:10.1038/s41398-018-0224-5 MiR-9, miR-153 and miR-124 are down-regulated by acute exposure to cocaine in a dopaminergic cell model and may contribute to cocaine dependence

Electronic ISSN: 2158-3188

Topics: Medicine

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19

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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? (2018)

Jakob A. Kaminski; Florian Schlagenhauf; Michael Rapp; Swapnil Awasthi; Barbara Ruggeri; Lorenz Deserno; Tobias Banaschewski; Arun L. W. Bokde; Uli Bromberg; Christian Büchel; Erin Burke Quinlan; Sylvane Desrivières; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Bernd Ittermann; Jean-Luc Martinot; Marie-Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Michael N. Smolka; Juliane H. Fröhner; Henrik Walter; Robert Whelan; Stephan Ripke; Gunter Schumann; Andreas Heinz

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-08-31

Description: Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?, Published online: 30 August 2018; doi:10.1038/s41398-018-0222-7 Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

Electronic ISSN: 2158-3188

Topics: Medicine

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Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer (2018)

Myoung-Hee Kang; Hyunji Choi; Masanobu Oshima; Jae-Ho Cheong; Seokho Kim; Jung Hoon Lee; Young Soo Park; Hueng-Sik Choi; Mi-Na Kweon; Chan-Gi Pack; Ju-Seog Lee; Gordon B. Mills; Seung-Jae Myung; Yun-Yong Park

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-01

Description: Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer, Published online: 31 August 2018; doi:10.1038/s41467-018-06061-z Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

Electronic ISSN: 2041-1723

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21

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Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction (2018)

Ilkka Paatero; Loïc Sauteur; Minkyoung Lee; Anne K. Lagendijk; Daniel Heutschi; Cora Wiesner; Camilo Guzmán; Dimitri Bieli; Benjamin M. Hogan; Markus Affolter; Heinz-Georg Belting

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-01

Description: Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction, Published online: 31 August 2018; doi:10.1038/s41467-018-05851-9 During the formation of the zebrafish dorsal longitudinal anastomotic vessel, blood vessels connect in a process called anastomosis. Using live imaging, the authors here show that endothelial cell movements during blood vessel anastomosis are associated with oscillating lamellipodia-like structures, oriented in the direction of the movements and emerging at endothelial cell junctions.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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22

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Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression (2018)

Rona J. Strawbridge; Joey Ward; Laura M. Lyall; Elizabeth M. Tunbridge; Breda Cullen; Nicholas Graham; Amy Ferguson; Keira J. A. Johnston; Donald M. Lyall; Daniel Mackay; Jonathan Cavanagh; David M. Howard; Mark J. Adams; Ian Deary; Valentina Escott-Price; Michael O’Donovan; Andrew M. McIntosh; Mark E. S. Bailey; Jill P. Pell; Paul J. Harrison; Daniel J. Smith

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-05

Description: Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression, Published online: 04 September 2018; doi:10.1038/s41398-018-0236-1 Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression

Electronic ISSN: 2158-3188

Topics: Medicine

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Gamma oscillations as a biomarker for major depression: an emerging topic (2018)

Paul J. Fitzgerald; Brendon O. Watson

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-05

Description: Gamma oscillations as a biomarker for major depression: an emerging topic Gamma oscillations as a biomarker for major depression: an emerging topic, Published online: 04 September 2018; doi:10.1038/s41398-018-0239-y Gamma oscillations as a biomarker for major depression: an emerging topic

Electronic ISSN: 2158-3188

Topics: Medicine

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Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles (2018)

Andrii Varenikov; Mark Gandelman

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles, Published online: 03 September 2018; doi:10.1038/s41467-018-05946-3 Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl alcohols and ethers.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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25

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Imaging soliton dynamics in optical microcavities (2018)

Xu Yi; Qi-Fan Yang; Ki Youl Yang; Kerry Vahala

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Imaging soliton dynamics in optical microcavities Imaging soliton dynamics in optical microcavities, Published online: 03 September 2018; doi:10.1038/s41467-018-06031-5 In order to study the dynamics of solitons in microresonators, which underlie nonlinear phenomena like Kerr comb generation, both high temporal resolution and long record times are needed. Here, the authors develop a coherent sampling method to directly image the temporal behavior of solitons.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Dynamic earthquake rupture preserved in a creeping serpentinite shear zone (2018)

Matthew S. Tarling; Steven A. F. Smith; Cecilia Viti; James M. Scott

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Dynamic earthquake rupture preserved in a creeping serpentinite shear zone Dynamic earthquake rupture preserved in a creeping serpentinite shear zone, Published online: 03 September 2018; doi:10.1038/s41467-018-05965-0 Creeping serpentinite shear zones may host large earthquakes, but direct evidence of frictional heating and rupture have been missing. Here, the authors demonstrate via laboratory experiments that earthquake ruptures can propagate through serpentinite shear zones shown by high-temperature reaction products.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis (2018)

Mingming Sun; Wei Wu; Liang Chen; Wenjing Yang; Xiangsheng Huang; Caiyun Ma; Feidi Chen; Yi Xiao; Ye Zhao; Chunyan Ma; Suxia Yao; Victor H. Carpio; Sara M. Dann; Qihong Zhao; Zhanju Liu; Yingzi Cong

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis, Published online: 03 September 2018; doi:10.1038/s41467-018-05901-2 T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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28

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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target (2018)

Prashant K. Srivastava; Jonathan van Eyll; Patrice Godard; Manuela Mazzuferi; Andree Delahaye-Duriez; Juliette Van Steenwinckel; Pierre Gressens; Benedicte Danis; Catherine Vandenplas; Patrik Foerch; Karine Leclercq; Georges Mairet-Coello; Alvaro Cardenas; Frederic Vanclef; Liisi Laaniste; Isabelle Niespodziany; James Keaney; Julien Gasser; Gaelle Gillet; Kirill Shkura; Seon-Ah Chong; Jacques Behmoaras; Irena Kadiu; Enrico Petretto; Rafal M. Kaminski; Michael R. Johnson

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target, Published online: 03 September 2018; doi:10.1038/s41467-018-06008-4 The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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29

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Predicting the evolution of Escherichia coli by a data-driven approach (2018)

Xiaokang Wang; Violeta Zorraquino; Minseung Kim; Athanasios Tsoukalas; Ilias Tagkopoulos

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Predicting the evolution of Escherichia coli by a data-driven approach Predicting the evolution of 〈i〉Escherichia coli〈/i〉 by a data-driven approach, Published online: 03 September 2018; doi:10.1038/s41467-018-05807-z How reproducible evolutionary processes are remains an important question in evolutionary biology. Here, the authors compile a compendium of more than 15,000 mutation events for Escherichia coli under 178 distinct environmental settings, and develop an ensemble of predictors to predict evolution at a gene level.

Electronic ISSN: 2041-1723

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30

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Reply to ‘Antipsychotics with similar association kinetics at dopamine D 2 receptors differ in extrapyramidal side-effects’ (2018)

David A. Sykes; J. Robert Lane; Monika Szabo; Ben Capuano; Jonathan A. Javitch; Steven J. Charlton

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-04

Description: Reply to ‘Antipsychotics with similar association kinetics at dopamine D 2 receptors differ in extrapyramidal side-effects’ Reply to ‘Antipsychotics with similar association kinetics at dopamine D〈sub〉2〈/sub〉 receptors differ in extrapyramidal side-effects’, Published online: 03 September 2018; doi:10.1038/s41467-018-05678-4 Reply to ‘Antipsychotics with similar association kinetics at dopamine D 2 receptors differ in extrapyramidal side-effects’

Electronic ISSN: 2041-1723

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31

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CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production (2018)

Lei Yu; Fei Yang; Fanghui Zhang; Danfeng Guo; Ling Li; Xian Wang; Tingbo Liang; Jianli Wang; Zhijian Cai; Hongchuan Jin

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-06

Description: CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production, Published online: 05 September 2018; doi:10.1038/s41419-018-0927-9 CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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32

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SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death (2018)

Yuan Yue; Neel R. Nabar; Chong-Shan Shi; Olena Kamenyeva; Xun Xiao; Il-Young Hwang; Min Wang; John H. Kehrl

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-06

Description: SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death, Published online: 05 September 2018; doi:10.1038/s41419-018-0917-y SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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33

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Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection (2018)

Lam Nhat Nguyen; Juan Zhao; Dechao Cao; Xindi Dang; Ling Wang; Jianqi Lian; Ying Zhang; Zhansheng Jia; Xiao Y. Wu; Zheng Morrison; Qian Xie; Yingjie Ji; Zheng Zhang; Mohamed El Gazzar; Shunbin Ning; Jonathan P. Moorman; Zhi Q. Yao

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-06

Description: Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection, Published online: 05 September 2018; doi:10.1038/s41419-018-0897-y Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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34

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Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death (2018)

E. Ottina; M. Sochalska; R. Sgonc; A. Villunger

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-06

Description: Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death, Published online: 05 September 2018; doi:10.1038/s41419-018-0947-5 Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death

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35

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TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation (2018)

Laura Faletti; Lukas Peintner; Simon Neumann; Sandra Sandler; Thomas Grabinger; Sabine Mac Nelly; Irmgard Merfort; Chun-Hao Huang; Darjus Tschaharganeh; Tae-Won Kang; Florian Heinzmann; Luana D’Artista; Ulrich Maurer; Thomas Brunner; Scott Lowe; Lars Zender; Christoph Borner

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-06

Description: TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation, Published online: 05 September 2018; doi:10.1038/s41419-018-0935-9 TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

Electronic ISSN: 2041-4889

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36

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Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload (2018)

Vanessa Kappel da Silva; Betânia Souza de Freitas; Rebeca Carvalho Lacerda Garcia; Ricardo Tavares Monteiro; Jaime Eduardo Hallak; Antônio Waldo Zuardi; José Alexandre S. Crippa; Nadja Schröder

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-04

Description: Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload, Published online: 03 September 2018; doi:10.1038/s41398-018-0232-5 Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload

Electronic ISSN: 2158-3188

Topics: Medicine

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37

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Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting Salmonella Cell Envelope Integrity and its Persistence in Chickens (2018)

Loïc Deblais; Yosra A. Helmy; Diapak Kathayat; Huang-chi Huang; Sally A. Miller; Gireesh Rajashekara

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-07

Description: Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting Salmonella Cell Envelope Integrity and its Persistence in Chickens Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting 〈i〉Salmonella〈/i〉 Cell Envelope Integrity and its Persistence in Chickens, Published online: 06 September 2018; doi:10.1038/s41598-018-31249-0 Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting Salmonella Cell Envelope Integrity and its Persistence in Chickens

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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38

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High Trapped Fields in C-doped MgB 2 Bulk Superconductors Fabricated by Infiltration and Growth Process (2018)

A. G. Bhagurkar; A. Yamamoto; L. Wang; M. Xia; A. R. Dennis; J. H. Durrell; T. A. Aljohani; N. H. Babu; D. A. Cardwell

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-07

Description: High Trapped Fields in C-doped MgB 2 Bulk Superconductors Fabricated by Infiltration and Growth Process High Trapped Fields in C-doped MgB〈sub〉2〈/sub〉 Bulk Superconductors Fabricated by Infiltration and Growth Process, Published online: 06 September 2018; doi:10.1038/s41598-018-31416-3 High Trapped Fields in C-doped MgB 2 Bulk Superconductors Fabricated by Infiltration and Growth Process

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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39

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Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus (2018)

Sante Roperto; Valeria Russo; Federica Corrado; Francesca De Falco; John S. Munday; Franco Roperto

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-07

Description: Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus, Published online: 06 September 2018; doi:10.1038/s41598-018-31529-9 Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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40

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Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens (2018)

Zihua Lin; Xiaobo Xu; Sheng Zhao; Xiaohong Yang; Jian Guo; Qun Zhang; Chunmei Jing; Shawn Chen; Yun He

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-05

Description: Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens, Published online: 04 September 2018; doi:10.1038/s41467-018-05821-1 Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ1, δ2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ2 as a strong agent against S. pneumoniae and S. aureus infections.

Electronic ISSN: 2041-1723

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41

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Optimal dynamic coding by mixed-dimensionality neurons in the head-direction system of bats (2018)

Arseny Finkelstein; Nachum Ulanovsky; Misha Tsodyks; Johnatan Aljadeff

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-05

Description: Optimal dynamic coding by mixed-dimensionality neurons in the head-direction system of bats Optimal dynamic coding by mixed-dimensionality neurons in the head-direction system of bats, Published online: 04 September 2018; doi:10.1038/s41467-018-05562-1 Multidimensional stimuli are often represented by neurons encoding only a single dimension and those encoding multiple dimensions. Here, the authors present theoretical and experimental analyses to show that mixed representations are optimal to efficiently encode such stimuli under different behavioral modes.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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42

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Deep reefs of the Great Barrier Reef offer limited thermal refuge during mass coral bleaching (2018)

Pedro R. Frade; Pim Bongaerts; Norbert Englebert; Alice Rogers; Manuel Gonzalez-Rivero; Ove Hoegh-Guldberg

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-05

Description: Deep reefs of the Great Barrier Reef offer limited thermal refuge during mass coral bleaching Deep reefs of the Great Barrier Reef offer limited thermal refuge during mass coral bleaching, Published online: 04 September 2018; doi:10.1038/s41467-018-05741-0 It has been suggested that deep coral reefs offer a refuge against warming and mass bleaching. Here Frade et al. look at the 2016 bleaching event in the northern Great Barrier Reef and found that deep reefs initially acted as thermal refuges, though this effect lessened in the late summer months.

Electronic ISSN: 2041-1723

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43

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Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits (2018)

Thorunn Rafnar; Bjarni Gunnarsson; Olafur A. Stefansson; Patrick Sulem; Andres Ingason; Michael L. Frigge; Lilja Stefansdottir; Jon K. Sigurdsson; Vinicius Tragante; Valgerdur Steinthorsdottir; Unnur Styrkarsdottir; Simon N. Stacey; Julius Gudmundsson; Gudny A. Arnadottir; Asmundur Oddsson; Florian Zink; Gisli Halldorsson; Gardar Sveinbjornsson; Ragnar P. Kristjansson; Olafur B. Davidsson; Anna Salvarsdottir; Asgeir Thoroddsen; Elisabet A. Helgadottir; Katrin Kristjansdottir; Orri Ingthorsson; Valur Gudmundsson; Reynir T. Geirsson; Ragnheidur Arnadottir; Daniel F. Gudbjartsson; Gisli Masson; Folkert W. Asselbergs; Jon G. Jonasson; Karl Olafsson; Unnur Thorsteinsdottir; Bjarni V. Halldorsson; Gudmar Thorleifsson; Kari Stefansson

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits, Published online: 07 September 2018; doi:10.1038/s41467-018-05428-6 Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.

Electronic ISSN: 2041-1723

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A global meta-analysis of yield stability in organic and conservation agriculture (2018)

Samuel Knapp; Marcel G. A. van der Heijden

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: A global meta-analysis of yield stability in organic and conservation agriculture A global meta-analysis of yield stability in organic and conservation agriculture, Published online: 07 September 2018; doi:10.1038/s41467-018-05956-1 Yields vary between different cropping systems, though their temporal stability has not been quantified. Here, Knapp and van der Heijden present a meta-analysis showing that yields in organic agriculture have, per unit food produced, a lower temporal stability.

Electronic ISSN: 2041-1723

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Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration (2018)

Sharan Paul; Warunee Dansithong; Karla P. Figueroa; Daniel R. Scoles; Stefan M. Pulst

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration, Published online: 07 September 2018; doi:10.1038/s41467-018-06041-3 Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.

Electronic ISSN: 2041-1723

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46

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Diabetes knowledge and its association with the weight status among residents of Jeddah City, Saudi Arabia (2018)

Hebah A. Kutbi; Hala H. Mosli; Ahmed H. Alhasan; Rana H. Mosli

Nature Publishing Group (NPG)

In: Nutrition and Diabetes

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Publication Date: 2018-09-08

Description: Diabetes knowledge and its association with the weight status among residents of Jeddah City, Saudi Arabia Diabetes knowledge and its association with the weight status among residents of Jeddah City, Saudi Arabia, Published online: 07 September 2018; doi:10.1038/s41387-018-0055-8 Diabetes knowledge and its association with the weight status among residents of Jeddah City, Saudi Arabia

Electronic ISSN: 2044-4052

Topics: Medicine

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47

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Body composition during early infancy and its relation with body composition at 4 years of age in Jimma, an Ethiopian prospective cohort study (2018)

Bitiya Admassu; Jonathan C. K. Wells; Tsinuel Girma; Tefera Belachew; Christian Ritz; Victor Owino; Mubarek Abera; Rasmus Wibaek; Kim F. Michaelsen; Pernille Kæstel; Henrik Friis; Gregers S. Andersen

Nature Publishing Group (NPG)

In: Nutrition and Diabetes

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Publication Date: 2018-09-08

Description: Body composition during early infancy and its relation with body composition at 4 years of age in Jimma, an Ethiopian prospective cohort study Body composition during early infancy and its relation with body composition at 4 years of age in Jimma, an Ethiopian prospective cohort study, Published online: 07 September 2018; doi:10.1038/s41387-018-0056-7 Body composition during early infancy and its relation with body composition at 4 years of age in Jimma, an Ethiopian prospective cohort study

Electronic ISSN: 2044-4052

Topics: Medicine

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48

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Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus (2018)

Kálmán Bódis; Sabine Kahl; Marie-Christine Simon; Zhou Zhou; Henrike Sell; Birgit Knebel; Andrea Tura; Klaus Strassburger; Volker Burkart; Karsten Müssig; Daniel Markgraf; Hadi Al-Hasani; Julia Szendroedi; Michael Roden; A. E. Buyken; B. Belgardt; G. Geerling; H. Al-Hasani; C. Herder; A. Icks; J. Kotzka; O. Kuss; E. Lammert; D. Markgraf; K. Müssig; W. Rathmann; J. Szendroedi; D. Ziegler; M. Roden

Nature Publishing Group (NPG)

In: Nutrition and Diabetes

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Publication Date: 2018-09-08

Description: Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus, Published online: 07 September 2018; doi:10.1038/s41387-018-0054-9 Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus

Electronic ISSN: 2044-4052

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49

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Bright GFP with subnanosecond fluorescence lifetime (2018)

Anastasia V. Mamontova; Ilya D. Solovyev; Alexander P. Savitsky; Alexander М. Shakhov; Konstantin A. Lukyanov; Alexey M. Bogdanov

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-06

Description: Bright GFP with subnanosecond fluorescence lifetime Bright GFP with subnanosecond fluorescence lifetime, Published online: 05 September 2018; doi:10.1038/s41598-018-31687-w Bright GFP with subnanosecond fluorescence lifetime

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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50

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Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity (2018)

Saray Varona; Mar Orriols; María Galán; Anna Guadall; Laia Cañes; Silvia AguilóMarc Sirvent; José Martínez-González; Cristina Rodríguez

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-06

Description: Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity, Published online: 05 September 2018; doi:10.1038/s41598-018-31312-w Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity

Electronic ISSN: 2045-2322

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Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc (2018)

Vivien Yeh; Tsung-Yen Lee; Chung-Wen Chen; Pai-Chia Kuo; Jessie Shiue; Li-Kang Chu; Tsyr-Yan Yu

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-11

Description: Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc, Published online: 10 September 2018; doi:10.1038/s41598-018-31925-1 Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Reconstruction of the cropland cover changes in eastern China between the 10 th century and 13 th century using historical documents (2018)

Meijiao Li; Fanneng He; Shicheng Li; Fan Yang

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-11

Description: Reconstruction of the cropland cover changes in eastern China between the 10 th century and 13 th century using historical documents Reconstruction of the cropland cover changes in eastern China between the 10〈sup〉th〈/sup〉 century and 13〈sup〉th〈/sup〉 century using historical documents, Published online: 10 September 2018; doi:10.1038/s41598-018-31807-6 Reconstruction of the cropland cover changes in eastern China between the 10 th century and 13 th century using historical documents

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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53

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Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model (2018)

Claire M. Naftalin; Rupangi Verma; Meera Gurumurthy; Kim Hor Hee; Qingshu Lu; Benjamin Chaik Meng Yeo; Kin Hup Tan; Wenwei Lin; Buduo Yu; Kok Yong Seng; Lawrence Soon-U Lee; Nicholas I. Paton

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-11

Description: Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model, Published online: 10 September 2018; doi:10.1038/s41598-018-31590-4 Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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54

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Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia (2018)

Ebrahim Haroon; Xiangchuan Chen; Zhihao Li; Thrusharth Patel; Bobbi J. Woolwine; Xiaoping P. Hu; Jennifer C. Felger; Andrew H. Miller

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-11

Description: Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia, Published online: 10 September 2018; doi:10.1038/s41398-018-0241-4 Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia

Electronic ISSN: 2158-3188

Topics: Medicine

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55

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Tropical peatland carbon storage linked to global latitudinal trends in peat recalcitrance (2018)

Suzanne B. Hodgkins; Curtis J. Richardson; René Dommain; Hongjun Wang; Paul H. Glaser; Brittany Verbeke; B. Rose Winkler; Alexander R. Cobb; Virginia I. Rich; Malak Missilmani; Neal Flanagan; Mengchi Ho; Alison M. Hoyt; Charles F. Harvey; S. Rose Vining; Moira A. Hough; Tim R. Moore; Pierre J. H. Richard; Florentino B. De La Cruz; Joumana Toufaily; Rasha Hamdan; William T. Cooper; Jeffrey P. Chanton

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: Tropical peatland carbon storage linked to global latitudinal trends in peat recalcitrance Tropical peatland carbon storage linked to global latitudinal trends in peat recalcitrance, Published online: 07 September 2018; doi:10.1038/s41467-018-06050-2 Large peatlands exist at high latitudes because flooded conditions and cold temperatures slow decomposition, so the presence of (sub)tropical peat is enigmatic. Here the authors show that low-latitude peat is preserved due to lower carbohydrate and greater aromatic content resulting in chemical recalcitrance.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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56

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Boosting potassium-ion batteries by few-layered composite anodes prepared via solution-triggered one-step shear exfoliation (2018)

Yajie Liu; Zhixin Tai; Jian Zhang; Wei Kong Pang; Qing Zhang; Haifeng Feng; Konstantin Konstantinov; Zaiping Guo; Hua Kun Liu

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: Boosting potassium-ion batteries by few-layered composite anodes prepared via solution-triggered one-step shear exfoliation Boosting potassium-ion batteries by few-layered composite anodes prepared via solution-triggered one-step shear exfoliation, Published online: 07 September 2018; doi:10.1038/s41467-018-05786-1 Developing high-performance potassium-ion batteries remains a challenge. Here, the authors show that few-layered Sb2S3/carbon composite anode synthesized via simple exfoliation minimizes the volume changes during (de)intercalation of K+ ions with boosted rate performance and cyclability.

Electronic ISSN: 2041-1723

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57

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Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells (2018)

Claudia Isabelle Keller Valsecchi; M. Felicia Basilicata; Giuseppe Semplicio; Plamen Georgiev; Noel Marie Gutierrez; Asifa Akhtar

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells, Published online: 07 September 2018; doi:10.1038/s41467-018-05642-2 In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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58

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T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells (2018)

Hye-Ran Kim; Ye; Vin Mun; Kyung-Sik Lee; Yoo-Jin Park; Jeong-Su Park; Jin-Hwa Park; Bu-Nam Jeon; Chang-Hyun Kim; Youngsoo Jun; Young-Min Hyun; Minsoo Kim; Sang-Myeong Lee; Chul-Seung Park; Sin-Hyeog Im; Chang-Duk Jun

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells, Published online: 07 September 2018; doi:10.1038/s41467-018-06090-8 Microvilli can participate in adhesion or migration of T cells, but whether they are involved in function regulation is unclear. Here the authors show that T cell microvilli form budding vesicles containing T cell signalling components for deposition onto antigen presenting cells (APC) and modulation of APC functions.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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59

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A rationally designed JAZ subtype-selective agonist of jasmonate perception (2018)

Yousuke Takaoka; Mana Iwahashi; Andrea Chini; Hiroaki Saito; Yasuhiro Ishimaru; Syusuke Egoshi; Nobuki Kato; Maho Tanaka; Khurram Bashir; Motoaki Seki; Roberto Solano; Minoru Ueda

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-08

Description: A rationally designed JAZ subtype-selective agonist of jasmonate perception A rationally designed JAZ subtype-selective agonist of jasmonate perception, Published online: 07 September 2018; doi:10.1038/s41467-018-06135-y The phytohormone JA-Ile can promote plant resistance against herbivores and fungal pathogens but also inhibits growth, limiting its potential use in agriculture. Here, the authors design a stereoisomer of JA-Ile analog and demonstrate that it can promote defense while having minimal impact on growth.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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60

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Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer (2018)

Liwei Cao; Matthias Pauthner; Raiees Andrabi; Kimmo Rantalainen; Zachary Berndsen; Jolene K. Diedrich; Sergey Menis; Devin Sok; Raiza Bastidas; Sung-Kyu Robin Park; Claire M. Delahunty; Lin He; Javier Guenaga; Richard T. Wyatt; William R. Schief; Andrew B. Ward; John R. Yates IIIDennis R. Burton; James C. Paulson

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-13

Description: Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer, Published online: 12 September 2018; doi:10.1038/s41467-018-06121-4 HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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61

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Evolution of the quantum Hall bulk spectrum into chiral edge states (2018)

T. Patlatiuk; C. P. Scheller; D. Hill; Y. Tserkovnyak; G. Barak; A. Yacoby; L. N. Pfeiffer; K. W. West; D. M. Zumbühl

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-13

Description: Evolution of the quantum Hall bulk spectrum into chiral edge states Evolution of the quantum Hall bulk spectrum into chiral edge states, Published online: 12 September 2018; doi:10.1038/s41467-018-06025-3 The evolution of the quantum Hall state from bulk spectrum to edge state remains obscure. Here, Patlatiuk and Scheller et al. observe magnetic compression against a hard edge followed by motion into the bulk and depopulation of the integer quantum Hall edge states, in agreement with the bulk-to-edge correspondence.

Electronic ISSN: 2041-1723

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62

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Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells (2018)

Dana Elster; Marie Tollot; Karin Schlegelmilch; Alessandro Ori; Andreas Rosenwald; Erik Sahai; Björn von Eyss

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-13

Description: Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells, Published online: 12 September 2018; doi:10.1038/s41467-018-06266-2 Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

Electronic ISSN: 2041-1723

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63

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Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses (2018)

Kate M. Smith; Sofiya Tsimbalyuk; Megan R. Edwards; Emily M. Cross; Jyoti Batra; Tatiana P. Soares da Costa; David Aragão; Christopher F. Basler; Jade K. Forwood

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-13

Description: Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses, Published online: 12 September 2018; doi:10.1038/s41467-018-05928-5 Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the structural basis for isoform-specific cargo recognition.

Electronic ISSN: 2041-1723

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64

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STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas (2018)

Yi-Ru Pan; Chih-Cheng Chen; Yu-Tien Chan; Hsiao-Jung Wang; Fan-Tso Chien; Yeng-Long Chen; Jing-Lan Liu; Muh-Hwa Yang

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-13

Description: STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas, Published online: 12 September 2018; doi:10.1038/s41467-018-06134-z The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.

Electronic ISSN: 2041-1723

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65

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Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo (2018)

Jaakko K. Sarin; Nikae C. R. te Moller; Irina A. D. Mancini; Harold Brommer; Jetze Visser; Jos Malda; P. René van Weeren; Isaac O. Afara; Juha Töyräs

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone 〈i〉in vivo〈/i〉, Published online: 07 September 2018; doi:10.1038/s41598-018-31670-5 Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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66

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Parameter-Free Multiscale Simulation Realising Quantitative Prediction of Hole and Electron Mobilities in Organic Amorphous System with Multiple Frontier Orbitals (2018)

Shosei Kubo; Hironori Kaji

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Parameter-Free Multiscale Simulation Realising Quantitative Prediction of Hole and Electron Mobilities in Organic Amorphous System with Multiple Frontier Orbitals Parameter-Free Multiscale Simulation Realising Quantitative Prediction of Hole and Electron Mobilities in Organic Amorphous System with Multiple Frontier Orbitals, Published online: 07 September 2018; doi:10.1038/s41598-018-31722-w Parameter-Free Multiscale Simulation Realising Quantitative Prediction of Hole and Electron Mobilities in Organic Amorphous System with Multiple Frontier Orbitals

Electronic ISSN: 2045-2322

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67

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Organizational principles of multidimensional predictions in human auditory attention (2018)

Indiana Wollman; Benjamin Morillon

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Organizational principles of multidimensional predictions in human auditory attention Organizational principles of multidimensional predictions in human auditory attention, Published online: 07 September 2018; doi:10.1038/s41598-018-31878-5 Organizational principles of multidimensional predictions in human auditory attention

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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68

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Multi-scale interplays of biotic and abiotic drivers shape mammalian sub-continental diversity over millions of years (2018)

Juan L. Cantalapiedra; M. Soledad Domingo; Laura Domingo

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Multi-scale interplays of biotic and abiotic drivers shape mammalian sub-continental diversity over millions of years Multi-scale interplays of biotic and abiotic drivers shape mammalian sub-continental diversity over millions of years, Published online: 07 September 2018; doi:10.1038/s41598-018-31699-6 Multi-scale interplays of biotic and abiotic drivers shape mammalian sub-continental diversity over millions of years

Electronic ISSN: 2045-2322

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69

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Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease (2018)

Takenori Inomata; Masao Iwagami; Yoshimune Hiratsuka; Keiichi Fujimoto; Yuichi Okumura; Tina Shiang; Akira Murakami

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease, Published online: 07 September 2018; doi:10.1038/s41598-018-31814-7 Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease

Electronic ISSN: 2045-2322

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70

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Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection (2018)

Hao Chen; Sriram Ambadapadi; Dara Wakefield; Meeyong Bartee; Jordan R. Yaron; Liqiang Zhang; Stephanie A. Archer-Hartmann; Parastoo Azadi; Michelle Burgin; Chad Borges; Donghang Zheng; Kevin Ergle; Vishnu Muppala; Sufi Morshed; Kenneth Rand; William Clapp; Amanda Proudfoot; Alexandra Lucas

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-08

Description: Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection, Published online: 07 September 2018; doi:10.1038/s41598-018-31779-7 Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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71

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Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex (2018)

Colleen A. Hanlon; Logan T. Dowdle; Nicole B. Gibson; Xingbao Li; Sarah Hamilton; Melanie Canterberry; Michaela Hoffman

Nature Publishing Group (NPG)

In: Translational Psychiatry

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Publication Date: 2018-09-08

Description: Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex, Published online: 07 September 2018; doi:10.1038/s41398-018-0220-9 Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex

Electronic ISSN: 2158-3188

Topics: Medicine

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72

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Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study (2018)

Y. E. Lentferink; M. P. van der Aa; E. G. A. H. van Mill; C. A. J. Knibbe; M. M. J. van der Vorst

Nature Publishing Group (NPG)

In: Nutrition and Diabetes

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Publication Date: 2018-09-10

Description: Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study, Published online: 10 September 2018; doi:10.1038/s41387-018-0057-6 Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

Electronic ISSN: 2044-4052

Topics: Medicine

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73

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Alterations of blood pulsations parameters in carotid basin due to body position change (2018)

Alexei A. Kamshilin; Tatiana V. Krasnikova; Maxim A. Volynsky; Serguei V. Miridonov; Oleg V. Mamontov

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-13

Description: Alterations of blood pulsations parameters in carotid basin due to body position change Alterations of blood pulsations parameters in carotid basin due to body position change, Published online: 12 September 2018; doi:10.1038/s41598-018-32036-7 Alterations of blood pulsations parameters in carotid basin due to body position change

Electronic ISSN: 2045-2322

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74

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Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens (2018)

Natacha Couto; Leonard Schuele; Erwin C. Raangs; Miguel P. Machado; Catarina I. Mendes; Tiago F. Jesus; Monika Chlebowicz; Sigrid Rosema; Mário Ramirez; João A. Carriço; Ingo B. Autenrieth; Alex W. Friedrich; Silke Peter; John W. Rossen

Nature Publishing Group (NPG)

In: Scientific Reports

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Publication Date: 2018-09-14

Description: Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens, Published online: 13 September 2018; doi:10.1038/s41598-018-31873-w Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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75

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Aerosol-induced intensification of cooling effect of clouds during Indian summer monsoon (2018)

Chandan Sarangi; Vijay P. Kanawade; Sachchida N. Tripathi; Abin Thomas; Dilip Ganguly

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-15

Description: Aerosol-induced intensification of cooling effect of clouds during Indian summer monsoon Aerosol-induced intensification of cooling effect of clouds during Indian summer monsoon, Published online: 14 September 2018; doi:10.1038/s41467-018-06015-5 The invigoration of deep convective clouds in the Indian summer monsoon region is associated with high aerosol loading. Here the authors show that convective clouds from high aerosol loads in the Indian Summer Monsoon region have a cooling effect.

Electronic ISSN: 2041-1723

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76

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Modular DNA strand-displacement controllers for directing material expansion (2018)

Joshua Fern; Rebecca Schulman

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-15

Description: Modular DNA strand-displacement controllers for directing material expansion Modular DNA strand-displacement controllers for directing material expansion, Published online: 14 September 2018; doi:10.1038/s41467-018-06218-w Materials which change shape in response to a trigger are of interest for soft robotics and targeted therapeutic delivery. Here, the authors report on the development of DNA-crosslinked hydrogels which can expand upon the detection of different biomolecular inputs mediated by DNA strand-displacement.

Electronic ISSN: 2041-1723

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77

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Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure (2018)

Christiaan A. de Leeuw; Sven Stringer; Ilona A. Dekkers; Tom Heskes; Danielle Posthuma

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-15

Description: Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure, Published online: 14 September 2018; doi:10.1038/s41467-018-06022-6 Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.

Electronic ISSN: 2041-1723

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78

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Mapping a hidden terrane boundary in the mantle lithosphere with lamprophyres (2018)

Arjan H. Dijkstra; Callum Hatch

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-15

Description: Mapping a hidden terrane boundary in the mantle lithosphere with lamprophyres Mapping a hidden terrane boundary in the mantle lithosphere with lamprophyres, Published online: 14 September 2018; doi:10.1038/s41467-018-06253-7 Lamprophyres represent hydrous alkaline mantle melts that are a unique source of information about the composition of continental lithosphere. Here the authors use isotopic compositions of lamprophyres to map a hidden terrain boundary and an unknown fragment of Armorica in the mantle lithosphere of southwest Britain.

Electronic ISSN: 2041-1723

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79

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Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization (2018)

Chih-Chan Lee; Jiunn-Chang Lin; Wei-Lun Hwang; Ying-Ju Kuo; Hung-Kai Chen; Shyh-Kuan Tai; Chun-Chi Lin; Muh-Hwa Yang

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-15

Description: Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization, Published online: 14 September 2018; doi:10.1038/s41467-018-06268-0 Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

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MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology (2018)

Guogui Sun; Xiao Ding; Nan Bi; Lihong Wu; Jingbo Wang; Wen; Jue Zhang; Xin Dong; Ning Lv; Yongmei Song; Qimin Zhan; Lu; Hua Wang

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-18

Description: MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology, Published online: 17 September 2018; doi:10.1038/s41419-018-0955-5 MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

Published by Nature Publishing Group (NPG)

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Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro (2018)

Hanhui Zhong; Rui Song; Qiongni Pang; Yawei Liu; Jinling Zhuang; Yeming Chen; Jijie Hu; Jian Hu; Youtan Liu; Zhifeng Liu; Jing Tang

Nature Publishing Group (NPG)

In: Cell Death & Disease

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Publication Date: 2018-09-18

Description: Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro, Published online: 17 September 2018; doi:10.1038/s41419-018-0996-9 Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro

Electronic ISSN: 2041-4889

Topics: Biology , Medicine

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A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis (2018)

Jinbo Shen; Qiong Zhao; Xiangfeng Wang; Caiji Gao; Ying Zhu; Yonglun Zeng; Liwen Jiang

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-18

Description: A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis, Published online: 17 September 2018; doi:10.1038/s41467-018-05913-y The ESCRT complex contributes to selective vacuolar degradation of membrane proteins. Here, the authors show that the plant-specific BRAF protein negatively regulates intraluminal vesicle formation and membrane protein degradation by preventing FREE1 binding to the ESCRT-I complex protein Vps23.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Three-dimensional X-ray diffraction imaging of dislocations in polycrystalline metals under tensile loading (2018)

Mathew J. Cherukara; Reeju Pokharel; Timothy S. O’Leary; J. Kevin Baldwin; Evan Maxey; Wonsuk Cha; Jorg Maser; Ross J. Harder; Saryu J. Fensin; Richard L. Sandberg

Nature Publishing Group (NPG)

In: Nature Communications

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Publication Date: 2018-09-18